Amino acid dipepetide frequency for Staphylococcus virus 55

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.504AlaAla: 0.504 ± 0.202
0.432AlaCys: 0.432 ± 0.204
2.09AlaAsp: 2.09 ± 0.321
3.315AlaGlu: 3.315 ± 0.465
3.098AlaPhe: 3.098 ± 0.479
3.603AlaGly: 3.603 ± 0.762
1.153AlaHis: 1.153 ± 0.266
4.9AlaIle: 4.9 ± 0.585
6.413AlaLys: 6.413 ± 0.771
4.828AlaLeu: 4.828 ± 0.695
1.513AlaMet: 1.513 ± 0.435
3.747AlaAsn: 3.747 ± 0.443
2.162AlaPro: 2.162 ± 0.371
3.243AlaGln: 3.243 ± 0.453
2.882AlaArg: 2.882 ± 0.41
4.756AlaSer: 4.756 ± 0.668
4.323AlaThr: 4.323 ± 0.55
3.026AlaVal: 3.026 ± 0.691
0.721AlaTrp: 0.721 ± 0.257
2.234AlaTyr: 2.234 ± 0.441
0.0AlaXaa: 0.0 ± 0.0
Cys
0.36CysAla: 0.36 ± 0.141
0.072CysCys: 0.072 ± 0.074
0.432CysAsp: 0.432 ± 0.188
0.432CysGlu: 0.432 ± 0.275
0.432CysPhe: 0.432 ± 0.155
0.432CysGly: 0.432 ± 0.172
0.144CysHis: 0.144 ± 0.094
0.144CysIle: 0.144 ± 0.103
0.36CysLys: 0.36 ± 0.175
0.432CysLeu: 0.432 ± 0.159
0.144CysMet: 0.144 ± 0.104
0.216CysAsn: 0.216 ± 0.129
0.432CysPro: 0.432 ± 0.198
0.288CysGln: 0.288 ± 0.137
0.432CysArg: 0.432 ± 0.175
0.432CysSer: 0.432 ± 0.178
0.36CysThr: 0.36 ± 0.201
0.36CysVal: 0.36 ± 0.168
0.072CysTrp: 0.072 ± 0.064
0.36CysTyr: 0.36 ± 0.141
0.0CysXaa: 0.0 ± 0.0
Asp
3.963AspAla: 3.963 ± 0.542
0.36AspCys: 0.36 ± 0.151
4.179AspAsp: 4.179 ± 0.7
5.26AspGlu: 5.26 ± 0.695
2.738AspPhe: 2.738 ± 0.509
4.107AspGly: 4.107 ± 0.591
0.36AspHis: 0.36 ± 0.137
4.395AspIle: 4.395 ± 0.606
5.837AspLys: 5.837 ± 0.865
5.26AspLeu: 5.26 ± 0.646
1.513AspMet: 1.513 ± 0.258
3.315AspAsn: 3.315 ± 0.486
0.937AspPro: 0.937 ± 0.279
1.297AspGln: 1.297 ± 0.305
1.873AspArg: 1.873 ± 0.392
3.819AspSer: 3.819 ± 0.48
3.17AspThr: 3.17 ± 0.433
3.747AspVal: 3.747 ± 0.597
0.432AspTrp: 0.432 ± 0.175
2.954AspTyr: 2.954 ± 0.435
0.0AspXaa: 0.0 ± 0.0
Glu
4.035GluAla: 4.035 ± 0.581
0.721GluCys: 0.721 ± 0.19
4.179GluAsp: 4.179 ± 0.726
4.972GluGlu: 4.972 ± 0.79
2.594GluPhe: 2.594 ± 0.443
2.594GluGly: 2.594 ± 0.336
1.441GluHis: 1.441 ± 0.38
4.756GluIle: 4.756 ± 0.579
4.828GluLys: 4.828 ± 0.671
7.926GluLeu: 7.926 ± 0.967
2.306GluMet: 2.306 ± 0.488
4.395GluAsn: 4.395 ± 0.659
2.018GluPro: 2.018 ± 0.363
4.035GluGln: 4.035 ± 0.527
3.098GluArg: 3.098 ± 0.509
3.098GluSer: 3.098 ± 0.403
3.531GluThr: 3.531 ± 0.437
5.404GluVal: 5.404 ± 0.73
1.225GluTrp: 1.225 ± 0.246
3.531GluTyr: 3.531 ± 0.632
0.0GluXaa: 0.0 ± 0.0
Phe
1.657PheAla: 1.657 ± 0.322
0.504PheCys: 0.504 ± 0.174
3.963PheAsp: 3.963 ± 0.436
3.387PheGlu: 3.387 ± 0.596
1.225PhePhe: 1.225 ± 0.283
2.738PheGly: 2.738 ± 0.669
0.649PheHis: 0.649 ± 0.192
3.891PheIle: 3.891 ± 0.61
4.179PheLys: 4.179 ± 0.461
3.17PheLeu: 3.17 ± 0.416
1.009PheMet: 1.009 ± 0.266
2.594PheAsn: 2.594 ± 0.401
0.937PhePro: 0.937 ± 0.312
1.297PheGln: 1.297 ± 0.299
1.369PheArg: 1.369 ± 0.296
2.522PheSer: 2.522 ± 0.424
3.315PheThr: 3.315 ± 0.538
2.882PheVal: 2.882 ± 0.43
0.432PheTrp: 0.432 ± 0.177
1.946PheTyr: 1.946 ± 0.42
0.0PheXaa: 0.0 ± 0.0
Gly
4.179GlyAla: 4.179 ± 0.676
0.288GlyCys: 0.288 ± 0.149
3.17GlyAsp: 3.17 ± 0.596
2.81GlyGlu: 2.81 ± 0.532
3.026GlyPhe: 3.026 ± 0.429
2.954GlyGly: 2.954 ± 0.544
1.729GlyHis: 1.729 ± 0.373
4.107GlyIle: 4.107 ± 0.462
4.828GlyLys: 4.828 ± 0.473
4.54GlyLeu: 4.54 ± 0.713
1.657GlyMet: 1.657 ± 0.284
2.738GlyAsn: 2.738 ± 0.443
0.432GlyPro: 0.432 ± 0.176
2.594GlyGln: 2.594 ± 0.426
2.234GlyArg: 2.234 ± 0.42
3.098GlySer: 3.098 ± 0.48
3.819GlyThr: 3.819 ± 0.471
4.9GlyVal: 4.9 ± 0.841
1.081GlyTrp: 1.081 ± 0.352
2.45GlyTyr: 2.45 ± 0.389
0.0GlyXaa: 0.0 ± 0.0
His
1.585HisAla: 1.585 ± 0.328
0.072HisCys: 0.072 ± 0.077
0.721HisAsp: 0.721 ± 0.215
1.081HisGlu: 1.081 ± 0.275
0.721HisPhe: 0.721 ± 0.213
1.369HisGly: 1.369 ± 0.247
0.504HisHis: 0.504 ± 0.202
1.441HisIle: 1.441 ± 0.312
1.297HisLys: 1.297 ± 0.301
1.657HisLeu: 1.657 ± 0.331
0.216HisMet: 0.216 ± 0.096
1.225HisAsn: 1.225 ± 0.249
0.865HisPro: 0.865 ± 0.279
1.153HisGln: 1.153 ± 0.284
0.432HisArg: 0.432 ± 0.187
1.153HisSer: 1.153 ± 0.245
1.729HisThr: 1.729 ± 0.308
1.009HisVal: 1.009 ± 0.278
0.072HisTrp: 0.072 ± 0.073
1.153HisTyr: 1.153 ± 0.388
0.0HisXaa: 0.0 ± 0.0
Ile
4.468IleAla: 4.468 ± 0.687
0.432IleCys: 0.432 ± 0.184
5.26IleAsp: 5.26 ± 0.675
5.981IleGlu: 5.981 ± 0.791
3.459IlePhe: 3.459 ± 0.712
4.972IleGly: 4.972 ± 0.77
1.297IleHis: 1.297 ± 0.32
4.54IleIle: 4.54 ± 0.64
7.782IleLys: 7.782 ± 0.835
3.459IleLeu: 3.459 ± 0.479
2.522IleMet: 2.522 ± 0.359
4.756IleAsn: 4.756 ± 0.719
2.234IlePro: 2.234 ± 0.39
2.594IleGln: 2.594 ± 0.499
3.315IleArg: 3.315 ± 0.573
4.251IleSer: 4.251 ± 0.599
4.828IleThr: 4.828 ± 0.504
4.035IleVal: 4.035 ± 0.481
1.009IleTrp: 1.009 ± 0.299
2.09IleTyr: 2.09 ± 0.552
0.0IleXaa: 0.0 ± 0.0
Lys
5.26LysAla: 5.26 ± 0.548
0.288LysCys: 0.288 ± 0.129
5.404LysAsp: 5.404 ± 0.67
7.71LysGlu: 7.71 ± 0.902
3.243LysPhe: 3.243 ± 0.484
5.116LysGly: 5.116 ± 0.772
2.09LysHis: 2.09 ± 0.391
5.692LysIle: 5.692 ± 0.668
8.142LysLys: 8.142 ± 0.951
7.134LysLeu: 7.134 ± 0.821
3.387LysMet: 3.387 ± 0.581
4.756LysAsn: 4.756 ± 0.673
2.738LysPro: 2.738 ± 0.478
4.684LysGln: 4.684 ± 0.564
4.972LysArg: 4.972 ± 0.677
4.684LysSer: 4.684 ± 0.519
5.26LysThr: 5.26 ± 0.59
5.188LysVal: 5.188 ± 0.593
0.937LysTrp: 0.937 ± 0.202
3.531LysTyr: 3.531 ± 0.529
0.0LysXaa: 0.0 ± 0.0
Leu
4.756LeuAla: 4.756 ± 0.69
0.504LeuCys: 0.504 ± 0.209
4.684LeuAsp: 4.684 ± 0.52
5.548LeuGlu: 5.548 ± 0.981
3.747LeuPhe: 3.747 ± 0.484
3.387LeuGly: 3.387 ± 0.475
1.369LeuHis: 1.369 ± 0.311
5.548LeuIle: 5.548 ± 0.613
7.278LeuLys: 7.278 ± 0.683
5.62LeuLeu: 5.62 ± 0.625
1.946LeuMet: 1.946 ± 0.46
5.188LeuAsn: 5.188 ± 0.495
2.738LeuPro: 2.738 ± 0.478
3.17LeuGln: 3.17 ± 0.387
3.459LeuArg: 3.459 ± 0.59
5.26LeuSer: 5.26 ± 0.618
6.269LeuThr: 6.269 ± 0.796
4.323LeuVal: 4.323 ± 0.753
0.649LeuTrp: 0.649 ± 0.248
3.459LeuTyr: 3.459 ± 0.548
0.0LeuXaa: 0.0 ± 0.0
Met
1.513MetAla: 1.513 ± 0.498
0.072MetCys: 0.072 ± 0.073
1.225MetAsp: 1.225 ± 0.294
1.585MetGlu: 1.585 ± 0.335
1.369MetPhe: 1.369 ± 0.297
1.153MetGly: 1.153 ± 0.265
0.576MetHis: 0.576 ± 0.219
1.873MetIle: 1.873 ± 0.342
1.729MetLys: 1.729 ± 0.341
2.522MetLeu: 2.522 ± 0.379
0.721MetMet: 0.721 ± 0.224
2.162MetAsn: 2.162 ± 0.473
1.153MetPro: 1.153 ± 0.255
1.946MetGln: 1.946 ± 0.441
0.793MetArg: 0.793 ± 0.249
2.45MetSer: 2.45 ± 0.429
1.946MetThr: 1.946 ± 0.378
1.369MetVal: 1.369 ± 0.244
0.36MetTrp: 0.36 ± 0.145
1.153MetTyr: 1.153 ± 0.307
0.0MetXaa: 0.0 ± 0.0
Asn
4.251AsnAla: 4.251 ± 0.622
0.288AsnCys: 0.288 ± 0.125
4.395AsnAsp: 4.395 ± 0.555
4.684AsnGlu: 4.684 ± 0.495
2.594AsnPhe: 2.594 ± 0.481
4.251AsnGly: 4.251 ± 0.687
1.009AsnHis: 1.009 ± 0.288
3.963AsnIle: 3.963 ± 0.625
5.692AsnLys: 5.692 ± 0.836
4.395AsnLeu: 4.395 ± 0.615
1.513AsnMet: 1.513 ± 0.336
5.116AsnAsn: 5.116 ± 0.933
2.882AsnPro: 2.882 ± 0.488
2.738AsnGln: 2.738 ± 0.531
2.018AsnArg: 2.018 ± 0.354
3.963AsnSer: 3.963 ± 0.597
3.459AsnThr: 3.459 ± 0.442
2.954AsnVal: 2.954 ± 0.543
0.865AsnTrp: 0.865 ± 0.231
2.378AsnTyr: 2.378 ± 0.406
0.0AsnXaa: 0.0 ± 0.0
Pro
1.441ProAla: 1.441 ± 0.323
0.288ProCys: 0.288 ± 0.168
1.369ProAsp: 1.369 ± 0.3
1.729ProGlu: 1.729 ± 0.354
1.369ProPhe: 1.369 ± 0.301
1.946ProGly: 1.946 ± 0.416
0.576ProHis: 0.576 ± 0.181
2.09ProIle: 2.09 ± 0.428
3.459ProLys: 3.459 ± 0.6
1.946ProLeu: 1.946 ± 0.366
0.721ProMet: 0.721 ± 0.219
1.801ProAsn: 1.801 ± 0.429
0.576ProPro: 0.576 ± 0.202
0.865ProGln: 0.865 ± 0.259
1.009ProArg: 1.009 ± 0.231
2.162ProSer: 2.162 ± 0.536
1.946ProThr: 1.946 ± 0.328
1.801ProVal: 1.801 ± 0.318
0.072ProTrp: 0.072 ± 0.076
1.297ProTyr: 1.297 ± 0.277
0.0ProXaa: 0.0 ± 0.0
Gln
3.819GlnAla: 3.819 ± 0.452
0.432GlnCys: 0.432 ± 0.182
1.729GlnAsp: 1.729 ± 0.364
2.666GlnGlu: 2.666 ± 0.447
1.873GlnPhe: 1.873 ± 0.349
2.594GlnGly: 2.594 ± 0.382
0.937GlnHis: 0.937 ± 0.194
3.17GlnIle: 3.17 ± 0.441
3.243GlnLys: 3.243 ± 0.503
3.026GlnLeu: 3.026 ± 0.606
1.297GlnMet: 1.297 ± 0.349
2.81GlnAsn: 2.81 ± 0.42
1.585GlnPro: 1.585 ± 0.366
2.162GlnGln: 2.162 ± 0.533
2.234GlnArg: 2.234 ± 0.381
2.522GlnSer: 2.522 ± 0.403
1.873GlnThr: 1.873 ± 0.369
3.315GlnVal: 3.315 ± 0.558
0.072GlnTrp: 0.072 ± 0.062
1.801GlnTyr: 1.801 ± 0.401
0.0GlnXaa: 0.0 ± 0.0
Arg
1.657ArgAla: 1.657 ± 0.343
0.36ArgCys: 0.36 ± 0.178
2.666ArgAsp: 2.666 ± 0.45
3.315ArgGlu: 3.315 ± 0.463
2.45ArgPhe: 2.45 ± 0.451
1.946ArgGly: 1.946 ± 0.385
1.441ArgHis: 1.441 ± 0.36
3.17ArgIle: 3.17 ± 0.536
3.963ArgLys: 3.963 ± 0.708
3.819ArgLeu: 3.819 ± 0.632
0.721ArgMet: 0.721 ± 0.243
2.666ArgAsn: 2.666 ± 0.435
1.081ArgPro: 1.081 ± 0.261
2.09ArgGln: 2.09 ± 0.438
1.801ArgArg: 1.801 ± 0.346
1.657ArgSer: 1.657 ± 0.317
1.657ArgThr: 1.657 ± 0.373
1.873ArgVal: 1.873 ± 0.359
0.288ArgTrp: 0.288 ± 0.14
2.738ArgTyr: 2.738 ± 0.42
0.0ArgXaa: 0.0 ± 0.0
Ser
3.891SerAla: 3.891 ± 0.643
0.288SerCys: 0.288 ± 0.156
3.747SerAsp: 3.747 ± 0.545
3.315SerGlu: 3.315 ± 0.412
2.522SerPhe: 2.522 ± 0.491
3.891SerGly: 3.891 ± 0.511
1.153SerHis: 1.153 ± 0.247
6.053SerIle: 6.053 ± 0.771
5.909SerLys: 5.909 ± 0.659
4.179SerLeu: 4.179 ± 0.445
2.162SerMet: 2.162 ± 0.361
5.188SerAsn: 5.188 ± 0.66
0.937SerPro: 0.937 ± 0.343
2.738SerGln: 2.738 ± 0.458
1.946SerArg: 1.946 ± 0.328
3.315SerSer: 3.315 ± 0.539
3.891SerThr: 3.891 ± 0.422
3.819SerVal: 3.819 ± 0.688
0.576SerTrp: 0.576 ± 0.154
2.018SerTyr: 2.018 ± 0.416
0.0SerXaa: 0.0 ± 0.0
Thr
3.963ThrAla: 3.963 ± 0.559
0.072ThrCys: 0.072 ± 0.076
3.459ThrAsp: 3.459 ± 0.462
3.963ThrGlu: 3.963 ± 0.429
2.45ThrPhe: 2.45 ± 0.392
3.459ThrGly: 3.459 ± 0.481
1.657ThrHis: 1.657 ± 0.347
4.972ThrIle: 4.972 ± 0.695
4.756ThrLys: 4.756 ± 0.562
6.053ThrLeu: 6.053 ± 0.898
1.153ThrMet: 1.153 ± 0.334
4.323ThrAsn: 4.323 ± 0.594
1.657ThrPro: 1.657 ± 0.317
2.378ThrGln: 2.378 ± 0.41
2.954ThrArg: 2.954 ± 0.435
5.332ThrSer: 5.332 ± 0.629
3.963ThrThr: 3.963 ± 0.573
3.315ThrVal: 3.315 ± 0.495
0.793ThrTrp: 0.793 ± 0.268
2.09ThrTyr: 2.09 ± 0.344
0.0ThrXaa: 0.0 ± 0.0
Val
4.828ValAla: 4.828 ± 0.815
0.288ValCys: 0.288 ± 0.148
4.684ValAsp: 4.684 ± 0.617
4.756ValGlu: 4.756 ± 0.729
2.45ValPhe: 2.45 ± 0.359
2.738ValGly: 2.738 ± 0.524
0.288ValHis: 0.288 ± 0.145
4.54ValIle: 4.54 ± 0.612
6.269ValLys: 6.269 ± 0.583
4.684ValLeu: 4.684 ± 0.572
1.873ValMet: 1.873 ± 0.386
3.026ValAsn: 3.026 ± 0.436
2.018ValPro: 2.018 ± 0.303
1.441ValGln: 1.441 ± 0.291
2.09ValArg: 2.09 ± 0.401
3.603ValSer: 3.603 ± 0.585
4.179ValThr: 4.179 ± 0.731
3.603ValVal: 3.603 ± 0.518
0.865ValTrp: 0.865 ± 0.273
2.378ValTyr: 2.378 ± 0.455
0.0ValXaa: 0.0 ± 0.0
Trp
0.576TrpAla: 0.576 ± 0.193
0.072TrpCys: 0.072 ± 0.064
0.432TrpAsp: 0.432 ± 0.164
1.009TrpGlu: 1.009 ± 0.241
0.504TrpPhe: 0.504 ± 0.168
0.865TrpGly: 0.865 ± 0.283
0.216TrpHis: 0.216 ± 0.118
0.793TrpIle: 0.793 ± 0.218
0.937TrpLys: 0.937 ± 0.296
0.937TrpLeu: 0.937 ± 0.248
0.216TrpMet: 0.216 ± 0.124
0.721TrpAsn: 0.721 ± 0.239
0.072TrpPro: 0.072 ± 0.074
0.576TrpGln: 0.576 ± 0.187
0.36TrpArg: 0.36 ± 0.154
0.721TrpSer: 0.721 ± 0.271
0.937TrpThr: 0.937 ± 0.212
0.793TrpVal: 0.793 ± 0.249
0.072TrpTrp: 0.072 ± 0.065
0.504TrpTyr: 0.504 ± 0.174
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.234TyrAla: 2.234 ± 0.423
0.504TyrCys: 0.504 ± 0.161
1.801TyrAsp: 1.801 ± 0.43
3.17TyrGlu: 3.17 ± 0.573
1.801TyrPhe: 1.801 ± 0.467
2.522TyrGly: 2.522 ± 0.506
0.865TyrHis: 0.865 ± 0.243
3.243TyrIle: 3.243 ± 0.602
3.315TyrLys: 3.315 ± 0.49
3.315TyrLeu: 3.315 ± 0.454
1.009TyrMet: 1.009 ± 0.294
2.666TyrAsn: 2.666 ± 0.456
1.009TyrPro: 1.009 ± 0.261
1.873TyrGln: 1.873 ± 0.319
2.09TyrArg: 2.09 ± 0.476
2.738TyrSer: 2.738 ± 0.477
2.306TyrThr: 2.306 ± 0.386
2.882TyrVal: 2.882 ± 0.434
0.721TyrTrp: 0.721 ± 0.24
2.018TyrTyr: 2.018 ± 0.355
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (13879 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski