Amino acid dipepetide frequency for Sorangiineae bacterium NIC37A_2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.823AlaAla: 12.823 ± 0.142	1.381AlaCys: 1.381 ± 0.036	4.976AlaAsp: 4.976 ± 0.072	8.312AlaGlu: 8.312 ± 0.104	3.924AlaPhe: 3.924 ± 0.055	8.331AlaGly: 8.331 ± 0.085	2.256AlaHis: 2.256 ± 0.04	4.569AlaIle: 4.569 ± 0.063	3.564AlaLys: 3.564 ± 0.067	14.201AlaLeu: 14.201 ± 0.155	1.889AlaMet: 1.889 ± 0.041	1.993AlaAsn: 1.993 ± 0.043	7.151AlaPro: 7.151 ± 0.097	3.871AlaGln: 3.871 ± 0.051	9.692AlaArg: 9.692 ± 0.107	7.202AlaSer: 7.202 ± 0.089	5.201AlaThr: 5.201 ± 0.06	6.882AlaVal: 6.882 ± 0.082	1.308AlaTrp: 1.308 ± 0.035	2.291AlaTyr: 2.291 ± 0.046	0.003AlaXaa: 0.003 ± 0.002
Cys	1.152CysAla: 1.152 ± 0.035	0.11CysCys: 0.11 ± 0.011	0.736CysAsp: 0.736 ± 0.037	0.757CysGlu: 0.757 ± 0.029	0.335CysPhe: 0.335 ± 0.016	1.119CysGly: 1.119 ± 0.043	0.289CysHis: 0.289 ± 0.019	0.336CysIle: 0.336 ± 0.014	0.282CysLys: 0.282 ± 0.017	0.944CysLeu: 0.944 ± 0.03	0.132CysMet: 0.132 ± 0.009	0.239CysAsn: 0.239 ± 0.015	0.677CysPro: 0.677 ± 0.028	0.327CysGln: 0.327 ± 0.019	0.673CysArg: 0.673 ± 0.022	0.811CysSer: 0.811 ± 0.027	0.525CysThr: 0.525 ± 0.024	0.843CysVal: 0.843 ± 0.031	0.095CysTrp: 0.095 ± 0.01	0.207CysTyr: 0.207 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	5.925AspAla: 5.925 ± 0.065	0.63AspCys: 0.63 ± 0.033	2.997AspAsp: 2.997 ± 0.068	4.102AspGlu: 4.102 ± 0.066	2.012AspPhe: 2.012 ± 0.038	4.977AspGly: 4.977 ± 0.086	0.973AspHis: 0.973 ± 0.026	1.891AspIle: 1.891 ± 0.045	1.598AspLys: 1.598 ± 0.037	5.775AspLeu: 5.775 ± 0.075	0.796AspMet: 0.796 ± 0.024	1.044AspAsn: 1.044 ± 0.031	3.911AspPro: 3.911 ± 0.059	1.598AspGln: 1.598 ± 0.038	3.75AspArg: 3.75 ± 0.052	2.803AspSer: 2.803 ± 0.04	2.116AspThr: 2.116 ± 0.045	3.895AspVal: 3.895 ± 0.048	0.672AspTrp: 0.672 ± 0.022	1.212AspTyr: 1.212 ± 0.031	0.002AspXaa: 0.002 ± 0.001
Glu	8.25GluAla: 8.25 ± 0.091	0.618GluCys: 0.618 ± 0.027	3.189GluAsp: 3.189 ± 0.05	5.034GluGlu: 5.034 ± 0.07	2.079GluPhe: 2.079 ± 0.038	5.447GluGly: 5.447 ± 0.065	1.343GluHis: 1.343 ± 0.031	2.97GluIle: 2.97 ± 0.046	2.981GluLys: 2.981 ± 0.049	9.106GluLeu: 9.106 ± 0.109	1.216GluMet: 1.216 ± 0.028	1.604GluAsn: 1.604 ± 0.033	4.095GluPro: 4.095 ± 0.062	2.423GluGln: 2.423 ± 0.044	6.818GluArg: 6.818 ± 0.081	3.986GluSer: 3.986 ± 0.056	3.558GluThr: 3.558 ± 0.052	5.014GluVal: 5.014 ± 0.063	0.727GluTrp: 0.727 ± 0.021	1.289GluTyr: 1.289 ± 0.031	0.002GluXaa: 0.002 ± 0.001
Phe	3.827PheAla: 3.827 ± 0.051	0.445PheCys: 0.445 ± 0.018	2.379PheAsp: 2.379 ± 0.043	2.887PheGlu: 2.887 ± 0.048	1.506PhePhe: 1.506 ± 0.034	3.588PheGly: 3.588 ± 0.056	0.732PheHis: 0.732 ± 0.025	1.274PheIle: 1.274 ± 0.035	0.842PheLys: 0.842 ± 0.024	3.543PheLeu: 3.543 ± 0.059	0.577PheMet: 0.577 ± 0.021	0.667PheAsn: 0.667 ± 0.021	1.763PhePro: 1.763 ± 0.036	1.059PheGln: 1.059 ± 0.027	2.605PheArg: 2.605 ± 0.04	2.57PheSer: 2.57 ± 0.044	1.622PheThr: 1.622 ± 0.037	3.061PheVal: 3.061 ± 0.048	0.49PheTrp: 0.49 ± 0.019	0.765PheTyr: 0.765 ± 0.024	0.001PheXaa: 0.001 ± 0.001
Gly	10.075GlyAla: 10.075 ± 0.111	1.087GlyCys: 1.087 ± 0.035	4.695GlyAsp: 4.695 ± 0.083	5.536GlyGlu: 5.536 ± 0.074	3.191GlyPhe: 3.191 ± 0.054	9.012GlyGly: 9.012 ± 0.189	1.664GlyHis: 1.664 ± 0.037	3.576GlyIle: 3.576 ± 0.058	3.259GlyLys: 3.259 ± 0.051	8.464GlyLeu: 8.464 ± 0.098	1.545GlyMet: 1.545 ± 0.034	2.054GlyAsn: 2.054 ± 0.053	4.646GlyPro: 4.646 ± 0.078	2.846GlyGln: 2.846 ± 0.042	6.401GlyArg: 6.401 ± 0.068	6.245GlySer: 6.245 ± 0.086	4.974GlyThr: 4.974 ± 0.068	6.004GlyVal: 6.004 ± 0.071	0.95GlyTrp: 0.95 ± 0.027	2.112GlyTyr: 2.112 ± 0.044	0.008GlyXaa: 0.008 ± 0.002
His	1.916HisAla: 1.916 ± 0.039	0.224HisCys: 0.224 ± 0.014	0.987HisAsp: 0.987 ± 0.03	1.349HisGlu: 1.349 ± 0.033	0.86HisPhe: 0.86 ± 0.025	1.683HisGly: 1.683 ± 0.039	0.543HisHis: 0.543 ± 0.023	0.749HisIle: 0.749 ± 0.024	0.5HisLys: 0.5 ± 0.017	2.068HisLeu: 2.068 ± 0.037	0.303HisMet: 0.303 ± 0.014	0.421HisAsn: 0.421 ± 0.017	1.337HisPro: 1.337 ± 0.03	0.567HisGln: 0.567 ± 0.019	1.429HisArg: 1.429 ± 0.03	1.054HisSer: 1.054 ± 0.031	0.81HisThr: 0.81 ± 0.025	1.468HisVal: 1.468 ± 0.03	0.207HisTrp: 0.207 ± 0.013	0.487HisTyr: 0.487 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.851IleAla: 4.851 ± 0.06	0.42IleCys: 0.42 ± 0.018	2.733IleAsp: 2.733 ± 0.046	3.496IleGlu: 3.496 ± 0.051	1.449IlePhe: 1.449 ± 0.031	3.504IleGly: 3.504 ± 0.055	0.819IleHis: 0.819 ± 0.027	1.447IleIle: 1.447 ± 0.033	1.003IleLys: 1.003 ± 0.029	3.858IleLeu: 3.858 ± 0.056	0.517IleMet: 0.517 ± 0.02	0.856IleAsn: 0.856 ± 0.029	2.254IlePro: 2.254 ± 0.046	1.282IleGln: 1.282 ± 0.028	2.733IleArg: 2.733 ± 0.044	2.371IleSer: 2.371 ± 0.048	1.968IleThr: 1.968 ± 0.035	3.52IleVal: 3.52 ± 0.057	0.466IleTrp: 0.466 ± 0.017	0.885IleTyr: 0.885 ± 0.025	0.001IleXaa: 0.001 ± 0.001
Lys	3.615LysAla: 3.615 ± 0.073	0.239LysCys: 0.239 ± 0.015	1.822LysAsp: 1.822 ± 0.035	2.261LysGlu: 2.261 ± 0.051	0.887LysPhe: 0.887 ± 0.025	2.52LysGly: 2.52 ± 0.043	0.581LysHis: 0.581 ± 0.021	1.55LysIle: 1.55 ± 0.037	2.008LysLys: 2.008 ± 0.055	3.283LysLeu: 3.283 ± 0.056	0.701LysMet: 0.701 ± 0.023	1.156LysAsn: 1.156 ± 0.028	1.773LysPro: 1.773 ± 0.038	1.043LysGln: 1.043 ± 0.029	2.505LysArg: 2.505 ± 0.039	2.16LysSer: 2.16 ± 0.044	1.966LysThr: 1.966 ± 0.038	2.54LysVal: 2.54 ± 0.046	0.334LysTrp: 0.334 ± 0.013	0.647LysTyr: 0.647 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	12.504LeuAla: 12.504 ± 0.126	1.085LeuCys: 1.085 ± 0.031	5.903LeuAsp: 5.903 ± 0.069	8.196LeuGlu: 8.196 ± 0.103	3.825LeuPhe: 3.825 ± 0.061	10.311LeuGly: 10.311 ± 0.095	1.88LeuHis: 1.88 ± 0.036	3.948LeuIle: 3.948 ± 0.053	3.431LeuLys: 3.431 ± 0.054	11.325LeuLeu: 11.325 ± 0.141	1.651LeuMet: 1.651 ± 0.033	1.947LeuAsn: 1.947 ± 0.04	5.938LeuPro: 5.938 ± 0.075	2.182LeuGln: 2.182 ± 0.043	8.507LeuArg: 8.507 ± 0.087	8.211LeuSer: 8.211 ± 0.088	5.837LeuThr: 5.837 ± 0.063	7.886LeuVal: 7.886 ± 0.087	1.205LeuTrp: 1.205 ± 0.034	2.088LeuTyr: 2.088 ± 0.038	0.005LeuXaa: 0.005 ± 0.002
Met	1.867MetAla: 1.867 ± 0.036	0.123MetCys: 0.123 ± 0.009	0.769MetAsp: 0.769 ± 0.023	0.834MetGlu: 0.834 ± 0.026	0.512MetPhe: 0.512 ± 0.019	1.415MetGly: 1.415 ± 0.035	0.305MetHis: 0.305 ± 0.017	0.762MetIle: 0.762 ± 0.023	0.78MetLys: 0.78 ± 0.023	1.599MetLeu: 1.599 ± 0.035	0.354MetMet: 0.354 ± 0.017	0.605MetAsn: 0.605 ± 0.022	0.978MetPro: 0.978 ± 0.027	0.541MetGln: 0.541 ± 0.021	1.346MetArg: 1.346 ± 0.03	1.387MetSer: 1.387 ± 0.027	1.172MetThr: 1.172 ± 0.029	1.187MetVal: 1.187 ± 0.029	0.146MetTrp: 0.146 ± 0.01	0.249MetTyr: 0.249 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.231AsnAla: 2.231 ± 0.045	0.272AsnCys: 0.272 ± 0.018	1.109AsnAsp: 1.109 ± 0.033	1.291AsnGlu: 1.291 ± 0.033	0.849AsnPhe: 0.849 ± 0.028	1.919AsnGly: 1.919 ± 0.053	0.446AsnHis: 0.446 ± 0.015	1.017AsnIle: 1.017 ± 0.033	0.648AsnLys: 0.648 ± 0.022	2.25AsnLeu: 2.25 ± 0.041	0.436AsnMet: 0.436 ± 0.017	0.592AsnAsn: 0.592 ± 0.024	1.648AsnPro: 1.648 ± 0.035	0.771AsnGln: 0.771 ± 0.023	1.392AsnArg: 1.392 ± 0.028	1.166AsnSer: 1.166 ± 0.03	0.962AsnThr: 0.962 ± 0.028	1.778AsnVal: 1.778 ± 0.042	0.336AsnTrp: 0.336 ± 0.016	0.603AsnTyr: 0.603 ± 0.021	0.001AsnXaa: 0.001 ± 0.001
Pro	6.099ProAla: 6.099 ± 0.08	0.523ProCys: 0.523 ± 0.018	3.353ProAsp: 3.353 ± 0.049	5.411ProGlu: 5.411 ± 0.064	2.032ProPhe: 2.032 ± 0.041	5.235ProGly: 5.235 ± 0.069	1.061ProHis: 1.061 ± 0.03	2.185ProIle: 2.185 ± 0.043	2.221ProLys: 2.221 ± 0.045	5.841ProLeu: 5.841 ± 0.082	1.04ProMet: 1.04 ± 0.027	1.43ProAsn: 1.43 ± 0.036	4.121ProPro: 4.121 ± 0.086	1.368ProGln: 1.368 ± 0.032	4.087ProArg: 4.087 ± 0.064	4.65ProSer: 4.65 ± 0.061	2.914ProThr: 2.914 ± 0.06	3.851ProVal: 3.851 ± 0.057	0.739ProTrp: 0.739 ± 0.025	1.111ProTyr: 1.111 ± 0.029	0.004ProXaa: 0.004 ± 0.002
Gln	3.635GlnAla: 3.635 ± 0.058	0.241GlnCys: 0.241 ± 0.014	1.282GlnAsp: 1.282 ± 0.031	1.831GlnGlu: 1.831 ± 0.037	0.933GlnPhe: 0.933 ± 0.026	2.544GlnGly: 2.544 ± 0.038	0.487GlnHis: 0.487 ± 0.02	1.482GlnIle: 1.482 ± 0.031	1.546GlnLys: 1.546 ± 0.035	2.883GlnLeu: 2.883 ± 0.049	0.59GlnMet: 0.59 ± 0.022	0.843GlnAsn: 0.843 ± 0.027	1.404GlnPro: 1.404 ± 0.03	0.74GlnGln: 0.74 ± 0.026	2.211GlnArg: 2.211 ± 0.04	1.856GlnSer: 1.856 ± 0.037	1.629GlnThr: 1.629 ± 0.035	2.354GlnVal: 2.354 ± 0.042	0.287GlnTrp: 0.287 ± 0.015	0.584GlnTyr: 0.584 ± 0.021	0.001GlnXaa: 0.001 ± 0.001
Arg	9.932ArgAla: 9.932 ± 0.111	0.611ArgCys: 0.611 ± 0.023	3.891ArgAsp: 3.891 ± 0.052	5.414ArgGlu: 5.414 ± 0.061	2.999ArgPhe: 2.999 ± 0.046	6.024ArgGly: 6.024 ± 0.078	1.278ArgHis: 1.278 ± 0.029	3.483ArgIle: 3.483 ± 0.053	2.456ArgLys: 2.456 ± 0.034	8.315ArgLeu: 8.315 ± 0.088	1.347ArgMet: 1.347 ± 0.031	1.422ArgAsn: 1.422 ± 0.029	4.259ArgPro: 4.259 ± 0.052	2.006ArgGln: 2.006 ± 0.036	6.18ArgArg: 6.18 ± 0.074	5.047ArgSer: 5.047 ± 0.059	3.711ArgThr: 3.711 ± 0.046	5.914ArgVal: 5.914 ± 0.068	0.822ArgTrp: 0.822 ± 0.025	1.878ArgTyr: 1.878 ± 0.036	0.002ArgXaa: 0.002 ± 0.001
Ser	7.468SerAla: 7.468 ± 0.069	0.807SerCys: 0.807 ± 0.031	3.517SerAsp: 3.517 ± 0.057	4.717SerGlu: 4.717 ± 0.062	2.591SerPhe: 2.591 ± 0.04	7.296SerGly: 7.296 ± 0.107	1.188SerHis: 1.188 ± 0.029	2.479SerIle: 2.479 ± 0.043	1.82SerLys: 1.82 ± 0.038	7.065SerLeu: 7.065 ± 0.073	1.207SerMet: 1.207 ± 0.028	1.203SerAsn: 1.203 ± 0.031	4.28SerPro: 4.28 ± 0.069	1.835SerGln: 1.835 ± 0.031	4.56SerArg: 4.56 ± 0.063	5.115SerSer: 5.115 ± 0.093	3.031SerThr: 3.031 ± 0.051	4.678SerVal: 4.678 ± 0.052	0.798SerTrp: 0.798 ± 0.024	1.48SerTyr: 1.48 ± 0.035	0.001SerXaa: 0.001 ± 0.001
Thr	4.808ThrAla: 4.808 ± 0.056	0.579ThrCys: 0.579 ± 0.022	2.504ThrAsp: 2.504 ± 0.048	3.097ThrGlu: 3.097 ± 0.048	2.061ThrPhe: 2.061 ± 0.036	4.784ThrGly: 4.784 ± 0.082	0.939ThrHis: 0.939 ± 0.026	2.435ThrIle: 2.435 ± 0.041	1.703ThrLys: 1.703 ± 0.039	5.625ThrLeu: 5.625 ± 0.061	0.881ThrMet: 0.881 ± 0.022	1.239ThrAsn: 1.239 ± 0.036	3.236ThrPro: 3.236 ± 0.054	1.419ThrGln: 1.419 ± 0.026	3.564ThrArg: 3.564 ± 0.05	3.367ThrSer: 3.367 ± 0.058	2.845ThrThr: 2.845 ± 0.054	3.74ThrVal: 3.74 ± 0.059	0.648ThrTrp: 0.648 ± 0.023	1.134ThrTyr: 1.134 ± 0.032	0.001ThrXaa: 0.001 ± 0.001
Val	7.615ValAla: 7.615 ± 0.083	0.801ValCys: 0.801 ± 0.031	4.001ValAsp: 4.001 ± 0.05	5.064ValGlu: 5.064 ± 0.066	2.667ValPhe: 2.667 ± 0.047	5.846ValGly: 5.846 ± 0.074	1.524ValHis: 1.524 ± 0.033	3.02ValIle: 3.02 ± 0.047	2.024ValLys: 2.024 ± 0.04	8.014ValLeu: 8.014 ± 0.092	1.175ValMet: 1.175 ± 0.027	1.534ValAsn: 1.534 ± 0.032	4.134ValPro: 4.134 ± 0.055	2.229ValGln: 2.229 ± 0.041	5.965ValArg: 5.965 ± 0.064	5.004ValSer: 5.004 ± 0.067	4.168ValThr: 4.168 ± 0.063	5.798ValVal: 5.798 ± 0.085	0.795ValTrp: 0.795 ± 0.024	1.469ValTyr: 1.469 ± 0.03	0.002ValXaa: 0.002 ± 0.001
Trp	1.151TrpAla: 1.151 ± 0.03	0.115TrpCys: 0.115 ± 0.009	0.58TrpAsp: 0.58 ± 0.021	0.58TrpGlu: 0.58 ± 0.02	0.481TrpPhe: 0.481 ± 0.019	0.875TrpGly: 0.875 ± 0.027	0.234TrpHis: 0.234 ± 0.014	0.595TrpIle: 0.595 ± 0.02	0.378TrpLys: 0.378 ± 0.014	1.447TrpLeu: 1.447 ± 0.037	0.225TrpMet: 0.225 ± 0.013	0.388TrpAsn: 0.388 ± 0.017	0.607TrpPro: 0.607 ± 0.02	0.384TrpGln: 0.384 ± 0.016	0.667TrpArg: 0.667 ± 0.023	0.796TrpSer: 0.796 ± 0.026	0.705TrpThr: 0.705 ± 0.024	0.891TrpVal: 0.891 ± 0.029	0.13TrpTrp: 0.13 ± 0.013	0.235TrpTyr: 0.235 ± 0.012	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.072TyrAla: 2.072 ± 0.036	0.276TyrCys: 0.276 ± 0.017	1.254TyrAsp: 1.254 ± 0.035	1.578TyrGlu: 1.578 ± 0.043	1.006TyrPhe: 1.006 ± 0.031	1.912TyrGly: 1.912 ± 0.041	0.419TyrHis: 0.419 ± 0.019	0.667TyrIle: 0.667 ± 0.022	0.543TyrLys: 0.543 ± 0.021	2.255TyrLeu: 2.255 ± 0.045	0.348TyrMet: 0.348 ± 0.016	0.479TyrAsn: 0.479 ± 0.022	1.061TyrPro: 1.061 ± 0.023	0.869TyrGln: 0.869 ± 0.026	1.902TyrArg: 1.902 ± 0.045	1.335TyrSer: 1.335 ± 0.032	0.897TyrThr: 0.897 ± 0.025	1.544TyrVal: 1.544 ± 0.032	0.31TyrTrp: 0.31 ± 0.016	0.668TyrTyr: 0.668 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.004XaaLeu: 0.004 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.005XaaPro: 0.005 ± 0.002	0.001XaaGln: 0.001 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.003XaaSer: 0.003 ± 0.002	0.001XaaThr: 0.001 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4071 proteins (1466748 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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