Amino acid dipepetide frequency for Confluentimicrobium lipolyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.192AlaAla: 15.192 ± 0.153	1.039AlaCys: 1.039 ± 0.03	6.982AlaAsp: 6.982 ± 0.086	8.109AlaGlu: 8.109 ± 0.106	4.352AlaPhe: 4.352 ± 0.066	9.781AlaGly: 9.781 ± 0.103	2.234AlaHis: 2.234 ± 0.052	6.028AlaIle: 6.028 ± 0.083	4.566AlaLys: 4.566 ± 0.081	13.0AlaLeu: 13.0 ± 0.132	3.636AlaMet: 3.636 ± 0.069	3.1AlaAsn: 3.1 ± 0.058	5.48AlaPro: 5.48 ± 0.083	4.425AlaGln: 4.425 ± 0.068	7.384AlaArg: 7.384 ± 0.095	5.642AlaSer: 5.642 ± 0.063	5.944AlaThr: 5.944 ± 0.068	8.33AlaVal: 8.33 ± 0.101	1.299AlaTrp: 1.299 ± 0.035	2.508AlaTyr: 2.508 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.037	0.108CysCys: 0.108 ± 0.009	0.656CysAsp: 0.656 ± 0.025	0.455CysGlu: 0.455 ± 0.023	0.358CysPhe: 0.358 ± 0.017	0.946CysGly: 0.946 ± 0.031	0.278CysHis: 0.278 ± 0.017	0.441CysIle: 0.441 ± 0.018	0.238CysLys: 0.238 ± 0.014	0.838CysLeu: 0.838 ± 0.028	0.171CysMet: 0.171 ± 0.014	0.22CysAsn: 0.22 ± 0.014	0.512CysPro: 0.512 ± 0.02	0.25CysGln: 0.25 ± 0.015	0.517CysArg: 0.517 ± 0.021	0.461CysSer: 0.461 ± 0.021	0.479CysThr: 0.479 ± 0.018	0.631CysVal: 0.631 ± 0.025	0.115CysTrp: 0.115 ± 0.009	0.215CysTyr: 0.215 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.459AspAla: 7.459 ± 0.085	0.504AspCys: 0.504 ± 0.019	3.701AspAsp: 3.701 ± 0.071	3.941AspGlu: 3.941 ± 0.07	2.383AspPhe: 2.383 ± 0.045	5.794AspGly: 5.794 ± 0.089	1.299AspHis: 1.299 ± 0.03	3.2AspIle: 3.2 ± 0.054	1.909AspLys: 1.909 ± 0.043	6.148AspLeu: 6.148 ± 0.075	1.751AspMet: 1.751 ± 0.042	1.357AspAsn: 1.357 ± 0.037	3.34AspPro: 3.34 ± 0.051	2.024AspGln: 2.024 ± 0.037	3.695AspArg: 3.695 ± 0.067	2.165AspSer: 2.165 ± 0.053	3.071AspThr: 3.071 ± 0.056	4.464AspVal: 4.464 ± 0.062	1.161AspTrp: 1.161 ± 0.033	1.559AspTyr: 1.559 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.466GluAla: 7.466 ± 0.103	0.384GluCys: 0.384 ± 0.019	3.352GluAsp: 3.352 ± 0.061	3.945GluGlu: 3.945 ± 0.073	2.072GluPhe: 2.072 ± 0.045	4.67GluGly: 4.67 ± 0.075	1.244GluHis: 1.244 ± 0.034	3.622GluIle: 3.622 ± 0.056	2.679GluLys: 2.679 ± 0.049	5.421GluLeu: 5.421 ± 0.072	1.835GluMet: 1.835 ± 0.041	2.06GluAsn: 2.06 ± 0.044	2.47GluPro: 2.47 ± 0.053	2.154GluGln: 2.154 ± 0.046	4.158GluArg: 4.158 ± 0.073	2.379GluSer: 2.379 ± 0.056	3.934GluThr: 3.934 ± 0.057	4.523GluVal: 4.523 ± 0.059	0.763GluTrp: 0.763 ± 0.026	1.192GluTyr: 1.192 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.674PheAla: 4.674 ± 0.078	0.424PheCys: 0.424 ± 0.022	2.978PheAsp: 2.978 ± 0.054	2.312PheGlu: 2.312 ± 0.042	1.565PhePhe: 1.565 ± 0.042	3.861PheGly: 3.861 ± 0.06	0.847PheHis: 0.847 ± 0.028	1.808PheIle: 1.808 ± 0.049	1.149PheLys: 1.149 ± 0.032	3.655PheLeu: 3.655 ± 0.068	0.956PheMet: 0.956 ± 0.03	1.171PheAsn: 1.171 ± 0.033	1.651PhePro: 1.651 ± 0.037	1.127PheGln: 1.127 ± 0.031	2.107PheArg: 2.107 ± 0.047	2.319PheSer: 2.319 ± 0.046	2.276PheThr: 2.276 ± 0.047	2.853PheVal: 2.853 ± 0.051	0.593PheTrp: 0.593 ± 0.026	1.002PheTyr: 1.002 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.428GlyAla: 9.428 ± 0.102	0.888GlyCys: 0.888 ± 0.03	4.737GlyAsp: 4.737 ± 0.08	4.756GlyGlu: 4.756 ± 0.066	3.766GlyPhe: 3.766 ± 0.061	7.177GlyGly: 7.177 ± 0.117	1.887GlyHis: 1.887 ± 0.041	4.457GlyIle: 4.457 ± 0.074	3.464GlyLys: 3.464 ± 0.049	8.894GlyLeu: 8.894 ± 0.1	2.497GlyMet: 2.497 ± 0.043	2.263GlyAsn: 2.263 ± 0.048	3.449GlyPro: 3.449 ± 0.062	3.151GlyGln: 3.151 ± 0.058	5.124GlyArg: 5.124 ± 0.065	4.082GlySer: 4.082 ± 0.062	4.656GlyThr: 4.656 ± 0.073	6.729GlyVal: 6.729 ± 0.08	1.352GlyTrp: 1.352 ± 0.031	2.331GlyTyr: 2.331 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.216HisAla: 2.216 ± 0.041	0.232HisCys: 0.232 ± 0.015	1.293HisAsp: 1.293 ± 0.034	1.048HisGlu: 1.048 ± 0.031	0.877HisPhe: 0.877 ± 0.03	1.845HisGly: 1.845 ± 0.043	0.542HisHis: 0.542 ± 0.024	1.009HisIle: 1.009 ± 0.029	0.62HisLys: 0.62 ± 0.025	2.013HisLeu: 2.013 ± 0.046	0.557HisMet: 0.557 ± 0.021	0.513HisAsn: 0.513 ± 0.021	1.343HisPro: 1.343 ± 0.042	0.615HisGln: 0.615 ± 0.021	1.185HisArg: 1.185 ± 0.031	0.97HisSer: 0.97 ± 0.032	0.873HisThr: 0.873 ± 0.028	1.558HisVal: 1.558 ± 0.032	0.354HisTrp: 0.354 ± 0.017	0.545HisTyr: 0.545 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.05IleAla: 7.05 ± 0.088	0.623IleCys: 0.623 ± 0.026	3.533IleAsp: 3.533 ± 0.053	3.564IleGlu: 3.564 ± 0.062	1.908IlePhe: 1.908 ± 0.04	4.893IleGly: 4.893 ± 0.071	0.92IleHis: 0.92 ± 0.024	2.471IleIle: 2.471 ± 0.056	1.644IleLys: 1.644 ± 0.037	4.797IleLeu: 4.797 ± 0.076	1.105IleMet: 1.105 ± 0.035	1.549IleAsn: 1.549 ± 0.036	2.414IlePro: 2.414 ± 0.05	1.27IleGln: 1.27 ± 0.035	2.999IleArg: 2.999 ± 0.054	3.232IleSer: 3.232 ± 0.059	3.115IleThr: 3.115 ± 0.052	3.925IleVal: 3.925 ± 0.066	0.724IleTrp: 0.724 ± 0.026	1.157IleTyr: 1.157 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.403LysAla: 4.403 ± 0.069	0.22LysCys: 0.22 ± 0.014	1.974LysAsp: 1.974 ± 0.042	1.95LysGlu: 1.95 ± 0.045	1.154LysPhe: 1.154 ± 0.033	2.987LysGly: 2.987 ± 0.056	0.746LysHis: 0.746 ± 0.024	1.909LysIle: 1.909 ± 0.041	1.525LysLys: 1.525 ± 0.049	3.522LysLeu: 3.522 ± 0.06	1.044LysMet: 1.044 ± 0.034	0.997LysAsn: 0.997 ± 0.035	1.98LysPro: 1.98 ± 0.043	1.075LysGln: 1.075 ± 0.035	2.616LysArg: 2.616 ± 0.054	2.156LysSer: 2.156 ± 0.049	2.345LysThr: 2.345 ± 0.051	2.611LysVal: 2.611 ± 0.056	0.464LysTrp: 0.464 ± 0.019	0.722LysTyr: 0.722 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.902LeuAla: 11.902 ± 0.126	0.956LeuCys: 0.956 ± 0.032	5.786LeuAsp: 5.786 ± 0.078	5.561LeuGlu: 5.561 ± 0.083	3.845LeuPhe: 3.845 ± 0.073	8.298LeuGly: 8.298 ± 0.085	1.793LeuHis: 1.793 ± 0.038	5.38LeuIle: 5.38 ± 0.083	3.705LeuLys: 3.705 ± 0.053	8.71LeuLeu: 8.71 ± 0.125	2.606LeuMet: 2.606 ± 0.05	3.124LeuAsn: 3.124 ± 0.052	5.34LeuPro: 5.34 ± 0.073	2.672LeuGln: 2.672 ± 0.05	6.428LeuArg: 6.428 ± 0.078	6.949LeuSer: 6.949 ± 0.092	6.05LeuThr: 6.05 ± 0.067	6.616LeuVal: 6.616 ± 0.082	1.247LeuTrp: 1.247 ± 0.037	1.946LeuTyr: 1.946 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.411MetAla: 3.411 ± 0.046	0.213MetCys: 0.213 ± 0.011	1.45MetAsp: 1.45 ± 0.034	1.397MetGlu: 1.397 ± 0.037	0.903MetPhe: 0.903 ± 0.026	2.247MetGly: 2.247 ± 0.05	0.468MetHis: 0.468 ± 0.02	1.579MetIle: 1.579 ± 0.036	1.178MetLys: 1.178 ± 0.03	2.532MetLeu: 2.532 ± 0.05	0.76MetMet: 0.76 ± 0.028	0.973MetAsn: 0.973 ± 0.027	1.472MetPro: 1.472 ± 0.033	0.939MetGln: 0.939 ± 0.027	1.852MetArg: 1.852 ± 0.045	1.715MetSer: 1.715 ± 0.037	2.026MetThr: 2.026 ± 0.044	1.891MetVal: 1.891 ± 0.043	0.277MetTrp: 0.277 ± 0.016	0.351MetTyr: 0.351 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.484AsnAla: 3.484 ± 0.056	0.283AsnCys: 0.283 ± 0.016	1.689AsnAsp: 1.689 ± 0.042	1.468AsnGlu: 1.468 ± 0.037	1.11AsnPhe: 1.11 ± 0.031	2.711AsnGly: 2.711 ± 0.061	0.557AsnHis: 0.557 ± 0.022	1.578AsnIle: 1.578 ± 0.038	0.871AsnLys: 0.871 ± 0.031	2.851AsnLeu: 2.851 ± 0.055	0.781AsnMet: 0.781 ± 0.03	0.767AsnAsn: 0.767 ± 0.026	1.949AsnPro: 1.949 ± 0.041	0.788AsnGln: 0.788 ± 0.025	1.763AsnArg: 1.763 ± 0.035	1.398AsnSer: 1.398 ± 0.036	1.491AsnThr: 1.491 ± 0.039	2.06AsnVal: 2.06 ± 0.049	0.475AsnTrp: 0.475 ± 0.022	0.722AsnTyr: 0.722 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	5.424ProAla: 5.424 ± 0.081	0.351ProCys: 0.351 ± 0.017	3.827ProAsp: 3.827 ± 0.068	3.935ProGlu: 3.935 ± 0.069	2.052ProPhe: 2.052 ± 0.047	3.913ProGly: 3.913 ± 0.054	0.988ProHis: 0.988 ± 0.029	2.431ProIle: 2.431 ± 0.047	1.836ProLys: 1.836 ± 0.041	4.494ProLeu: 4.494 ± 0.059	1.298ProMet: 1.298 ± 0.035	1.554ProAsn: 1.554 ± 0.033	2.05ProPro: 2.05 ± 0.047	1.58ProGln: 1.58 ± 0.036	2.462ProArg: 2.462 ± 0.049	2.595ProSer: 2.595 ± 0.048	2.61ProThr: 2.61 ± 0.047	4.006ProVal: 4.006 ± 0.061	0.623ProTrp: 0.623 ± 0.026	1.125ProTyr: 1.125 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.837GlnAla: 3.837 ± 0.065	0.264GlnCys: 0.264 ± 0.015	1.654GlnAsp: 1.654 ± 0.036	1.688GlnGlu: 1.688 ± 0.043	1.138GlnPhe: 1.138 ± 0.03	2.457GlnGly: 2.457 ± 0.045	0.613GlnHis: 0.613 ± 0.022	1.97GlnIle: 1.97 ± 0.035	1.285GlnLys: 1.285 ± 0.036	2.987GlnLeu: 2.987 ± 0.051	1.111GlnMet: 1.111 ± 0.03	1.077GlnAsn: 1.077 ± 0.03	1.616GlnPro: 1.616 ± 0.037	1.157GlnGln: 1.157 ± 0.038	2.153GlnArg: 2.153 ± 0.042	1.833GlnSer: 1.833 ± 0.044	1.853GlnThr: 1.853 ± 0.042	2.385GlnVal: 2.385 ± 0.045	0.408GlnTrp: 0.408 ± 0.021	0.608GlnTyr: 0.608 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.218ArgAla: 7.218 ± 0.095	0.446ArgCys: 0.446 ± 0.019	3.855ArgAsp: 3.855 ± 0.067	3.575ArgGlu: 3.575 ± 0.064	2.593ArgPhe: 2.593 ± 0.046	4.216ArgGly: 4.216 ± 0.063	1.346ArgHis: 1.346 ± 0.037	3.507ArgIle: 3.507 ± 0.055	2.41ArgLys: 2.41 ± 0.05	6.648ArgLeu: 6.648 ± 0.098	1.822ArgMet: 1.822 ± 0.038	1.786ArgAsn: 1.786 ± 0.039	2.888ArgPro: 2.888 ± 0.053	2.109ArgGln: 2.109 ± 0.039	4.262ArgArg: 4.262 ± 0.074	3.053ArgSer: 3.053 ± 0.049	2.911ArgThr: 2.911 ± 0.047	4.608ArgVal: 4.608 ± 0.073	0.836ArgTrp: 0.836 ± 0.026	1.5ArgTyr: 1.5 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	5.936SerAla: 5.936 ± 0.068	0.452SerCys: 0.452 ± 0.023	3.45SerAsp: 3.45 ± 0.052	2.967SerGlu: 2.967 ± 0.052	2.382SerPhe: 2.382 ± 0.044	5.361SerGly: 5.361 ± 0.071	1.1SerHis: 1.1 ± 0.029	2.699SerIle: 2.699 ± 0.05	1.816SerLys: 1.816 ± 0.044	5.073SerLeu: 5.073 ± 0.079	1.397SerMet: 1.397 ± 0.034	1.528SerAsn: 1.528 ± 0.035	2.502SerPro: 2.502 ± 0.045	1.639SerGln: 1.639 ± 0.034	3.107SerArg: 3.107 ± 0.049	2.749SerSer: 2.749 ± 0.053	2.667SerThr: 2.667 ± 0.048	4.056SerVal: 4.056 ± 0.057	0.7SerTrp: 0.7 ± 0.027	1.375SerTyr: 1.375 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.323ThrAla: 6.323 ± 0.087	0.513ThrCys: 0.513 ± 0.019	3.356ThrAsp: 3.356 ± 0.049	2.948ThrGlu: 2.948 ± 0.051	2.099ThrPhe: 2.099 ± 0.043	5.313ThrGly: 5.313 ± 0.064	1.157ThrHis: 1.157 ± 0.027	2.92ThrIle: 2.92 ± 0.046	1.782ThrLys: 1.782 ± 0.037	6.007ThrLeu: 6.007 ± 0.072	1.315ThrMet: 1.315 ± 0.03	1.514ThrAsn: 1.514 ± 0.036	3.483ThrPro: 3.483 ± 0.061	1.677ThrGln: 1.677 ± 0.039	3.285ThrArg: 3.285 ± 0.051	2.794ThrSer: 2.794 ± 0.049	2.912ThrThr: 2.912 ± 0.05	4.364ThrVal: 4.364 ± 0.07	0.661ThrTrp: 0.661 ± 0.022	1.332ThrTyr: 1.332 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.662ValAla: 8.662 ± 0.099	0.661ValCys: 0.661 ± 0.026	4.218ValAsp: 4.218 ± 0.071	4.701ValGlu: 4.701 ± 0.065	3.216ValPhe: 3.216 ± 0.055	5.56ValGly: 5.56 ± 0.078	1.325ValHis: 1.325 ± 0.034	4.305ValIle: 4.305 ± 0.067	2.551ValLys: 2.551 ± 0.059	7.467ValLeu: 7.467 ± 0.096	2.093ValMet: 2.093 ± 0.042	2.116ValAsn: 2.116 ± 0.045	3.515ValPro: 3.515 ± 0.051	2.174ValGln: 2.174 ± 0.045	3.999ValArg: 3.999 ± 0.062	4.396ValSer: 4.396 ± 0.069	4.737ValThr: 4.737 ± 0.071	5.77ValVal: 5.77 ± 0.077	0.954ValTrp: 0.954 ± 0.03	1.461ValTyr: 1.461 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.403TrpAla: 1.403 ± 0.037	0.128TrpCys: 0.128 ± 0.011	0.782TrpAsp: 0.782 ± 0.029	0.689TrpGlu: 0.689 ± 0.022	0.562TrpPhe: 0.562 ± 0.024	0.979TrpGly: 0.979 ± 0.032	0.348TrpHis: 0.348 ± 0.017	0.607TrpIle: 0.607 ± 0.019	0.504TrpLys: 0.504 ± 0.02	1.574TrpLeu: 1.574 ± 0.04	0.401TrpMet: 0.401 ± 0.018	0.473TrpAsn: 0.473 ± 0.019	0.641TrpPro: 0.641 ± 0.024	0.563TrpGln: 0.563 ± 0.023	1.004TrpArg: 1.004 ± 0.031	0.757TrpSer: 0.757 ± 0.027	0.702TrpThr: 0.702 ± 0.027	0.937TrpVal: 0.937 ± 0.033	0.209TrpTrp: 0.209 ± 0.012	0.284TrpTyr: 0.284 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.493TyrAla: 2.493 ± 0.048	0.248TyrCys: 0.248 ± 0.013	1.653TyrAsp: 1.653 ± 0.039	1.315TyrGlu: 1.315 ± 0.034	0.993TyrPhe: 0.993 ± 0.031	2.079TyrGly: 2.079 ± 0.042	0.515TyrHis: 0.515 ± 0.023	0.97TyrIle: 0.97 ± 0.029	0.668TyrLys: 0.668 ± 0.026	2.282TyrLeu: 2.282 ± 0.045	0.496TyrMet: 0.496 ± 0.022	0.657TyrAsn: 0.657 ± 0.024	1.057TyrPro: 1.057 ± 0.031	0.705TyrGln: 0.705 ± 0.026	1.49TyrArg: 1.49 ± 0.04	1.311TyrSer: 1.311 ± 0.033	1.102TyrThr: 1.102 ± 0.038	1.564TyrVal: 1.564 ± 0.035	0.335TyrTrp: 0.335 ± 0.016	0.619TyrTyr: 0.619 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3757 proteins (1183618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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