Amino acid dipepetide frequency for Oceanotoga teriensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	2.778AlaAla: 2.778 ± 0.081	0.34AlaCys: 0.34 ± 0.025	2.147AlaAsp: 2.147 ± 0.052	2.584AlaGlu: 2.584 ± 0.066	2.424AlaPhe: 2.424 ± 0.055	3.175AlaGly: 3.175 ± 0.069	0.667AlaHis: 0.667 ± 0.03	4.743AlaIle: 4.743 ± 0.09	3.779AlaLys: 3.779 ± 0.073	4.691AlaLeu: 4.691 ± 0.094	1.236AlaMet: 1.236 ± 0.039	2.118AlaAsn: 2.118 ± 0.05	1.066AlaPro: 1.066 ± 0.04	1.164AlaGln: 1.164 ± 0.046	1.425AlaArg: 1.425 ± 0.039	2.72AlaSer: 2.72 ± 0.061	1.977AlaThr: 1.977 ± 0.054	2.781AlaVal: 2.781 ± 0.072	0.313AlaTrp: 0.313 ± 0.019	1.817AlaTyr: 1.817 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.27CysAla: 0.27 ± 0.02	0.063CysCys: 0.063 ± 0.009	0.445CysAsp: 0.445 ± 0.024	0.425CysGlu: 0.425 ± 0.025	0.32CysPhe: 0.32 ± 0.021	0.588CysGly: 0.588 ± 0.03	0.139CysHis: 0.139 ± 0.014	0.619CysIle: 0.619 ± 0.028	0.538CysLys: 0.538 ± 0.024	0.438CysLeu: 0.438 ± 0.022	0.146CysMet: 0.146 ± 0.014	0.407CysAsn: 0.407 ± 0.024	0.322CysPro: 0.322 ± 0.024	0.129CysGln: 0.129 ± 0.013	0.204CysArg: 0.204 ± 0.015	0.468CysSer: 0.468 ± 0.024	0.283CysThr: 0.283 ± 0.02	0.353CysVal: 0.353 ± 0.02	0.044CysTrp: 0.044 ± 0.007	0.213CysTyr: 0.213 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	1.971AspAla: 1.971 ± 0.048	0.327AspCys: 0.327 ± 0.019	2.929AspAsp: 2.929 ± 0.073	5.076AspGlu: 5.076 ± 0.088	3.944AspPhe: 3.944 ± 0.079	2.852AspGly: 2.852 ± 0.055	0.627AspHis: 0.627 ± 0.024	7.184AspIle: 7.184 ± 0.104	5.182AspLys: 5.182 ± 0.095	5.478AspLeu: 5.478 ± 0.085	1.42AspMet: 1.42 ± 0.043	3.19AspAsn: 3.19 ± 0.062	1.583AspPro: 1.583 ± 0.043	0.959AspGln: 0.959 ± 0.034	1.435AspArg: 1.435 ± 0.045	3.37AspSer: 3.37 ± 0.062	2.148AspThr: 2.148 ± 0.048	2.73AspVal: 2.73 ± 0.061	0.484AspTrp: 0.484 ± 0.026	3.193AspTyr: 3.193 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	2.839GluAla: 2.839 ± 0.076	0.349GluCys: 0.349 ± 0.019	4.491GluAsp: 4.491 ± 0.092	6.336GluGlu: 6.336 ± 0.107	3.51GluPhe: 3.51 ± 0.061	3.082GluGly: 3.082 ± 0.063	0.746GluHis: 0.746 ± 0.032	8.849GluIle: 8.849 ± 0.126	9.497GluLys: 9.497 ± 0.146	6.418GluLeu: 6.418 ± 0.096	1.86GluMet: 1.86 ± 0.05	7.131GluAsn: 7.131 ± 0.111	1.418GluPro: 1.418 ± 0.041	1.564GluGln: 1.564 ± 0.045	2.093GluArg: 2.093 ± 0.054	3.586GluSer: 3.586 ± 0.072	2.866GluThr: 2.866 ± 0.053	3.581GluVal: 3.581 ± 0.074	0.467GluTrp: 0.467 ± 0.027	3.405GluTyr: 3.405 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	2.154PheAla: 2.154 ± 0.053	0.354PheCys: 0.354 ± 0.019	3.429PheAsp: 3.429 ± 0.087	4.269PheGlu: 4.269 ± 0.078	3.293PhePhe: 3.293 ± 0.081	3.304PheGly: 3.304 ± 0.061	0.616PheHis: 0.616 ± 0.027	6.132PheIle: 6.132 ± 0.111	5.041PheLys: 5.041 ± 0.077	5.387PheLeu: 5.387 ± 0.109	1.395PheMet: 1.395 ± 0.046	3.661PheAsn: 3.661 ± 0.078	1.341PhePro: 1.341 ± 0.042	1.146PheGln: 1.146 ± 0.041	1.25PheArg: 1.25 ± 0.043	4.249PheSer: 4.249 ± 0.075	2.325PheThr: 2.325 ± 0.055	2.722PheVal: 2.722 ± 0.061	0.467PheTrp: 0.467 ± 0.023	2.708PheTyr: 2.708 ± 0.064	0.0PheXaa: 0.0 ± 0.0
Gly	3.114GlyAla: 3.114 ± 0.073	0.511GlyCys: 0.511 ± 0.024	2.639GlyAsp: 2.639 ± 0.061	3.433GlyGlu: 3.433 ± 0.069	3.384GlyPhe: 3.384 ± 0.074	3.689GlyGly: 3.689 ± 0.082	0.857GlyHis: 0.857 ± 0.033	6.757GlyIle: 6.757 ± 0.116	4.912GlyLys: 4.912 ± 0.085	4.943GlyLeu: 4.943 ± 0.083	1.623GlyMet: 1.623 ± 0.047	3.115GlyAsn: 3.115 ± 0.063	1.245GlyPro: 1.245 ± 0.036	1.137GlyGln: 1.137 ± 0.035	1.624GlyArg: 1.624 ± 0.054	3.189GlySer: 3.189 ± 0.072	2.816GlyThr: 2.816 ± 0.059	3.527GlyVal: 3.527 ± 0.079	0.541GlyTrp: 0.541 ± 0.028	2.729GlyTyr: 2.729 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.612HisAla: 0.612 ± 0.027	0.1HisCys: 0.1 ± 0.011	0.736HisAsp: 0.736 ± 0.027	0.861HisGlu: 0.861 ± 0.032	0.665HisPhe: 0.665 ± 0.029	0.82HisGly: 0.82 ± 0.031	0.218HisHis: 0.218 ± 0.019	1.296HisIle: 1.296 ± 0.038	1.006HisLys: 1.006 ± 0.031	1.08HisLeu: 1.08 ± 0.037	0.29HisMet: 0.29 ± 0.021	0.742HisAsn: 0.742 ± 0.028	0.583HisPro: 0.583 ± 0.025	0.281HisGln: 0.281 ± 0.017	0.418HisArg: 0.418 ± 0.021	0.756HisSer: 0.756 ± 0.029	0.608HisThr: 0.608 ± 0.03	0.661HisVal: 0.661 ± 0.029	0.116HisTrp: 0.116 ± 0.01	0.577HisTyr: 0.577 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.047IleAla: 5.047 ± 0.088	0.692IleCys: 0.692 ± 0.032	6.518IleAsp: 6.518 ± 0.075	8.166IleGlu: 8.166 ± 0.105	6.552IlePhe: 6.552 ± 0.128	5.941IleGly: 5.941 ± 0.103	1.205IleHis: 1.205 ± 0.043	13.087IleIle: 13.087 ± 0.181	11.981IleLys: 11.981 ± 0.14	10.664IleLeu: 10.664 ± 0.143	2.746IleMet: 2.746 ± 0.066	8.464IleAsn: 8.464 ± 0.137	3.859IlePro: 3.859 ± 0.078	2.381IleGln: 2.381 ± 0.058	2.876IleArg: 2.876 ± 0.066	8.615IleSer: 8.615 ± 0.126	4.907IleThr: 4.907 ± 0.089	5.348IleVal: 5.348 ± 0.09	0.681IleTrp: 0.681 ± 0.029	4.7IleTyr: 4.7 ± 0.088	0.0IleXaa: 0.0 ± 0.0
Lys	3.795LysAla: 3.795 ± 0.077	0.52LysCys: 0.52 ± 0.028	6.348LysAsp: 6.348 ± 0.086	8.664LysGlu: 8.664 ± 0.118	4.139LysPhe: 4.139 ± 0.071	4.543LysGly: 4.543 ± 0.071	1.076LysHis: 1.076 ± 0.037	12.123LysIle: 12.123 ± 0.155	11.236LysLys: 11.236 ± 0.137	7.798LysLeu: 7.798 ± 0.102	2.619LysMet: 2.619 ± 0.061	10.351LysAsn: 10.351 ± 0.152	2.183LysPro: 2.183 ± 0.048	1.944LysGln: 1.944 ± 0.052	3.011LysArg: 3.011 ± 0.057	5.653LysSer: 5.653 ± 0.093	4.75LysThr: 4.75 ± 0.072	4.972LysVal: 4.972 ± 0.079	0.658LysTrp: 0.658 ± 0.029	5.091LysTyr: 5.091 ± 0.089	0.0LysXaa: 0.0 ± 0.0
Leu	3.864LeuAla: 3.864 ± 0.075	0.572LeuCys: 0.572 ± 0.027	4.632LeuAsp: 4.632 ± 0.071	6.38LeuGlu: 6.38 ± 0.096	4.809LeuPhe: 4.809 ± 0.094	4.858LeuGly: 4.858 ± 0.09	0.981LeuHis: 0.981 ± 0.035	9.833LeuIle: 9.833 ± 0.139	10.893LeuLys: 10.893 ± 0.129	7.602LeuLeu: 7.602 ± 0.111	2.355LeuMet: 2.355 ± 0.056	7.981LeuAsn: 7.981 ± 0.107	2.589LeuPro: 2.589 ± 0.057	1.735LeuGln: 1.735 ± 0.047	2.591LeuArg: 2.591 ± 0.055	6.889LeuSer: 6.889 ± 0.099	4.001LeuThr: 4.001 ± 0.077	3.596LeuVal: 3.596 ± 0.066	0.601LeuTrp: 0.601 ± 0.027	3.621LeuTyr: 3.621 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	1.466MetAla: 1.466 ± 0.043	0.132MetCys: 0.132 ± 0.014	1.339MetAsp: 1.339 ± 0.042	1.55MetGlu: 1.55 ± 0.044	1.133MetPhe: 1.133 ± 0.041	1.747MetGly: 1.747 ± 0.047	0.299MetHis: 0.299 ± 0.019	2.792MetIle: 2.792 ± 0.054	2.864MetLys: 2.864 ± 0.059	1.869MetLeu: 1.869 ± 0.047	0.737MetMet: 0.737 ± 0.03	2.075MetAsn: 2.075 ± 0.044	0.851MetPro: 0.851 ± 0.037	0.587MetGln: 0.587 ± 0.028	0.783MetArg: 0.783 ± 0.029	1.589MetSer: 1.589 ± 0.046	1.161MetThr: 1.161 ± 0.038	1.276MetVal: 1.276 ± 0.043	0.148MetTrp: 0.148 ± 0.013	0.921MetTyr: 0.921 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	2.552AsnAla: 2.552 ± 0.056	0.438AsnCys: 0.438 ± 0.025	3.865AsnAsp: 3.865 ± 0.074	5.072AsnGlu: 5.072 ± 0.093	4.359AsnPhe: 4.359 ± 0.079	3.368AsnGly: 3.368 ± 0.063	0.871AsnHis: 0.871 ± 0.035	9.885AsnIle: 9.885 ± 0.14	7.312AsnLys: 7.312 ± 0.106	6.749AsnLeu: 6.749 ± 0.104	1.768AsnMet: 1.768 ± 0.049	5.39AsnAsn: 5.39 ± 0.11	2.515AsnPro: 2.515 ± 0.062	1.64AsnGln: 1.64 ± 0.053	1.766AsnArg: 1.766 ± 0.043	4.962AsnSer: 4.962 ± 0.089	3.238AsnThr: 3.238 ± 0.068	3.217AsnVal: 3.217 ± 0.061	0.596AsnTrp: 0.596 ± 0.028	3.921AsnTyr: 3.921 ± 0.079	0.0AsnXaa: 0.0 ± 0.0
Pro	1.275ProAla: 1.275 ± 0.038	0.175ProCys: 0.175 ± 0.016	1.738ProAsp: 1.738 ± 0.042	2.562ProGlu: 2.562 ± 0.053	1.617ProPhe: 1.617 ± 0.043	1.643ProGly: 1.643 ± 0.05	0.466ProHis: 0.466 ± 0.026	2.793ProIle: 2.793 ± 0.059	2.217ProLys: 2.217 ± 0.049	2.625ProLeu: 2.625 ± 0.064	0.617ProMet: 0.617 ± 0.03	1.658ProAsn: 1.658 ± 0.049	0.604ProPro: 0.604 ± 0.032	0.701ProGln: 0.701 ± 0.03	0.639ProArg: 0.639 ± 0.029	1.703ProSer: 1.703 ± 0.042	1.354ProThr: 1.354 ± 0.042	1.943ProVal: 1.943 ± 0.052	0.285ProTrp: 0.285 ± 0.02	1.431ProTyr: 1.431 ± 0.046	0.0ProXaa: 0.0 ± 0.0
Gln	1.114GlnAla: 1.114 ± 0.035	0.109GlnCys: 0.109 ± 0.014	1.05GlnAsp: 1.05 ± 0.035	1.557GlnGlu: 1.557 ± 0.045	0.889GlnPhe: 0.889 ± 0.028	1.018GlnGly: 1.018 ± 0.038	0.253GlnHis: 0.253 ± 0.019	2.534GlnIle: 2.534 ± 0.057	2.697GlnLys: 2.697 ± 0.072	1.714GlnLeu: 1.714 ± 0.048	0.616GlnMet: 0.616 ± 0.03	1.845GlnAsn: 1.845 ± 0.06	0.501GlnPro: 0.501 ± 0.025	0.532GlnGln: 0.532 ± 0.031	0.811GlnArg: 0.811 ± 0.033	1.222GlnSer: 1.222 ± 0.045	1.033GlnThr: 1.033 ± 0.036	0.995GlnVal: 0.995 ± 0.041	0.162GlnTrp: 0.162 ± 0.014	0.849GlnTyr: 0.849 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	1.366ArgAla: 1.366 ± 0.044	0.226ArgCys: 0.226 ± 0.017	1.516ArgAsp: 1.516 ± 0.043	1.92ArgGlu: 1.92 ± 0.054	1.432ArgPhe: 1.432 ± 0.04	1.637ArgGly: 1.637 ± 0.047	0.366ArgHis: 0.366 ± 0.023	3.086ArgIle: 3.086 ± 0.059	2.767ArgLys: 2.767 ± 0.063	2.381ArgLeu: 2.381 ± 0.054	0.774ArgMet: 0.774 ± 0.03	1.894ArgAsn: 1.894 ± 0.049	0.729ArgPro: 0.729 ± 0.029	0.591ArgGln: 0.591 ± 0.026	1.033ArgArg: 1.033 ± 0.037	1.524ArgSer: 1.524 ± 0.042	1.26ArgThr: 1.26 ± 0.045	1.664ArgVal: 1.664 ± 0.045	0.235ArgTrp: 0.235 ± 0.016	1.276ArgTyr: 1.276 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	2.827SerAla: 2.827 ± 0.064	0.437SerCys: 0.437 ± 0.022	3.423SerAsp: 3.423 ± 0.067	4.599SerGlu: 4.599 ± 0.075	4.078SerPhe: 4.078 ± 0.081	4.138SerGly: 4.138 ± 0.069	0.879SerHis: 0.879 ± 0.031	7.398SerIle: 7.398 ± 0.106	6.579SerLys: 6.579 ± 0.091	6.152SerLeu: 6.152 ± 0.106	1.589SerMet: 1.589 ± 0.043	4.209SerAsn: 4.209 ± 0.078	1.668SerPro: 1.668 ± 0.04	1.619SerGln: 1.619 ± 0.045	1.717SerArg: 1.717 ± 0.05	4.281SerSer: 4.281 ± 0.086	2.929SerThr: 2.929 ± 0.063	3.267SerVal: 3.267 ± 0.057	0.515SerTrp: 0.515 ± 0.025	2.819SerTyr: 2.819 ± 0.067	0.0SerXaa: 0.0 ± 0.0
Thr	2.233ThrAla: 2.233 ± 0.05	0.262ThrCys: 0.262 ± 0.021	2.389ThrAsp: 2.389 ± 0.052	2.757ThrGlu: 2.757 ± 0.059	2.525ThrPhe: 2.525 ± 0.054	3.177ThrGly: 3.177 ± 0.058	0.735ThrHis: 0.735 ± 0.026	4.693ThrIle: 4.693 ± 0.078	3.615ThrLys: 3.615 ± 0.07	4.586ThrLeu: 4.586 ± 0.072	0.971ThrMet: 0.971 ± 0.033	2.587ThrAsn: 2.587 ± 0.073	1.724ThrPro: 1.724 ± 0.051	1.083ThrGln: 1.083 ± 0.037	1.171ThrArg: 1.171 ± 0.038	2.871ThrSer: 2.871 ± 0.054	2.113ThrThr: 2.113 ± 0.064	2.594ThrVal: 2.594 ± 0.063	0.35ThrTrp: 0.35 ± 0.021	1.954ThrTyr: 1.954 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	2.552ValAla: 2.552 ± 0.06	0.4ValCys: 0.4 ± 0.025	3.014ValAsp: 3.014 ± 0.061	3.801ValGlu: 3.801 ± 0.074	2.938ValPhe: 2.938 ± 0.055	3.132ValGly: 3.132 ± 0.077	0.687ValHis: 0.687 ± 0.027	4.911ValIle: 4.911 ± 0.071	4.395ValLys: 4.395 ± 0.072	4.866ValLeu: 4.866 ± 0.076	1.275ValMet: 1.275 ± 0.038	2.917ValAsn: 2.917 ± 0.068	1.664ValPro: 1.664 ± 0.051	1.165ValGln: 1.165 ± 0.037	1.363ValArg: 1.363 ± 0.045	3.614ValSer: 3.614 ± 0.066	2.082ValThr: 2.082 ± 0.057	2.874ValVal: 2.874 ± 0.069	0.425ValTrp: 0.425 ± 0.022	2.362ValTyr: 2.362 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.389TrpAla: 0.389 ± 0.024	0.062TrpCys: 0.062 ± 0.009	0.426TrpAsp: 0.426 ± 0.023	0.496TrpGlu: 0.496 ± 0.025	0.391TrpPhe: 0.391 ± 0.023	0.523TrpGly: 0.523 ± 0.028	0.118TrpHis: 0.118 ± 0.012	0.745TrpIle: 0.745 ± 0.035	0.674TrpLys: 0.674 ± 0.028	0.637TrpLeu: 0.637 ± 0.029	0.225TrpMet: 0.225 ± 0.017	0.595TrpAsn: 0.595 ± 0.027	0.212TrpPro: 0.212 ± 0.017	0.196TrpGln: 0.196 ± 0.016	0.237TrpArg: 0.237 ± 0.017	0.435TrpSer: 0.435 ± 0.022	0.335TrpThr: 0.335 ± 0.02	0.398TrpVal: 0.398 ± 0.023	0.114TrpTrp: 0.114 ± 0.01	0.333TrpTyr: 0.333 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.728TyrAla: 1.728 ± 0.046	0.346TyrCys: 0.346 ± 0.021	3.011TyrAsp: 3.011 ± 0.066	3.582TyrGlu: 3.582 ± 0.068	2.838TyrPhe: 2.838 ± 0.066	2.554TyrGly: 2.554 ± 0.05	0.622TyrHis: 0.622 ± 0.029	4.969TyrIle: 4.969 ± 0.089	4.289TyrLys: 4.289 ± 0.076	4.307TyrLeu: 4.307 ± 0.07	1.052TyrMet: 1.052 ± 0.034	3.155TyrAsn: 3.155 ± 0.07	1.388TyrPro: 1.388 ± 0.038	0.948TyrGln: 0.948 ± 0.031	1.227TyrArg: 1.227 ± 0.034	3.425TyrSer: 3.425 ± 0.066	2.204TyrThr: 2.204 ± 0.051	1.937TyrVal: 1.937 ± 0.046	0.338TyrTrp: 0.338 ± 0.02	2.303TyrTyr: 2.303 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2638 proteins (858968 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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