Amino acid dipepetide frequency for Caulobacter virus phiCbK

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.462AlaAla: 14.462 ± 0.695
1.073AlaCys: 1.073 ± 0.144
7.383AlaAsp: 7.383 ± 0.37
7.367AlaGlu: 7.367 ± 0.541
4.628AlaPhe: 4.628 ± 0.26
9.321AlaGly: 9.321 ± 0.702
2.098AlaHis: 2.098 ± 0.209
5.157AlaIle: 5.157 ± 0.266
5.333AlaLys: 5.333 ± 0.396
10.554AlaLeu: 10.554 ± 0.577
3.459AlaMet: 3.459 ± 0.278
3.075AlaAsn: 3.075 ± 0.283
6.198AlaPro: 6.198 ± 0.392
4.404AlaGln: 4.404 ± 0.366
7.415AlaArg: 7.415 ± 0.458
5.75AlaSer: 5.75 ± 0.421
5.717AlaThr: 5.717 ± 0.474
7.687AlaVal: 7.687 ± 0.385
2.098AlaTrp: 2.098 ± 0.203
3.347AlaTyr: 3.347 ± 0.227
0.0AlaXaa: 0.0 ± 0.0
Cys
0.977CysAla: 0.977 ± 0.113
0.176CysCys: 0.176 ± 0.058
0.609CysAsp: 0.609 ± 0.087
0.641CysGlu: 0.641 ± 0.116
0.224CysPhe: 0.224 ± 0.056
0.689CysGly: 0.689 ± 0.107
0.256CysHis: 0.256 ± 0.069
0.288CysIle: 0.288 ± 0.079
0.256CysLys: 0.256 ± 0.067
0.785CysLeu: 0.785 ± 0.117
0.24CysMet: 0.24 ± 0.059
0.16CysAsn: 0.16 ± 0.049
0.4CysPro: 0.4 ± 0.089
0.4CysGln: 0.4 ± 0.09
0.929CysArg: 0.929 ± 0.117
0.352CysSer: 0.352 ± 0.074
0.512CysThr: 0.512 ± 0.104
0.769CysVal: 0.769 ± 0.106
0.112CysTrp: 0.112 ± 0.041
0.4CysTyr: 0.4 ± 0.082
0.0CysXaa: 0.0 ± 0.0
Asp
7.591AspAla: 7.591 ± 0.41
0.625AspCys: 0.625 ± 0.097
4.02AspAsp: 4.02 ± 0.319
4.965AspGlu: 4.965 ± 0.357
2.386AspPhe: 2.386 ± 0.199
6.038AspGly: 6.038 ± 0.312
1.457AspHis: 1.457 ± 0.188
3.155AspIle: 3.155 ± 0.229
2.37AspLys: 2.37 ± 0.22
6.598AspLeu: 6.598 ± 0.37
1.602AspMet: 1.602 ± 0.184
1.441AspAsn: 1.441 ± 0.143
4.26AspPro: 4.26 ± 0.282
1.73AspGln: 1.73 ± 0.151
4.036AspArg: 4.036 ± 0.308
1.938AspSer: 1.938 ± 0.179
2.899AspThr: 2.899 ± 0.29
4.757AspVal: 4.757 ± 0.306
1.329AspTrp: 1.329 ± 0.146
2.354AspTyr: 2.354 ± 0.207
0.0AspXaa: 0.0 ± 0.0
Glu
8.953GluAla: 8.953 ± 0.475
0.384GluCys: 0.384 ± 0.075
4.34GluAsp: 4.34 ± 0.364
4.196GluGlu: 4.196 ± 0.359
2.739GluPhe: 2.739 ± 0.246
4.292GluGly: 4.292 ± 0.286
1.57GluHis: 1.57 ± 0.184
3.523GluIle: 3.523 ± 0.223
2.819GluLys: 2.819 ± 0.257
3.652GluLeu: 3.652 ± 0.291
1.634GluMet: 1.634 ± 0.171
1.618GluAsn: 1.618 ± 0.179
3.011GluPro: 3.011 ± 0.28
2.034GluGln: 2.034 ± 0.179
4.853GluArg: 4.853 ± 0.372
2.162GluSer: 2.162 ± 0.188
4.244GluThr: 4.244 ± 0.302
4.484GluVal: 4.484 ± 0.244
0.833GluTrp: 0.833 ± 0.138
1.409GluTyr: 1.409 ± 0.199
0.0GluXaa: 0.0 ± 0.0
Phe
3.748PheAla: 3.748 ± 0.296
0.352PheCys: 0.352 ± 0.069
3.267PheAsp: 3.267 ± 0.246
2.162PheGlu: 2.162 ± 0.212
1.249PhePhe: 1.249 ± 0.142
2.546PheGly: 2.546 ± 0.194
1.185PheHis: 1.185 ± 0.137
1.586PheIle: 1.586 ± 0.151
1.874PheLys: 1.874 ± 0.167
3.043PheLeu: 3.043 ± 0.221
0.801PheMet: 0.801 ± 0.116
1.185PheAsn: 1.185 ± 0.145
1.666PhePro: 1.666 ± 0.147
1.153PheGln: 1.153 ± 0.158
2.146PheArg: 2.146 ± 0.206
2.194PheSer: 2.194 ± 0.215
2.082PheThr: 2.082 ± 0.222
2.611PheVal: 2.611 ± 0.206
0.689PheTrp: 0.689 ± 0.11
1.265PheTyr: 1.265 ± 0.134
0.0PheXaa: 0.0 ± 0.0
Gly
8.632GlyAla: 8.632 ± 0.818
0.561GlyCys: 0.561 ± 0.097
5.269GlyAsp: 5.269 ± 0.381
5.237GlyGlu: 5.237 ± 0.363
3.299GlyPhe: 3.299 ± 0.224
9.93GlyGly: 9.93 ± 2.617
1.73GlyHis: 1.73 ± 0.187
2.354GlyIle: 2.354 ± 0.197
4.036GlyLys: 4.036 ± 0.265
6.294GlyLeu: 6.294 ± 0.411
2.018GlyMet: 2.018 ± 0.156
2.082GlyAsn: 2.082 ± 0.313
2.947GlyPro: 2.947 ± 0.225
2.915GlyGln: 2.915 ± 0.277
5.621GlyArg: 5.621 ± 0.349
4.821GlySer: 4.821 ± 0.536
4.596GlyThr: 4.596 ± 0.707
5.91GlyVal: 5.91 ± 0.39
1.794GlyTrp: 1.794 ± 0.199
2.787GlyTyr: 2.787 ± 0.285
0.0GlyXaa: 0.0 ± 0.0
His
2.675HisAla: 2.675 ± 0.275
0.336HisCys: 0.336 ± 0.073
1.634HisAsp: 1.634 ± 0.174
1.409HisGlu: 1.409 ± 0.164
0.737HisPhe: 0.737 ± 0.136
2.178HisGly: 2.178 ± 0.205
0.432HisHis: 0.432 ± 0.089
0.689HisIle: 0.689 ± 0.118
0.641HisLys: 0.641 ± 0.109
1.842HisLeu: 1.842 ± 0.161
0.384HisMet: 0.384 ± 0.089
0.593HisAsn: 0.593 ± 0.103
1.217HisPro: 1.217 ± 0.175
0.609HisGln: 0.609 ± 0.111
1.537HisArg: 1.537 ± 0.189
0.753HisSer: 0.753 ± 0.106
0.977HisThr: 0.977 ± 0.153
1.393HisVal: 1.393 ± 0.162
0.496HisTrp: 0.496 ± 0.091
0.849HisTyr: 0.849 ± 0.103
0.0HisXaa: 0.0 ± 0.0
Ile
5.782IleAla: 5.782 ± 0.348
0.416IleCys: 0.416 ± 0.082
3.299IleAsp: 3.299 ± 0.213
3.796IleGlu: 3.796 ± 0.282
1.185IlePhe: 1.185 ± 0.145
3.443IleGly: 3.443 ± 0.299
1.153IleHis: 1.153 ± 0.168
2.226IleIle: 2.226 ± 0.218
2.274IleLys: 2.274 ± 0.207
3.443IleLeu: 3.443 ± 0.24
0.673IleMet: 0.673 ± 0.096
1.505IleAsn: 1.505 ± 0.139
2.37IlePro: 2.37 ± 0.197
1.425IleGln: 1.425 ± 0.146
2.883IleArg: 2.883 ± 0.235
2.05IleSer: 2.05 ± 0.176
2.995IleThr: 2.995 ± 0.291
3.379IleVal: 3.379 ± 0.305
0.529IleTrp: 0.529 ± 0.099
1.233IleTyr: 1.233 ± 0.126
0.0IleXaa: 0.0 ± 0.0
Lys
6.166LysAla: 6.166 ± 0.42
0.112LysCys: 0.112 ± 0.04
2.611LysAsp: 2.611 ± 0.254
1.986LysGlu: 1.986 ± 0.206
1.361LysPhe: 1.361 ± 0.156
2.883LysGly: 2.883 ± 0.24
0.993LysHis: 0.993 ± 0.145
2.178LysIle: 2.178 ± 0.196
2.29LysLys: 2.29 ± 0.251
3.828LysLeu: 3.828 ± 0.313
0.833LysMet: 0.833 ± 0.129
1.137LysAsn: 1.137 ± 0.112
2.707LysPro: 2.707 ± 0.227
1.073LysGln: 1.073 ± 0.144
3.507LysArg: 3.507 ± 0.298
2.386LysSer: 2.386 ± 0.217
3.187LysThr: 3.187 ± 0.243
3.539LysVal: 3.539 ± 0.248
0.737LysTrp: 0.737 ± 0.097
0.833LysTyr: 0.833 ± 0.09
0.0LysXaa: 0.0 ± 0.0
Leu
9.93LeuAla: 9.93 ± 0.546
0.849LeuCys: 0.849 ± 0.135
6.07LeuAsp: 6.07 ± 0.349
5.029LeuGlu: 5.029 ± 0.356
2.627LeuPhe: 2.627 ± 0.212
6.582LeuGly: 6.582 ± 0.402
1.906LeuHis: 1.906 ± 0.201
4.116LeuIle: 4.116 ± 0.257
4.18LeuLys: 4.18 ± 0.327
6.198LeuLeu: 6.198 ± 0.389
1.602LeuMet: 1.602 ± 0.171
2.739LeuAsn: 2.739 ± 0.209
4.42LeuPro: 4.42 ± 0.299
2.514LeuGln: 2.514 ± 0.219
5.766LeuArg: 5.766 ± 0.4
4.917LeuSer: 4.917 ± 0.343
5.317LeuThr: 5.317 ± 0.305
4.997LeuVal: 4.997 ± 0.258
1.313LeuTrp: 1.313 ± 0.136
2.194LeuTyr: 2.194 ± 0.188
0.0LeuXaa: 0.0 ± 0.0
Met
2.434MetAla: 2.434 ± 0.203
0.144MetCys: 0.144 ± 0.046
1.201MetAsp: 1.201 ± 0.148
0.977MetGlu: 0.977 ± 0.136
0.689MetPhe: 0.689 ± 0.098
1.473MetGly: 1.473 ± 0.195
0.368MetHis: 0.368 ± 0.08
1.393MetIle: 1.393 ± 0.161
1.009MetLys: 1.009 ± 0.145
1.778MetLeu: 1.778 ± 0.2
0.352MetMet: 0.352 ± 0.088
0.753MetAsn: 0.753 ± 0.111
1.377MetPro: 1.377 ± 0.15
0.625MetGln: 0.625 ± 0.12
1.794MetArg: 1.794 ± 0.194
1.858MetSer: 1.858 ± 0.189
2.37MetThr: 2.37 ± 0.187
1.377MetVal: 1.377 ± 0.155
0.256MetTrp: 0.256 ± 0.065
0.288MetTyr: 0.288 ± 0.056
0.0MetXaa: 0.0 ± 0.0
Asn
3.251AsnAla: 3.251 ± 0.27
0.32AsnCys: 0.32 ± 0.073
1.714AsnAsp: 1.714 ± 0.144
1.409AsnGlu: 1.409 ± 0.151
1.057AsnPhe: 1.057 ± 0.144
3.187AsnGly: 3.187 ± 0.367
0.545AsnHis: 0.545 ± 0.111
1.441AsnIle: 1.441 ± 0.141
1.137AsnLys: 1.137 ± 0.149
2.851AsnLeu: 2.851 ± 0.231
0.496AsnMet: 0.496 ± 0.085
1.105AsnAsn: 1.105 ± 0.158
2.018AsnPro: 2.018 ± 0.155
0.705AsnGln: 0.705 ± 0.114
1.874AsnArg: 1.874 ± 0.213
1.313AsnSer: 1.313 ± 0.192
1.553AsnThr: 1.553 ± 0.256
1.922AsnVal: 1.922 ± 0.172
0.496AsnTrp: 0.496 ± 0.084
0.801AsnTyr: 0.801 ± 0.142
0.0AsnXaa: 0.0 ± 0.0
Pro
6.118ProAla: 6.118 ± 0.326
0.432ProCys: 0.432 ± 0.078
3.732ProAsp: 3.732 ± 0.239
3.78ProGlu: 3.78 ± 0.267
2.098ProPhe: 2.098 ± 0.175
4.693ProGly: 4.693 ± 0.294
1.041ProHis: 1.041 ± 0.152
2.498ProIle: 2.498 ± 0.232
2.098ProLys: 2.098 ± 0.177
3.828ProLeu: 3.828 ± 0.279
1.185ProMet: 1.185 ± 0.132
1.81ProAsn: 1.81 ± 0.203
3.139ProPro: 3.139 ± 0.329
1.73ProGln: 1.73 ± 0.173
3.011ProArg: 3.011 ± 0.302
2.771ProSer: 2.771 ± 0.216
3.427ProThr: 3.427 ± 0.267
3.571ProVal: 3.571 ± 0.245
0.673ProTrp: 0.673 ± 0.105
1.618ProTyr: 1.618 ± 0.145
0.0ProXaa: 0.0 ± 0.0
Gln
4.356GlnAla: 4.356 ± 0.316
0.24GlnCys: 0.24 ± 0.069
1.938GlnAsp: 1.938 ± 0.174
2.082GlnGlu: 2.082 ± 0.226
1.153GlnPhe: 1.153 ± 0.141
2.53GlnGly: 2.53 ± 0.243
0.545GlnHis: 0.545 ± 0.093
1.618GlnIle: 1.618 ± 0.146
1.586GlnLys: 1.586 ± 0.154
1.73GlnLeu: 1.73 ± 0.224
0.833GlnMet: 0.833 ± 0.131
0.929GlnAsn: 0.929 ± 0.12
1.65GlnPro: 1.65 ± 0.15
1.137GlnGln: 1.137 ± 0.156
2.498GlnArg: 2.498 ± 0.229
1.313GlnSer: 1.313 ± 0.168
2.05GlnThr: 2.05 ± 0.165
2.226GlnVal: 2.226 ± 0.19
0.496GlnTrp: 0.496 ± 0.078
0.897GlnTyr: 0.897 ± 0.118
0.0GlnXaa: 0.0 ± 0.0
Arg
7.095ArgAla: 7.095 ± 0.499
0.833ArgCys: 0.833 ± 0.135
4.596ArgAsp: 4.596 ± 0.371
4.116ArgGlu: 4.116 ± 0.354
2.867ArgPhe: 2.867 ± 0.251
4.725ArgGly: 4.725 ± 0.259
1.618ArgHis: 1.618 ± 0.176
2.899ArgIle: 2.899 ± 0.248
2.963ArgLys: 2.963 ± 0.256
6.967ArgLeu: 6.967 ± 0.42
1.826ArgMet: 1.826 ± 0.201
2.034ArgAsn: 2.034 ± 0.15
3.299ArgPro: 3.299 ± 0.258
2.226ArgGln: 2.226 ± 0.205
5.894ArgArg: 5.894 ± 0.491
2.915ArgSer: 2.915 ± 0.28
3.267ArgThr: 3.267 ± 0.247
4.58ArgVal: 4.58 ± 0.271
1.521ArgTrp: 1.521 ± 0.184
2.739ArgTyr: 2.739 ± 0.211
0.0ArgXaa: 0.0 ± 0.0
Ser
5.157SerAla: 5.157 ± 0.365
0.48SerCys: 0.48 ± 0.099
2.755SerAsp: 2.755 ± 0.253
2.803SerGlu: 2.803 ± 0.21
2.018SerPhe: 2.018 ± 0.259
5.109SerGly: 5.109 ± 0.788
1.025SerHis: 1.025 ± 0.123
2.37SerIle: 2.37 ± 0.235
1.986SerLys: 1.986 ± 0.197
4.1SerLeu: 4.1 ± 0.263
1.297SerMet: 1.297 ± 0.169
1.425SerAsn: 1.425 ± 0.188
2.659SerPro: 2.659 ± 0.2
1.505SerGln: 1.505 ± 0.166
3.315SerArg: 3.315 ± 0.258
2.594SerSer: 2.594 ± 0.28
3.219SerThr: 3.219 ± 0.325
3.075SerVal: 3.075 ± 0.209
0.769SerTrp: 0.769 ± 0.122
1.714SerTyr: 1.714 ± 0.159
0.0SerXaa: 0.0 ± 0.0
Thr
7.063ThrAla: 7.063 ± 0.546
0.416ThrCys: 0.416 ± 0.109
3.443ThrAsp: 3.443 ± 0.315
3.203ThrGlu: 3.203 ± 0.222
2.418ThrPhe: 2.418 ± 0.261
5.045ThrGly: 5.045 ± 0.567
1.217ThrHis: 1.217 ± 0.148
3.203ThrIle: 3.203 ± 0.37
1.938ThrLys: 1.938 ± 0.201
5.589ThrLeu: 5.589 ± 0.268
1.201ThrMet: 1.201 ± 0.141
1.553ThrAsn: 1.553 ± 0.187
4.516ThrPro: 4.516 ± 0.356
1.938ThrGln: 1.938 ± 0.198
3.716ThrArg: 3.716 ± 0.222
2.819ThrSer: 2.819 ± 0.343
3.331ThrThr: 3.331 ± 0.422
4.1ThrVal: 4.1 ± 0.395
0.993ThrTrp: 0.993 ± 0.1
1.986ThrTyr: 1.986 ± 0.217
0.0ThrXaa: 0.0 ± 0.0
Val
7.223ValAla: 7.223 ± 0.332
0.897ValCys: 0.897 ± 0.132
4.516ValAsp: 4.516 ± 0.271
4.693ValGlu: 4.693 ± 0.286
2.482ValPhe: 2.482 ± 0.204
4.356ValGly: 4.356 ± 0.358
1.393ValHis: 1.393 ± 0.152
3.395ValIle: 3.395 ± 0.272
3.235ValLys: 3.235 ± 0.254
6.118ValLeu: 6.118 ± 0.329
1.361ValMet: 1.361 ± 0.146
2.274ValAsn: 2.274 ± 0.267
3.443ValPro: 3.443 ± 0.297
2.226ValGln: 2.226 ± 0.152
4.612ValArg: 4.612 ± 0.322
3.748ValSer: 3.748 ± 0.322
4.58ValThr: 4.58 ± 0.369
5.093ValVal: 5.093 ± 0.311
1.361ValTrp: 1.361 ± 0.156
2.13ValTyr: 2.13 ± 0.177
0.0ValXaa: 0.0 ± 0.0
Trp
1.602TrpAla: 1.602 ± 0.141
0.176TrpCys: 0.176 ± 0.052
1.185TrpAsp: 1.185 ± 0.152
0.993TrpGlu: 0.993 ± 0.119
0.737TrpPhe: 0.737 ± 0.124
1.185TrpGly: 1.185 ± 0.146
0.256TrpHis: 0.256 ± 0.063
0.689TrpIle: 0.689 ± 0.095
1.041TrpLys: 1.041 ± 0.134
1.602TrpLeu: 1.602 ± 0.169
0.32TrpMet: 0.32 ± 0.076
0.849TrpAsn: 0.849 ± 0.122
0.641TrpPro: 0.641 ± 0.113
0.4TrpGln: 0.4 ± 0.079
1.329TrpArg: 1.329 ± 0.174
1.089TrpSer: 1.089 ± 0.123
1.281TrpThr: 1.281 ± 0.146
1.185TrpVal: 1.185 ± 0.158
0.336TrpTrp: 0.336 ± 0.087
0.32TrpTyr: 0.32 ± 0.072
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.315TyrAla: 3.315 ± 0.204
0.352TyrCys: 0.352 ± 0.088
1.97TyrAsp: 1.97 ± 0.169
1.906TyrGlu: 1.906 ± 0.172
0.849TyrPhe: 0.849 ± 0.131
2.643TyrGly: 2.643 ± 0.209
0.593TyrHis: 0.593 ± 0.095
1.281TyrIle: 1.281 ± 0.141
1.281TyrLys: 1.281 ± 0.158
2.466TyrLeu: 2.466 ± 0.179
0.384TyrMet: 0.384 ± 0.068
0.929TyrAsn: 0.929 ± 0.139
1.313TyrPro: 1.313 ± 0.13
1.057TyrGln: 1.057 ± 0.125
2.242TyrArg: 2.242 ± 0.17
1.634TyrSer: 1.634 ± 0.201
2.082TyrThr: 2.082 ± 0.239
2.482TyrVal: 2.482 ± 0.229
0.384TyrTrp: 0.384 ± 0.084
0.977TyrTyr: 0.977 ± 0.121
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 318 proteins (62441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski