Amino acid dipepetide frequency for Crocosphaera watsonii WH 8501

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.362AlaAla: 4.362 ± 0.07	0.661AlaCys: 0.661 ± 0.02	3.169AlaAsp: 3.169 ± 0.049	4.108AlaGlu: 4.108 ± 0.061	2.219AlaPhe: 2.219 ± 0.043	3.863AlaGly: 3.863 ± 0.056	1.08AlaHis: 1.08 ± 0.024	5.484AlaIle: 5.484 ± 0.066	4.333AlaLys: 4.333 ± 0.058	6.513AlaLeu: 6.513 ± 0.076	1.479AlaMet: 1.479 ± 0.034	2.75AlaAsn: 2.75 ± 0.049	2.13AlaPro: 2.13 ± 0.04	2.815AlaGln: 2.815 ± 0.049	2.754AlaArg: 2.754 ± 0.042	3.418AlaSer: 3.418 ± 0.05	3.388AlaThr: 3.388 ± 0.057	3.652AlaVal: 3.652 ± 0.058	0.791AlaTrp: 0.791 ± 0.022	1.976AlaTyr: 1.976 ± 0.04	0.001AlaXaa: 0.001 ± 0.001
Cys	0.563CysAla: 0.563 ± 0.019	0.166CysCys: 0.166 ± 0.01	0.526CysAsp: 0.526 ± 0.019	0.602CysGlu: 0.602 ± 0.02	0.659CysPhe: 0.659 ± 0.02	0.87CysGly: 0.87 ± 0.024	0.407CysHis: 0.407 ± 0.015	0.474CysIle: 0.474 ± 0.017	0.553CysLys: 0.553 ± 0.019	1.555CysLeu: 1.555 ± 0.029	0.158CysMet: 0.158 ± 0.01	0.347CysAsn: 0.347 ± 0.015	0.731CysPro: 0.731 ± 0.022	0.671CysGln: 0.671 ± 0.022	0.477CysArg: 0.477 ± 0.017	0.652CysSer: 0.652 ± 0.021	0.376CysThr: 0.376 ± 0.015	0.665CysVal: 0.665 ± 0.02	0.223CysTrp: 0.223 ± 0.01	0.732CysTyr: 0.732 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	2.713AspAla: 2.713 ± 0.045	0.666AspCys: 0.666 ± 0.017	2.491AspAsp: 2.491 ± 0.052	3.474AspGlu: 3.474 ± 0.049	2.531AspPhe: 2.531 ± 0.041	3.125AspGly: 3.125 ± 0.06	1.139AspHis: 1.139 ± 0.029	3.73AspIle: 3.73 ± 0.056	3.563AspLys: 3.563 ± 0.053	5.448AspLeu: 5.448 ± 0.059	0.823AspMet: 0.823 ± 0.021	2.754AspAsn: 2.754 ± 0.047	2.29AspPro: 2.29 ± 0.043	1.855AspGln: 1.855 ± 0.031	2.619AspArg: 2.619 ± 0.047	3.025AspSer: 3.025 ± 0.053	2.124AspThr: 2.124 ± 0.048	2.918AspVal: 2.918 ± 0.048	0.811AspTrp: 0.811 ± 0.024	2.349AspTyr: 2.349 ± 0.039	0.001AspXaa: 0.001 ± 0.001
Glu	4.27GluAla: 4.27 ± 0.066	0.625GluCys: 0.625 ± 0.02	3.265GluAsp: 3.265 ± 0.053	5.684GluGlu: 5.684 ± 0.077	2.476GluPhe: 2.476 ± 0.036	3.424GluGly: 3.424 ± 0.055	0.971GluHis: 0.971 ± 0.025	5.19GluIle: 5.19 ± 0.064	6.278GluLys: 6.278 ± 0.084	6.898GluLeu: 6.898 ± 0.069	1.4GluMet: 1.4 ± 0.029	4.044GluAsn: 4.044 ± 0.061	2.143GluPro: 2.143 ± 0.04	3.833GluGln: 3.833 ± 0.047	3.478GluArg: 3.478 ± 0.045	3.775GluSer: 3.775 ± 0.052	4.641GluThr: 4.641 ± 0.067	4.163GluVal: 4.163 ± 0.057	0.8GluTrp: 0.8 ± 0.024	2.139GluTyr: 2.139 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	2.346PheAla: 2.346 ± 0.039	0.609PheCys: 0.609 ± 0.02	2.265PheAsp: 2.265 ± 0.043	2.566PheGlu: 2.566 ± 0.048	1.827PhePhe: 1.827 ± 0.037	2.905PheGly: 2.905 ± 0.049	0.646PheHis: 0.646 ± 0.021	3.015PheIle: 3.015 ± 0.05	2.176PheLys: 2.176 ± 0.04	4.615PheLeu: 4.615 ± 0.063	0.723PheMet: 0.723 ± 0.02	2.078PheAsn: 2.078 ± 0.043	1.834PhePro: 1.834 ± 0.038	1.841PheGln: 1.841 ± 0.037	2.145PheArg: 2.145 ± 0.035	3.434PheSer: 3.434 ± 0.044	2.2PheThr: 2.2 ± 0.038	2.22PheVal: 2.22 ± 0.041	0.567PheTrp: 0.567 ± 0.022	1.472PheTyr: 1.472 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	3.685GlyAla: 3.685 ± 0.062	0.655GlyCys: 0.655 ± 0.023	3.104GlyAsp: 3.104 ± 0.063	4.127GlyGlu: 4.127 ± 0.058	2.937GlyPhe: 2.937 ± 0.05	3.998GlyGly: 3.998 ± 0.077	1.111GlyHis: 1.111 ± 0.028	5.494GlyIle: 5.494 ± 0.061	4.924GlyLys: 4.924 ± 0.063	6.157GlyLeu: 6.157 ± 0.077	1.305GlyMet: 1.305 ± 0.029	3.038GlyAsn: 3.038 ± 0.058	1.232GlyPro: 1.232 ± 0.031	2.525GlyGln: 2.525 ± 0.042	2.762GlyArg: 2.762 ± 0.05	3.513GlySer: 3.513 ± 0.062	3.789GlyThr: 3.789 ± 0.056	4.041GlyVal: 4.041 ± 0.051	1.084GlyTrp: 1.084 ± 0.03	2.299GlyTyr: 2.299 ± 0.037	0.001GlyXaa: 0.001 ± 0.001
His	0.718HisAla: 0.718 ± 0.024	0.344HisCys: 0.344 ± 0.016	0.873HisAsp: 0.873 ± 0.022	0.941HisGlu: 0.941 ± 0.027	0.95HisPhe: 0.95 ± 0.027	1.084HisGly: 1.084 ± 0.025	0.699HisHis: 0.699 ± 0.027	1.216HisIle: 1.216 ± 0.029	1.0HisLys: 1.0 ± 0.026	2.331HisLeu: 2.331 ± 0.041	0.164HisMet: 0.164 ± 0.009	0.742HisAsn: 0.742 ± 0.022	1.194HisPro: 1.194 ± 0.025	1.007HisGln: 1.007 ± 0.03	1.093HisArg: 1.093 ± 0.023	1.308HisSer: 1.308 ± 0.028	0.754HisThr: 0.754 ± 0.026	0.793HisVal: 0.793 ± 0.023	0.385HisTrp: 0.385 ± 0.015	0.801HisTyr: 0.801 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.592IleAla: 5.592 ± 0.073	0.698IleCys: 0.698 ± 0.019	4.552IleAsp: 4.552 ± 0.056	5.607IleGlu: 5.607 ± 0.058	2.833IlePhe: 2.833 ± 0.044	4.287IleGly: 4.287 ± 0.06	1.273IleHis: 1.273 ± 0.028	5.44IleIle: 5.44 ± 0.073	5.277IleLys: 5.277 ± 0.066	7.373IleLeu: 7.373 ± 0.084	1.152IleMet: 1.152 ± 0.027	4.199IleAsn: 4.199 ± 0.069	3.549IlePro: 3.549 ± 0.049	2.813IleGln: 2.813 ± 0.041	3.3IleArg: 3.3 ± 0.041	4.914IleSer: 4.914 ± 0.055	4.321IleThr: 4.321 ± 0.055	4.558IleVal: 4.558 ± 0.053	0.784IleTrp: 0.784 ± 0.024	2.189IleTyr: 2.189 ± 0.04	0.001IleXaa: 0.001 ± 0.001
Lys	4.322LysAla: 4.322 ± 0.061	0.473LysCys: 0.473 ± 0.018	2.832LysAsp: 2.832 ± 0.041	4.969LysGlu: 4.969 ± 0.071	2.194LysPhe: 2.194 ± 0.032	3.837LysGly: 3.837 ± 0.048	1.067LysHis: 1.067 ± 0.03	5.48LysIle: 5.48 ± 0.065	5.679LysLys: 5.679 ± 0.092	7.742LysLeu: 7.742 ± 0.093	1.256LysMet: 1.256 ± 0.028	3.281LysAsn: 3.281 ± 0.048	3.047LysPro: 3.047 ± 0.048	3.642LysGln: 3.642 ± 0.047	3.654LysArg: 3.654 ± 0.056	3.801LysSer: 3.801 ± 0.054	3.802LysThr: 3.802 ± 0.052	3.943LysVal: 3.943 ± 0.054	0.692LysTrp: 0.692 ± 0.023	2.199LysTyr: 2.199 ± 0.037	0.002LysXaa: 0.002 ± 0.001
Leu	7.113LeuAla: 7.113 ± 0.074	0.966LeuCys: 0.966 ± 0.027	5.418LeuAsp: 5.418 ± 0.062	8.113LeuGlu: 8.113 ± 0.071	4.348LeuPhe: 4.348 ± 0.06	7.512LeuGly: 7.512 ± 0.066	1.427LeuHis: 1.427 ± 0.032	7.964LeuIle: 7.964 ± 0.077	7.483LeuLys: 7.483 ± 0.079	9.916LeuLeu: 9.916 ± 0.107	2.144LeuMet: 2.144 ± 0.039	5.278LeuAsn: 5.278 ± 0.069	4.906LeuPro: 4.906 ± 0.063	4.631LeuGln: 4.631 ± 0.061	4.772LeuArg: 4.772 ± 0.051	8.378LeuSer: 8.378 ± 0.085	6.116LeuThr: 6.116 ± 0.075	6.668LeuVal: 6.668 ± 0.064	1.226LeuTrp: 1.226 ± 0.03	2.87LeuTyr: 2.87 ± 0.055	0.001LeuXaa: 0.001 ± 0.001
Met	1.584MetAla: 1.584 ± 0.035	0.161MetCys: 0.161 ± 0.011	0.957MetAsp: 0.957 ± 0.025	1.083MetGlu: 1.083 ± 0.026	0.581MetPhe: 0.581 ± 0.021	1.377MetGly: 1.377 ± 0.031	0.2MetHis: 0.2 ± 0.012	1.333MetIle: 1.333 ± 0.028	1.06MetLys: 1.06 ± 0.027	1.919MetLeu: 1.919 ± 0.033	0.437MetMet: 0.437 ± 0.017	0.83MetAsn: 0.83 ± 0.023	0.628MetPro: 0.628 ± 0.021	0.552MetGln: 0.552 ± 0.018	0.881MetArg: 0.881 ± 0.027	1.41MetSer: 1.41 ± 0.03	1.494MetThr: 1.494 ± 0.034	1.289MetVal: 1.289 ± 0.028	0.281MetTrp: 0.281 ± 0.011	0.421MetTyr: 0.421 ± 0.016	0.001MetXaa: 0.001 ± 0.001
Asn	2.438AsnAla: 2.438 ± 0.049	0.902AsnCys: 0.902 ± 0.027	2.059AsnAsp: 2.059 ± 0.05	2.205AsnGlu: 2.205 ± 0.041	2.423AsnPhe: 2.423 ± 0.045	2.608AsnGly: 2.608 ± 0.056	0.981AsnHis: 0.981 ± 0.027	3.357AsnIle: 3.357 ± 0.065	3.097AsnLys: 3.097 ± 0.051	6.344AsnLeu: 6.344 ± 0.086	0.704AsnMet: 0.704 ± 0.021	3.305AsnAsn: 3.305 ± 0.056	2.867AsnPro: 2.867 ± 0.043	2.906AsnGln: 2.906 ± 0.044	2.541AsnArg: 2.541 ± 0.046	3.248AsnSer: 3.248 ± 0.056	2.189AsnThr: 2.189 ± 0.047	2.145AsnVal: 2.145 ± 0.035	0.972AsnTrp: 0.972 ± 0.022	1.971AsnTyr: 1.971 ± 0.04	0.001AsnXaa: 0.001 ± 0.001
Pro	2.133ProAla: 2.133 ± 0.033	0.364ProCys: 0.364 ± 0.015	2.543ProAsp: 2.543 ± 0.038	3.627ProGlu: 3.627 ± 0.05	1.893ProPhe: 1.893 ± 0.031	2.341ProGly: 2.341 ± 0.046	0.872ProHis: 0.872 ± 0.022	3.336ProIle: 3.336 ± 0.055	2.572ProLys: 2.572 ± 0.044	4.779ProLeu: 4.779 ± 0.068	0.785ProMet: 0.785 ± 0.023	2.31ProAsn: 2.31 ± 0.04	2.469ProPro: 2.469 ± 0.058	2.259ProGln: 2.259 ± 0.045	1.9ProArg: 1.9 ± 0.037	2.984ProSer: 2.984 ± 0.053	2.404ProThr: 2.404 ± 0.046	2.418ProVal: 2.418 ± 0.047	0.616ProTrp: 0.616 ± 0.018	1.426ProTyr: 1.426 ± 0.029	0.002ProXaa: 0.002 ± 0.001
Gln	3.529GlnAla: 3.529 ± 0.052	0.462GlnCys: 0.462 ± 0.019	2.095GlnAsp: 2.095 ± 0.037	3.958GlnGlu: 3.958 ± 0.051	1.753GlnPhe: 1.753 ± 0.033	3.188GlnGly: 3.188 ± 0.05	0.703GlnHis: 0.703 ± 0.021	3.038GlnIle: 3.038 ± 0.04	3.29GlnLys: 3.29 ± 0.048	5.118GlnLeu: 5.118 ± 0.066	0.836GlnMet: 0.836 ± 0.021	1.755GlnAsn: 1.755 ± 0.037	2.043GlnPro: 2.043 ± 0.037	3.583GlnGln: 3.583 ± 0.066	2.718GlnArg: 2.718 ± 0.04	2.813GlnSer: 2.813 ± 0.042	2.629GlnThr: 2.629 ± 0.04	3.243GlnVal: 3.243 ± 0.044	0.747GlnTrp: 0.747 ± 0.02	1.289GlnTyr: 1.289 ± 0.028	0.001GlnXaa: 0.001 ± 0.001
Arg	2.194ArgAla: 2.194 ± 0.038	0.465ArgCys: 0.465 ± 0.018	2.275ArgAsp: 2.275 ± 0.049	3.552ArgGlu: 3.552 ± 0.054	2.224ArgPhe: 2.224 ± 0.038	3.046ArgGly: 3.046 ± 0.045	1.195ArgHis: 1.195 ± 0.031	3.922ArgIle: 3.922 ± 0.054	3.333ArgLys: 3.333 ± 0.058	5.109ArgLeu: 5.109 ± 0.072	0.874ArgMet: 0.874 ± 0.023	2.327ArgAsn: 2.327 ± 0.036	2.086ArgPro: 2.086 ± 0.044	2.835ArgGln: 2.835 ± 0.047	2.98ArgArg: 2.98 ± 0.045	2.829ArgSer: 2.829 ± 0.041	2.441ArgThr: 2.441 ± 0.044	2.899ArgVal: 2.899 ± 0.046	0.795ArgTrp: 0.795 ± 0.024	1.773ArgTyr: 1.773 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	3.38SerAla: 3.38 ± 0.046	1.058SerCys: 1.058 ± 0.025	3.757SerAsp: 3.757 ± 0.054	3.793SerGlu: 3.793 ± 0.054	2.545SerPhe: 2.545 ± 0.038	3.993SerGly: 3.993 ± 0.072	1.364SerHis: 1.364 ± 0.031	4.464SerIle: 4.464 ± 0.049	3.59SerLys: 3.59 ± 0.049	8.221SerLeu: 8.221 ± 0.073	1.381SerMet: 1.381 ± 0.031	2.886SerAsn: 2.886 ± 0.052	3.305SerPro: 3.305 ± 0.055	3.393SerGln: 3.393 ± 0.052	3.225SerArg: 3.225 ± 0.046	4.383SerSer: 4.383 ± 0.06	2.946SerThr: 2.946 ± 0.045	3.658SerVal: 3.658 ± 0.057	1.136SerTrp: 1.136 ± 0.027	2.354SerTyr: 2.354 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	3.328ThrAla: 3.328 ± 0.052	0.496ThrCys: 0.496 ± 0.018	2.463ThrAsp: 2.463 ± 0.038	3.776ThrGlu: 3.776 ± 0.049	2.393ThrPhe: 2.393 ± 0.039	3.591ThrGly: 3.591 ± 0.055	0.94ThrHis: 0.94 ± 0.023	4.515ThrIle: 4.515 ± 0.056	2.709ThrLys: 2.709 ± 0.037	6.109ThrLeu: 6.109 ± 0.069	0.915ThrMet: 0.915 ± 0.026	2.417ThrAsn: 2.417 ± 0.034	2.982ThrPro: 2.982 ± 0.049	2.447ThrGln: 2.447 ± 0.044	2.192ThrArg: 2.192 ± 0.037	3.934ThrSer: 3.934 ± 0.052	2.915ThrThr: 2.915 ± 0.059	3.603ThrVal: 3.603 ± 0.056	0.795ThrTrp: 0.795 ± 0.023	1.684ThrTyr: 1.684 ± 0.037	0.002ThrXaa: 0.002 ± 0.001
Val	4.297ValAla: 4.297 ± 0.062	0.839ValCys: 0.839 ± 0.023	3.418ValAsp: 3.418 ± 0.048	4.211ValGlu: 4.211 ± 0.051	2.33ValPhe: 2.33 ± 0.037	3.629ValGly: 3.629 ± 0.056	1.231ValHis: 1.231 ± 0.034	4.471ValIle: 4.471 ± 0.057	4.06ValLys: 4.06 ± 0.054	5.299ValLeu: 5.299 ± 0.057	1.329ValMet: 1.329 ± 0.027	2.911ValAsn: 2.911 ± 0.046	2.6ValPro: 2.6 ± 0.042	2.02ValGln: 2.02 ± 0.038	2.826ValArg: 2.826 ± 0.045	4.118ValSer: 4.118 ± 0.055	3.478ValThr: 3.478 ± 0.047	3.874ValVal: 3.874 ± 0.051	0.774ValTrp: 0.774 ± 0.022	1.754ValTyr: 1.754 ± 0.032	0.001ValXaa: 0.001 ± 0.001
Trp	0.667TrpAla: 0.667 ± 0.022	0.272TrpCys: 0.272 ± 0.014	0.769TrpAsp: 0.769 ± 0.024	1.101TrpGlu: 1.101 ± 0.028	0.778TrpPhe: 0.778 ± 0.025	0.917TrpGly: 0.917 ± 0.027	0.254TrpHis: 0.254 ± 0.013	1.003TrpIle: 1.003 ± 0.026	0.918TrpLys: 0.918 ± 0.027	1.887TrpLeu: 1.887 ± 0.04	0.233TrpMet: 0.233 ± 0.014	0.517TrpAsn: 0.517 ± 0.019	0.246TrpPro: 0.246 ± 0.014	0.883TrpGln: 0.883 ± 0.026	0.701TrpArg: 0.701 ± 0.023	0.887TrpSer: 0.887 ± 0.026	0.668TrpThr: 0.668 ± 0.023	0.885TrpVal: 0.885 ± 0.025	0.192TrpTrp: 0.192 ± 0.01	0.509TrpTyr: 0.509 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.709TyrAla: 1.709 ± 0.029	0.526TyrCys: 0.526 ± 0.019	1.619TyrAsp: 1.619 ± 0.042	2.0TyrGlu: 2.0 ± 0.033	1.588TyrPhe: 1.588 ± 0.034	2.186TyrGly: 2.186 ± 0.038	0.837TyrHis: 0.837 ± 0.023	1.785TyrIle: 1.785 ± 0.039	2.019TyrLys: 2.019 ± 0.041	3.914TyrLeu: 3.914 ± 0.047	0.381TyrMet: 0.381 ± 0.017	1.494TyrAsn: 1.494 ± 0.034	1.751TyrPro: 1.751 ± 0.036	2.28TyrGln: 2.28 ± 0.036	2.134TyrArg: 2.134 ± 0.037	2.007TyrSer: 2.007 ± 0.034	1.531TyrThr: 1.531 ± 0.034	1.834TyrVal: 1.834 ± 0.036	0.614TyrTrp: 0.614 ± 0.024	1.42TyrTyr: 1.42 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.006

Statistics based on 5659 proteins (1581675 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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