Amino acid dipepetide frequency for Streptococcus phage CHPC1041

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.454AlaAla: 2.454 ± 0.57
0.169AlaCys: 0.169 ± 0.125
4.57AlaAsp: 4.57 ± 0.656
3.216AlaGlu: 3.216 ± 0.51
1.862AlaPhe: 1.862 ± 0.511
4.739AlaGly: 4.739 ± 1.076
0.846AlaHis: 0.846 ± 0.339
4.231AlaIle: 4.231 ± 0.806
5.924AlaLys: 5.924 ± 1.198
6.008AlaLeu: 6.008 ± 0.978
2.116AlaMet: 2.116 ± 0.436
3.554AlaAsn: 3.554 ± 0.57
1.523AlaPro: 1.523 ± 0.33
2.116AlaGln: 2.116 ± 0.433
2.708AlaArg: 2.708 ± 0.424
4.824AlaSer: 4.824 ± 0.77
4.4AlaThr: 4.4 ± 0.595
4.062AlaVal: 4.062 ± 0.731
1.269AlaTrp: 1.269 ± 0.378
2.793AlaTyr: 2.793 ± 0.591
0.0AlaXaa: 0.0 ± 0.0
Cys
0.254CysAla: 0.254 ± 0.139
0.085CysCys: 0.085 ± 0.079
0.762CysAsp: 0.762 ± 0.374
0.338CysGlu: 0.338 ± 0.216
0.254CysPhe: 0.254 ± 0.174
0.423CysGly: 0.423 ± 0.225
0.254CysHis: 0.254 ± 0.163
0.254CysIle: 0.254 ± 0.154
0.592CysLys: 0.592 ± 0.258
0.677CysLeu: 0.677 ± 0.325
0.0CysMet: 0.0 ± 0.0
0.338CysAsn: 0.338 ± 0.153
0.085CysPro: 0.085 ± 0.097
0.169CysGln: 0.169 ± 0.133
0.423CysArg: 0.423 ± 0.234
0.508CysSer: 0.508 ± 0.294
0.338CysThr: 0.338 ± 0.162
0.169CysVal: 0.169 ± 0.096
0.169CysTrp: 0.169 ± 0.123
0.169CysTyr: 0.169 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
2.962AspAla: 2.962 ± 0.641
0.423AspCys: 0.423 ± 0.227
3.47AspAsp: 3.47 ± 0.6
3.893AspGlu: 3.893 ± 0.734
4.147AspPhe: 4.147 ± 0.65
6.855AspGly: 6.855 ± 1.446
1.1AspHis: 1.1 ± 0.288
4.485AspIle: 4.485 ± 0.676
5.416AspLys: 5.416 ± 0.723
3.47AspLeu: 3.47 ± 0.66
1.777AspMet: 1.777 ± 0.402
4.316AspAsn: 4.316 ± 0.665
2.2AspPro: 2.2 ± 0.416
1.354AspGln: 1.354 ± 0.266
2.369AspArg: 2.369 ± 0.502
4.062AspSer: 4.062 ± 0.578
3.808AspThr: 3.808 ± 0.65
4.316AspVal: 4.316 ± 0.582
1.523AspTrp: 1.523 ± 0.247
3.47AspTyr: 3.47 ± 0.524
0.0AspXaa: 0.0 ± 0.0
Glu
3.977GluAla: 3.977 ± 0.582
0.423GluCys: 0.423 ± 0.195
2.962GluAsp: 2.962 ± 0.516
4.4GluGlu: 4.4 ± 0.892
2.708GluPhe: 2.708 ± 0.522
3.3GluGly: 3.3 ± 0.424
1.015GluHis: 1.015 ± 0.326
5.754GluIle: 5.754 ± 0.662
4.147GluLys: 4.147 ± 0.701
6.77GluLeu: 6.77 ± 0.817
2.116GluMet: 2.116 ± 0.521
4.654GluAsn: 4.654 ± 0.57
2.116GluPro: 2.116 ± 0.665
2.454GluGln: 2.454 ± 0.381
2.708GluArg: 2.708 ± 0.559
2.962GluSer: 2.962 ± 0.425
3.046GluThr: 3.046 ± 0.475
4.739GluVal: 4.739 ± 0.738
1.523GluTrp: 1.523 ± 0.455
2.623GluTyr: 2.623 ± 0.513
0.0GluXaa: 0.0 ± 0.0
Phe
2.877PheAla: 2.877 ± 0.454
0.508PheCys: 0.508 ± 0.224
3.808PheAsp: 3.808 ± 0.537
2.539PheGlu: 2.539 ± 0.445
1.862PhePhe: 1.862 ± 0.321
3.47PheGly: 3.47 ± 0.722
0.592PheHis: 0.592 ± 0.196
2.623PheIle: 2.623 ± 0.526
3.893PheLys: 3.893 ± 0.744
2.708PheLeu: 2.708 ± 0.534
0.423PheMet: 0.423 ± 0.154
3.046PheAsn: 3.046 ± 0.74
0.254PhePro: 0.254 ± 0.153
0.931PheGln: 0.931 ± 0.307
1.608PheArg: 1.608 ± 0.353
2.539PheSer: 2.539 ± 0.567
2.623PheThr: 2.623 ± 0.69
2.793PheVal: 2.793 ± 0.479
0.762PheTrp: 0.762 ± 0.225
1.777PheTyr: 1.777 ± 0.431
0.0PheXaa: 0.0 ± 0.0
Gly
4.231GlyAla: 4.231 ± 0.783
0.169GlyCys: 0.169 ± 0.124
3.977GlyAsp: 3.977 ± 0.624
3.131GlyGlu: 3.131 ± 0.512
2.962GlyPhe: 2.962 ± 0.481
4.654GlyGly: 4.654 ± 0.942
0.931GlyHis: 0.931 ± 0.236
6.685GlyIle: 6.685 ± 0.827
6.431GlyLys: 6.431 ± 0.848
5.501GlyLeu: 5.501 ± 0.738
1.777GlyMet: 1.777 ± 0.399
3.977GlyAsn: 3.977 ± 0.681
0.762GlyPro: 0.762 ± 0.341
3.046GlyGln: 3.046 ± 0.548
3.385GlyArg: 3.385 ± 0.684
4.739GlySer: 4.739 ± 0.772
4.231GlyThr: 4.231 ± 0.87
3.554GlyVal: 3.554 ± 0.657
1.862GlyTrp: 1.862 ± 0.448
2.708GlyTyr: 2.708 ± 0.458
0.0GlyXaa: 0.0 ± 0.0
His
0.592HisAla: 0.592 ± 0.238
0.085HisCys: 0.085 ± 0.094
0.677HisAsp: 0.677 ± 0.207
0.762HisGlu: 0.762 ± 0.247
0.592HisPhe: 0.592 ± 0.223
0.931HisGly: 0.931 ± 0.337
0.762HisHis: 0.762 ± 0.191
1.185HisIle: 1.185 ± 0.287
1.1HisLys: 1.1 ± 0.282
0.846HisLeu: 0.846 ± 0.275
0.423HisMet: 0.423 ± 0.17
0.846HisAsn: 0.846 ± 0.256
0.677HisPro: 0.677 ± 0.202
0.508HisGln: 0.508 ± 0.236
0.592HisArg: 0.592 ± 0.215
1.354HisSer: 1.354 ± 0.274
0.677HisThr: 0.677 ± 0.232
1.269HisVal: 1.269 ± 0.371
0.085HisTrp: 0.085 ± 0.095
0.846HisTyr: 0.846 ± 0.336
0.0HisXaa: 0.0 ± 0.0
Ile
4.993IleAla: 4.993 ± 0.665
0.423IleCys: 0.423 ± 0.173
5.331IleAsp: 5.331 ± 0.575
5.924IleGlu: 5.924 ± 0.764
2.369IlePhe: 2.369 ± 0.519
3.893IleGly: 3.893 ± 0.542
0.846IleHis: 0.846 ± 0.211
3.554IleIle: 3.554 ± 0.7
5.416IleLys: 5.416 ± 0.552
4.231IleLeu: 4.231 ± 0.729
1.946IleMet: 1.946 ± 0.519
5.077IleAsn: 5.077 ± 0.607
3.131IlePro: 3.131 ± 0.543
3.216IleGln: 3.216 ± 0.498
2.793IleArg: 2.793 ± 0.452
4.908IleSer: 4.908 ± 0.526
3.723IleThr: 3.723 ± 0.507
2.623IleVal: 2.623 ± 0.607
0.931IleTrp: 0.931 ± 0.212
2.285IleTyr: 2.285 ± 0.504
0.0IleXaa: 0.0 ± 0.0
Lys
5.331LysAla: 5.331 ± 0.685
0.254LysCys: 0.254 ± 0.17
5.331LysAsp: 5.331 ± 0.756
6.77LysGlu: 6.77 ± 0.825
3.385LysPhe: 3.385 ± 0.763
5.247LysGly: 5.247 ± 0.672
1.354LysHis: 1.354 ± 0.478
5.754LysIle: 5.754 ± 0.77
7.87LysLys: 7.87 ± 1.187
7.362LysLeu: 7.362 ± 0.663
1.862LysMet: 1.862 ± 0.449
4.993LysAsn: 4.993 ± 0.616
2.623LysPro: 2.623 ± 0.423
3.385LysGln: 3.385 ± 0.428
3.723LysArg: 3.723 ± 0.625
4.739LysSer: 4.739 ± 0.597
5.247LysThr: 5.247 ± 0.753
3.808LysVal: 3.808 ± 0.65
1.354LysTrp: 1.354 ± 0.289
3.216LysTyr: 3.216 ± 0.727
0.0LysXaa: 0.0 ± 0.0
Leu
6.855LeuAla: 6.855 ± 0.841
0.762LeuCys: 0.762 ± 0.289
5.416LeuAsp: 5.416 ± 0.813
6.008LeuGlu: 6.008 ± 0.997
3.131LeuPhe: 3.131 ± 0.528
4.231LeuGly: 4.231 ± 0.742
0.762LeuHis: 0.762 ± 0.257
4.739LeuIle: 4.739 ± 0.587
7.193LeuLys: 7.193 ± 0.765
5.162LeuLeu: 5.162 ± 0.607
2.116LeuMet: 2.116 ± 0.365
6.178LeuAsn: 6.178 ± 0.677
2.623LeuPro: 2.623 ± 0.389
2.2LeuGln: 2.2 ± 0.479
2.877LeuArg: 2.877 ± 0.547
5.162LeuSer: 5.162 ± 0.723
6.008LeuThr: 6.008 ± 0.867
4.316LeuVal: 4.316 ± 0.559
1.015LeuTrp: 1.015 ± 0.321
2.285LeuTyr: 2.285 ± 0.477
0.0LeuXaa: 0.0 ± 0.0
Met
2.031MetAla: 2.031 ± 0.411
0.0MetCys: 0.0 ± 0.0
0.677MetAsp: 0.677 ± 0.267
1.185MetGlu: 1.185 ± 0.407
0.846MetPhe: 0.846 ± 0.208
1.185MetGly: 1.185 ± 0.29
0.338MetHis: 0.338 ± 0.211
1.523MetIle: 1.523 ± 0.351
2.877MetLys: 2.877 ± 0.554
2.031MetLeu: 2.031 ± 0.329
0.592MetMet: 0.592 ± 0.303
1.015MetAsn: 1.015 ± 0.225
1.185MetPro: 1.185 ± 0.278
1.269MetGln: 1.269 ± 0.261
0.931MetArg: 0.931 ± 0.248
1.946MetSer: 1.946 ± 0.389
1.269MetThr: 1.269 ± 0.309
1.777MetVal: 1.777 ± 0.399
0.085MetTrp: 0.085 ± 0.073
0.931MetTyr: 0.931 ± 0.297
0.0MetXaa: 0.0 ± 0.0
Asn
4.908AsnAla: 4.908 ± 0.711
0.338AsnCys: 0.338 ± 0.164
4.316AsnAsp: 4.316 ± 0.625
3.808AsnGlu: 3.808 ± 0.484
2.539AsnPhe: 2.539 ± 0.374
6.855AsnGly: 6.855 ± 1.207
1.269AsnHis: 1.269 ± 0.237
3.046AsnIle: 3.046 ± 0.564
4.231AsnLys: 4.231 ± 0.524
4.316AsnLeu: 4.316 ± 0.557
1.269AsnMet: 1.269 ± 0.344
4.824AsnAsn: 4.824 ± 0.717
2.877AsnPro: 2.877 ± 0.401
2.623AsnGln: 2.623 ± 0.307
2.369AsnArg: 2.369 ± 0.411
3.47AsnSer: 3.47 ± 0.504
3.808AsnThr: 3.808 ± 0.547
3.554AsnVal: 3.554 ± 0.41
1.439AsnTrp: 1.439 ± 0.292
2.285AsnTyr: 2.285 ± 0.463
0.0AsnXaa: 0.0 ± 0.0
Pro
1.608ProAla: 1.608 ± 0.359
0.169ProCys: 0.169 ± 0.126
1.608ProAsp: 1.608 ± 0.423
2.539ProGlu: 2.539 ± 0.506
1.015ProPhe: 1.015 ± 0.298
1.439ProGly: 1.439 ± 0.404
0.338ProHis: 0.338 ± 0.159
1.692ProIle: 1.692 ± 0.322
3.131ProLys: 3.131 ± 0.463
2.285ProLeu: 2.285 ± 0.439
0.338ProMet: 0.338 ± 0.19
2.369ProAsn: 2.369 ± 0.391
0.931ProPro: 0.931 ± 0.307
1.608ProGln: 1.608 ± 0.26
1.1ProArg: 1.1 ± 0.292
2.793ProSer: 2.793 ± 0.458
2.369ProThr: 2.369 ± 0.329
1.608ProVal: 1.608 ± 0.444
0.423ProTrp: 0.423 ± 0.143
0.931ProTyr: 0.931 ± 0.376
0.0ProXaa: 0.0 ± 0.0
Gln
3.385GlnAla: 3.385 ± 0.499
0.169GlnCys: 0.169 ± 0.13
1.608GlnAsp: 1.608 ± 0.402
2.539GlnGlu: 2.539 ± 0.455
1.185GlnPhe: 1.185 ± 0.371
3.131GlnGly: 3.131 ± 0.734
0.423GlnHis: 0.423 ± 0.184
2.116GlnIle: 2.116 ± 0.39
2.454GlnLys: 2.454 ± 0.293
3.723GlnLeu: 3.723 ± 0.486
1.1GlnMet: 1.1 ± 0.365
2.116GlnAsn: 2.116 ± 0.44
0.931GlnPro: 0.931 ± 0.332
2.031GlnGln: 2.031 ± 0.405
1.692GlnArg: 1.692 ± 0.324
2.539GlnSer: 2.539 ± 0.37
2.793GlnThr: 2.793 ± 0.431
2.708GlnVal: 2.708 ± 0.505
0.592GlnTrp: 0.592 ± 0.363
2.116GlnTyr: 2.116 ± 0.345
0.0GlnXaa: 0.0 ± 0.0
Arg
1.608ArgAla: 1.608 ± 0.392
0.254ArgCys: 0.254 ± 0.148
2.708ArgAsp: 2.708 ± 0.433
2.793ArgGlu: 2.793 ± 0.465
1.777ArgPhe: 1.777 ± 0.347
2.708ArgGly: 2.708 ± 0.534
0.762ArgHis: 0.762 ± 0.265
3.385ArgIle: 3.385 ± 0.599
3.131ArgLys: 3.131 ± 0.513
3.3ArgLeu: 3.3 ± 0.592
0.931ArgMet: 0.931 ± 0.319
2.2ArgAsn: 2.2 ± 0.323
1.015ArgPro: 1.015 ± 0.285
1.777ArgGln: 1.777 ± 0.387
1.523ArgArg: 1.523 ± 0.357
1.608ArgSer: 1.608 ± 0.343
2.623ArgThr: 2.623 ± 0.668
2.793ArgVal: 2.793 ± 0.467
1.015ArgTrp: 1.015 ± 0.284
2.454ArgTyr: 2.454 ± 0.482
0.0ArgXaa: 0.0 ± 0.0
Ser
3.3SerAla: 3.3 ± 0.716
0.677SerCys: 0.677 ± 0.218
4.231SerAsp: 4.231 ± 0.603
4.4SerGlu: 4.4 ± 0.528
2.708SerPhe: 2.708 ± 0.44
5.162SerGly: 5.162 ± 0.577
0.846SerHis: 0.846 ± 0.293
4.316SerIle: 4.316 ± 0.564
5.416SerLys: 5.416 ± 1.096
4.824SerLeu: 4.824 ± 0.676
1.692SerMet: 1.692 ± 0.36
4.57SerAsn: 4.57 ± 0.564
1.862SerPro: 1.862 ± 0.336
2.708SerGln: 2.708 ± 0.624
2.454SerArg: 2.454 ± 0.601
4.062SerSer: 4.062 ± 0.83
3.554SerThr: 3.554 ± 0.498
5.331SerVal: 5.331 ± 0.701
0.762SerTrp: 0.762 ± 0.366
2.116SerTyr: 2.116 ± 0.403
0.0SerXaa: 0.0 ± 0.0
Thr
4.231ThrAla: 4.231 ± 0.699
0.423ThrCys: 0.423 ± 0.171
3.723ThrAsp: 3.723 ± 0.562
2.962ThrGlu: 2.962 ± 0.455
3.216ThrPhe: 3.216 ± 0.469
3.131ThrGly: 3.131 ± 0.499
0.762ThrHis: 0.762 ± 0.254
4.316ThrIle: 4.316 ± 0.803
5.077ThrLys: 5.077 ± 0.593
6.262ThrLeu: 6.262 ± 0.883
0.931ThrMet: 0.931 ± 0.256
3.554ThrAsn: 3.554 ± 0.562
1.777ThrPro: 1.777 ± 0.473
3.046ThrGln: 3.046 ± 0.594
1.777ThrArg: 1.777 ± 0.377
3.723ThrSer: 3.723 ± 0.538
3.216ThrThr: 3.216 ± 0.596
4.824ThrVal: 4.824 ± 0.578
0.931ThrTrp: 0.931 ± 0.258
3.723ThrTyr: 3.723 ± 0.655
0.0ThrXaa: 0.0 ± 0.0
Val
4.062ValAla: 4.062 ± 0.699
0.338ValCys: 0.338 ± 0.155
5.585ValAsp: 5.585 ± 0.674
3.808ValGlu: 3.808 ± 0.763
2.369ValPhe: 2.369 ± 0.6
4.57ValGly: 4.57 ± 0.583
0.592ValHis: 0.592 ± 0.19
4.316ValIle: 4.316 ± 0.522
5.67ValLys: 5.67 ± 0.682
4.654ValLeu: 4.654 ± 0.763
1.269ValMet: 1.269 ± 0.343
3.639ValAsn: 3.639 ± 0.575
2.116ValPro: 2.116 ± 0.41
1.777ValGln: 1.777 ± 0.436
1.862ValArg: 1.862 ± 0.462
4.908ValSer: 4.908 ± 0.666
4.062ValThr: 4.062 ± 0.84
3.808ValVal: 3.808 ± 0.567
0.931ValTrp: 0.931 ± 0.212
1.862ValTyr: 1.862 ± 0.448
0.0ValXaa: 0.0 ± 0.0
Trp
0.846TrpAla: 0.846 ± 0.266
0.085TrpCys: 0.085 ± 0.084
1.608TrpAsp: 1.608 ± 0.514
1.1TrpGlu: 1.1 ± 0.252
1.1TrpPhe: 1.1 ± 0.331
0.677TrpGly: 0.677 ± 0.216
0.338TrpHis: 0.338 ± 0.16
1.1TrpIle: 1.1 ± 0.287
0.931TrpLys: 0.931 ± 0.213
1.185TrpLeu: 1.185 ± 0.378
0.254TrpMet: 0.254 ± 0.136
1.185TrpAsn: 1.185 ± 0.34
0.169TrpPro: 0.169 ± 0.133
0.846TrpGln: 0.846 ± 0.242
0.762TrpArg: 0.762 ± 0.234
1.862TrpSer: 1.862 ± 0.667
1.185TrpThr: 1.185 ± 0.483
1.439TrpVal: 1.439 ± 0.286
0.338TrpTrp: 0.338 ± 0.196
0.254TrpTyr: 0.254 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.877TyrAla: 2.877 ± 0.446
0.508TyrCys: 0.508 ± 0.255
3.046TyrAsp: 3.046 ± 0.609
2.369TyrGlu: 2.369 ± 0.406
1.608TyrPhe: 1.608 ± 0.27
2.116TyrGly: 2.116 ± 0.382
0.677TyrHis: 0.677 ± 0.233
2.539TyrIle: 2.539 ± 0.449
2.708TyrLys: 2.708 ± 0.495
3.723TyrLeu: 3.723 ± 0.559
0.677TyrMet: 0.677 ± 0.253
1.692TyrAsn: 1.692 ± 0.394
1.439TyrPro: 1.439 ± 0.406
2.285TyrGln: 2.285 ± 0.346
2.708TyrArg: 2.708 ± 0.606
2.285TyrSer: 2.285 ± 0.538
2.623TyrThr: 2.623 ± 0.586
2.708TyrVal: 2.708 ± 0.428
0.254TyrTrp: 0.254 ± 0.143
2.369TyrTyr: 2.369 ± 0.563
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (11818 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski