Amino acid dipepetide frequency for Holospora undulata HU1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.579AlaAla: 3.579 ± 0.113
1.201AlaCys: 1.201 ± 0.065
2.204AlaAsp: 2.204 ± 0.09
3.024AlaGlu: 3.024 ± 0.103
3.395AlaPhe: 3.395 ± 0.109
3.757AlaGly: 3.757 ± 0.141
1.507AlaHis: 1.507 ± 0.068
3.712AlaIle: 3.712 ± 0.119
4.212AlaLys: 4.212 ± 0.134
9.192AlaLeu: 9.192 ± 0.168
1.417AlaMet: 1.417 ± 0.074
1.882AlaAsn: 1.882 ± 0.095
2.33AlaPro: 2.33 ± 0.086
3.198AlaGln: 3.198 ± 0.11
2.895AlaArg: 2.895 ± 0.12
4.176AlaSer: 4.176 ± 0.126
2.253AlaThr: 2.253 ± 0.082
3.724AlaVal: 3.724 ± 0.118
0.784AlaTrp: 0.784 ± 0.051
2.059AlaTyr: 2.059 ± 0.105
0.0AlaXaa: 0.0 ± 0.0
Cys
1.323CysAla: 1.323 ± 0.069
0.313CysCys: 0.313 ± 0.037
0.675CysAsp: 0.675 ± 0.044
0.755CysGlu: 0.755 ± 0.048
1.094CysPhe: 1.094 ± 0.058
1.178CysGly: 1.178 ± 0.066
0.423CysHis: 0.423 ± 0.032
1.181CysIle: 1.181 ± 0.067
0.955CysLys: 0.955 ± 0.055
1.74CysLeu: 1.74 ± 0.081
0.352CysMet: 0.352 ± 0.035
0.416CysAsn: 0.416 ± 0.035
0.742CysPro: 0.742 ± 0.055
0.678CysGln: 0.678 ± 0.047
0.613CysArg: 0.613 ± 0.054
1.404CysSer: 1.404 ± 0.069
0.726CysThr: 0.726 ± 0.053
1.414CysVal: 1.414 ± 0.073
0.242CysTrp: 0.242 ± 0.027
0.623CysTyr: 0.623 ± 0.045
0.0CysXaa: 0.0 ± 0.0
Asp
3.008AspAla: 3.008 ± 0.093
0.558AspCys: 0.558 ± 0.045
1.917AspAsp: 1.917 ± 0.09
2.818AspGlu: 2.818 ± 0.123
3.169AspPhe: 3.169 ± 0.128
2.259AspGly: 2.259 ± 0.098
1.068AspHis: 1.068 ± 0.068
3.027AspIle: 3.027 ± 0.101
2.711AspLys: 2.711 ± 0.11
5.183AspLeu: 5.183 ± 0.149
0.971AspMet: 0.971 ± 0.055
1.51AspAsn: 1.51 ± 0.084
2.075AspPro: 2.075 ± 0.079
2.082AspGln: 2.082 ± 0.082
2.288AspArg: 2.288 ± 0.096
3.25AspSer: 3.25 ± 0.136
2.12AspThr: 2.12 ± 0.076
3.011AspVal: 3.011 ± 0.106
0.581AspTrp: 0.581 ± 0.044
1.494AspTyr: 1.494 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
4.044GluAla: 4.044 ± 0.109
0.781GluCys: 0.781 ± 0.049
3.392GluAsp: 3.392 ± 0.14
5.535GluGlu: 5.535 ± 0.216
2.595GluPhe: 2.595 ± 0.087
3.489GluGly: 3.489 ± 0.101
1.41GluHis: 1.41 ± 0.072
4.757GluIle: 4.757 ± 0.16
7.181GluLys: 7.181 ± 0.247
5.606GluLeu: 5.606 ± 0.159
1.481GluMet: 1.481 ± 0.074
3.963GluAsn: 3.963 ± 0.168
1.501GluPro: 1.501 ± 0.078
2.792GluGln: 2.792 ± 0.137
3.415GluArg: 3.415 ± 0.107
4.034GluSer: 4.034 ± 0.136
2.724GluThr: 2.724 ± 0.107
3.931GluVal: 3.931 ± 0.153
0.555GluTrp: 0.555 ± 0.044
1.898GluTyr: 1.898 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
2.505PheAla: 2.505 ± 0.095
1.139PheCys: 1.139 ± 0.062
2.534PheAsp: 2.534 ± 0.109
3.005PheGlu: 3.005 ± 0.145
4.635PhePhe: 4.635 ± 0.182
3.153PheGly: 3.153 ± 0.126
1.226PheHis: 1.226 ± 0.064
3.45PheIle: 3.45 ± 0.126
2.995PheLys: 2.995 ± 0.129
7.036PheLeu: 7.036 ± 0.171
1.152PheMet: 1.152 ± 0.059
1.959PheAsn: 1.959 ± 0.105
2.362PhePro: 2.362 ± 0.102
2.217PheGln: 2.217 ± 0.096
2.111PheArg: 2.111 ± 0.08
6.239PheSer: 6.239 ± 0.185
1.936PheThr: 1.936 ± 0.079
2.995PheVal: 2.995 ± 0.103
0.959PheTrp: 0.959 ± 0.056
1.978PheTyr: 1.978 ± 0.086
0.0PheXaa: 0.0 ± 0.0
Gly
4.428GlyAla: 4.428 ± 0.15
1.062GlyCys: 1.062 ± 0.058
2.414GlyAsp: 2.414 ± 0.093
3.192GlyGlu: 3.192 ± 0.124
2.908GlyPhe: 2.908 ± 0.108
4.05GlyGly: 4.05 ± 0.147
1.239GlyHis: 1.239 ± 0.076
5.671GlyIle: 5.671 ± 0.155
4.56GlyLys: 4.56 ± 0.139
5.341GlyLeu: 5.341 ± 0.139
1.824GlyMet: 1.824 ± 0.075
2.172GlyAsn: 2.172 ± 0.1
1.727GlyPro: 1.727 ± 0.084
1.969GlyGln: 1.969 ± 0.093
2.772GlyArg: 2.772 ± 0.101
3.912GlySer: 3.912 ± 0.116
3.002GlyThr: 3.002 ± 0.126
4.802GlyVal: 4.802 ± 0.168
1.026GlyTrp: 1.026 ± 0.064
2.24GlyTyr: 2.24 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.452HisAla: 1.452 ± 0.067
0.465HisCys: 0.465 ± 0.047
0.768HisAsp: 0.768 ± 0.053
0.994HisGlu: 0.994 ± 0.063
1.126HisPhe: 1.126 ± 0.061
1.388HisGly: 1.388 ± 0.064
0.923HisHis: 0.923 ± 0.064
1.665HisIle: 1.665 ± 0.085
1.362HisLys: 1.362 ± 0.069
2.501HisLeu: 2.501 ± 0.11
0.568HisMet: 0.568 ± 0.039
0.81HisAsn: 0.81 ± 0.056
1.407HisPro: 1.407 ± 0.08
1.168HisGln: 1.168 ± 0.073
1.346HisArg: 1.346 ± 0.057
1.63HisSer: 1.63 ± 0.08
0.92HisThr: 0.92 ± 0.048
1.352HisVal: 1.352 ± 0.078
0.452HisTrp: 0.452 ± 0.041
0.952HisTyr: 0.952 ± 0.064
0.0HisXaa: 0.0 ± 0.0
Ile
4.409IleAla: 4.409 ± 0.134
1.042IleCys: 1.042 ± 0.066
3.328IleAsp: 3.328 ± 0.124
4.622IleGlu: 4.622 ± 0.157
4.483IlePhe: 4.483 ± 0.139
3.731IleGly: 3.731 ± 0.14
1.723IleHis: 1.723 ± 0.079
4.138IleIle: 4.138 ± 0.136
4.738IleLys: 4.738 ± 0.172
7.962IleLeu: 7.962 ± 0.183
1.194IleMet: 1.194 ± 0.059
2.721IleAsn: 2.721 ± 0.129
3.082IlePro: 3.082 ± 0.124
3.466IleGln: 3.466 ± 0.099
2.821IleArg: 2.821 ± 0.089
5.603IleSer: 5.603 ± 0.126
3.179IleThr: 3.179 ± 0.103
4.289IleVal: 4.289 ± 0.119
0.72IleTrp: 0.72 ± 0.054
1.824IleTyr: 1.824 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
4.506LysAla: 4.506 ± 0.131
0.658LysCys: 0.658 ± 0.051
4.344LysAsp: 4.344 ± 0.131
6.81LysGlu: 6.81 ± 0.256
2.924LysPhe: 2.924 ± 0.122
4.315LysGly: 4.315 ± 0.136
1.433LysHis: 1.433 ± 0.076
6.907LysIle: 6.907 ± 0.217
8.153LysLys: 8.153 ± 0.286
5.464LysLeu: 5.464 ± 0.176
1.824LysMet: 1.824 ± 0.082
5.606LysAsn: 5.606 ± 0.25
1.84LysPro: 1.84 ± 0.083
2.543LysGln: 2.543 ± 0.091
3.424LysArg: 3.424 ± 0.117
5.258LysSer: 5.258 ± 0.146
4.102LysThr: 4.102 ± 0.128
3.944LysVal: 3.944 ± 0.129
0.668LysTrp: 0.668 ± 0.051
2.033LysTyr: 2.033 ± 0.09
0.0LysXaa: 0.0 ± 0.0
Leu
5.968LeuAla: 5.968 ± 0.147
2.101LeuCys: 2.101 ± 0.086
5.264LeuAsp: 5.264 ± 0.153
8.104LeuGlu: 8.104 ± 0.221
5.248LeuPhe: 5.248 ± 0.151
6.968LeuGly: 6.968 ± 0.187
2.411LeuHis: 2.411 ± 0.092
6.187LeuIle: 6.187 ± 0.17
9.295LeuLys: 9.295 ± 0.247
9.653LeuLeu: 9.653 ± 0.243
2.637LeuMet: 2.637 ± 0.093
4.819LeuAsn: 4.819 ± 0.159
4.38LeuPro: 4.38 ± 0.107
4.254LeuGln: 4.254 ± 0.161
5.148LeuArg: 5.148 ± 0.154
9.166LeuSer: 9.166 ± 0.213
4.79LeuThr: 4.79 ± 0.136
5.061LeuVal: 5.061 ± 0.155
1.627LeuTrp: 1.627 ± 0.086
3.263LeuTyr: 3.263 ± 0.115
0.0LeuXaa: 0.0 ± 0.0
Met
1.552MetAla: 1.552 ± 0.069
0.31MetCys: 0.31 ± 0.029
1.023MetAsp: 1.023 ± 0.056
1.397MetGlu: 1.397 ± 0.061
0.923MetPhe: 0.923 ± 0.055
1.481MetGly: 1.481 ± 0.074
0.597MetHis: 0.597 ± 0.045
1.556MetIle: 1.556 ± 0.067
1.978MetLys: 1.978 ± 0.074
2.266MetLeu: 2.266 ± 0.111
0.665MetMet: 0.665 ± 0.043
1.272MetAsn: 1.272 ± 0.062
0.884MetPro: 0.884 ± 0.056
0.933MetGln: 0.933 ± 0.056
1.136MetArg: 1.136 ± 0.062
1.385MetSer: 1.385 ± 0.063
1.184MetThr: 1.184 ± 0.063
1.417MetVal: 1.417 ± 0.074
0.232MetTrp: 0.232 ± 0.027
0.507MetTyr: 0.507 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
2.872AsnAla: 2.872 ± 0.112
0.474AsnCys: 0.474 ± 0.043
1.643AsnAsp: 1.643 ± 0.075
2.275AsnGlu: 2.275 ± 0.15
3.205AsnPhe: 3.205 ± 0.17
2.143AsnGly: 2.143 ± 0.08
0.881AsnHis: 0.881 ± 0.052
3.321AsnIle: 3.321 ± 0.107
3.018AsnLys: 3.018 ± 0.145
4.877AsnLeu: 4.877 ± 0.177
0.82AsnMet: 0.82 ± 0.056
1.901AsnAsn: 1.901 ± 0.119
1.991AsnPro: 1.991 ± 0.09
1.914AsnGln: 1.914 ± 0.103
2.043AsnArg: 2.043 ± 0.086
2.966AsnSer: 2.966 ± 0.122
2.34AsnThr: 2.34 ± 0.107
2.576AsnVal: 2.576 ± 0.09
0.465AsnTrp: 0.465 ± 0.038
1.32AsnTyr: 1.32 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.853ProAla: 1.853 ± 0.097
0.742ProCys: 0.742 ± 0.048
1.714ProAsp: 1.714 ± 0.079
3.331ProGlu: 3.331 ± 0.123
2.379ProPhe: 2.379 ± 0.093
2.382ProGly: 2.382 ± 0.088
1.001ProHis: 1.001 ± 0.059
2.149ProIle: 2.149 ± 0.084
2.837ProLys: 2.837 ± 0.089
4.296ProLeu: 4.296 ± 0.119
0.72ProMet: 0.72 ± 0.048
1.494ProAsn: 1.494 ± 0.084
1.323ProPro: 1.323 ± 0.075
1.462ProGln: 1.462 ± 0.07
1.149ProArg: 1.149 ± 0.066
3.269ProSer: 3.269 ± 0.121
1.459ProThr: 1.459 ± 0.067
2.601ProVal: 2.601 ± 0.105
0.616ProTrp: 0.616 ± 0.045
1.498ProTyr: 1.498 ± 0.083
0.0ProXaa: 0.0 ± 0.0
Gln
2.753GlnAla: 2.753 ± 0.101
0.668GlnCys: 0.668 ± 0.046
2.559GlnAsp: 2.559 ± 0.087
4.183GlnGlu: 4.183 ± 0.138
1.478GlnPhe: 1.478 ± 0.067
2.956GlnGly: 2.956 ± 0.107
1.107GlnHis: 1.107 ± 0.064
2.443GlnIle: 2.443 ± 0.076
4.26GlnLys: 4.26 ± 0.164
3.153GlnLeu: 3.153 ± 0.117
0.752GlnMet: 0.752 ± 0.046
2.324GlnAsn: 2.324 ± 0.114
0.913GlnPro: 0.913 ± 0.069
1.572GlnGln: 1.572 ± 0.14
2.201GlnArg: 2.201 ± 0.096
2.772GlnSer: 2.772 ± 0.101
1.765GlnThr: 1.765 ± 0.081
2.23GlnVal: 2.23 ± 0.087
0.813GlnTrp: 0.813 ± 0.07
1.336GlnTyr: 1.336 ± 0.063
0.0GlnXaa: 0.0 ± 0.0
Arg
2.698ArgAla: 2.698 ± 0.098
0.959ArgCys: 0.959 ± 0.065
1.746ArgAsp: 1.746 ± 0.077
2.324ArgGlu: 2.324 ± 0.091
2.643ArgPhe: 2.643 ± 0.093
2.285ArgGly: 2.285 ± 0.094
1.049ArgHis: 1.049 ± 0.065
3.899ArgIle: 3.899 ± 0.135
3.428ArgLys: 3.428 ± 0.121
4.883ArgLeu: 4.883 ± 0.132
1.165ArgMet: 1.165 ± 0.069
1.895ArgAsn: 1.895 ± 0.082
1.73ArgPro: 1.73 ± 0.084
1.743ArgGln: 1.743 ± 0.076
2.411ArgArg: 2.411 ± 0.09
3.337ArgSer: 3.337 ± 0.114
1.969ArgThr: 1.969 ± 0.071
3.05ArgVal: 3.05 ± 0.115
0.823ArgTrp: 0.823 ± 0.06
1.723ArgTyr: 1.723 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
4.635SerAla: 4.635 ± 0.127
1.481SerCys: 1.481 ± 0.075
3.298SerAsp: 3.298 ± 0.13
4.293SerGlu: 4.293 ± 0.16
4.793SerPhe: 4.793 ± 0.15
5.209SerGly: 5.209 ± 0.138
1.501SerHis: 1.501 ± 0.073
5.103SerIle: 5.103 ± 0.13
5.354SerLys: 5.354 ± 0.155
8.282SerLeu: 8.282 ± 0.182
1.798SerMet: 1.798 ± 0.083
2.682SerAsn: 2.682 ± 0.098
2.976SerPro: 2.976 ± 0.107
3.163SerGln: 3.163 ± 0.105
2.918SerArg: 2.918 ± 0.103
6.958SerSer: 6.958 ± 0.184
2.969SerThr: 2.969 ± 0.114
5.6SerVal: 5.6 ± 0.15
1.117SerTrp: 1.117 ± 0.062
2.608SerTyr: 2.608 ± 0.09
0.0SerXaa: 0.0 ± 0.0
Thr
2.634ThrAla: 2.634 ± 0.088
0.697ThrCys: 0.697 ± 0.052
1.646ThrAsp: 1.646 ± 0.085
2.566ThrGlu: 2.566 ± 0.105
2.566ThrPhe: 2.566 ± 0.101
2.911ThrGly: 2.911 ± 0.101
1.113ThrHis: 1.113 ± 0.061
2.659ThrIle: 2.659 ± 0.105
2.634ThrLys: 2.634 ± 0.105
5.993ThrLeu: 5.993 ± 0.138
0.891ThrMet: 0.891 ± 0.062
1.481ThrAsn: 1.481 ± 0.078
2.44ThrPro: 2.44 ± 0.1
2.398ThrGln: 2.398 ± 0.102
1.843ThrArg: 1.843 ± 0.08
3.043ThrSer: 3.043 ± 0.093
2.014ThrThr: 2.014 ± 0.097
2.863ThrVal: 2.863 ± 0.101
0.633ThrTrp: 0.633 ± 0.046
1.381ThrTyr: 1.381 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
3.424ValAla: 3.424 ± 0.119
1.317ValCys: 1.317 ± 0.075
2.63ValAsp: 2.63 ± 0.085
3.405ValGlu: 3.405 ± 0.114
3.686ValPhe: 3.686 ± 0.122
3.482ValGly: 3.482 ± 0.133
1.517ValHis: 1.517 ± 0.082
3.786ValIle: 3.786 ± 0.108
3.918ValLys: 3.918 ± 0.135
8.117ValLeu: 8.117 ± 0.2
1.468ValMet: 1.468 ± 0.074
2.275ValAsn: 2.275 ± 0.092
2.676ValPro: 2.676 ± 0.085
2.734ValGln: 2.734 ± 0.11
2.805ValArg: 2.805 ± 0.106
4.967ValSer: 4.967 ± 0.132
2.721ValThr: 2.721 ± 0.1
4.057ValVal: 4.057 ± 0.133
0.91ValTrp: 0.91 ± 0.051
2.011ValTyr: 2.011 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.807TrpAla: 0.807 ± 0.055
0.242TrpCys: 0.242 ± 0.028
0.652TrpAsp: 0.652 ± 0.052
0.713TrpGlu: 0.713 ± 0.053
0.507TrpPhe: 0.507 ± 0.046
1.084TrpGly: 1.084 ± 0.068
0.307TrpHis: 0.307 ± 0.031
1.459TrpIle: 1.459 ± 0.077
1.214TrpLys: 1.214 ± 0.078
1.188TrpLeu: 1.188 ± 0.076
0.387TrpMet: 0.387 ± 0.03
0.797TrpAsn: 0.797 ± 0.054
0.491TrpPro: 0.491 ± 0.043
0.413TrpGln: 0.413 ± 0.042
0.71TrpArg: 0.71 ± 0.059
0.93TrpSer: 0.93 ± 0.06
0.578TrpThr: 0.578 ± 0.046
0.904TrpVal: 0.904 ± 0.061
0.207TrpTrp: 0.207 ± 0.027
0.342TrpTyr: 0.342 ± 0.035
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.053TyrAla: 2.053 ± 0.074
0.636TyrCys: 0.636 ± 0.056
1.352TyrAsp: 1.352 ± 0.071
1.74TyrGlu: 1.74 ± 0.081
1.83TyrPhe: 1.83 ± 0.083
2.088TyrGly: 2.088 ± 0.094
0.813TyrHis: 0.813 ± 0.056
2.007TyrIle: 2.007 ± 0.085
1.953TyrLys: 1.953 ± 0.087
3.608TyrLeu: 3.608 ± 0.125
0.61TyrMet: 0.61 ± 0.048
1.065TyrAsn: 1.065 ± 0.062
1.404TyrPro: 1.404 ± 0.069
1.543TyrGln: 1.543 ± 0.068
1.711TyrArg: 1.711 ± 0.085
2.437TyrSer: 2.437 ± 0.085
1.656TyrThr: 1.656 ± 0.074
2.085TyrVal: 2.085 ± 0.075
0.5TyrTrp: 0.5 ± 0.044
1.059TyrTyr: 1.059 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1184 proteins (309843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski