Amino acid dipepetide frequency for Bhargavaea cecembensis DSE10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.725AlaAla: 9.725 ± 0.132
0.571AlaCys: 0.571 ± 0.025
5.325AlaAsp: 5.325 ± 0.084
7.156AlaGlu: 7.156 ± 0.105
3.886AlaPhe: 3.886 ± 0.073
8.719AlaGly: 8.719 ± 0.107
1.576AlaHis: 1.576 ± 0.042
5.931AlaIle: 5.931 ± 0.082
3.957AlaLys: 3.957 ± 0.073
8.629AlaLeu: 8.629 ± 0.106
2.582AlaMet: 2.582 ± 0.057
2.255AlaAsn: 2.255 ± 0.056
2.806AlaPro: 2.806 ± 0.066
2.347AlaGln: 2.347 ± 0.049
3.957AlaArg: 3.957 ± 0.064
4.582AlaSer: 4.582 ± 0.073
3.682AlaThr: 3.682 ± 0.061
7.569AlaVal: 7.569 ± 0.102
0.803AlaTrp: 0.803 ± 0.034
2.597AlaTyr: 2.597 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
0.402CysAla: 0.402 ± 0.022
0.064CysCys: 0.064 ± 0.008
0.331CysAsp: 0.331 ± 0.019
0.351CysGlu: 0.351 ± 0.019
0.205CysPhe: 0.205 ± 0.015
0.711CysGly: 0.711 ± 0.031
0.174CysHis: 0.174 ± 0.014
0.374CysIle: 0.374 ± 0.027
0.185CysLys: 0.185 ± 0.015
0.528CysLeu: 0.528 ± 0.026
0.152CysMet: 0.152 ± 0.014
0.197CysAsn: 0.197 ± 0.015
0.372CysPro: 0.372 ± 0.02
0.128CysGln: 0.128 ± 0.012
0.39CysArg: 0.39 ± 0.02
0.395CysSer: 0.395 ± 0.023
0.346CysThr: 0.346 ± 0.019
0.323CysVal: 0.323 ± 0.02
0.055CysTrp: 0.055 ± 0.008
0.159CysTyr: 0.159 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.708AspAla: 4.708 ± 0.083
0.321AspCys: 0.321 ± 0.019
2.882AspAsp: 2.882 ± 0.07
4.933AspGlu: 4.933 ± 0.074
2.437AspPhe: 2.437 ± 0.053
4.979AspGly: 4.979 ± 0.098
1.239AspHis: 1.239 ± 0.034
3.51AspIle: 3.51 ± 0.058
2.363AspLys: 2.363 ± 0.061
5.126AspLeu: 5.126 ± 0.08
1.499AspMet: 1.499 ± 0.043
1.497AspAsn: 1.497 ± 0.042
2.818AspPro: 2.818 ± 0.058
1.686AspGln: 1.686 ± 0.045
3.583AspArg: 3.583 ± 0.067
2.725AspSer: 2.725 ± 0.062
2.573AspThr: 2.573 ± 0.048
4.159AspVal: 4.159 ± 0.077
0.723AspTrp: 0.723 ± 0.029
2.012AspTyr: 2.012 ± 0.047
0.0AspXaa: 0.0 ± 0.0
Glu
7.431GluAla: 7.431 ± 0.115
0.321GluCys: 0.321 ± 0.018
4.408GluAsp: 4.408 ± 0.075
8.001GluGlu: 8.001 ± 0.132
2.573GluPhe: 2.573 ± 0.056
5.751GluGly: 5.751 ± 0.088
1.488GluHis: 1.488 ± 0.043
4.728GluIle: 4.728 ± 0.086
4.996GluLys: 4.996 ± 0.092
7.093GluLeu: 7.093 ± 0.089
2.409GluMet: 2.409 ± 0.058
2.715GluAsn: 2.715 ± 0.057
2.769GluPro: 2.769 ± 0.062
3.202GluGln: 3.202 ± 0.065
4.69GluArg: 4.69 ± 0.085
3.673GluSer: 3.673 ± 0.061
4.417GluThr: 4.417 ± 0.072
5.077GluVal: 5.077 ± 0.077
0.92GluTrp: 0.92 ± 0.033
1.975GluTyr: 1.975 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
3.494PheAla: 3.494 ± 0.066
0.279PheCys: 0.279 ± 0.019
2.474PheAsp: 2.474 ± 0.05
2.664PheGlu: 2.664 ± 0.05
2.065PhePhe: 2.065 ± 0.055
4.04PheGly: 4.04 ± 0.066
0.891PheHis: 0.891 ± 0.034
3.241PheIle: 3.241 ± 0.066
1.633PheLys: 1.633 ± 0.043
4.204PheLeu: 4.204 ± 0.083
1.197PheMet: 1.197 ± 0.038
1.394PheAsn: 1.394 ± 0.043
1.615PhePro: 1.615 ± 0.039
1.049PheGln: 1.049 ± 0.032
2.464PheArg: 2.464 ± 0.06
2.804PheSer: 2.804 ± 0.062
2.544PheThr: 2.544 ± 0.065
3.012PheVal: 3.012 ± 0.062
0.515PheTrp: 0.515 ± 0.028
1.427PheTyr: 1.427 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
6.748GlyAla: 6.748 ± 0.086
0.556GlyCys: 0.556 ± 0.026
4.153GlyAsp: 4.153 ± 0.077
5.997GlyGlu: 5.997 ± 0.088
3.676GlyPhe: 3.676 ± 0.065
6.715GlyGly: 6.715 ± 0.11
1.769GlyHis: 1.769 ± 0.043
6.266GlyIle: 6.266 ± 0.086
5.049GlyLys: 5.049 ± 0.085
7.793GlyLeu: 7.793 ± 0.095
2.643GlyMet: 2.643 ± 0.055
2.75GlyAsn: 2.75 ± 0.06
2.553GlyPro: 2.553 ± 0.057
2.535GlyGln: 2.535 ± 0.055
4.604GlyArg: 4.604 ± 0.072
4.584GlySer: 4.584 ± 0.079
5.05GlyThr: 5.05 ± 0.074
5.726GlyVal: 5.726 ± 0.091
0.989GlyTrp: 0.989 ± 0.033
2.814GlyTyr: 2.814 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.717HisAla: 1.717 ± 0.04
0.15HisCys: 0.15 ± 0.012
1.143HisAsp: 1.143 ± 0.032
1.489HisGlu: 1.489 ± 0.043
0.921HisPhe: 0.921 ± 0.034
1.671HisGly: 1.671 ± 0.045
0.596HisHis: 0.596 ± 0.026
1.173HisIle: 1.173 ± 0.039
0.651HisLys: 0.651 ± 0.029
2.083HisLeu: 2.083 ± 0.043
0.536HisMet: 0.536 ± 0.024
0.525HisAsn: 0.525 ± 0.021
1.401HisPro: 1.401 ± 0.042
0.674HisGln: 0.674 ± 0.024
1.157HisArg: 1.157 ± 0.04
1.109HisSer: 1.109 ± 0.037
0.966HisThr: 0.966 ± 0.038
1.432HisVal: 1.432 ± 0.038
0.207HisTrp: 0.207 ± 0.014
0.71HisTyr: 0.71 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.38IleAla: 6.38 ± 0.082
0.461IleCys: 0.461 ± 0.025
3.712IleAsp: 3.712 ± 0.067
4.499IleGlu: 4.499 ± 0.062
2.474IlePhe: 2.474 ± 0.059
6.263IleGly: 6.263 ± 0.082
1.421IleHis: 1.421 ± 0.039
4.326IleIle: 4.326 ± 0.086
2.282IleLys: 2.282 ± 0.054
6.346IleLeu: 6.346 ± 0.101
1.552IleMet: 1.552 ± 0.046
1.878IleAsn: 1.878 ± 0.043
3.23IlePro: 3.23 ± 0.067
1.845IleGln: 1.845 ± 0.049
4.744IleArg: 4.744 ± 0.079
3.903IleSer: 3.903 ± 0.069
3.638IleThr: 3.638 ± 0.068
4.917IleVal: 4.917 ± 0.087
0.592IleTrp: 0.592 ± 0.024
1.714IleTyr: 1.714 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.321LysAla: 4.321 ± 0.075
0.175LysCys: 0.175 ± 0.014
2.864LysAsp: 2.864 ± 0.051
4.842LysGlu: 4.842 ± 0.08
1.525LysPhe: 1.525 ± 0.044
3.774LysGly: 3.774 ± 0.06
0.877LysHis: 0.877 ± 0.031
2.921LysIle: 2.921 ± 0.061
3.603LysLys: 3.603 ± 0.074
4.36LysLeu: 4.36 ± 0.073
1.674LysMet: 1.674 ± 0.044
1.875LysAsn: 1.875 ± 0.051
2.123LysPro: 2.123 ± 0.047
1.943LysGln: 1.943 ± 0.047
2.967LysArg: 2.967 ± 0.053
2.618LysSer: 2.618 ± 0.054
2.94LysThr: 2.94 ± 0.06
3.596LysVal: 3.596 ± 0.07
0.624LysTrp: 0.624 ± 0.027
1.382LysTyr: 1.382 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
8.769LeuAla: 8.769 ± 0.105
0.579LeuCys: 0.579 ± 0.025
5.191LeuAsp: 5.191 ± 0.079
6.642LeuGlu: 6.642 ± 0.084
4.784LeuPhe: 4.784 ± 0.094
7.246LeuGly: 7.246 ± 0.086
1.847LeuHis: 1.847 ± 0.046
6.622LeuIle: 6.622 ± 0.1
5.245LeuLys: 5.245 ± 0.078
9.802LeuLeu: 9.802 ± 0.157
2.661LeuMet: 2.661 ± 0.059
3.281LeuAsn: 3.281 ± 0.062
4.42LeuPro: 4.42 ± 0.063
2.827LeuGln: 2.827 ± 0.055
4.588LeuArg: 4.588 ± 0.072
6.409LeuSer: 6.409 ± 0.084
5.368LeuThr: 5.368 ± 0.081
6.2LeuVal: 6.2 ± 0.101
0.8LeuTrp: 0.8 ± 0.031
2.909LeuTyr: 2.909 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.681MetAla: 2.681 ± 0.051
0.124MetCys: 0.124 ± 0.013
1.768MetAsp: 1.768 ± 0.05
2.262MetGlu: 2.262 ± 0.052
1.081MetPhe: 1.081 ± 0.035
1.909MetGly: 1.909 ± 0.047
0.459MetHis: 0.459 ± 0.023
1.961MetIle: 1.961 ± 0.045
2.211MetLys: 2.211 ± 0.05
2.639MetLeu: 2.639 ± 0.049
0.907MetMet: 0.907 ± 0.033
1.366MetAsn: 1.366 ± 0.041
1.273MetPro: 1.273 ± 0.038
0.889MetGln: 0.889 ± 0.029
1.334MetArg: 1.334 ± 0.035
1.544MetSer: 1.544 ± 0.038
2.05MetThr: 2.05 ± 0.045
1.682MetVal: 1.682 ± 0.045
0.194MetTrp: 0.194 ± 0.015
0.72MetTyr: 0.72 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.614AsnAla: 2.614 ± 0.053
0.208AsnCys: 0.208 ± 0.016
1.706AsnAsp: 1.706 ± 0.052
2.343AsnGlu: 2.343 ± 0.047
1.259AsnPhe: 1.259 ± 0.039
2.866AsnGly: 2.866 ± 0.068
0.706AsnHis: 0.706 ± 0.029
2.117AsnIle: 2.117 ± 0.043
1.452AsnLys: 1.452 ± 0.042
2.975AsnLeu: 2.975 ± 0.061
1.016AsnMet: 1.016 ± 0.034
1.093AsnAsn: 1.093 ± 0.045
1.989AsnPro: 1.989 ± 0.043
1.027AsnGln: 1.027 ± 0.039
2.101AsnArg: 2.101 ± 0.054
1.55AsnSer: 1.55 ± 0.04
1.644AsnThr: 1.644 ± 0.044
2.381AsnVal: 2.381 ± 0.057
0.384AsnTrp: 0.384 ± 0.021
0.976AsnTyr: 0.976 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
3.978ProAla: 3.978 ± 0.074
0.185ProCys: 0.185 ± 0.014
3.141ProAsp: 3.141 ± 0.059
4.47ProGlu: 4.47 ± 0.086
2.062ProPhe: 2.062 ± 0.05
3.603ProGly: 3.603 ± 0.063
0.917ProHis: 0.917 ± 0.035
2.34ProIle: 2.34 ± 0.052
1.89ProLys: 1.89 ± 0.043
3.727ProLeu: 3.727 ± 0.055
1.013ProMet: 1.013 ± 0.038
1.263ProAsn: 1.263 ± 0.042
1.307ProPro: 1.307 ± 0.046
1.109ProGln: 1.109 ± 0.035
1.347ProArg: 1.347 ± 0.035
2.308ProSer: 2.308 ± 0.051
1.73ProThr: 1.73 ± 0.044
4.03ProVal: 4.03 ± 0.069
0.359ProTrp: 0.359 ± 0.019
1.358ProTyr: 1.358 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.874GlnAla: 2.874 ± 0.055
0.144GlnCys: 0.144 ± 0.015
1.515GlnAsp: 1.515 ± 0.042
2.576GlnGlu: 2.576 ± 0.052
1.234GlnPhe: 1.234 ± 0.034
1.94GlnGly: 1.94 ± 0.049
0.584GlnHis: 0.584 ± 0.024
1.901GlnIle: 1.901 ± 0.042
1.674GlnLys: 1.674 ± 0.038
3.14GlnLeu: 3.14 ± 0.062
1.027GlnMet: 1.027 ± 0.039
1.095GlnAsn: 1.095 ± 0.035
1.283GlnPro: 1.283 ± 0.038
1.255GlnGln: 1.255 ± 0.044
1.505GlnArg: 1.505 ± 0.043
1.718GlnSer: 1.718 ± 0.045
1.546GlnThr: 1.546 ± 0.041
2.152GlnVal: 2.152 ± 0.043
0.36GlnTrp: 0.36 ± 0.021
0.99GlnTyr: 0.99 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
3.909ArgAla: 3.909 ± 0.077
0.3ArgCys: 0.3 ± 0.018
2.919ArgAsp: 2.919 ± 0.056
4.886ArgGlu: 4.886 ± 0.077
2.577ArgPhe: 2.577 ± 0.051
3.288ArgGly: 3.288 ± 0.06
1.288ArgHis: 1.288 ± 0.04
3.608ArgIle: 3.608 ± 0.063
3.549ArgLys: 3.549 ± 0.06
5.65ArgLeu: 5.65 ± 0.088
1.832ArgMet: 1.832 ± 0.044
1.986ArgAsn: 1.986 ± 0.044
2.163ArgPro: 2.163 ± 0.05
2.086ArgGln: 2.086 ± 0.044
3.156ArgArg: 3.156 ± 0.071
2.865ArgSer: 2.865 ± 0.061
2.986ArgThr: 2.986 ± 0.06
3.336ArgVal: 3.336 ± 0.066
0.543ArgTrp: 0.543 ± 0.024
1.751ArgTyr: 1.751 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.716SerAla: 4.716 ± 0.076
0.33SerCys: 0.33 ± 0.021
2.991SerAsp: 2.991 ± 0.056
3.879SerGlu: 3.879 ± 0.065
2.748SerPhe: 2.748 ± 0.053
5.778SerGly: 5.778 ± 0.088
1.103SerHis: 1.103 ± 0.034
3.568SerIle: 3.568 ± 0.063
2.403SerLys: 2.403 ± 0.053
5.372SerLeu: 5.372 ± 0.069
1.687SerMet: 1.687 ± 0.046
1.616SerAsn: 1.616 ± 0.046
2.334SerPro: 2.334 ± 0.05
1.447SerGln: 1.447 ± 0.033
3.059SerArg: 3.059 ± 0.06
3.042SerSer: 3.042 ± 0.064
2.581SerThr: 2.581 ± 0.052
4.493SerVal: 4.493 ± 0.07
0.57SerTrp: 0.57 ± 0.029
1.737SerTyr: 1.737 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.206ThrAla: 5.206 ± 0.078
0.281ThrCys: 0.281 ± 0.019
3.268ThrAsp: 3.268 ± 0.06
4.014ThrGlu: 4.014 ± 0.071
2.338ThrPhe: 2.338 ± 0.058
5.287ThrGly: 5.287 ± 0.082
0.999ThrHis: 0.999 ± 0.031
3.572ThrIle: 3.572 ± 0.064
2.321ThrLys: 2.321 ± 0.054
5.042ThrLeu: 5.042 ± 0.076
1.322ThrMet: 1.322 ± 0.04
1.597ThrAsn: 1.597 ± 0.045
2.488ThrPro: 2.488 ± 0.046
1.154ThrGln: 1.154 ± 0.03
2.184ThrArg: 2.184 ± 0.047
2.762ThrSer: 2.762 ± 0.057
2.54ThrThr: 2.54 ± 0.063
4.996ThrVal: 4.996 ± 0.077
0.463ThrTrp: 0.463 ± 0.02
1.752ThrTyr: 1.752 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
5.893ValAla: 5.893 ± 0.083
0.515ValCys: 0.515 ± 0.025
3.635ValAsp: 3.635 ± 0.067
4.604ValGlu: 4.604 ± 0.082
3.283ValPhe: 3.283 ± 0.067
4.986ValGly: 4.986 ± 0.084
1.508ValHis: 1.508 ± 0.037
5.451ValIle: 5.451 ± 0.089
3.637ValLys: 3.637 ± 0.059
7.558ValLeu: 7.558 ± 0.104
2.105ValMet: 2.105 ± 0.05
2.556ValAsn: 2.556 ± 0.059
3.474ValPro: 3.474 ± 0.063
2.057ValGln: 2.057 ± 0.044
4.421ValArg: 4.421 ± 0.071
4.505ValSer: 4.505 ± 0.067
4.675ValThr: 4.675 ± 0.069
5.134ValVal: 5.134 ± 0.088
0.68ValTrp: 0.68 ± 0.031
2.148ValTyr: 2.148 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.746TrpAla: 0.746 ± 0.029
0.072TrpCys: 0.072 ± 0.009
0.498TrpAsp: 0.498 ± 0.024
0.677TrpGlu: 0.677 ± 0.027
0.508TrpPhe: 0.508 ± 0.026
0.716TrpGly: 0.716 ± 0.029
0.238TrpHis: 0.238 ± 0.017
0.76TrpIle: 0.76 ± 0.031
0.592TrpLys: 0.592 ± 0.027
1.167TrpLeu: 1.167 ± 0.04
0.4TrpMet: 0.4 ± 0.021
0.466TrpAsn: 0.466 ± 0.02
0.339TrpPro: 0.339 ± 0.02
0.337TrpGln: 0.337 ± 0.02
0.506TrpArg: 0.506 ± 0.024
0.582TrpSer: 0.582 ± 0.024
0.637TrpThr: 0.637 ± 0.028
0.612TrpVal: 0.612 ± 0.027
0.158TrpTrp: 0.158 ± 0.014
0.293TrpTyr: 0.293 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.344TyrAla: 2.344 ± 0.054
0.206TyrCys: 0.206 ± 0.016
1.85TyrAsp: 1.85 ± 0.055
2.35TyrGlu: 2.35 ± 0.047
1.373TyrPhe: 1.373 ± 0.044
2.727TyrGly: 2.727 ± 0.059
0.632TyrHis: 0.632 ± 0.026
1.809TyrIle: 1.809 ± 0.041
1.312TyrLys: 1.312 ± 0.042
2.954TyrLeu: 2.954 ± 0.069
0.837TyrMet: 0.837 ± 0.028
1.003TyrAsn: 1.003 ± 0.035
1.38TyrPro: 1.38 ± 0.04
0.915TyrGln: 0.915 ± 0.031
1.919TyrArg: 1.919 ± 0.038
1.776TyrSer: 1.776 ± 0.046
1.672TyrThr: 1.672 ± 0.038
1.998TyrVal: 1.998 ± 0.05
0.366TyrTrp: 0.366 ± 0.02
1.052TyrTyr: 1.052 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3168 proteins (941780 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski