Amino acid dipepetide frequency for Pannonibacter phragmitetus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.791AlaAla: 18.791 ± 0.161
1.126AlaCys: 1.126 ± 0.029
6.745AlaAsp: 6.745 ± 0.069
7.98AlaGlu: 7.98 ± 0.085
4.66AlaPhe: 4.66 ± 0.062
12.063AlaGly: 12.063 ± 0.11
2.159AlaHis: 2.159 ± 0.037
6.162AlaIle: 6.162 ± 0.071
3.598AlaLys: 3.598 ± 0.048
13.81AlaLeu: 13.81 ± 0.107
3.612AlaMet: 3.612 ± 0.047
2.762AlaAsn: 2.762 ± 0.046
5.581AlaPro: 5.581 ± 0.077
4.045AlaGln: 4.045 ± 0.048
8.864AlaArg: 8.864 ± 0.094
7.072AlaSer: 7.072 ± 0.079
5.487AlaThr: 5.487 ± 0.058
8.955AlaVal: 8.955 ± 0.074
1.388AlaTrp: 1.388 ± 0.029
2.603AlaTyr: 2.603 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
0.967CysAla: 0.967 ± 0.028
0.112CysCys: 0.112 ± 0.008
0.464CysAsp: 0.464 ± 0.018
0.433CysGlu: 0.433 ± 0.018
0.318CysPhe: 0.318 ± 0.013
0.987CysGly: 0.987 ± 0.026
0.227CysHis: 0.227 ± 0.012
0.396CysIle: 0.396 ± 0.013
0.202CysLys: 0.202 ± 0.012
0.875CysLeu: 0.875 ± 0.027
0.176CysMet: 0.176 ± 0.011
0.207CysAsn: 0.207 ± 0.011
0.426CysPro: 0.426 ± 0.019
0.224CysGln: 0.224 ± 0.011
0.595CysArg: 0.595 ± 0.019
0.45CysSer: 0.45 ± 0.018
0.381CysThr: 0.381 ± 0.017
0.551CysVal: 0.551 ± 0.018
0.102CysTrp: 0.102 ± 0.008
0.179CysTyr: 0.179 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.435AspAla: 6.435 ± 0.061
0.475AspCys: 0.475 ± 0.019
2.595AspAsp: 2.595 ± 0.049
3.424AspGlu: 3.424 ± 0.05
2.104AspPhe: 2.104 ± 0.039
5.071AspGly: 5.071 ± 0.073
1.168AspHis: 1.168 ± 0.031
2.827AspIle: 2.827 ± 0.044
1.635AspLys: 1.635 ± 0.034
6.091AspLeu: 6.091 ± 0.072
1.468AspMet: 1.468 ± 0.032
1.173AspAsn: 1.173 ± 0.03
3.262AspPro: 3.262 ± 0.048
1.67AspGln: 1.67 ± 0.032
3.797AspArg: 3.797 ± 0.051
2.023AspSer: 2.023 ± 0.04
2.554AspThr: 2.554 ± 0.039
3.949AspVal: 3.949 ± 0.054
0.947AspTrp: 0.947 ± 0.027
1.433AspTyr: 1.433 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
8.533GluAla: 8.533 ± 0.089
0.317GluCys: 0.317 ± 0.014
3.254GluAsp: 3.254 ± 0.052
3.668GluGlu: 3.668 ± 0.054
1.706GluPhe: 1.706 ± 0.033
4.847GluGly: 4.847 ± 0.058
1.148GluHis: 1.148 ± 0.03
3.434GluIle: 3.434 ± 0.052
2.206GluLys: 2.206 ± 0.045
5.499GluLeu: 5.499 ± 0.071
1.545GluMet: 1.545 ± 0.034
1.519GluAsn: 1.519 ± 0.034
2.72GluPro: 2.72 ± 0.048
1.957GluGln: 1.957 ± 0.039
4.674GluArg: 4.674 ± 0.062
2.265GluSer: 2.265 ± 0.037
3.691GluThr: 3.691 ± 0.05
3.949GluVal: 3.949 ± 0.051
0.615GluTrp: 0.615 ± 0.019
0.893GluTyr: 0.893 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.646PheAla: 4.646 ± 0.061
0.385PheCys: 0.385 ± 0.016
2.442PheAsp: 2.442 ± 0.038
2.132PheGlu: 2.132 ± 0.037
1.487PhePhe: 1.487 ± 0.038
3.616PheGly: 3.616 ± 0.043
0.775PheHis: 0.775 ± 0.02
1.838PheIle: 1.838 ± 0.036
0.979PheLys: 0.979 ± 0.027
3.711PheLeu: 3.711 ± 0.052
0.877PheMet: 0.877 ± 0.025
1.111PheAsn: 1.111 ± 0.03
1.557PhePro: 1.557 ± 0.034
1.102PheGln: 1.102 ± 0.024
2.359PheArg: 2.359 ± 0.04
2.32PheSer: 2.32 ± 0.033
2.113PheThr: 2.113 ± 0.037
2.63PheVal: 2.63 ± 0.049
0.576PheTrp: 0.576 ± 0.022
0.886PheTyr: 0.886 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
9.437GlyAla: 9.437 ± 0.092
0.851GlyCys: 0.851 ± 0.025
4.072GlyAsp: 4.072 ± 0.056
5.084GlyGlu: 5.084 ± 0.061
3.759GlyPhe: 3.759 ± 0.049
7.584GlyGly: 7.584 ± 0.147
1.962GlyHis: 1.962 ± 0.033
4.761GlyIle: 4.761 ± 0.066
3.354GlyLys: 3.354 ± 0.048
9.822GlyLeu: 9.822 ± 0.093
2.405GlyMet: 2.405 ± 0.043
2.203GlyAsn: 2.203 ± 0.045
3.501GlyPro: 3.501 ± 0.051
3.109GlyGln: 3.109 ± 0.045
6.076GlyArg: 6.076 ± 0.071
5.115GlySer: 5.115 ± 0.083
5.037GlyThr: 5.037 ± 0.081
5.892GlyVal: 5.892 ± 0.064
1.373GlyTrp: 1.373 ± 0.028
2.274GlyTyr: 2.274 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.22HisAla: 2.22 ± 0.043
0.205HisCys: 0.205 ± 0.012
1.163HisAsp: 1.163 ± 0.028
1.051HisGlu: 1.051 ± 0.026
0.823HisPhe: 0.823 ± 0.026
1.957HisGly: 1.957 ± 0.039
0.56HisHis: 0.56 ± 0.024
0.92HisIle: 0.92 ± 0.025
0.504HisLys: 0.504 ± 0.015
2.124HisLeu: 2.124 ± 0.04
0.576HisMet: 0.576 ± 0.019
0.403HisAsn: 0.403 ± 0.017
1.254HisPro: 1.254 ± 0.029
0.58HisGln: 0.58 ± 0.018
1.266HisArg: 1.266 ± 0.03
0.861HisSer: 0.861 ± 0.024
0.841HisThr: 0.841 ± 0.025
1.565HisVal: 1.565 ± 0.031
0.323HisTrp: 0.323 ± 0.014
0.504HisTyr: 0.504 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.273IleAla: 7.273 ± 0.079
0.543IleCys: 0.543 ± 0.018
3.138IleAsp: 3.138 ± 0.048
3.404IleGlu: 3.404 ± 0.05
1.783IlePhe: 1.783 ± 0.037
4.828IleGly: 4.828 ± 0.063
0.876IleHis: 0.876 ± 0.024
2.476IleIle: 2.476 ± 0.043
1.263IleLys: 1.263 ± 0.033
4.91IleLeu: 4.91 ± 0.065
1.05IleMet: 1.05 ± 0.026
1.421IleAsn: 1.421 ± 0.032
2.338IlePro: 2.338 ± 0.043
1.217IleGln: 1.217 ± 0.028
3.398IleArg: 3.398 ± 0.045
3.239IleSer: 3.239 ± 0.048
2.897IleThr: 2.897 ± 0.046
3.674IleVal: 3.674 ± 0.058
0.601IleTrp: 0.601 ± 0.018
1.153IleTyr: 1.153 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
4.491LysAla: 4.491 ± 0.062
0.141LysCys: 0.141 ± 0.009
1.79LysAsp: 1.79 ± 0.036
1.601LysGlu: 1.601 ± 0.038
0.824LysPhe: 0.824 ± 0.024
2.779LysGly: 2.779 ± 0.044
0.545LysHis: 0.545 ± 0.017
1.613LysIle: 1.613 ± 0.039
1.05LysLys: 1.05 ± 0.032
3.282LysLeu: 3.282 ± 0.05
0.74LysMet: 0.74 ± 0.02
0.751LysAsn: 0.751 ± 0.024
1.952LysPro: 1.952 ± 0.04
0.895LysGln: 0.895 ± 0.025
2.073LysArg: 2.073 ± 0.038
1.658LysSer: 1.658 ± 0.036
1.931LysThr: 1.931 ± 0.042
2.475LysVal: 2.475 ± 0.039
0.296LysTrp: 0.296 ± 0.013
0.523LysTyr: 0.523 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.645LeuAla: 14.645 ± 0.105
0.888LeuCys: 0.888 ± 0.022
6.009LeuAsp: 6.009 ± 0.07
5.779LeuGlu: 5.779 ± 0.065
3.79LeuPhe: 3.79 ± 0.058
8.387LeuGly: 8.387 ± 0.082
1.817LeuHis: 1.817 ± 0.034
5.162LeuIle: 5.162 ± 0.071
3.833LeuLys: 3.833 ± 0.056
9.886LeuLeu: 9.886 ± 0.117
2.678LeuMet: 2.678 ± 0.043
2.709LeuAsn: 2.709 ± 0.042
5.989LeuPro: 5.989 ± 0.065
3.034LeuGln: 3.034 ± 0.046
6.926LeuArg: 6.926 ± 0.076
6.918LeuSer: 6.918 ± 0.06
6.382LeuThr: 6.382 ± 0.07
7.392LeuVal: 7.392 ± 0.075
1.165LeuTrp: 1.165 ± 0.03
2.074LeuTyr: 2.074 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.348MetAla: 3.348 ± 0.047
0.156MetCys: 0.156 ± 0.011
1.268MetAsp: 1.268 ± 0.026
1.306MetGlu: 1.306 ± 0.031
0.761MetPhe: 0.761 ± 0.024
1.906MetGly: 1.906 ± 0.035
0.414MetHis: 0.414 ± 0.017
1.454MetIle: 1.454 ± 0.035
0.987MetLys: 0.987 ± 0.024
2.628MetLeu: 2.628 ± 0.047
0.709MetMet: 0.709 ± 0.023
0.749MetAsn: 0.749 ± 0.023
1.604MetPro: 1.604 ± 0.032
0.903MetGln: 0.903 ± 0.023
1.81MetArg: 1.81 ± 0.033
1.699MetSer: 1.699 ± 0.035
2.053MetThr: 2.053 ± 0.04
1.785MetVal: 1.785 ± 0.032
0.226MetTrp: 0.226 ± 0.011
0.281MetTyr: 0.281 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.059AsnAla: 3.059 ± 0.054
0.215AsnCys: 0.215 ± 0.012
1.222AsnAsp: 1.222 ± 0.028
1.215AsnGlu: 1.215 ± 0.032
0.868AsnPhe: 0.868 ± 0.027
2.391AsnGly: 2.391 ± 0.049
0.454AsnHis: 0.454 ± 0.017
1.341AsnIle: 1.341 ± 0.029
0.636AsnLys: 0.636 ± 0.022
2.591AsnLeu: 2.591 ± 0.046
0.634AsnMet: 0.634 ± 0.021
0.634AsnAsn: 0.634 ± 0.021
1.778AsnPro: 1.778 ± 0.031
0.747AsnGln: 0.747 ± 0.023
1.814AsnArg: 1.814 ± 0.034
1.211AsnSer: 1.211 ± 0.03
1.314AsnThr: 1.314 ± 0.032
1.763AsnVal: 1.763 ± 0.038
0.44AsnTrp: 0.44 ± 0.018
0.608AsnTyr: 0.608 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.712ProAla: 6.712 ± 0.082
0.337ProCys: 0.337 ± 0.015
3.503ProAsp: 3.503 ± 0.052
3.97ProGlu: 3.97 ± 0.056
2.027ProPhe: 2.027 ± 0.04
4.652ProGly: 4.652 ± 0.058
1.097ProHis: 1.097 ± 0.026
1.81ProIle: 1.81 ± 0.035
1.515ProLys: 1.515 ± 0.031
5.07ProLeu: 5.07 ± 0.067
1.172ProMet: 1.172 ± 0.028
1.111ProAsn: 1.111 ± 0.028
2.251ProPro: 2.251 ± 0.043
2.098ProGln: 2.098 ± 0.042
2.765ProArg: 2.765 ± 0.039
2.637ProSer: 2.637 ± 0.041
1.78ProThr: 1.78 ± 0.036
4.853ProVal: 4.853 ± 0.061
0.608ProTrp: 0.608 ± 0.019
1.123ProTyr: 1.123 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
4.196GlnAla: 4.196 ± 0.062
0.182GlnCys: 0.182 ± 0.01
1.694GlnAsp: 1.694 ± 0.029
1.723GlnGlu: 1.723 ± 0.034
1.055GlnPhe: 1.055 ± 0.022
2.563GlnGly: 2.563 ± 0.041
0.655GlnHis: 0.655 ± 0.019
2.047GlnIle: 2.047 ± 0.039
1.099GlnLys: 1.099 ± 0.028
3.053GlnLeu: 3.053 ± 0.046
0.998GlnMet: 0.998 ± 0.029
0.876GlnAsn: 0.876 ± 0.026
1.78GlnPro: 1.78 ± 0.039
1.338GlnGln: 1.338 ± 0.036
2.29GlnArg: 2.29 ± 0.041
1.817GlnSer: 1.817 ± 0.037
1.909GlnThr: 1.909 ± 0.038
2.304GlnVal: 2.304 ± 0.042
0.366GlnTrp: 0.366 ± 0.014
0.516GlnTyr: 0.516 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
7.356ArgAla: 7.356 ± 0.077
0.502ArgCys: 0.502 ± 0.019
3.724ArgAsp: 3.724 ± 0.061
4.092ArgGlu: 4.092 ± 0.051
2.889ArgPhe: 2.889 ± 0.043
4.5ArgGly: 4.5 ± 0.049
1.641ArgHis: 1.641 ± 0.032
3.947ArgIle: 3.947 ± 0.055
2.555ArgLys: 2.555 ± 0.041
8.102ArgLeu: 8.102 ± 0.088
1.935ArgMet: 1.935 ± 0.032
1.821ArgAsn: 1.821 ± 0.037
3.46ArgPro: 3.46 ± 0.055
2.865ArgGln: 2.865 ± 0.04
5.267ArgArg: 5.267 ± 0.073
3.652ArgSer: 3.652 ± 0.054
3.34ArgThr: 3.34 ± 0.046
4.314ArgVal: 4.314 ± 0.059
0.89ArgTrp: 0.89 ± 0.023
1.565ArgTyr: 1.565 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.722SerAla: 6.722 ± 0.077
0.443SerCys: 0.443 ± 0.017
2.74SerAsp: 2.74 ± 0.043
2.82SerGlu: 2.82 ± 0.047
2.445SerPhe: 2.445 ± 0.041
6.274SerGly: 6.274 ± 0.087
1.138SerHis: 1.138 ± 0.027
2.822SerIle: 2.822 ± 0.041
1.423SerLys: 1.423 ± 0.03
6.151SerLeu: 6.151 ± 0.075
1.419SerMet: 1.419 ± 0.029
1.33SerAsn: 1.33 ± 0.033
2.773SerPro: 2.773 ± 0.045
1.722SerGln: 1.722 ± 0.038
3.753SerArg: 3.753 ± 0.047
3.282SerSer: 3.282 ± 0.059
2.648SerThr: 2.648 ± 0.044
4.003SerVal: 4.003 ± 0.048
0.75SerTrp: 0.75 ± 0.022
1.283SerTyr: 1.283 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.725ThrAla: 6.725 ± 0.075
0.452ThrCys: 0.452 ± 0.016
2.697ThrAsp: 2.697 ± 0.045
2.557ThrGlu: 2.557 ± 0.047
1.96ThrPhe: 1.96 ± 0.038
5.965ThrGly: 5.965 ± 0.084
0.984ThrHis: 0.984 ± 0.024
2.716ThrIle: 2.716 ± 0.045
1.251ThrLys: 1.251 ± 0.028
5.928ThrLeu: 5.928 ± 0.064
1.146ThrMet: 1.146 ± 0.026
1.199ThrAsn: 1.199 ± 0.033
3.214ThrPro: 3.214 ± 0.043
1.54ThrGln: 1.54 ± 0.032
3.361ThrArg: 3.361 ± 0.049
3.017ThrSer: 3.017 ± 0.046
2.541ThrThr: 2.541 ± 0.05
4.436ThrVal: 4.436 ± 0.068
0.614ThrTrp: 0.614 ± 0.019
1.197ThrTyr: 1.197 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
8.359ValAla: 8.359 ± 0.075
0.599ValCys: 0.599 ± 0.019
3.607ValAsp: 3.607 ± 0.048
4.454ValGlu: 4.454 ± 0.055
2.865ValPhe: 2.865 ± 0.046
4.405ValGly: 4.405 ± 0.063
1.344ValHis: 1.344 ± 0.032
4.218ValIle: 4.218 ± 0.052
2.294ValLys: 2.294 ± 0.043
8.053ValLeu: 8.053 ± 0.082
2.055ValMet: 2.055 ± 0.038
1.974ValAsn: 1.974 ± 0.04
3.909ValPro: 3.909 ± 0.058
2.123ValGln: 2.123 ± 0.037
4.652ValArg: 4.652 ± 0.065
4.769ValSer: 4.769 ± 0.066
4.707ValThr: 4.707 ± 0.071
5.14ValVal: 5.14 ± 0.069
0.918ValTrp: 0.918 ± 0.026
1.493ValTyr: 1.493 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
1.18TrpAla: 1.18 ± 0.03
0.122TrpCys: 0.122 ± 0.009
0.624TrpAsp: 0.624 ± 0.019
0.508TrpGlu: 0.508 ± 0.018
0.533TrpPhe: 0.533 ± 0.018
0.856TrpGly: 0.856 ± 0.025
0.315TrpHis: 0.315 ± 0.017
0.642TrpIle: 0.642 ± 0.023
0.438TrpLys: 0.438 ± 0.016
1.606TrpLeu: 1.606 ± 0.033
0.364TrpMet: 0.364 ± 0.016
0.42TrpAsn: 0.42 ± 0.018
0.679TrpPro: 0.679 ± 0.02
0.59TrpGln: 0.59 ± 0.019
1.032TrpArg: 1.032 ± 0.027
0.793TrpSer: 0.793 ± 0.024
0.755TrpThr: 0.755 ± 0.018
0.774TrpVal: 0.774 ± 0.022
0.212TrpTrp: 0.212 ± 0.013
0.274TrpTyr: 0.274 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.37TyrAla: 2.37 ± 0.039
0.223TyrCys: 0.223 ± 0.012
1.349TyrAsp: 1.349 ± 0.031
1.239TyrGlu: 1.239 ± 0.026
0.885TyrPhe: 0.885 ± 0.026
2.041TyrGly: 2.041 ± 0.039
0.42TyrHis: 0.42 ± 0.019
0.896TyrIle: 0.896 ± 0.023
0.587TyrLys: 0.587 ± 0.019
2.27TyrLeu: 2.27 ± 0.039
0.487TyrMet: 0.487 ± 0.019
0.558TyrAsn: 0.558 ± 0.019
1.065TyrPro: 1.065 ± 0.03
0.698TyrGln: 0.698 ± 0.022
1.643TyrArg: 1.643 ± 0.031
1.146TyrSer: 1.146 ± 0.024
1.138TyrThr: 1.138 ± 0.031
1.535TyrVal: 1.535 ± 0.031
0.31TyrTrp: 0.31 ± 0.013
0.548TyrTyr: 0.548 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4943 proteins (1591901 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski