Amino acid dipepetide frequency for Lactococcus phage LL-H (Lactococcus delbrueckii bacteriophage LL-H)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.485AlaAla: 6.485 ± 0.941
0.968AlaCys: 0.968 ± 0.297
4.356AlaAsp: 4.356 ± 0.764
4.356AlaGlu: 4.356 ± 0.563
2.71AlaPhe: 2.71 ± 0.425
5.614AlaGly: 5.614 ± 0.746
0.968AlaHis: 0.968 ± 0.262
5.421AlaIle: 5.421 ± 0.894
8.518AlaLys: 8.518 ± 0.911
6.098AlaLeu: 6.098 ± 0.793
1.936AlaMet: 1.936 ± 0.412
4.549AlaAsn: 4.549 ± 0.649
1.355AlaPro: 1.355 ± 0.39
3.678AlaGln: 3.678 ± 0.59
3.097AlaArg: 3.097 ± 0.547
6.001AlaSer: 6.001 ± 0.923
6.001AlaThr: 6.001 ± 0.742
5.711AlaVal: 5.711 ± 0.784
1.258AlaTrp: 1.258 ± 0.387
3.969AlaTyr: 3.969 ± 0.779
0.0AlaXaa: 0.0 ± 0.0
Cys
0.484CysAla: 0.484 ± 0.209
0.0CysCys: 0.0 ± 0.0
0.484CysAsp: 0.484 ± 0.183
0.0CysGlu: 0.0 ± 0.0
0.194CysPhe: 0.194 ± 0.115
0.678CysGly: 0.678 ± 0.265
0.29CysHis: 0.29 ± 0.18
0.581CysIle: 0.581 ± 0.227
0.097CysLys: 0.097 ± 0.103
0.774CysLeu: 0.774 ± 0.251
0.29CysMet: 0.29 ± 0.153
0.29CysAsn: 0.29 ± 0.154
0.484CysPro: 0.484 ± 0.297
0.29CysGln: 0.29 ± 0.162
0.29CysArg: 0.29 ± 0.166
0.774CysSer: 0.774 ± 0.295
0.387CysThr: 0.387 ± 0.22
0.678CysVal: 0.678 ± 0.246
0.097CysTrp: 0.097 ± 0.098
0.387CysTyr: 0.387 ± 0.193
0.0CysXaa: 0.0 ± 0.0
Asp
5.227AspAla: 5.227 ± 0.581
0.387AspCys: 0.387 ± 0.18
3.775AspAsp: 3.775 ± 0.555
3.775AspGlu: 3.775 ± 0.611
3.194AspPhe: 3.194 ± 0.621
5.711AspGly: 5.711 ± 0.773
1.258AspHis: 1.258 ± 0.321
2.904AspIle: 2.904 ± 0.589
3.291AspLys: 3.291 ± 0.484
5.517AspLeu: 5.517 ± 0.608
2.517AspMet: 2.517 ± 0.444
3.097AspAsn: 3.097 ± 0.633
2.613AspPro: 2.613 ± 0.435
2.613AspGln: 2.613 ± 0.574
3.001AspArg: 3.001 ± 0.617
4.453AspSer: 4.453 ± 0.82
3.678AspThr: 3.678 ± 0.676
3.678AspVal: 3.678 ± 0.538
1.452AspTrp: 1.452 ± 0.373
3.291AspTyr: 3.291 ± 0.531
0.0AspXaa: 0.0 ± 0.0
Glu
5.324GluAla: 5.324 ± 0.943
0.387GluCys: 0.387 ± 0.173
3.872GluAsp: 3.872 ± 0.643
4.259GluGlu: 4.259 ± 0.559
2.13GluPhe: 2.13 ± 0.408
2.517GluGly: 2.517 ± 0.395
0.581GluHis: 0.581 ± 0.276
3.291GluIle: 3.291 ± 0.496
3.388GluLys: 3.388 ± 0.605
4.549GluLeu: 4.549 ± 0.72
1.646GluMet: 1.646 ± 0.437
3.581GluAsn: 3.581 ± 0.526
1.065GluPro: 1.065 ± 0.316
2.226GluGln: 2.226 ± 0.509
2.904GluArg: 2.904 ± 0.495
2.71GluSer: 2.71 ± 0.376
2.71GluThr: 2.71 ± 0.472
4.065GluVal: 4.065 ± 0.76
1.452GluTrp: 1.452 ± 0.381
2.323GluTyr: 2.323 ± 0.479
0.0GluXaa: 0.0 ± 0.0
Phe
2.904PheAla: 2.904 ± 0.557
0.097PheCys: 0.097 ± 0.105
3.485PheAsp: 3.485 ± 0.638
2.13PheGlu: 2.13 ± 0.438
1.355PhePhe: 1.355 ± 0.311
2.517PheGly: 2.517 ± 0.526
0.484PheHis: 0.484 ± 0.226
2.323PheIle: 2.323 ± 0.457
2.226PheLys: 2.226 ± 0.535
1.646PheLeu: 1.646 ± 0.45
0.484PheMet: 0.484 ± 0.22
2.807PheAsn: 2.807 ± 0.478
0.871PhePro: 0.871 ± 0.266
1.355PheGln: 1.355 ± 0.521
2.13PheArg: 2.13 ± 0.44
1.742PheSer: 1.742 ± 0.411
2.71PheThr: 2.71 ± 0.475
1.936PheVal: 1.936 ± 0.455
0.774PheTrp: 0.774 ± 0.368
0.968PheTyr: 0.968 ± 0.297
0.0PheXaa: 0.0 ± 0.0
Gly
4.453GlyAla: 4.453 ± 0.539
0.678GlyCys: 0.678 ± 0.256
4.356GlyAsp: 4.356 ± 0.599
3.097GlyGlu: 3.097 ± 0.667
2.613GlyPhe: 2.613 ± 0.387
4.743GlyGly: 4.743 ± 0.959
2.13GlyHis: 2.13 ± 0.334
4.065GlyIle: 4.065 ± 0.706
6.195GlyLys: 6.195 ± 0.77
4.743GlyLeu: 4.743 ± 0.948
1.839GlyMet: 1.839 ± 0.497
5.227GlyAsn: 5.227 ± 0.722
1.162GlyPro: 1.162 ± 0.414
4.743GlyGln: 4.743 ± 0.908
2.71GlyArg: 2.71 ± 0.56
6.001GlySer: 6.001 ± 0.824
4.743GlyThr: 4.743 ± 0.684
4.065GlyVal: 4.065 ± 0.541
0.387GlyTrp: 0.387 ± 0.194
3.291GlyTyr: 3.291 ± 0.734
0.0GlyXaa: 0.0 ± 0.0
His
1.355HisAla: 1.355 ± 0.32
0.194HisCys: 0.194 ± 0.133
1.162HisAsp: 1.162 ± 0.483
0.484HisGlu: 0.484 ± 0.208
0.678HisPhe: 0.678 ± 0.272
1.742HisGly: 1.742 ± 0.542
1.065HisHis: 1.065 ± 0.403
1.065HisIle: 1.065 ± 0.457
1.355HisLys: 1.355 ± 0.386
1.065HisLeu: 1.065 ± 0.326
0.29HisMet: 0.29 ± 0.157
0.581HisAsn: 0.581 ± 0.234
0.871HisPro: 0.871 ± 0.259
0.871HisGln: 0.871 ± 0.257
1.258HisArg: 1.258 ± 0.358
0.871HisSer: 0.871 ± 0.38
1.258HisThr: 1.258 ± 0.455
1.162HisVal: 1.162 ± 0.309
0.387HisTrp: 0.387 ± 0.205
0.871HisTyr: 0.871 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
3.872IleAla: 3.872 ± 0.574
0.29IleCys: 0.29 ± 0.164
6.776IleAsp: 6.776 ± 0.807
3.388IleGlu: 3.388 ± 0.601
2.226IlePhe: 2.226 ± 0.475
3.581IleGly: 3.581 ± 0.525
0.484IleHis: 0.484 ± 0.246
1.549IleIle: 1.549 ± 0.257
6.001IleLys: 6.001 ± 0.837
3.001IleLeu: 3.001 ± 0.501
1.258IleMet: 1.258 ± 0.326
4.259IleAsn: 4.259 ± 0.709
1.936IlePro: 1.936 ± 0.34
1.936IleGln: 1.936 ± 0.346
2.226IleArg: 2.226 ± 0.417
3.291IleSer: 3.291 ± 0.516
5.517IleThr: 5.517 ± 0.805
3.872IleVal: 3.872 ± 0.687
0.871IleTrp: 0.871 ± 0.328
2.13IleTyr: 2.13 ± 0.409
0.0IleXaa: 0.0 ± 0.0
Lys
7.066LysAla: 7.066 ± 0.847
1.162LysCys: 1.162 ± 0.36
3.872LysAsp: 3.872 ± 0.808
6.001LysGlu: 6.001 ± 0.763
1.936LysPhe: 1.936 ± 0.36
6.485LysGly: 6.485 ± 0.832
2.517LysHis: 2.517 ± 0.452
4.065LysIle: 4.065 ± 0.662
7.066LysLys: 7.066 ± 1.016
6.485LysLeu: 6.485 ± 0.92
1.839LysMet: 1.839 ± 0.437
3.194LysAsn: 3.194 ± 0.512
2.904LysPro: 2.904 ± 0.691
2.517LysGln: 2.517 ± 0.424
3.291LysArg: 3.291 ± 0.651
4.356LysSer: 4.356 ± 0.618
5.711LysThr: 5.711 ± 0.657
4.549LysVal: 4.549 ± 0.859
0.968LysTrp: 0.968 ± 0.349
2.13LysTyr: 2.13 ± 0.595
0.0LysXaa: 0.0 ± 0.0
Leu
6.485LeuAla: 6.485 ± 0.84
0.581LeuCys: 0.581 ± 0.264
6.582LeuAsp: 6.582 ± 0.786
4.259LeuGlu: 4.259 ± 0.667
1.936LeuPhe: 1.936 ± 0.48
5.614LeuGly: 5.614 ± 0.755
0.968LeuHis: 0.968 ± 0.429
5.033LeuIle: 5.033 ± 0.9
7.937LeuLys: 7.937 ± 1.021
5.227LeuLeu: 5.227 ± 0.737
1.452LeuMet: 1.452 ± 0.282
3.872LeuAsn: 3.872 ± 0.616
2.323LeuPro: 2.323 ± 0.45
2.226LeuGln: 2.226 ± 0.403
2.323LeuArg: 2.323 ± 0.586
4.937LeuSer: 4.937 ± 0.698
5.13LeuThr: 5.13 ± 0.631
3.097LeuVal: 3.097 ± 0.542
1.258LeuTrp: 1.258 ± 0.341
2.42LeuTyr: 2.42 ± 0.451
0.0LeuXaa: 0.0 ± 0.0
Met
3.388MetAla: 3.388 ± 0.515
0.0MetCys: 0.0 ± 0.0
1.646MetAsp: 1.646 ± 0.494
1.065MetGlu: 1.065 ± 0.368
0.678MetPhe: 0.678 ± 0.249
1.355MetGly: 1.355 ± 0.432
0.387MetHis: 0.387 ± 0.235
1.936MetIle: 1.936 ± 0.483
1.355MetLys: 1.355 ± 0.389
1.549MetLeu: 1.549 ± 0.387
0.194MetMet: 0.194 ± 0.142
0.968MetAsn: 0.968 ± 0.308
0.484MetPro: 0.484 ± 0.195
2.033MetGln: 2.033 ± 0.478
0.871MetArg: 0.871 ± 0.335
1.742MetSer: 1.742 ± 0.3
2.13MetThr: 2.13 ± 0.385
1.452MetVal: 1.452 ± 0.334
0.29MetTrp: 0.29 ± 0.168
1.065MetTyr: 1.065 ± 0.253
0.0MetXaa: 0.0 ± 0.0
Asn
4.549AsnAla: 4.549 ± 0.891
0.581AsnCys: 0.581 ± 0.243
2.613AsnAsp: 2.613 ± 0.479
3.001AsnGlu: 3.001 ± 0.652
1.936AsnPhe: 1.936 ± 0.398
5.324AsnGly: 5.324 ± 0.675
1.162AsnHis: 1.162 ± 0.323
2.613AsnIle: 2.613 ± 0.466
2.13AsnLys: 2.13 ± 0.489
4.162AsnLeu: 4.162 ± 0.551
0.774AsnMet: 0.774 ± 0.256
2.323AsnAsn: 2.323 ± 0.467
3.485AsnPro: 3.485 ± 0.729
2.323AsnGln: 2.323 ± 0.501
2.517AsnArg: 2.517 ± 0.443
3.969AsnSer: 3.969 ± 0.667
3.001AsnThr: 3.001 ± 0.527
2.613AsnVal: 2.613 ± 0.426
0.678AsnTrp: 0.678 ± 0.209
2.42AsnTyr: 2.42 ± 0.681
0.0AsnXaa: 0.0 ± 0.0
Pro
2.904ProAla: 2.904 ± 0.526
0.0ProCys: 0.0 ± 0.0
2.226ProAsp: 2.226 ± 0.343
2.13ProGlu: 2.13 ± 0.599
0.968ProPhe: 0.968 ± 0.301
1.742ProGly: 1.742 ± 0.372
0.968ProHis: 0.968 ± 0.271
1.839ProIle: 1.839 ± 0.463
2.71ProLys: 2.71 ± 0.578
1.936ProLeu: 1.936 ± 0.434
0.678ProMet: 0.678 ± 0.259
1.162ProAsn: 1.162 ± 0.391
0.968ProPro: 0.968 ± 0.308
1.549ProGln: 1.549 ± 0.313
1.355ProArg: 1.355 ± 0.313
2.807ProSer: 2.807 ± 0.318
2.613ProThr: 2.613 ± 0.48
2.42ProVal: 2.42 ± 0.539
0.387ProTrp: 0.387 ± 0.168
1.549ProTyr: 1.549 ± 0.346
0.0ProXaa: 0.0 ± 0.0
Gln
5.13GlnAla: 5.13 ± 0.907
0.387GlnCys: 0.387 ± 0.196
2.517GlnAsp: 2.517 ± 0.512
1.742GlnGlu: 1.742 ± 0.459
1.452GlnPhe: 1.452 ± 0.378
2.42GlnGly: 2.42 ± 0.597
0.484GlnHis: 0.484 ± 0.226
2.71GlnIle: 2.71 ± 0.486
3.291GlnLys: 3.291 ± 0.708
3.194GlnLeu: 3.194 ± 0.686
1.162GlnMet: 1.162 ± 0.37
1.742GlnAsn: 1.742 ± 0.56
1.549GlnPro: 1.549 ± 0.409
1.258GlnGln: 1.258 ± 0.546
1.839GlnArg: 1.839 ± 0.449
3.194GlnSer: 3.194 ± 0.494
3.291GlnThr: 3.291 ± 0.663
2.517GlnVal: 2.517 ± 0.802
0.484GlnTrp: 0.484 ± 0.171
1.742GlnTyr: 1.742 ± 0.739
0.0GlnXaa: 0.0 ± 0.0
Arg
3.291ArgAla: 3.291 ± 0.634
0.194ArgCys: 0.194 ± 0.129
2.517ArgAsp: 2.517 ± 0.57
2.517ArgGlu: 2.517 ± 0.422
1.355ArgPhe: 1.355 ± 0.35
2.13ArgGly: 2.13 ± 0.397
0.29ArgHis: 0.29 ± 0.153
3.485ArgIle: 3.485 ± 0.633
3.485ArgLys: 3.485 ± 0.546
4.646ArgLeu: 4.646 ± 0.855
1.258ArgMet: 1.258 ± 0.33
1.452ArgAsn: 1.452 ± 0.44
1.936ArgPro: 1.936 ± 0.409
1.742ArgGln: 1.742 ± 0.497
1.646ArgArg: 1.646 ± 0.45
2.033ArgSer: 2.033 ± 0.458
3.291ArgThr: 3.291 ± 0.464
3.194ArgVal: 3.194 ± 0.548
1.452ArgTrp: 1.452 ± 0.339
1.646ArgTyr: 1.646 ± 0.37
0.0ArgXaa: 0.0 ± 0.0
Ser
5.905SerAla: 5.905 ± 0.675
0.097SerCys: 0.097 ± 0.096
4.065SerAsp: 4.065 ± 0.579
3.678SerGlu: 3.678 ± 0.574
2.71SerPhe: 2.71 ± 0.453
4.937SerGly: 4.937 ± 0.59
0.871SerHis: 0.871 ± 0.27
3.581SerIle: 3.581 ± 0.575
5.808SerLys: 5.808 ± 0.742
5.711SerLeu: 5.711 ± 0.778
1.742SerMet: 1.742 ± 0.319
3.678SerAsn: 3.678 ± 0.623
1.839SerPro: 1.839 ± 0.452
2.807SerGln: 2.807 ± 0.494
3.001SerArg: 3.001 ± 0.543
4.84SerSer: 4.84 ± 0.872
3.969SerThr: 3.969 ± 0.544
4.453SerVal: 4.453 ± 0.636
0.774SerTrp: 0.774 ± 0.291
3.485SerTyr: 3.485 ± 0.471
0.0SerXaa: 0.0 ± 0.0
Thr
5.324ThrAla: 5.324 ± 0.836
0.678ThrCys: 0.678 ± 0.252
3.581ThrAsp: 3.581 ± 0.463
2.613ThrGlu: 2.613 ± 0.371
2.807ThrPhe: 2.807 ± 0.468
5.421ThrGly: 5.421 ± 0.836
1.452ThrHis: 1.452 ± 0.454
4.356ThrIle: 4.356 ± 0.825
4.356ThrLys: 4.356 ± 0.755
5.227ThrLeu: 5.227 ± 0.902
2.323ThrMet: 2.323 ± 0.546
3.097ThrAsn: 3.097 ± 0.53
2.807ThrPro: 2.807 ± 0.489
2.613ThrGln: 2.613 ± 0.343
2.807ThrArg: 2.807 ± 0.472
5.808ThrSer: 5.808 ± 0.838
4.937ThrThr: 4.937 ± 0.814
5.711ThrVal: 5.711 ± 0.819
0.774ThrTrp: 0.774 ± 0.299
2.613ThrTyr: 2.613 ± 0.429
0.0ThrXaa: 0.0 ± 0.0
Val
5.517ValAla: 5.517 ± 0.778
0.097ValCys: 0.097 ± 0.085
3.581ValAsp: 3.581 ± 0.69
3.775ValGlu: 3.775 ± 0.522
1.549ValPhe: 1.549 ± 0.419
4.549ValGly: 4.549 ± 0.625
1.065ValHis: 1.065 ± 0.371
3.969ValIle: 3.969 ± 0.605
5.033ValLys: 5.033 ± 0.583
3.388ValLeu: 3.388 ± 0.538
1.839ValMet: 1.839 ± 0.31
3.388ValAsn: 3.388 ± 0.6
2.226ValPro: 2.226 ± 0.478
1.646ValGln: 1.646 ± 0.363
4.065ValArg: 4.065 ± 0.56
5.13ValSer: 5.13 ± 0.859
4.162ValThr: 4.162 ± 0.743
5.13ValVal: 5.13 ± 0.831
1.065ValTrp: 1.065 ± 0.314
3.291ValTyr: 3.291 ± 0.679
0.0ValXaa: 0.0 ± 0.0
Trp
1.065TrpAla: 1.065 ± 0.281
0.0TrpCys: 0.0 ± 0.0
1.065TrpAsp: 1.065 ± 0.283
0.774TrpGlu: 0.774 ± 0.261
0.871TrpPhe: 0.871 ± 0.291
0.194TrpGly: 0.194 ± 0.129
0.29TrpHis: 0.29 ± 0.205
1.355TrpIle: 1.355 ± 0.343
1.646TrpLys: 1.646 ± 0.542
1.549TrpLeu: 1.549 ± 0.328
0.484TrpMet: 0.484 ± 0.19
1.065TrpAsn: 1.065 ± 0.273
0.871TrpPro: 0.871 ± 0.327
0.968TrpGln: 0.968 ± 0.286
0.678TrpArg: 0.678 ± 0.219
0.387TrpSer: 0.387 ± 0.167
0.871TrpThr: 0.871 ± 0.272
0.968TrpVal: 0.968 ± 0.351
0.0TrpTrp: 0.0 ± 0.0
0.194TrpTyr: 0.194 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.323TyrAla: 2.323 ± 0.503
0.774TyrCys: 0.774 ± 0.252
2.904TyrAsp: 2.904 ± 0.606
2.033TyrGlu: 2.033 ± 0.402
1.646TyrPhe: 1.646 ± 0.384
3.969TyrGly: 3.969 ± 0.562
0.871TyrHis: 0.871 ± 0.332
2.323TyrIle: 2.323 ± 0.465
2.226TyrLys: 2.226 ± 0.533
3.194TyrLeu: 3.194 ± 0.741
0.484TyrMet: 0.484 ± 0.235
1.839TyrAsn: 1.839 ± 0.441
1.162TyrPro: 1.162 ± 0.308
2.71TyrGln: 2.71 ± 0.517
1.549TyrArg: 1.549 ± 0.412
2.904TyrSer: 2.904 ± 0.549
3.194TyrThr: 3.194 ± 0.473
3.194TyrVal: 3.194 ± 0.545
0.484TyrTrp: 0.484 ± 0.216
1.839TyrTyr: 1.839 ± 0.612
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (10332 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski