Amino acid dipepetide frequency for Celeribacter marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.928AlaAla: 14.928 ± 0.175	1.109AlaCys: 1.109 ± 0.04	7.218AlaAsp: 7.218 ± 0.095	6.281AlaGlu: 6.281 ± 0.108	4.464AlaPhe: 4.464 ± 0.081	9.546AlaGly: 9.546 ± 0.124	2.529AlaHis: 2.529 ± 0.059	6.182AlaIle: 6.182 ± 0.087	4.618AlaLys: 4.618 ± 0.08	12.759AlaLeu: 12.759 ± 0.144	3.939AlaMet: 3.939 ± 0.071	3.047AlaAsn: 3.047 ± 0.058	5.497AlaPro: 5.497 ± 0.098	5.289AlaGln: 5.289 ± 0.091	8.024AlaArg: 8.024 ± 0.119	6.122AlaSer: 6.122 ± 0.085	6.451AlaThr: 6.451 ± 0.1	8.204AlaVal: 8.204 ± 0.107	1.439AlaTrp: 1.439 ± 0.041	2.66AlaTyr: 2.66 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.107CysAla: 1.107 ± 0.035	0.093CysCys: 0.093 ± 0.011	0.711CysAsp: 0.711 ± 0.028	0.53CysGlu: 0.53 ± 0.027	0.319CysPhe: 0.319 ± 0.019	0.915CysGly: 0.915 ± 0.034	0.259CysHis: 0.259 ± 0.016	0.431CysIle: 0.431 ± 0.022	0.232CysLys: 0.232 ± 0.018	0.804CysLeu: 0.804 ± 0.03	0.188CysMet: 0.188 ± 0.016	0.223CysAsn: 0.223 ± 0.016	0.47CysPro: 0.47 ± 0.025	0.214CysGln: 0.214 ± 0.016	0.479CysArg: 0.479 ± 0.025	0.435CysSer: 0.435 ± 0.022	0.44CysThr: 0.44 ± 0.021	0.709CysVal: 0.709 ± 0.028	0.078CysTrp: 0.078 ± 0.008	0.185CysTyr: 0.185 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.133AspAla: 8.133 ± 0.121	0.501AspCys: 0.501 ± 0.027	4.018AspAsp: 4.018 ± 0.112	3.893AspGlu: 3.893 ± 0.076	2.324AspPhe: 2.324 ± 0.05	5.79AspGly: 5.79 ± 0.108	1.478AspHis: 1.478 ± 0.046	3.744AspIle: 3.744 ± 0.072	2.011AspLys: 2.011 ± 0.055	6.384AspLeu: 6.384 ± 0.086	1.942AspMet: 1.942 ± 0.047	1.534AspAsn: 1.534 ± 0.042	3.258AspPro: 3.258 ± 0.06	1.935AspGln: 1.935 ± 0.047	3.688AspArg: 3.688 ± 0.065	2.154AspSer: 2.154 ± 0.056	3.541AspThr: 3.541 ± 0.093	5.046AspVal: 5.046 ± 0.079	1.026AspTrp: 1.026 ± 0.03	1.65AspTyr: 1.65 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.449GluAla: 7.449 ± 0.107	0.379GluCys: 0.379 ± 0.024	3.161GluAsp: 3.161 ± 0.072	2.932GluGlu: 2.932 ± 0.071	1.921GluPhe: 1.921 ± 0.049	4.505GluGly: 4.505 ± 0.079	1.206GluHis: 1.206 ± 0.04	3.711GluIle: 3.711 ± 0.07	2.239GluLys: 2.239 ± 0.058	4.855GluLeu: 4.855 ± 0.081	1.772GluMet: 1.772 ± 0.047	1.819GluAsn: 1.819 ± 0.038	2.1GluPro: 2.1 ± 0.056	1.858GluGln: 1.858 ± 0.046	4.04GluArg: 4.04 ± 0.071	2.179GluSer: 2.179 ± 0.055	3.755GluThr: 3.755 ± 0.064	4.111GluVal: 4.111 ± 0.076	0.69GluTrp: 0.69 ± 0.027	1.021GluTyr: 1.021 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.537PheAla: 4.537 ± 0.081	0.396PheCys: 0.396 ± 0.022	3.072PheAsp: 3.072 ± 0.063	2.445PheGlu: 2.445 ± 0.05	1.511PhePhe: 1.511 ± 0.05	3.887PheGly: 3.887 ± 0.075	0.725PheHis: 0.725 ± 0.03	1.811PheIle: 1.811 ± 0.056	1.231PheLys: 1.231 ± 0.045	3.172PheLeu: 3.172 ± 0.069	0.981PheMet: 0.981 ± 0.037	1.205PheAsn: 1.205 ± 0.04	1.407PhePro: 1.407 ± 0.037	0.953PheGln: 0.953 ± 0.033	1.812PheArg: 1.812 ± 0.049	2.322PheSer: 2.322 ± 0.052	2.176PheThr: 2.176 ± 0.051	2.949PheVal: 2.949 ± 0.056	0.548PheTrp: 0.548 ± 0.027	0.974PheTyr: 0.974 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	9.868GlyAla: 9.868 ± 0.12	0.786GlyCys: 0.786 ± 0.03	5.014GlyAsp: 5.014 ± 0.1	4.595GlyGlu: 4.595 ± 0.071	3.699GlyPhe: 3.699 ± 0.071	7.202GlyGly: 7.202 ± 0.122	1.873GlyHis: 1.873 ± 0.052	4.503GlyIle: 4.503 ± 0.076	3.478GlyLys: 3.478 ± 0.069	8.536GlyLeu: 8.536 ± 0.115	2.545GlyMet: 2.545 ± 0.057	2.134GlyAsn: 2.134 ± 0.063	3.019GlyPro: 3.019 ± 0.06	2.885GlyGln: 2.885 ± 0.054	4.973GlyArg: 4.973 ± 0.081	4.13GlySer: 4.13 ± 0.072	4.728GlyThr: 4.728 ± 0.079	6.64GlyVal: 6.64 ± 0.089	1.241GlyTrp: 1.241 ± 0.042	2.28GlyTyr: 2.28 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.522HisAla: 2.522 ± 0.056	0.231HisCys: 0.231 ± 0.017	1.391HisAsp: 1.391 ± 0.044	1.089HisGlu: 1.089 ± 0.032	0.831HisPhe: 0.831 ± 0.029	1.938HisGly: 1.938 ± 0.046	0.591HisHis: 0.591 ± 0.026	1.122HisIle: 1.122 ± 0.037	0.62HisLys: 0.62 ± 0.026	2.068HisLeu: 2.068 ± 0.047	0.63HisMet: 0.63 ± 0.024	0.567HisAsn: 0.567 ± 0.022	1.268HisPro: 1.268 ± 0.046	0.536HisGln: 0.536 ± 0.022	1.232HisArg: 1.232 ± 0.039	0.979HisSer: 0.979 ± 0.038	1.068HisThr: 1.068 ± 0.035	1.534HisVal: 1.534 ± 0.04	0.322HisTrp: 0.322 ± 0.019	0.593HisTyr: 0.593 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.405IleAla: 7.405 ± 0.099	0.64IleCys: 0.64 ± 0.027	3.986IleAsp: 3.986 ± 0.061	3.798IleGlu: 3.798 ± 0.058	1.841IlePhe: 1.841 ± 0.055	5.069IleGly: 5.069 ± 0.083	0.994IleHis: 0.994 ± 0.035	2.778IleIle: 2.778 ± 0.07	1.961IleLys: 1.961 ± 0.041	4.755IleLeu: 4.755 ± 0.081	1.267IleMet: 1.267 ± 0.036	1.683IleAsn: 1.683 ± 0.046	2.267IlePro: 2.267 ± 0.054	1.3IleGln: 1.3 ± 0.042	2.892IleArg: 2.892 ± 0.057	3.384IleSer: 3.384 ± 0.059	3.32IleThr: 3.32 ± 0.059	4.252IleVal: 4.252 ± 0.074	0.703IleTrp: 0.703 ± 0.029	1.261IleTyr: 1.261 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.491LysAla: 4.491 ± 0.086	0.233LysCys: 0.233 ± 0.017	2.127LysAsp: 2.127 ± 0.05	1.824LysGlu: 1.824 ± 0.048	1.125LysPhe: 1.125 ± 0.036	3.037LysGly: 3.037 ± 0.065	0.741LysHis: 0.741 ± 0.031	2.068LysIle: 2.068 ± 0.049	1.552LysLys: 1.552 ± 0.054	3.384LysLeu: 3.384 ± 0.067	1.087LysMet: 1.087 ± 0.034	1.036LysAsn: 1.036 ± 0.032	1.916LysPro: 1.916 ± 0.048	1.066LysGln: 1.066 ± 0.036	2.59LysArg: 2.59 ± 0.054	2.398LysSer: 2.398 ± 0.055	2.36LysThr: 2.36 ± 0.053	2.557LysVal: 2.557 ± 0.061	0.443LysTrp: 0.443 ± 0.024	0.763LysTyr: 0.763 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.435LeuAla: 11.435 ± 0.136	0.913LeuCys: 0.913 ± 0.035	6.083LeuAsp: 6.083 ± 0.092	5.13LeuGlu: 5.13 ± 0.088	3.508LeuPhe: 3.508 ± 0.077	8.02LeuGly: 8.02 ± 0.099	1.75LeuHis: 1.75 ± 0.045	5.501LeuIle: 5.501 ± 0.091	3.734LeuLys: 3.734 ± 0.065	7.856LeuLeu: 7.856 ± 0.133	2.762LeuMet: 2.762 ± 0.062	2.86LeuAsn: 2.86 ± 0.063	4.799LeuPro: 4.799 ± 0.083	2.449LeuGln: 2.449 ± 0.051	5.903LeuArg: 5.903 ± 0.084	6.849LeuSer: 6.849 ± 0.1	6.018LeuThr: 6.018 ± 0.1	6.49LeuVal: 6.49 ± 0.093	1.153LeuTrp: 1.153 ± 0.038	1.966LeuTyr: 1.966 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.483MetAla: 3.483 ± 0.066	0.24MetCys: 0.24 ± 0.015	1.652MetAsp: 1.652 ± 0.043	1.403MetGlu: 1.403 ± 0.043	0.904MetPhe: 0.904 ± 0.035	2.388MetGly: 2.388 ± 0.057	0.512MetHis: 0.512 ± 0.023	1.76MetIle: 1.76 ± 0.047	1.111MetLys: 1.111 ± 0.035	2.581MetLeu: 2.581 ± 0.055	0.88MetMet: 0.88 ± 0.03	0.935MetAsn: 0.935 ± 0.031	1.473MetPro: 1.473 ± 0.04	0.953MetGln: 0.953 ± 0.028	1.904MetArg: 1.904 ± 0.045	2.14MetSer: 2.14 ± 0.046	2.306MetThr: 2.306 ± 0.049	2.029MetVal: 2.029 ± 0.044	0.269MetTrp: 0.269 ± 0.018	0.385MetTyr: 0.385 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.559AsnAla: 3.559 ± 0.064	0.275AsnCys: 0.275 ± 0.015	1.661AsnAsp: 1.661 ± 0.068	1.378AsnGlu: 1.378 ± 0.042	1.066AsnPhe: 1.066 ± 0.035	2.75AsnGly: 2.75 ± 0.067	0.574AsnHis: 0.574 ± 0.024	1.539AsnIle: 1.539 ± 0.048	0.865AsnLys: 0.865 ± 0.035	2.646AsnLeu: 2.646 ± 0.052	0.79AsnMet: 0.79 ± 0.025	0.761AsnAsn: 0.761 ± 0.028	1.756AsnPro: 1.756 ± 0.045	0.744AsnGln: 0.744 ± 0.031	1.597AsnArg: 1.597 ± 0.043	1.354AsnSer: 1.354 ± 0.036	1.672AsnThr: 1.672 ± 0.045	2.251AsnVal: 2.251 ± 0.059	0.475AsnTrp: 0.475 ± 0.024	0.659AsnTyr: 0.659 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.93ProAla: 4.93 ± 0.074	0.346ProCys: 0.346 ± 0.022	3.618ProAsp: 3.618 ± 0.069	3.248ProGlu: 3.248 ± 0.062	1.842ProPhe: 1.842 ± 0.046	2.52ProGly: 2.52 ± 0.048	1.12ProHis: 1.12 ± 0.04	2.315ProIle: 2.315 ± 0.05	1.996ProLys: 1.996 ± 0.056	4.263ProLeu: 4.263 ± 0.076	1.343ProMet: 1.343 ± 0.039	1.532ProAsn: 1.532 ± 0.041	1.763ProPro: 1.763 ± 0.048	1.613ProGln: 1.613 ± 0.049	2.532ProArg: 2.532 ± 0.054	2.69ProSer: 2.69 ± 0.052	2.651ProThr: 2.651 ± 0.054	3.929ProVal: 3.929 ± 0.071	0.566ProTrp: 0.566 ± 0.026	1.075ProTyr: 1.075 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.729GlnAla: 3.729 ± 0.087	0.214GlnCys: 0.214 ± 0.015	1.628GlnAsp: 1.628 ± 0.046	1.536GlnGlu: 1.536 ± 0.045	1.213GlnPhe: 1.213 ± 0.04	2.518GlnGly: 2.518 ± 0.059	0.575GlnHis: 0.575 ± 0.029	2.299GlnIle: 2.299 ± 0.052	1.239GlnLys: 1.239 ± 0.038	2.767GlnLeu: 2.767 ± 0.058	1.247GlnMet: 1.247 ± 0.039	1.07GlnAsn: 1.07 ± 0.036	1.397GlnPro: 1.397 ± 0.043	1.021GlnGln: 1.021 ± 0.041	1.878GlnArg: 1.878 ± 0.051	2.053GlnSer: 2.053 ± 0.05	2.169GlnThr: 2.169 ± 0.052	2.334GlnVal: 2.334 ± 0.048	0.445GlnTrp: 0.445 ± 0.023	0.603GlnTyr: 0.603 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.396ArgAla: 7.396 ± 0.107	0.418ArgCys: 0.418 ± 0.023	4.2ArgAsp: 4.2 ± 0.076	3.497ArgGlu: 3.497 ± 0.068	2.435ArgPhe: 2.435 ± 0.052	4.328ArgGly: 4.328 ± 0.081	1.396ArgHis: 1.396 ± 0.045	3.536ArgIle: 3.536 ± 0.085	2.364ArgLys: 2.364 ± 0.055	6.313ArgLeu: 6.313 ± 0.116	1.806ArgMet: 1.806 ± 0.044	1.641ArgAsn: 1.641 ± 0.043	2.622ArgPro: 2.622 ± 0.052	1.934ArgGln: 1.934 ± 0.052	4.106ArgArg: 4.106 ± 0.096	3.007ArgSer: 3.007 ± 0.058	3.06ArgThr: 3.06 ± 0.066	4.49ArgVal: 4.49 ± 0.075	0.744ArgTrp: 0.744 ± 0.028	1.436ArgTyr: 1.436 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.095SerAla: 6.095 ± 0.085	0.453SerCys: 0.453 ± 0.025	3.738SerAsp: 3.738 ± 0.072	3.027SerGlu: 3.027 ± 0.068	2.31SerPhe: 2.31 ± 0.053	5.493SerGly: 5.493 ± 0.08	1.258SerHis: 1.258 ± 0.036	2.8SerIle: 2.8 ± 0.064	1.96SerLys: 1.96 ± 0.048	5.171SerLeu: 5.171 ± 0.074	1.461SerMet: 1.461 ± 0.045	1.713SerAsn: 1.713 ± 0.044	2.366SerPro: 2.366 ± 0.053	1.82SerGln: 1.82 ± 0.046	3.096SerArg: 3.096 ± 0.063	2.832SerSer: 2.832 ± 0.063	2.862SerThr: 2.862 ± 0.063	4.258SerVal: 4.258 ± 0.069	0.57SerTrp: 0.57 ± 0.026	1.429SerTyr: 1.429 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.528ThrAla: 6.528 ± 0.104	0.55ThrCys: 0.55 ± 0.025	3.675ThrAsp: 3.675 ± 0.074	2.651ThrGlu: 2.651 ± 0.064	2.263ThrPhe: 2.263 ± 0.051	5.428ThrGly: 5.428 ± 0.082	1.33ThrHis: 1.33 ± 0.039	3.079ThrIle: 3.079 ± 0.061	1.886ThrLys: 1.886 ± 0.046	6.282ThrLeu: 6.282 ± 0.091	1.491ThrMet: 1.491 ± 0.039	1.563ThrAsn: 1.563 ± 0.043	3.651ThrPro: 3.651 ± 0.068	2.084ThrGln: 2.084 ± 0.057	3.466ThrArg: 3.466 ± 0.062	3.154ThrSer: 3.154 ± 0.058	3.226ThrThr: 3.226 ± 0.071	4.526ThrVal: 4.526 ± 0.086	0.678ThrTrp: 0.678 ± 0.029	1.425ThrTyr: 1.425 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	8.775ValAla: 8.775 ± 0.109	0.688ValCys: 0.688 ± 0.026	4.639ValAsp: 4.639 ± 0.077	4.552ValGlu: 4.552 ± 0.076	3.103ValPhe: 3.103 ± 0.062	5.658ValGly: 5.658 ± 0.081	1.35ValHis: 1.35 ± 0.036	4.583ValIle: 4.583 ± 0.071	2.534ValLys: 2.534 ± 0.054	7.008ValLeu: 7.008 ± 0.096	2.269ValMet: 2.269 ± 0.052	2.026ValAsn: 2.026 ± 0.05	3.22ValPro: 3.22 ± 0.051	2.072ValGln: 2.072 ± 0.05	4.205ValArg: 4.205 ± 0.068	4.66ValSer: 4.66 ± 0.082	5.125ValThr: 5.125 ± 0.085	5.834ValVal: 5.834 ± 0.09	0.923ValTrp: 0.923 ± 0.035	1.539ValTyr: 1.539 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.295TrpAla: 1.295 ± 0.047	0.115TrpCys: 0.115 ± 0.011	0.809TrpAsp: 0.809 ± 0.032	0.588TrpGlu: 0.588 ± 0.028	0.507TrpPhe: 0.507 ± 0.022	0.97TrpGly: 0.97 ± 0.033	0.353TrpHis: 0.353 ± 0.018	0.724TrpIle: 0.724 ± 0.028	0.424TrpLys: 0.424 ± 0.02	1.369TrpLeu: 1.369 ± 0.041	0.399TrpMet: 0.399 ± 0.023	0.388TrpAsn: 0.388 ± 0.021	0.595TrpPro: 0.595 ± 0.024	0.529TrpGln: 0.529 ± 0.026	0.956TrpArg: 0.956 ± 0.033	0.724TrpSer: 0.724 ± 0.032	0.697TrpThr: 0.697 ± 0.028	0.95TrpVal: 0.95 ± 0.036	0.191TrpTrp: 0.191 ± 0.013	0.257TrpTyr: 0.257 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.64TyrAla: 2.64 ± 0.053	0.244TyrCys: 0.244 ± 0.018	1.651TyrAsp: 1.651 ± 0.047	1.307TyrGlu: 1.307 ± 0.037	0.926TyrPhe: 0.926 ± 0.033	2.169TyrGly: 2.169 ± 0.06	0.523TyrHis: 0.523 ± 0.025	1.069TyrIle: 1.069 ± 0.034	0.743TyrLys: 0.743 ± 0.032	2.204TyrLeu: 2.204 ± 0.05	0.506TyrMet: 0.506 ± 0.027	0.634TyrAsn: 0.634 ± 0.026	1.047TyrPro: 1.047 ± 0.037	0.682TyrGln: 0.682 ± 0.03	1.355TyrArg: 1.355 ± 0.04	1.144TyrSer: 1.144 ± 0.037	1.312TyrThr: 1.312 ± 0.047	1.669TyrVal: 1.669 ± 0.042	0.334TyrTrp: 0.334 ± 0.021	0.558TyrTyr: 0.558 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3134 proteins (909897 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---