Amino acid dipepetide frequency for Helicobacter apodemus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.063AlaAla: 3.063 ± 0.101
0.794AlaCys: 0.794 ± 0.039
2.153AlaAsp: 2.153 ± 0.083
2.811AlaGlu: 2.811 ± 0.08
3.551AlaPhe: 3.551 ± 0.09
3.771AlaGly: 3.771 ± 0.087
0.975AlaHis: 0.975 ± 0.045
6.275AlaIle: 6.275 ± 0.113
6.479AlaLys: 6.479 ± 0.106
8.54AlaLeu: 8.54 ± 0.137
1.768AlaMet: 1.768 ± 0.058
3.677AlaAsn: 3.677 ± 0.098
1.783AlaPro: 1.783 ± 0.054
2.511AlaGln: 2.511 ± 0.075
2.501AlaArg: 2.501 ± 0.063
3.708AlaSer: 3.708 ± 0.09
3.14AlaThr: 3.14 ± 0.075
2.893AlaVal: 2.893 ± 0.08
0.457AlaTrp: 0.457 ± 0.027
2.741AlaTyr: 2.741 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.815CysAla: 0.815 ± 0.044
0.177CysCys: 0.177 ± 0.023
0.639CysAsp: 0.639 ± 0.036
0.907CysGlu: 0.907 ± 0.046
0.786CysPhe: 0.786 ± 0.044
1.088CysGly: 1.088 ± 0.042
0.235CysHis: 0.235 ± 0.021
1.111CysIle: 1.111 ± 0.044
0.9CysLys: 0.9 ± 0.042
1.062CysLeu: 1.062 ± 0.049
0.251CysMet: 0.251 ± 0.022
0.586CysAsn: 0.586 ± 0.037
0.426CysPro: 0.426 ± 0.033
0.348CysGln: 0.348 ± 0.024
0.274CysArg: 0.274 ± 0.026
0.735CysSer: 0.735 ± 0.039
0.319CysThr: 0.319 ± 0.025
0.878CysVal: 0.878 ± 0.044
0.095CysTrp: 0.095 ± 0.012
0.515CysTyr: 0.515 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
2.136AspAla: 2.136 ± 0.075
0.794AspCys: 0.794 ± 0.035
1.722AspAsp: 1.722 ± 0.057
3.263AspGlu: 3.263 ± 0.079
3.769AspPhe: 3.769 ± 0.08
2.429AspGly: 2.429 ± 0.073
0.39AspHis: 0.39 ± 0.024
4.679AspIle: 4.679 ± 0.104
4.313AspLys: 4.313 ± 0.082
4.816AspLeu: 4.816 ± 0.082
1.064AspMet: 1.064 ± 0.042
2.502AspAsn: 2.502 ± 0.066
1.06AspPro: 1.06 ± 0.048
0.505AspGln: 0.505 ± 0.03
1.536AspArg: 1.536 ± 0.051
3.738AspSer: 3.738 ± 0.079
2.368AspThr: 2.368 ± 0.057
2.075AspVal: 2.075 ± 0.068
0.358AspTrp: 0.358 ± 0.024
2.296AspTyr: 2.296 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
4.657GluAla: 4.657 ± 0.092
0.868GluCys: 0.868 ± 0.04
3.375GluAsp: 3.375 ± 0.082
5.603GluGlu: 5.603 ± 0.124
3.481GluPhe: 3.481 ± 0.079
3.665GluGly: 3.665 ± 0.075
0.98GluHis: 0.98 ± 0.041
7.397GluIle: 7.397 ± 0.121
5.67GluLys: 5.67 ± 0.139
6.243GluLeu: 6.243 ± 0.12
1.674GluMet: 1.674 ± 0.054
4.328GluAsn: 4.328 ± 0.089
1.359GluPro: 1.359 ± 0.051
2.4GluGln: 2.4 ± 0.074
2.547GluArg: 2.547 ± 0.067
4.783GluSer: 4.783 ± 0.086
2.571GluThr: 2.571 ± 0.078
4.826GluVal: 4.826 ± 0.114
0.607GluTrp: 0.607 ± 0.033
2.651GluTyr: 2.651 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.374PheAla: 3.374 ± 0.08
0.936PheCys: 0.936 ± 0.037
2.668PheAsp: 2.668 ± 0.074
3.203PheGlu: 3.203 ± 0.071
3.109PhePhe: 3.109 ± 0.086
3.677PheGly: 3.677 ± 0.095
0.892PheHis: 0.892 ± 0.038
4.713PheIle: 4.713 ± 0.103
4.173PheLys: 4.173 ± 0.083
6.486PheLeu: 6.486 ± 0.142
1.279PheMet: 1.279 ± 0.046
2.872PheAsn: 2.872 ± 0.081
1.406PhePro: 1.406 ± 0.044
1.415PheGln: 1.415 ± 0.051
1.543PheArg: 1.543 ± 0.045
4.107PheSer: 4.107 ± 0.08
2.247PheThr: 2.247 ± 0.063
3.072PheVal: 3.072 ± 0.082
0.489PheTrp: 0.489 ± 0.025
2.485PheTyr: 2.485 ± 0.068
0.0PheXaa: 0.0 ± 0.0
Gly
4.1GlyAla: 4.1 ± 0.105
0.724GlyCys: 0.724 ± 0.04
3.031GlyAsp: 3.031 ± 0.079
4.328GlyGlu: 4.328 ± 0.106
3.638GlyPhe: 3.638 ± 0.08
4.598GlyGly: 4.598 ± 0.109
0.975GlyHis: 0.975 ± 0.039
6.56GlyIle: 6.56 ± 0.125
4.349GlyLys: 4.349 ± 0.081
5.38GlyLeu: 5.38 ± 0.099
1.512GlyMet: 1.512 ± 0.054
2.956GlyAsn: 2.956 ± 0.098
0.76GlyPro: 0.76 ± 0.039
1.468GlyGln: 1.468 ± 0.051
2.061GlyArg: 2.061 ± 0.071
3.68GlySer: 3.68 ± 0.084
2.187GlyThr: 2.187 ± 0.095
4.497GlyVal: 4.497 ± 0.098
0.474GlyTrp: 0.474 ± 0.03
2.652GlyTyr: 2.652 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
0.646HisAla: 0.646 ± 0.036
0.28HisCys: 0.28 ± 0.023
0.46HisAsp: 0.46 ± 0.03
0.488HisGlu: 0.488 ± 0.031
1.156HisPhe: 1.156 ± 0.047
0.605HisGly: 0.605 ± 0.039
0.448HisHis: 0.448 ± 0.029
1.642HisIle: 1.642 ± 0.055
1.654HisLys: 1.654 ± 0.059
2.243HisLeu: 2.243 ± 0.071
0.303HisMet: 0.303 ± 0.02
1.144HisAsn: 1.144 ± 0.047
0.784HisPro: 0.784 ± 0.038
0.883HisGln: 0.883 ± 0.044
0.724HisArg: 0.724 ± 0.036
1.343HisSer: 1.343 ± 0.047
1.089HisThr: 1.089 ± 0.04
0.21HisVal: 0.21 ± 0.019
0.138HisTrp: 0.138 ± 0.019
0.914HisTyr: 0.914 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
6.987IleAla: 6.987 ± 0.118
1.139IleCys: 1.139 ± 0.055
4.323IleAsp: 4.323 ± 0.089
5.695IleGlu: 5.695 ± 0.11
4.777IlePhe: 4.777 ± 0.101
5.542IleGly: 5.542 ± 0.102
1.696IleHis: 1.696 ± 0.055
6.959IleIle: 6.959 ± 0.114
6.923IleLys: 6.923 ± 0.103
10.388IleLeu: 10.388 ± 0.163
1.614IleMet: 1.614 ± 0.066
4.684IleAsn: 4.684 ± 0.09
3.801IlePro: 3.801 ± 0.082
3.612IleGln: 3.612 ± 0.081
2.763IleArg: 2.763 ± 0.068
5.632IleSer: 5.632 ± 0.087
4.703IleThr: 4.703 ± 0.093
4.869IleVal: 4.869 ± 0.106
0.586IleTrp: 0.586 ± 0.034
3.218IleTyr: 3.218 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
5.481LysAla: 5.481 ± 0.107
0.578LysCys: 0.578 ± 0.035
5.068LysAsp: 5.068 ± 0.093
9.43LysGlu: 9.43 ± 0.161
2.806LysPhe: 2.806 ± 0.076
4.427LysGly: 4.427 ± 0.098
1.405LysHis: 1.405 ± 0.053
8.135LysIle: 8.135 ± 0.138
7.224LysLys: 7.224 ± 0.151
6.345LysLeu: 6.345 ± 0.12
1.96LysMet: 1.96 ± 0.063
6.186LysAsn: 6.186 ± 0.111
2.557LysPro: 2.557 ± 0.071
3.266LysGln: 3.266 ± 0.088
3.207LysArg: 3.207 ± 0.075
5.039LysSer: 5.039 ± 0.088
4.248LysThr: 4.248 ± 0.099
4.483LysVal: 4.483 ± 0.093
0.527LysTrp: 0.527 ± 0.029
2.756LysTyr: 2.756 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
6.953LeuAla: 6.953 ± 0.128
1.498LeuCys: 1.498 ± 0.065
5.204LeuAsp: 5.204 ± 0.098
9.326LeuGlu: 9.326 ± 0.147
5.153LeuPhe: 5.153 ± 0.097
6.773LeuGly: 6.773 ± 0.125
1.868LeuHis: 1.868 ± 0.062
7.531LeuIle: 7.531 ± 0.119
10.223LeuLys: 10.223 ± 0.164
10.961LeuLeu: 10.961 ± 0.191
2.206LeuMet: 2.206 ± 0.069
5.823LeuAsn: 5.823 ± 0.139
3.878LeuPro: 3.878 ± 0.095
5.134LeuGln: 5.134 ± 0.106
3.861LeuArg: 3.861 ± 0.084
7.927LeuSer: 7.927 ± 0.126
4.241LeuThr: 4.241 ± 0.093
5.041LeuVal: 5.041 ± 0.107
0.898LeuTrp: 0.898 ± 0.045
3.605LeuTyr: 3.605 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
1.638MetAla: 1.638 ± 0.058
0.222MetCys: 0.222 ± 0.019
1.071MetAsp: 1.071 ± 0.047
1.423MetGlu: 1.423 ± 0.057
0.883MetPhe: 0.883 ± 0.04
1.486MetGly: 1.486 ± 0.057
0.314MetHis: 0.314 ± 0.024
1.744MetIle: 1.744 ± 0.057
1.677MetLys: 1.677 ± 0.053
2.511MetLeu: 2.511 ± 0.074
0.506MetMet: 0.506 ± 0.031
1.002MetAsn: 1.002 ± 0.037
1.002MetPro: 1.002 ± 0.044
1.568MetGln: 1.568 ± 0.055
1.05MetArg: 1.05 ± 0.04
1.26MetSer: 1.26 ± 0.051
0.663MetThr: 0.663 ± 0.036
1.275MetVal: 1.275 ± 0.049
0.148MetTrp: 0.148 ± 0.018
0.508MetTyr: 0.508 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
4.563AsnAla: 4.563 ± 0.101
0.54AsnCys: 0.54 ± 0.029
2.17AsnAsp: 2.17 ± 0.063
3.328AsnGlu: 3.328 ± 0.081
3.203AsnPhe: 3.203 ± 0.09
3.176AsnGly: 3.176 ± 0.079
1.115AsnHis: 1.115 ± 0.049
5.481AsnIle: 5.481 ± 0.114
4.234AsnLys: 4.234 ± 0.091
6.461AsnLeu: 6.461 ± 0.119
0.943AsnMet: 0.943 ± 0.042
3.292AsnAsn: 3.292 ± 0.109
3.058AsnPro: 3.058 ± 0.078
2.208AsnGln: 2.208 ± 0.074
1.788AsnArg: 1.788 ± 0.049
3.166AsnSer: 3.166 ± 0.092
3.305AsnThr: 3.305 ± 0.12
2.678AsnVal: 2.678 ± 0.081
0.361AsnTrp: 0.361 ± 0.023
2.104AsnTyr: 2.104 ± 0.067
0.0AsnXaa: 0.0 ± 0.0
Pro
1.483ProAla: 1.483 ± 0.052
0.312ProCys: 0.312 ± 0.026
1.149ProAsp: 1.149 ± 0.043
1.454ProGlu: 1.454 ± 0.053
2.068ProPhe: 2.068 ± 0.059
1.033ProGly: 1.033 ± 0.049
0.769ProHis: 0.769 ± 0.035
2.978ProIle: 2.978 ± 0.067
3.404ProLys: 3.404 ± 0.097
4.272ProLeu: 4.272 ± 0.099
0.67ProMet: 0.67 ± 0.033
2.325ProAsn: 2.325 ± 0.06
1.088ProPro: 1.088 ± 0.048
1.652ProGln: 1.652 ± 0.052
0.847ProArg: 0.847 ± 0.035
2.005ProSer: 2.005 ± 0.055
1.839ProThr: 1.839 ± 0.065
1.306ProVal: 1.306 ± 0.053
0.223ProTrp: 0.223 ± 0.019
1.529ProTyr: 1.529 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
2.322GlnAla: 2.322 ± 0.071
0.375GlnCys: 0.375 ± 0.025
1.957GlnAsp: 1.957 ± 0.062
3.945GlnGlu: 3.945 ± 0.09
1.079GlnPhe: 1.079 ± 0.046
2.042GlnGly: 2.042 ± 0.059
0.522GlnHis: 0.522 ± 0.029
3.225GlnIle: 3.225 ± 0.075
4.528GlnLys: 4.528 ± 0.095
2.427GlnLeu: 2.427 ± 0.065
0.951GlnMet: 0.951 ± 0.042
3.029GlnAsn: 3.029 ± 0.094
0.837GlnPro: 0.837 ± 0.036
1.565GlnGln: 1.565 ± 0.063
1.674GlnArg: 1.674 ± 0.051
3.126GlnSer: 3.126 ± 0.079
2.119GlnThr: 2.119 ± 0.067
1.642GlnVal: 1.642 ± 0.055
0.367GlnTrp: 0.367 ± 0.025
1.169GlnTyr: 1.169 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
2.151ArgAla: 2.151 ± 0.06
0.302ArgCys: 0.302 ± 0.022
2.08ArgAsp: 2.08 ± 0.064
2.951ArgGlu: 2.951 ± 0.069
1.952ArgPhe: 1.952 ± 0.063
2.243ArgGly: 2.243 ± 0.066
0.532ArgHis: 0.532 ± 0.03
3.488ArgIle: 3.488 ± 0.074
2.496ArgLys: 2.496 ± 0.073
3.414ArgLeu: 3.414 ± 0.061
0.818ArgMet: 0.818 ± 0.034
1.962ArgAsn: 1.962 ± 0.056
0.834ArgPro: 0.834 ± 0.04
1.156ArgGln: 1.156 ± 0.054
1.168ArgArg: 1.168 ± 0.052
1.875ArgSer: 1.875 ± 0.06
1.175ArgThr: 1.175 ± 0.042
2.283ArgVal: 2.283 ± 0.069
0.239ArgTrp: 0.239 ± 0.02
1.42ArgTyr: 1.42 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
3.851SerAla: 3.851 ± 0.082
0.713SerCys: 0.713 ± 0.041
2.542SerAsp: 2.542 ± 0.064
3.029SerGlu: 3.029 ± 0.082
4.347SerPhe: 4.347 ± 0.099
4.129SerGly: 4.129 ± 0.093
1.313SerHis: 1.313 ± 0.046
6.115SerIle: 6.115 ± 0.094
5.542SerLys: 5.542 ± 0.109
8.622SerLeu: 8.622 ± 0.132
1.444SerMet: 1.444 ± 0.058
3.457SerAsn: 3.457 ± 0.093
2.233SerPro: 2.233 ± 0.074
2.69SerGln: 2.69 ± 0.072
1.86SerArg: 1.86 ± 0.059
4.253SerSer: 4.253 ± 0.089
2.763SerThr: 2.763 ± 0.072
3.328SerVal: 3.328 ± 0.077
0.518SerTrp: 0.518 ± 0.029
2.774SerTyr: 2.774 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
2.453ThrAla: 2.453 ± 0.064
0.411ThrCys: 0.411 ± 0.03
1.514ThrAsp: 1.514 ± 0.05
1.751ThrGlu: 1.751 ± 0.064
2.499ThrPhe: 2.499 ± 0.07
2.283ThrGly: 2.283 ± 0.081
1.076ThrHis: 1.076 ± 0.047
3.975ThrIle: 3.975 ± 0.097
4.079ThrLys: 4.079 ± 0.092
6.797ThrLeu: 6.797 ± 0.127
0.968ThrMet: 0.968 ± 0.04
2.548ThrAsn: 2.548 ± 0.112
2.436ThrPro: 2.436 ± 0.065
2.97ThrGln: 2.97 ± 0.071
1.529ThrArg: 1.529 ± 0.055
2.906ThrSer: 2.906 ± 0.076
2.588ThrThr: 2.588 ± 0.09
0.667ThrVal: 0.667 ± 0.043
0.324ThrTrp: 0.324 ± 0.022
1.763ThrTyr: 1.763 ± 0.066
0.0ThrXaa: 0.0 ± 0.0
Val
3.846ValAla: 3.846 ± 0.103
0.849ValCys: 0.849 ± 0.041
2.511ValAsp: 2.511 ± 0.075
3.484ValGlu: 3.484 ± 0.092
3.067ValPhe: 3.067 ± 0.081
3.868ValGly: 3.868 ± 0.098
0.643ValHis: 0.643 ± 0.036
4.483ValIle: 4.483 ± 0.087
3.645ValLys: 3.645 ± 0.078
6.161ValLeu: 6.161 ± 0.111
1.255ValMet: 1.255 ± 0.053
2.431ValAsn: 2.431 ± 0.068
1.348ValPro: 1.348 ± 0.053
1.279ValGln: 1.279 ± 0.047
1.822ValArg: 1.822 ± 0.064
3.459ValSer: 3.459 ± 0.073
1.848ValThr: 1.848 ± 0.058
3.566ValVal: 3.566 ± 0.084
0.421ValTrp: 0.421 ± 0.027
1.775ValTyr: 1.775 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.39TrpAla: 0.39 ± 0.026
0.109TrpCys: 0.109 ± 0.014
0.399TrpAsp: 0.399 ± 0.024
0.554TrpGlu: 0.554 ± 0.03
0.387TrpPhe: 0.387 ± 0.029
0.576TrpGly: 0.576 ± 0.035
0.196TrpHis: 0.196 ± 0.021
0.799TrpIle: 0.799 ± 0.041
0.459TrpLys: 0.459 ± 0.029
0.866TrpLeu: 0.866 ± 0.041
0.153TrpMet: 0.153 ± 0.016
0.469TrpAsn: 0.469 ± 0.028
0.08TrpPro: 0.08 ± 0.011
0.314TrpGln: 0.314 ± 0.021
0.344TrpArg: 0.344 ± 0.025
0.406TrpSer: 0.406 ± 0.028
0.228TrpThr: 0.228 ± 0.02
0.537TrpVal: 0.537 ± 0.03
0.101TrpTrp: 0.101 ± 0.012
0.295TrpTyr: 0.295 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.681TyrAla: 2.681 ± 0.067
0.527TyrCys: 0.527 ± 0.036
1.778TyrAsp: 1.778 ± 0.054
2.71TyrGlu: 2.71 ± 0.067
2.436TyrPhe: 2.436 ± 0.075
2.52TyrGly: 2.52 ± 0.077
0.811TyrHis: 0.811 ± 0.04
2.624TyrIle: 2.624 ± 0.066
3.159TyrLys: 3.159 ± 0.077
4.112TyrLeu: 4.112 ± 0.101
0.612TyrMet: 0.612 ± 0.033
1.897TyrAsn: 1.897 ± 0.056
1.674TyrPro: 1.674 ± 0.049
1.959TyrGln: 1.959 ± 0.071
1.437TyrArg: 1.437 ± 0.046
2.373TyrSer: 2.373 ± 0.067
1.894TyrThr: 1.894 ± 0.06
1.636TyrVal: 1.636 ± 0.056
0.331TyrTrp: 0.331 ± 0.024
1.766TyrTyr: 1.766 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2029 proteins (586621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski