Amino acid dipepetide frequency for Sulfitobacter sp. CB2047

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.251AlaAla: 16.251 ± 0.174	1.076AlaCys: 1.076 ± 0.034	7.201AlaAsp: 7.201 ± 0.082	7.742AlaGlu: 7.742 ± 0.104	4.241AlaPhe: 4.241 ± 0.07	10.103AlaGly: 10.103 ± 0.112	2.357AlaHis: 2.357 ± 0.048	5.877AlaIle: 5.877 ± 0.083	4.308AlaLys: 4.308 ± 0.081	13.278AlaLeu: 13.278 ± 0.149	3.823AlaMet: 3.823 ± 0.065	2.756AlaAsn: 2.756 ± 0.048	5.69AlaPro: 5.69 ± 0.084	5.27AlaGln: 5.27 ± 0.077	7.783AlaArg: 7.783 ± 0.093	5.705AlaSer: 5.705 ± 0.08	6.073AlaThr: 6.073 ± 0.08	8.283AlaVal: 8.283 ± 0.086	1.411AlaTrp: 1.411 ± 0.04	2.591AlaTyr: 2.591 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.1CysAla: 1.1 ± 0.033	0.112CysCys: 0.112 ± 0.01	0.61CysAsp: 0.61 ± 0.022	0.404CysGlu: 0.404 ± 0.019	0.351CysPhe: 0.351 ± 0.018	0.886CysGly: 0.886 ± 0.037	0.261CysHis: 0.261 ± 0.015	0.433CysIle: 0.433 ± 0.019	0.243CysLys: 0.243 ± 0.015	0.774CysLeu: 0.774 ± 0.026	0.195CysMet: 0.195 ± 0.015	0.236CysAsn: 0.236 ± 0.013	0.473CysPro: 0.473 ± 0.023	0.253CysGln: 0.253 ± 0.014	0.455CysArg: 0.455 ± 0.023	0.416CysSer: 0.416 ± 0.021	0.469CysThr: 0.469 ± 0.023	0.641CysVal: 0.641 ± 0.027	0.093CysTrp: 0.093 ± 0.009	0.214CysTyr: 0.214 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.203AspAla: 8.203 ± 0.108	0.511AspCys: 0.511 ± 0.027	3.828AspAsp: 3.828 ± 0.084	3.308AspGlu: 3.308 ± 0.056	2.229AspPhe: 2.229 ± 0.042	5.651AspGly: 5.651 ± 0.102	1.456AspHis: 1.456 ± 0.042	3.43AspIle: 3.43 ± 0.058	1.965AspLys: 1.965 ± 0.049	6.294AspLeu: 6.294 ± 0.075	1.87AspMet: 1.87 ± 0.039	1.506AspAsn: 1.506 ± 0.048	3.499AspPro: 3.499 ± 0.061	2.114AspGln: 2.114 ± 0.039	4.064AspArg: 4.064 ± 0.067	2.416AspSer: 2.416 ± 0.054	3.511AspThr: 3.511 ± 0.082	4.806AspVal: 4.806 ± 0.074	1.131AspTrp: 1.131 ± 0.036	1.556AspTyr: 1.556 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.255GluAla: 7.255 ± 0.093	0.332GluCys: 0.332 ± 0.018	3.425GluAsp: 3.425 ± 0.06	3.214GluGlu: 3.214 ± 0.071	1.716GluPhe: 1.716 ± 0.037	4.603GluGly: 4.603 ± 0.064	1.046GluHis: 1.046 ± 0.031	3.305GluIle: 3.305 ± 0.053	2.295GluLys: 2.295 ± 0.047	4.981GluLeu: 4.981 ± 0.068	1.891GluMet: 1.891 ± 0.037	1.925GluAsn: 1.925 ± 0.041	2.19GluPro: 2.19 ± 0.048	2.015GluGln: 2.015 ± 0.05	3.664GluArg: 3.664 ± 0.069	2.004GluSer: 2.004 ± 0.044	3.844GluThr: 3.844 ± 0.066	4.303GluVal: 4.303 ± 0.08	0.654GluTrp: 0.654 ± 0.026	1.127GluTyr: 1.127 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.444PheAla: 4.444 ± 0.076	0.407PheCys: 0.407 ± 0.02	3.059PheAsp: 3.059 ± 0.055	2.175PheGlu: 2.175 ± 0.046	1.394PhePhe: 1.394 ± 0.041	3.815PheGly: 3.815 ± 0.064	0.709PheHis: 0.709 ± 0.028	1.743PheIle: 1.743 ± 0.037	1.147PheLys: 1.147 ± 0.034	3.232PheLeu: 3.232 ± 0.055	0.995PheMet: 0.995 ± 0.033	1.171PheAsn: 1.171 ± 0.035	1.474PhePro: 1.474 ± 0.036	1.032PheGln: 1.032 ± 0.034	1.884PheArg: 1.884 ± 0.04	2.124PheSer: 2.124 ± 0.046	2.222PheThr: 2.222 ± 0.051	2.676PheVal: 2.676 ± 0.054	0.56PheTrp: 0.56 ± 0.023	0.963PheTyr: 0.963 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.719GlyAla: 9.719 ± 0.107	0.823GlyCys: 0.823 ± 0.026	4.964GlyAsp: 4.964 ± 0.092	4.322GlyGlu: 4.322 ± 0.074	3.741GlyPhe: 3.741 ± 0.061	7.422GlyGly: 7.422 ± 0.126	1.811GlyHis: 1.811 ± 0.046	4.431GlyIle: 4.431 ± 0.068	3.439GlyLys: 3.439 ± 0.073	8.687GlyLeu: 8.687 ± 0.103	2.733GlyMet: 2.733 ± 0.057	2.297GlyAsn: 2.297 ± 0.078	3.413GlyPro: 3.413 ± 0.057	3.284GlyGln: 3.284 ± 0.055	5.076GlyArg: 5.076 ± 0.067	4.295GlySer: 4.295 ± 0.07	4.901GlyThr: 4.901 ± 0.084	6.629GlyVal: 6.629 ± 0.082	1.385GlyTrp: 1.385 ± 0.038	2.306GlyTyr: 2.306 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.319HisAla: 2.319 ± 0.052	0.218HisCys: 0.218 ± 0.013	1.326HisAsp: 1.326 ± 0.041	1.02HisGlu: 1.02 ± 0.033	0.779HisPhe: 0.779 ± 0.024	1.807HisGly: 1.807 ± 0.045	0.554HisHis: 0.554 ± 0.025	1.057HisIle: 1.057 ± 0.036	0.593HisLys: 0.593 ± 0.022	1.978HisLeu: 1.978 ± 0.042	0.587HisMet: 0.587 ± 0.022	0.522HisAsn: 0.522 ± 0.022	1.337HisPro: 1.337 ± 0.037	0.632HisGln: 0.632 ± 0.025	1.185HisArg: 1.185 ± 0.04	0.943HisSer: 0.943 ± 0.03	0.913HisThr: 0.913 ± 0.035	1.472HisVal: 1.472 ± 0.037	0.309HisTrp: 0.309 ± 0.019	0.547HisTyr: 0.547 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.09IleAla: 7.09 ± 0.089	0.625IleCys: 0.625 ± 0.027	3.755IleAsp: 3.755 ± 0.059	3.453IleGlu: 3.453 ± 0.051	1.82IlePhe: 1.82 ± 0.044	4.869IleGly: 4.869 ± 0.084	0.946IleHis: 0.946 ± 0.027	2.539IleIle: 2.539 ± 0.056	1.825IleLys: 1.825 ± 0.044	4.619IleLeu: 4.619 ± 0.073	1.177IleMet: 1.177 ± 0.035	1.606IleAsn: 1.606 ± 0.042	2.407IlePro: 2.407 ± 0.049	1.279IleGln: 1.279 ± 0.037	2.938IleArg: 2.938 ± 0.055	3.107IleSer: 3.107 ± 0.059	3.252IleThr: 3.252 ± 0.059	3.858IleVal: 3.858 ± 0.066	0.738IleTrp: 0.738 ± 0.025	1.247IleTyr: 1.247 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.147LysAla: 4.147 ± 0.082	0.222LysCys: 0.222 ± 0.015	1.985LysAsp: 1.985 ± 0.047	1.677LysGlu: 1.677 ± 0.042	1.075LysPhe: 1.075 ± 0.03	2.972LysGly: 2.972 ± 0.063	0.719LysHis: 0.719 ± 0.026	1.941LysIle: 1.941 ± 0.042	1.342LysLys: 1.342 ± 0.04	3.316LysLeu: 3.316 ± 0.06	1.075LysMet: 1.075 ± 0.034	0.935LysAsn: 0.935 ± 0.034	1.944LysPro: 1.944 ± 0.049	1.091LysGln: 1.091 ± 0.031	2.488LysArg: 2.488 ± 0.05	2.039LysSer: 2.039 ± 0.045	2.234LysThr: 2.234 ± 0.045	2.385LysVal: 2.385 ± 0.048	0.399LysTrp: 0.399 ± 0.02	0.724LysTyr: 0.724 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	11.955LeuAla: 11.955 ± 0.141	0.91LeuCys: 0.91 ± 0.029	5.94LeuAsp: 5.94 ± 0.079	5.029LeuGlu: 5.029 ± 0.082	3.44LeuPhe: 3.44 ± 0.063	8.137LeuGly: 8.137 ± 0.111	1.847LeuHis: 1.847 ± 0.04	5.386LeuIle: 5.386 ± 0.082	3.237LeuLys: 3.237 ± 0.058	8.564LeuLeu: 8.564 ± 0.138	2.789LeuMet: 2.789 ± 0.05	2.86LeuAsn: 2.86 ± 0.054	5.323LeuPro: 5.323 ± 0.078	2.817LeuGln: 2.817 ± 0.052	6.731LeuArg: 6.731 ± 0.084	6.573LeuSer: 6.573 ± 0.088	6.138LeuThr: 6.138 ± 0.077	6.646LeuVal: 6.646 ± 0.083	1.246LeuTrp: 1.246 ± 0.034	1.891LeuTyr: 1.891 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.54MetAla: 3.54 ± 0.063	0.203MetCys: 0.203 ± 0.014	1.559MetAsp: 1.559 ± 0.038	1.326MetGlu: 1.326 ± 0.036	0.913MetPhe: 0.913 ± 0.032	2.487MetGly: 2.487 ± 0.058	0.495MetHis: 0.495 ± 0.023	1.766MetIle: 1.766 ± 0.043	1.176MetLys: 1.176 ± 0.03	2.696MetLeu: 2.696 ± 0.048	0.895MetMet: 0.895 ± 0.029	0.956MetAsn: 0.956 ± 0.03	1.59MetPro: 1.59 ± 0.037	1.101MetGln: 1.101 ± 0.028	1.919MetArg: 1.919 ± 0.04	1.768MetSer: 1.768 ± 0.042	2.299MetThr: 2.299 ± 0.049	1.948MetVal: 1.948 ± 0.043	0.284MetTrp: 0.284 ± 0.015	0.415MetTyr: 0.415 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.496AsnAla: 3.496 ± 0.058	0.279AsnCys: 0.279 ± 0.016	1.725AsnAsp: 1.725 ± 0.063	1.269AsnGlu: 1.269 ± 0.035	1.023AsnPhe: 1.023 ± 0.034	2.625AsnGly: 2.625 ± 0.058	0.531AsnHis: 0.531 ± 0.021	1.485AsnIle: 1.485 ± 0.039	0.81AsnLys: 0.81 ± 0.029	2.614AsnLeu: 2.614 ± 0.045	0.754AsnMet: 0.754 ± 0.026	0.805AsnAsn: 0.805 ± 0.027	1.873AsnPro: 1.873 ± 0.04	0.776AsnGln: 0.776 ± 0.026	1.754AsnArg: 1.754 ± 0.034	1.231AsnSer: 1.231 ± 0.034	1.567AsnThr: 1.567 ± 0.04	1.998AsnVal: 1.998 ± 0.049	0.424AsnTrp: 0.424 ± 0.02	0.718AsnTyr: 0.718 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.651ProAla: 5.651 ± 0.082	0.347ProCys: 0.347 ± 0.019	3.998ProAsp: 3.998 ± 0.064	3.643ProGlu: 3.643 ± 0.061	1.949ProPhe: 1.949 ± 0.038	3.698ProGly: 3.698 ± 0.068	1.013ProHis: 1.013 ± 0.033	2.257ProIle: 2.257 ± 0.045	1.86ProLys: 1.86 ± 0.048	4.564ProLeu: 4.564 ± 0.07	1.332ProMet: 1.332 ± 0.032	1.394ProAsn: 1.394 ± 0.035	2.021ProPro: 2.021 ± 0.046	1.91ProGln: 1.91 ± 0.046	2.565ProArg: 2.565 ± 0.059	2.539ProSer: 2.539 ± 0.044	2.556ProThr: 2.556 ± 0.053	4.108ProVal: 4.108 ± 0.057	0.594ProTrp: 0.594 ± 0.025	1.134ProTyr: 1.134 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.368GlnAla: 4.368 ± 0.071	0.201GlnCys: 0.201 ± 0.013	1.932GlnAsp: 1.932 ± 0.043	1.715GlnGlu: 1.715 ± 0.039	1.167GlnPhe: 1.167 ± 0.032	2.829GlnGly: 2.829 ± 0.048	0.654GlnHis: 0.654 ± 0.025	2.277GlnIle: 2.277 ± 0.046	1.211GlnLys: 1.211 ± 0.031	3.011GlnLeu: 3.011 ± 0.059	1.232GlnMet: 1.232 ± 0.035	1.022GlnAsn: 1.022 ± 0.029	1.655GlnPro: 1.655 ± 0.04	1.261GlnGln: 1.261 ± 0.038	2.294GlnArg: 2.294 ± 0.051	2.105GlnSer: 2.105 ± 0.052	2.156GlnThr: 2.156 ± 0.043	2.386GlnVal: 2.386 ± 0.048	0.42GlnTrp: 0.42 ± 0.019	0.617GlnTyr: 0.617 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.43ArgAla: 7.43 ± 0.079	0.435ArgCys: 0.435 ± 0.018	4.255ArgAsp: 4.255 ± 0.064	3.467ArgGlu: 3.467 ± 0.056	2.537ArgPhe: 2.537 ± 0.052	4.332ArgGly: 4.332 ± 0.068	1.324ArgHis: 1.324 ± 0.034	3.48ArgIle: 3.48 ± 0.057	2.36ArgLys: 2.36 ± 0.052	6.4ArgLeu: 6.4 ± 0.095	1.927ArgMet: 1.927 ± 0.037	1.73ArgAsn: 1.73 ± 0.037	2.882ArgPro: 2.882 ± 0.05	2.184ArgGln: 2.184 ± 0.046	4.245ArgArg: 4.245 ± 0.073	3.223ArgSer: 3.223 ± 0.054	2.812ArgThr: 2.812 ± 0.051	4.479ArgVal: 4.479 ± 0.071	0.822ArgTrp: 0.822 ± 0.03	1.539ArgTyr: 1.539 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.908SerAla: 5.908 ± 0.078	0.427SerCys: 0.427 ± 0.022	3.598SerAsp: 3.598 ± 0.056	2.789SerGlu: 2.789 ± 0.055	2.422SerPhe: 2.422 ± 0.043	5.282SerGly: 5.282 ± 0.074	1.048SerHis: 1.048 ± 0.032	2.673SerIle: 2.673 ± 0.053	1.766SerLys: 1.766 ± 0.042	5.04SerLeu: 5.04 ± 0.068	1.444SerMet: 1.444 ± 0.034	1.493SerAsn: 1.493 ± 0.037	2.41SerPro: 2.41 ± 0.048	1.702SerGln: 1.702 ± 0.045	2.984SerArg: 2.984 ± 0.053	2.706SerSer: 2.706 ± 0.051	2.682SerThr: 2.682 ± 0.056	4.009SerVal: 4.009 ± 0.069	0.656SerTrp: 0.656 ± 0.027	1.415SerTyr: 1.415 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.487ThrAla: 6.487 ± 0.082	0.484ThrCys: 0.484 ± 0.024	3.404ThrAsp: 3.404 ± 0.054	3.015ThrGlu: 3.015 ± 0.053	1.964ThrPhe: 1.964 ± 0.045	5.37ThrGly: 5.37 ± 0.081	1.169ThrHis: 1.169 ± 0.034	2.947ThrIle: 2.947 ± 0.067	1.712ThrLys: 1.712 ± 0.043	6.383ThrLeu: 6.383 ± 0.073	1.438ThrMet: 1.438 ± 0.032	1.392ThrAsn: 1.392 ± 0.037	3.789ThrPro: 3.789 ± 0.061	2.047ThrGln: 2.047 ± 0.049	3.488ThrArg: 3.488 ± 0.058	3.048ThrSer: 3.048 ± 0.049	3.074ThrThr: 3.074 ± 0.055	4.438ThrVal: 4.438 ± 0.069	0.649ThrTrp: 0.649 ± 0.023	1.34ThrTyr: 1.34 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.556ValAla: 8.556 ± 0.098	0.64ValCys: 0.64 ± 0.028	4.342ValAsp: 4.342 ± 0.066	4.358ValGlu: 4.358 ± 0.061	3.003ValPhe: 3.003 ± 0.057	5.579ValGly: 5.579 ± 0.074	1.292ValHis: 1.292 ± 0.037	4.357ValIle: 4.357 ± 0.067	2.337ValLys: 2.337 ± 0.051	7.289ValLeu: 7.289 ± 0.085	2.226ValMet: 2.226 ± 0.048	2.094ValAsn: 2.094 ± 0.05	3.51ValPro: 3.51 ± 0.058	2.427ValGln: 2.427 ± 0.048	3.852ValArg: 3.852 ± 0.062	4.298ValSer: 4.298 ± 0.066	4.944ValThr: 4.944 ± 0.073	5.775ValVal: 5.775 ± 0.089	0.923ValTrp: 0.923 ± 0.029	1.569ValTyr: 1.569 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.278TrpAla: 1.278 ± 0.04	0.14TrpCys: 0.14 ± 0.012	0.743TrpAsp: 0.743 ± 0.027	0.611TrpGlu: 0.611 ± 0.025	0.518TrpPhe: 0.518 ± 0.022	1.049TrpGly: 1.049 ± 0.035	0.333TrpHis: 0.333 ± 0.018	0.688TrpIle: 0.688 ± 0.027	0.446TrpLys: 0.446 ± 0.019	1.462TrpLeu: 1.462 ± 0.043	0.422TrpMet: 0.422 ± 0.02	0.419TrpAsn: 0.419 ± 0.022	0.622TrpPro: 0.622 ± 0.026	0.596TrpGln: 0.596 ± 0.026	0.978TrpArg: 0.978 ± 0.032	0.762TrpSer: 0.762 ± 0.029	0.74TrpThr: 0.74 ± 0.027	0.95TrpVal: 0.95 ± 0.03	0.205TrpTrp: 0.205 ± 0.014	0.289TrpTyr: 0.289 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.624TyrAla: 2.624 ± 0.045	0.229TyrCys: 0.229 ± 0.015	1.698TyrAsp: 1.698 ± 0.04	1.252TyrGlu: 1.252 ± 0.042	0.944TyrPhe: 0.944 ± 0.03	2.162TyrGly: 2.162 ± 0.04	0.533TyrHis: 0.533 ± 0.021	1.078TyrIle: 1.078 ± 0.033	0.638TyrLys: 0.638 ± 0.026	2.277TyrLeu: 2.277 ± 0.041	0.533TyrMet: 0.533 ± 0.019	0.637TyrAsn: 0.637 ± 0.022	1.033TyrPro: 1.033 ± 0.028	0.723TyrGln: 0.723 ± 0.026	1.514TyrArg: 1.514 ± 0.036	1.151TyrSer: 1.151 ± 0.031	1.25TyrThr: 1.25 ± 0.033	1.58TyrVal: 1.58 ± 0.038	0.347TyrTrp: 0.347 ± 0.015	0.588TyrTyr: 0.588 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3563 proteins (1115998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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