Amino acid dipepetide frequency for Exophiala aquamarina CBS 119918

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.685AlaAla: 8.685 ± 0.052	1.074AlaCys: 1.074 ± 0.014	4.197AlaAsp: 4.197 ± 0.031	4.893AlaGlu: 4.893 ± 0.032	3.368AlaPhe: 3.368 ± 0.026	5.954AlaGly: 5.954 ± 0.037	1.813AlaHis: 1.813 ± 0.018	4.644AlaIle: 4.644 ± 0.031	4.035AlaLys: 4.035 ± 0.032	7.985AlaLeu: 7.985 ± 0.037	1.954AlaMet: 1.954 ± 0.019	3.057AlaAsn: 3.057 ± 0.023	4.315AlaPro: 4.315 ± 0.035	3.427AlaGln: 3.427 ± 0.027	4.869AlaArg: 4.869 ± 0.032	7.156AlaSer: 7.156 ± 0.035	5.425AlaThr: 5.425 ± 0.031	5.429AlaVal: 5.429 ± 0.031	1.206AlaTrp: 1.206 ± 0.016	2.245AlaTyr: 2.245 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.969CysAla: 0.969 ± 0.014	0.225CysCys: 0.225 ± 0.007	0.627CysAsp: 0.627 ± 0.01	0.573CysGlu: 0.573 ± 0.009	0.572CysPhe: 0.572 ± 0.01	0.91CysGly: 0.91 ± 0.015	0.321CysHis: 0.321 ± 0.008	0.743CysIle: 0.743 ± 0.012	0.486CysLys: 0.486 ± 0.009	1.291CysLeu: 1.291 ± 0.015	0.269CysMet: 0.269 ± 0.006	0.409CysAsn: 0.409 ± 0.009	0.601CysPro: 0.601 ± 0.012	0.44CysGln: 0.44 ± 0.009	0.719CysArg: 0.719 ± 0.011	0.869CysSer: 0.869 ± 0.013	0.686CysThr: 0.686 ± 0.012	0.785CysVal: 0.785 ± 0.014	0.211CysTrp: 0.211 ± 0.006	0.355CysTyr: 0.355 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.56AspAla: 4.56 ± 0.03	0.596AspCys: 0.596 ± 0.011	4.007AspAsp: 4.007 ± 0.043	4.181AspGlu: 4.181 ± 0.031	2.295AspPhe: 2.295 ± 0.02	3.902AspGly: 3.902 ± 0.032	1.328AspHis: 1.328 ± 0.016	3.087AspIle: 3.087 ± 0.026	2.317AspLys: 2.317 ± 0.021	5.272AspLeu: 5.272 ± 0.03	1.182AspMet: 1.182 ± 0.014	1.85AspAsn: 1.85 ± 0.019	3.345AspPro: 3.345 ± 0.026	2.042AspGln: 2.042 ± 0.021	3.039AspArg: 3.039 ± 0.025	4.067AspSer: 4.067 ± 0.027	2.881AspThr: 2.881 ± 0.022	3.657AspVal: 3.657 ± 0.026	0.903AspTrp: 0.903 ± 0.014	1.59AspTyr: 1.59 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.142GluAla: 5.142 ± 0.032	0.564GluCys: 0.564 ± 0.01	3.925GluAsp: 3.925 ± 0.033	4.649GluGlu: 4.649 ± 0.043	1.932GluPhe: 1.932 ± 0.017	3.53GluGly: 3.53 ± 0.027	1.427GluHis: 1.427 ± 0.017	3.19GluIle: 3.19 ± 0.023	3.492GluLys: 3.492 ± 0.027	5.125GluLeu: 5.125 ± 0.035	1.381GluMet: 1.381 ± 0.016	2.275GluAsn: 2.275 ± 0.021	2.518GluPro: 2.518 ± 0.023	2.443GluGln: 2.443 ± 0.022	3.684GluArg: 3.684 ± 0.028	4.127GluSer: 4.127 ± 0.028	3.341GluThr: 3.341 ± 0.022	3.54GluVal: 3.54 ± 0.026	0.862GluTrp: 0.862 ± 0.013	1.625GluTyr: 1.625 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.215PheAla: 3.215 ± 0.028	0.589PheCys: 0.589 ± 0.01	2.388PheAsp: 2.388 ± 0.018	2.223PheGlu: 2.223 ± 0.018	1.713PhePhe: 1.713 ± 0.023	3.06PheGly: 3.06 ± 0.026	0.92PheHis: 0.92 ± 0.013	1.948PheIle: 1.948 ± 0.02	1.528PheLys: 1.528 ± 0.016	3.756PheLeu: 3.756 ± 0.031	0.818PheMet: 0.818 ± 0.013	1.493PheAsn: 1.493 ± 0.016	1.991PhePro: 1.991 ± 0.019	1.487PheGln: 1.487 ± 0.015	1.969PheArg: 1.969 ± 0.02	3.105PheSer: 3.105 ± 0.025	2.219PheThr: 2.219 ± 0.021	2.525PheVal: 2.525 ± 0.023	0.683PheTrp: 0.683 ± 0.011	1.162PheTyr: 1.162 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.417GlyAla: 5.417 ± 0.037	0.854GlyCys: 0.854 ± 0.015	3.463GlyAsp: 3.463 ± 0.027	3.405GlyGlu: 3.405 ± 0.028	3.017GlyPhe: 3.017 ± 0.025	5.695GlyGly: 5.695 ± 0.05	1.74GlyHis: 1.74 ± 0.019	3.786GlyIle: 3.786 ± 0.028	3.417GlyLys: 3.417 ± 0.029	6.465GlyLeu: 6.465 ± 0.038	1.643GlyMet: 1.643 ± 0.016	2.491GlyAsn: 2.491 ± 0.021	3.295GlyPro: 3.295 ± 0.025	2.662GlyGln: 2.662 ± 0.022	4.073GlyArg: 4.073 ± 0.031	5.573GlySer: 5.573 ± 0.032	4.065GlyThr: 4.065 ± 0.029	4.474GlyVal: 4.474 ± 0.033	1.19GlyTrp: 1.19 ± 0.016	2.179GlyTyr: 2.179 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.911HisAla: 1.911 ± 0.017	0.335HisCys: 0.335 ± 0.008	1.382HisAsp: 1.382 ± 0.015	1.378HisGlu: 1.378 ± 0.014	0.994HisPhe: 0.994 ± 0.013	1.759HisGly: 1.759 ± 0.018	0.842HisHis: 0.842 ± 0.015	1.268HisIle: 1.268 ± 0.014	0.964HisLys: 0.964 ± 0.012	2.365HisLeu: 2.365 ± 0.02	0.502HisMet: 0.502 ± 0.009	0.873HisAsn: 0.873 ± 0.012	1.655HisPro: 1.655 ± 0.018	1.044HisGln: 1.044 ± 0.016	1.548HisArg: 1.548 ± 0.017	1.864HisSer: 1.864 ± 0.021	1.278HisThr: 1.278 ± 0.016	1.479HisVal: 1.479 ± 0.017	0.376HisTrp: 0.376 ± 0.008	0.713HisTyr: 0.713 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.545IleAla: 4.545 ± 0.031	0.801IleCys: 0.801 ± 0.014	3.019IleAsp: 3.019 ± 0.022	2.966IleGlu: 2.966 ± 0.025	2.172IlePhe: 2.172 ± 0.021	3.542IleGly: 3.542 ± 0.028	1.263IleHis: 1.263 ± 0.014	2.684IleIle: 2.684 ± 0.027	2.181IleLys: 2.181 ± 0.017	4.909IleLeu: 4.909 ± 0.033	1.032IleMet: 1.032 ± 0.013	1.919IleAsn: 1.919 ± 0.019	3.176IlePro: 3.176 ± 0.022	2.007IleGln: 2.007 ± 0.016	2.756IleArg: 2.756 ± 0.022	4.178IleSer: 4.178 ± 0.03	2.992IleThr: 2.992 ± 0.024	3.387IleVal: 3.387 ± 0.028	0.79IleTrp: 0.79 ± 0.011	1.5IleTyr: 1.5 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.259LysAla: 4.259 ± 0.031	0.496LysCys: 0.496 ± 0.01	2.813LysAsp: 2.813 ± 0.023	3.09LysGlu: 3.09 ± 0.028	1.548LysPhe: 1.548 ± 0.018	2.889LysGly: 2.889 ± 0.021	1.205LysHis: 1.205 ± 0.014	2.362LysIle: 2.362 ± 0.02	2.927LysLys: 2.927 ± 0.036	4.088LysLeu: 4.088 ± 0.027	0.967LysMet: 0.967 ± 0.012	1.683LysAsn: 1.683 ± 0.018	2.573LysPro: 2.573 ± 0.025	1.878LysGln: 1.878 ± 0.018	3.22LysArg: 3.22 ± 0.028	3.548LysSer: 3.548 ± 0.027	2.766LysThr: 2.766 ± 0.023	2.879LysVal: 2.879 ± 0.026	0.706LysTrp: 0.706 ± 0.011	1.417LysTyr: 1.417 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.078LeuAla: 8.078 ± 0.042	1.235LeuCys: 1.235 ± 0.017	5.305LeuAsp: 5.305 ± 0.033	5.541LeuGlu: 5.541 ± 0.032	3.486LeuPhe: 3.486 ± 0.024	6.227LeuGly: 6.227 ± 0.036	2.321LeuHis: 2.321 ± 0.021	4.303LeuIle: 4.303 ± 0.03	4.3LeuLys: 4.3 ± 0.031	8.726LeuLeu: 8.726 ± 0.058	1.873LeuMet: 1.873 ± 0.019	3.365LeuAsn: 3.365 ± 0.023	5.523LeuPro: 5.523 ± 0.034	4.03LeuGln: 4.03 ± 0.029	5.641LeuArg: 5.641 ± 0.035	7.482LeuSer: 7.482 ± 0.04	5.067LeuThr: 5.067 ± 0.033	5.626LeuVal: 5.626 ± 0.035	1.26LeuTrp: 1.26 ± 0.016	2.462LeuTyr: 2.462 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.215MetAla: 2.215 ± 0.022	0.252MetCys: 0.252 ± 0.007	1.161MetAsp: 1.161 ± 0.013	1.137MetGlu: 1.137 ± 0.013	0.782MetPhe: 0.782 ± 0.012	1.442MetGly: 1.442 ± 0.018	0.506MetHis: 0.506 ± 0.01	1.061MetIle: 1.061 ± 0.013	0.987MetLys: 0.987 ± 0.012	1.899MetLeu: 1.899 ± 0.018	0.532MetMet: 0.532 ± 0.01	0.811MetAsn: 0.811 ± 0.01	1.213MetPro: 1.213 ± 0.016	0.865MetGln: 0.865 ± 0.013	1.179MetArg: 1.179 ± 0.013	1.87MetSer: 1.87 ± 0.019	1.35MetThr: 1.35 ± 0.015	1.331MetVal: 1.331 ± 0.014	0.26MetTrp: 0.26 ± 0.007	0.523MetTyr: 0.523 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.227AsnAla: 3.227 ± 0.024	0.451AsnCys: 0.451 ± 0.01	1.988AsnAsp: 1.988 ± 0.019	1.993AsnGlu: 1.993 ± 0.018	1.464AsnPhe: 1.464 ± 0.017	2.998AsnGly: 2.998 ± 0.03	0.919AsnHis: 0.919 ± 0.014	2.154AsnIle: 2.154 ± 0.02	1.521AsnLys: 1.521 ± 0.018	3.437AsnLeu: 3.437 ± 0.028	0.812AsnMet: 0.812 ± 0.012	1.483AsnAsn: 1.483 ± 0.019	2.45AsnPro: 2.45 ± 0.021	1.388AsnGln: 1.388 ± 0.014	1.878AsnArg: 1.878 ± 0.019	2.845AsnSer: 2.845 ± 0.027	2.212AsnThr: 2.212 ± 0.022	2.411AsnVal: 2.411 ± 0.018	0.573AsnTrp: 0.573 ± 0.01	1.081AsnTyr: 1.081 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	4.796ProAla: 4.796 ± 0.038	0.475ProCys: 0.475 ± 0.01	3.118ProAsp: 3.118 ± 0.024	3.609ProGlu: 3.609 ± 0.029	2.096ProPhe: 2.096 ± 0.017	3.901ProGly: 3.901 ± 0.028	1.307ProHis: 1.307 ± 0.016	2.621ProIle: 2.621 ± 0.022	2.541ProLys: 2.541 ± 0.024	4.806ProLeu: 4.806 ± 0.037	1.02ProMet: 1.02 ± 0.014	2.229ProAsn: 2.229 ± 0.021	4.579ProPro: 4.579 ± 0.063	2.436ProGln: 2.436 ± 0.03	3.221ProArg: 3.221 ± 0.028	5.667ProSer: 5.667 ± 0.043	3.925ProThr: 3.925 ± 0.029	3.399ProVal: 3.399 ± 0.026	0.774ProTrp: 0.774 ± 0.012	1.509ProTyr: 1.509 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.584GlnAla: 3.584 ± 0.027	0.447GlnCys: 0.447 ± 0.01	2.172GlnAsp: 2.172 ± 0.02	2.369GlnGlu: 2.369 ± 0.022	1.333GlnPhe: 1.333 ± 0.014	2.482GlnGly: 2.482 ± 0.02	1.126GlnHis: 1.126 ± 0.015	2.078GlnIle: 2.078 ± 0.019	2.018GlnLys: 2.018 ± 0.02	3.548GlnLeu: 3.548 ± 0.026	0.895GlnMet: 0.895 ± 0.014	1.654GlnAsn: 1.654 ± 0.018	2.477GlnPro: 2.477 ± 0.025	2.338GlnGln: 2.338 ± 0.037	2.636GlnArg: 2.636 ± 0.022	3.277GlnSer: 3.277 ± 0.029	2.366GlnThr: 2.366 ± 0.02	2.244GlnVal: 2.244 ± 0.016	0.595GlnTrp: 0.595 ± 0.009	1.223GlnTyr: 1.223 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.562ArgAla: 4.562 ± 0.033	0.654ArgCys: 0.654 ± 0.01	3.313ArgAsp: 3.313 ± 0.029	3.552ArgGlu: 3.552 ± 0.031	2.097ArgPhe: 2.097 ± 0.019	3.582ArgGly: 3.582 ± 0.03	1.562ArgHis: 1.562 ± 0.017	2.892ArgIle: 2.892 ± 0.023	3.428ArgLys: 3.428 ± 0.03	5.443ArgLeu: 5.443 ± 0.03	1.231ArgMet: 1.231 ± 0.015	2.225ArgAsn: 2.225 ± 0.02	3.398ArgPro: 3.398 ± 0.028	2.584ArgGln: 2.584 ± 0.019	4.751ArgArg: 4.751 ± 0.041	4.722ArgSer: 4.722 ± 0.034	3.326ArgThr: 3.326 ± 0.028	3.221ArgVal: 3.221 ± 0.025	0.942ArgTrp: 0.942 ± 0.013	1.717ArgTyr: 1.717 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.502SerAla: 6.502 ± 0.039	0.871SerCys: 0.871 ± 0.013	4.171SerAsp: 4.171 ± 0.032	4.104SerGlu: 4.104 ± 0.028	3.14SerPhe: 3.14 ± 0.024	5.502SerGly: 5.502 ± 0.035	1.989SerHis: 1.989 ± 0.019	4.253SerIle: 4.253 ± 0.029	3.754SerLys: 3.754 ± 0.028	7.354SerLeu: 7.354 ± 0.04	1.762SerMet: 1.762 ± 0.017	3.096SerAsn: 3.096 ± 0.025	5.277SerPro: 5.277 ± 0.049	3.391SerGln: 3.391 ± 0.027	4.933SerArg: 4.933 ± 0.039	8.567SerSer: 8.567 ± 0.071	5.803SerThr: 5.803 ± 0.044	4.592SerVal: 4.592 ± 0.03	1.176SerTrp: 1.176 ± 0.016	2.085SerTyr: 2.085 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.298ThrAla: 5.298 ± 0.028	0.714ThrCys: 0.714 ± 0.013	2.839ThrAsp: 2.839 ± 0.021	3.013ThrGlu: 3.013 ± 0.025	2.357ThrPhe: 2.357 ± 0.021	4.274ThrGly: 4.274 ± 0.029	1.292ThrHis: 1.292 ± 0.015	3.338ThrIle: 3.338 ± 0.026	2.653ThrLys: 2.653 ± 0.022	5.347ThrLeu: 5.347 ± 0.035	1.226ThrMet: 1.226 ± 0.014	2.263ThrAsn: 2.263 ± 0.018	4.039ThrPro: 4.039 ± 0.031	2.181ThrGln: 2.181 ± 0.02	3.122ThrArg: 3.122 ± 0.02	5.566ThrSer: 5.566 ± 0.044	4.463ThrThr: 4.463 ± 0.056	3.693ThrVal: 3.693 ± 0.026	0.898ThrTrp: 0.898 ± 0.013	1.646ThrTyr: 1.646 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.325ValAla: 5.325 ± 0.032	0.812ValCys: 0.812 ± 0.011	3.701ValAsp: 3.701 ± 0.025	3.766ValGlu: 3.766 ± 0.026	2.562ValPhe: 2.562 ± 0.026	4.193ValGly: 4.193 ± 0.033	1.457ValHis: 1.457 ± 0.015	3.125ValIle: 3.125 ± 0.023	2.845ValLys: 2.845 ± 0.026	5.796ValLeu: 5.796 ± 0.036	1.297ValMet: 1.297 ± 0.014	2.327ValAsn: 2.327 ± 0.023	3.456ValPro: 3.456 ± 0.025	2.486ValGln: 2.486 ± 0.021	3.389ValArg: 3.389 ± 0.024	4.63ValSer: 4.63 ± 0.03	3.472ValThr: 3.472 ± 0.026	4.41ValVal: 4.41 ± 0.031	0.892ValTrp: 0.892 ± 0.013	1.702ValTyr: 1.702 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.18TrpAla: 1.18 ± 0.014	0.193TrpCys: 0.193 ± 0.005	0.855TrpAsp: 0.855 ± 0.014	0.807TrpGlu: 0.807 ± 0.012	0.574TrpPhe: 0.574 ± 0.01	0.925TrpGly: 0.925 ± 0.012	0.394TrpHis: 0.394 ± 0.009	0.848TrpIle: 0.848 ± 0.013	0.826TrpLys: 0.826 ± 0.011	1.448TrpLeu: 1.448 ± 0.018	0.366TrpMet: 0.366 ± 0.008	0.656TrpAsn: 0.656 ± 0.011	0.636TrpPro: 0.636 ± 0.013	0.6TrpGln: 0.6 ± 0.009	0.986TrpArg: 0.986 ± 0.012	1.108TrpSer: 1.108 ± 0.014	0.976TrpThr: 0.976 ± 0.012	0.89TrpVal: 0.89 ± 0.012	0.293TrpTrp: 0.293 ± 0.007	0.478TrpTyr: 0.478 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.26TyrAla: 2.26 ± 0.02	0.424TyrCys: 0.424 ± 0.009	1.658TyrAsp: 1.658 ± 0.017	1.521TyrGlu: 1.521 ± 0.016	1.29TyrPhe: 1.29 ± 0.017	2.137TyrGly: 2.137 ± 0.02	0.799TyrHis: 0.799 ± 0.011	1.433TyrIle: 1.433 ± 0.016	1.095TyrLys: 1.095 ± 0.014	2.791TyrLeu: 2.791 ± 0.023	0.613TyrMet: 0.613 ± 0.011	1.128TyrAsn: 1.128 ± 0.015	1.512TyrPro: 1.512 ± 0.017	1.135TyrGln: 1.135 ± 0.014	1.588TyrArg: 1.588 ± 0.018	2.1TyrSer: 2.1 ± 0.017	1.607TyrThr: 1.607 ± 0.016	1.671TyrVal: 1.671 ± 0.017	0.449TyrTrp: 0.449 ± 0.009	0.929TyrTyr: 0.929 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13118 proteins (6064173 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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