Amino acid dipepetide frequency for Privet leaf blotch-associated virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.827AlaAla: 3.827 ± 1.293
0.85AlaCys: 0.85 ± 0.414
2.126AlaAsp: 2.126 ± 0.438
2.551AlaGlu: 2.551 ± 0.547
1.276AlaPhe: 1.276 ± 0.483
2.551AlaGly: 2.551 ± 1.895
2.126AlaHis: 2.126 ± 0.633
2.976AlaIle: 2.976 ± 0.162
2.976AlaLys: 2.976 ± 1.054
7.228AlaLeu: 7.228 ± 0.511
0.85AlaMet: 0.85 ± 0.35
2.976AlaAsn: 2.976 ± 1.032
2.126AlaPro: 2.126 ± 1.369
1.701AlaGln: 1.701 ± 0.742
2.551AlaArg: 2.551 ± 1.19
5.527AlaSer: 5.527 ± 4.432
2.976AlaThr: 2.976 ± 0.93
5.952AlaVal: 5.952 ± 1.819
2.126AlaTrp: 2.126 ± 0.539
0.85AlaTyr: 0.85 ± 0.59
0.0AlaXaa: 0.0 ± 0.0
Cys
0.425CysAla: 0.425 ± 0.207
0.85CysCys: 0.85 ± 0.414
1.276CysAsp: 1.276 ± 0.621
1.701CysGlu: 1.701 ± 0.828
0.425CysPhe: 0.425 ± 0.207
2.126CysGly: 2.126 ± 1.036
0.85CysHis: 0.85 ± 0.414
0.85CysIle: 0.85 ± 0.414
3.401CysLys: 3.401 ± 1.107
0.85CysLeu: 0.85 ± 0.414
0.85CysMet: 0.85 ± 0.414
0.85CysAsn: 0.85 ± 0.414
1.701CysPro: 1.701 ± 0.828
0.425CysGln: 0.425 ± 0.207
0.0CysArg: 0.0 ± 0.0
0.425CysSer: 0.425 ± 0.207
0.425CysThr: 0.425 ± 0.207
1.276CysVal: 1.276 ± 0.621
0.0CysTrp: 0.0 ± 0.0
0.425CysTyr: 0.425 ± 0.207
0.0CysXaa: 0.0 ± 0.0
Asp
2.551AspAla: 2.551 ± 0.34
2.126AspCys: 2.126 ± 0.633
5.952AspAsp: 5.952 ± 0.544
4.252AspGlu: 4.252 ± 0.523
5.952AspPhe: 5.952 ± 0.544
2.551AspGly: 2.551 ± 0.768
2.126AspHis: 2.126 ± 0.438
5.527AspIle: 5.527 ± 0.386
4.677AspLys: 4.677 ± 2.278
7.228AspLeu: 7.228 ± 3.521
1.276AspMet: 1.276 ± 0.621
2.976AspAsn: 2.976 ± 0.702
2.551AspPro: 2.551 ± 0.34
3.401AspGln: 3.401 ± 2.279
3.827AspArg: 3.827 ± 0.645
3.401AspSer: 3.401 ± 0.879
3.827AspThr: 3.827 ± 1.293
2.126AspVal: 2.126 ± 0.438
0.0AspTrp: 0.0 ± 0.0
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
2.126GluAla: 2.126 ± 1.369
0.425GluCys: 0.425 ± 0.207
4.252GluAsp: 4.252 ± 1.43
5.952GluGlu: 5.952 ± 1.405
3.827GluPhe: 3.827 ± 1.614
2.551GluGly: 2.551 ± 0.965
0.425GluHis: 0.425 ± 0.786
3.827GluIle: 3.827 ± 1.163
5.102GluLys: 5.102 ± 1.658
3.827GluLeu: 3.827 ± 0.645
1.276GluMet: 1.276 ± 0.483
3.827GluAsn: 3.827 ± 0.324
1.276GluPro: 1.276 ± 0.621
1.276GluGln: 1.276 ± 0.947
1.276GluArg: 1.276 ± 0.483
3.827GluSer: 3.827 ± 0.324
2.976GluThr: 2.976 ± 1.45
5.102GluVal: 5.102 ± 1.878
0.0GluTrp: 0.0 ± 0.0
2.976GluTyr: 2.976 ± 0.93
0.0GluXaa: 0.0 ± 0.0
Phe
1.276PheAla: 1.276 ± 1.288
0.425PheCys: 0.425 ± 0.207
4.677PheAsp: 4.677 ± 0.726
2.126PheGlu: 2.126 ± 0.438
2.551PhePhe: 2.551 ± 1.243
4.677PheGly: 4.677 ± 1.732
2.126PheHis: 2.126 ± 1.09
2.126PheIle: 2.126 ± 0.438
2.126PheLys: 2.126 ± 1.09
4.677PheLeu: 4.677 ± 0.643
0.0PheMet: 0.0 ± 0.0
1.276PheAsn: 1.276 ± 0.483
2.551PhePro: 2.551 ± 1.243
1.276PheGln: 1.276 ± 0.621
1.701PheArg: 1.701 ± 0.828
5.952PheSer: 5.952 ± 2.062
2.976PheThr: 2.976 ± 0.93
2.551PheVal: 2.551 ± 0.34
0.425PheTrp: 0.425 ± 0.709
0.85PheTyr: 0.85 ± 0.414
0.0PheXaa: 0.0 ± 0.0
Gly
3.401GlyAla: 3.401 ± 0.835
2.126GlyCys: 2.126 ± 1.036
4.677GlyAsp: 4.677 ± 2.278
1.701GlyGlu: 1.701 ± 0.742
2.551GlyPhe: 2.551 ± 0.768
2.976GlyGly: 2.976 ± 0.162
0.85GlyHis: 0.85 ± 0.59
2.551GlyIle: 2.551 ± 0.965
3.401GlyLys: 3.401 ± 0.835
4.677GlyLeu: 4.677 ± 1.336
0.425GlyMet: 0.425 ± 0.786
3.827GlyAsn: 3.827 ± 0.824
1.276GlyPro: 1.276 ± 0.483
1.276GlyGln: 1.276 ± 0.947
2.551GlyArg: 2.551 ± 0.768
4.677GlySer: 4.677 ± 3.285
1.276GlyThr: 1.276 ± 0.621
3.827GlyVal: 3.827 ± 1.067
1.701GlyTrp: 1.701 ± 0.411
3.827GlyTyr: 3.827 ± 1.067
0.0GlyXaa: 0.0 ± 0.0
His
1.276HisAla: 1.276 ± 0.621
0.0HisCys: 0.0 ± 0.0
1.276HisAsp: 1.276 ± 0.483
1.276HisGlu: 1.276 ± 0.483
1.701HisPhe: 1.701 ± 0.545
0.85HisGly: 0.85 ± 0.414
0.425HisHis: 0.425 ± 0.207
0.85HisIle: 0.85 ± 0.414
0.85HisLys: 0.85 ± 0.618
3.401HisLeu: 3.401 ± 1.484
0.425HisMet: 0.425 ± 0.207
1.276HisAsn: 1.276 ± 0.621
2.126HisPro: 2.126 ± 1.09
1.276HisGln: 1.276 ± 0.621
1.276HisArg: 1.276 ± 0.621
2.551HisSer: 2.551 ± 1.243
0.0HisThr: 0.0 ± 0.0
0.85HisVal: 0.85 ± 0.414
0.0HisTrp: 0.0 ± 0.0
0.425HisTyr: 0.425 ± 0.207
0.0HisXaa: 0.0 ± 0.0
Ile
2.976IleAla: 2.976 ± 0.93
1.276IleCys: 1.276 ± 0.621
4.252IleAsp: 4.252 ± 1.261
3.827IleGlu: 3.827 ± 1.067
1.701IlePhe: 1.701 ± 1.993
1.701IleGly: 1.701 ± 0.411
0.0IleHis: 0.0 ± 0.0
2.551IleIle: 2.551 ± 0.34
4.677IleLys: 4.677 ± 0.969
5.102IleLeu: 5.102 ± 1.878
0.85IleMet: 0.85 ± 0.414
2.126IleAsn: 2.126 ± 1.036
3.827IlePro: 3.827 ± 1.067
2.976IleGln: 2.976 ± 0.702
2.976IleArg: 2.976 ± 0.702
4.252IleSer: 4.252 ± 0.47
5.102IleThr: 5.102 ± 2.227
3.827IleVal: 3.827 ± 1.28
1.276IleTrp: 1.276 ± 0.621
1.701IleTyr: 1.701 ± 0.828
0.0IleXaa: 0.0 ± 0.0
Lys
3.827LysAla: 3.827 ± 1.293
1.276LysCys: 1.276 ± 0.621
3.401LysAsp: 3.401 ± 0.879
2.976LysGlu: 2.976 ± 0.702
2.976LysPhe: 2.976 ± 1.45
3.827LysGly: 3.827 ± 3.25
0.85LysHis: 0.85 ± 0.618
3.401LysIle: 3.401 ± 0.879
4.677LysLys: 4.677 ± 1.254
6.803LysLeu: 6.803 ± 0.709
0.85LysMet: 0.85 ± 0.59
0.425LysAsn: 0.425 ± 0.786
2.126LysPro: 2.126 ± 0.438
2.551LysGln: 2.551 ± 1.243
5.527LysArg: 5.527 ± 1.191
6.378LysSer: 6.378 ± 1.182
4.252LysThr: 4.252 ± 0.523
5.102LysVal: 5.102 ± 1.088
1.276LysTrp: 1.276 ± 0.529
2.126LysTyr: 2.126 ± 0.539
0.0LysXaa: 0.0 ± 0.0
Leu
7.653LeuAla: 7.653 ± 4.289
0.425LeuCys: 0.425 ± 0.207
5.952LeuAsp: 5.952 ± 1.405
5.952LeuGlu: 5.952 ± 0.544
4.677LeuPhe: 4.677 ± 1.276
3.827LeuGly: 3.827 ± 0.324
0.425LeuHis: 0.425 ± 0.207
5.102LeuIle: 5.102 ± 0.931
6.378LeuLys: 6.378 ± 1.032
6.803LeuLeu: 6.803 ± 2.683
1.276LeuMet: 1.276 ± 0.483
2.976LeuAsn: 2.976 ± 1.032
8.078LeuPro: 8.078 ± 0.845
3.827LeuGln: 3.827 ± 1.067
8.078LeuArg: 8.078 ± 0.845
11.054LeuSer: 11.054 ± 2.007
6.378LeuThr: 6.378 ± 1.554
8.929LeuVal: 8.929 ± 0.934
0.0LeuTrp: 0.0 ± 0.0
2.976LeuTyr: 2.976 ± 0.162
0.0LeuXaa: 0.0 ± 0.0
Met
2.551MetAla: 2.551 ± 0.768
0.425MetCys: 0.425 ± 0.207
0.425MetAsp: 0.425 ± 0.786
1.276MetGlu: 1.276 ± 0.483
0.425MetPhe: 0.425 ± 0.207
0.85MetGly: 0.85 ± 0.414
0.0MetHis: 0.0 ± 0.0
0.85MetIle: 0.85 ± 0.414
0.85MetLys: 0.85 ± 0.59
3.827MetLeu: 3.827 ± 2.322
0.85MetMet: 0.85 ± 0.414
0.85MetAsn: 0.85 ± 0.59
0.85MetPro: 0.85 ± 0.59
1.701MetGln: 1.701 ± 0.411
0.425MetArg: 0.425 ± 0.786
1.701MetSer: 1.701 ± 0.545
1.276MetThr: 1.276 ± 0.947
1.276MetVal: 1.276 ± 0.621
0.0MetTrp: 0.0 ± 0.0
1.701MetTyr: 1.701 ± 0.411
0.0MetXaa: 0.0 ± 0.0
Asn
2.126AsnAla: 2.126 ± 1.434
0.85AsnCys: 0.85 ± 0.414
4.677AsnAsp: 4.677 ± 1.336
2.126AsnGlu: 2.126 ± 0.438
2.126AsnPhe: 2.126 ± 1.036
2.976AsnGly: 2.976 ± 1.45
0.0AsnHis: 0.0 ± 0.0
2.126AsnIle: 2.126 ± 0.438
0.85AsnLys: 0.85 ± 0.414
5.527AsnLeu: 5.527 ± 3.222
1.701AsnMet: 1.701 ± 0.411
1.276AsnAsn: 1.276 ± 0.483
1.701AsnPro: 1.701 ± 0.545
0.425AsnGln: 0.425 ± 0.207
2.126AsnArg: 2.126 ± 1.09
1.701AsnSer: 1.701 ± 1.237
2.551AsnThr: 2.551 ± 0.965
2.976AsnVal: 2.976 ± 1.45
1.276AsnTrp: 1.276 ± 0.621
0.425AsnTyr: 0.425 ± 0.786
0.0AsnXaa: 0.0 ± 0.0
Pro
3.401ProAla: 3.401 ± 1.803
0.85ProCys: 0.85 ± 0.414
2.551ProAsp: 2.551 ± 1.243
2.976ProGlu: 2.976 ± 1.032
0.85ProPhe: 0.85 ± 0.414
3.401ProGly: 3.401 ± 0.835
0.425ProHis: 0.425 ± 0.207
3.827ProIle: 3.827 ± 0.645
1.276ProLys: 1.276 ± 0.483
6.378ProLeu: 6.378 ± 2.413
1.701ProMet: 1.701 ± 0.678
1.276ProAsn: 1.276 ± 0.621
1.276ProPro: 1.276 ± 0.529
2.976ProGln: 2.976 ± 1.032
0.85ProArg: 0.85 ± 0.618
4.677ProSer: 4.677 ± 2.154
1.276ProThr: 1.276 ± 0.529
4.677ProVal: 4.677 ± 0.726
0.0ProTrp: 0.0 ± 0.0
1.701ProTyr: 1.701 ± 0.828
0.0ProXaa: 0.0 ± 0.0
Gln
3.827GlnAla: 3.827 ± 1.28
0.85GlnCys: 0.85 ± 0.414
2.551GlnAsp: 2.551 ± 0.34
1.276GlnGlu: 1.276 ± 0.483
1.701GlnPhe: 1.701 ± 0.545
1.701GlnGly: 1.701 ± 0.828
1.276GlnHis: 1.276 ± 0.529
2.551GlnIle: 2.551 ± 0.768
2.976GlnLys: 2.976 ± 2.962
2.976GlnLeu: 2.976 ± 0.873
0.85GlnMet: 0.85 ± 0.414
0.425GlnAsn: 0.425 ± 0.207
2.126GlnPro: 2.126 ± 2.388
2.976GlnGln: 2.976 ± 2.475
1.701GlnArg: 1.701 ± 0.828
2.976GlnSer: 2.976 ± 1.883
2.551GlnThr: 2.551 ± 0.768
3.401GlnVal: 3.401 ± 0.151
0.0GlnTrp: 0.0 ± 0.0
1.276GlnTyr: 1.276 ± 0.529
0.0GlnXaa: 0.0 ± 0.0
Arg
3.401ArgAla: 3.401 ± 1.484
1.701ArgCys: 1.701 ± 0.828
5.102ArgAsp: 5.102 ± 1.878
1.701ArgGlu: 1.701 ± 0.828
1.701ArgPhe: 1.701 ± 0.742
1.276ArgGly: 1.276 ± 0.621
2.551ArgHis: 2.551 ± 1.243
3.401ArgIle: 3.401 ± 0.151
4.677ArgLys: 4.677 ± 0.643
3.827ArgLeu: 3.827 ± 0.645
2.126ArgMet: 2.126 ± 0.625
1.276ArgAsn: 1.276 ± 0.621
2.976ArgPro: 2.976 ± 1.686
0.85ArgGln: 0.85 ± 0.618
4.252ArgArg: 4.252 ± 1.077
3.401ArgSer: 3.401 ± 0.871
3.827ArgThr: 3.827 ± 1.067
3.401ArgVal: 3.401 ± 0.879
0.85ArgTrp: 0.85 ± 0.414
2.976ArgTyr: 2.976 ± 0.93
0.0ArgXaa: 0.0 ± 0.0
Ser
3.827SerAla: 3.827 ± 1.28
1.276SerCys: 1.276 ± 0.621
2.976SerAsp: 2.976 ± 0.873
4.677SerGlu: 4.677 ± 1.336
5.102SerPhe: 5.102 ± 1.93
3.827SerGly: 3.827 ± 1.614
1.276SerHis: 1.276 ± 0.483
3.827SerIle: 3.827 ± 0.324
5.527SerLys: 5.527 ± 2.022
8.503SerLeu: 8.503 ± 1.727
1.701SerMet: 1.701 ± 0.742
4.252SerAsn: 4.252 ± 1.077
3.401SerPro: 3.401 ± 0.879
3.401SerGln: 3.401 ± 0.151
5.527SerArg: 5.527 ± 2.725
5.952SerSer: 5.952 ± 5.452
5.527SerThr: 5.527 ± 2.815
6.803SerVal: 6.803 ± 2.233
0.0SerTrp: 0.0 ± 0.0
2.551SerTyr: 2.551 ± 1.243
0.0SerXaa: 0.0 ± 0.0
Thr
1.701ThrAla: 1.701 ± 1.555
0.425ThrCys: 0.425 ± 0.207
3.827ThrAsp: 3.827 ± 1.587
3.827ThrGlu: 3.827 ± 1.293
0.85ThrPhe: 0.85 ± 0.59
5.102ThrGly: 5.102 ± 0.686
1.276ThrHis: 1.276 ± 0.621
3.827ThrIle: 3.827 ± 0.324
3.827ThrLys: 3.827 ± 1.864
7.653ThrLeu: 7.653 ± 0.811
0.85ThrMet: 0.85 ± 0.59
2.126ThrAsn: 2.126 ± 2.015
1.701ThrPro: 1.701 ± 2.183
2.126ThrGln: 2.126 ± 1.09
3.401ThrArg: 3.401 ± 1.657
3.827ThrSer: 3.827 ± 2.432
2.126ThrThr: 2.126 ± 1.036
5.527ThrVal: 5.527 ± 0.783
0.425ThrTrp: 0.425 ± 0.207
2.126ThrTyr: 2.126 ± 1.036
0.0ThrXaa: 0.0 ± 0.0
Val
4.252ValAla: 4.252 ± 0.523
2.126ValCys: 2.126 ± 1.036
3.401ValAsp: 3.401 ± 1.107
4.677ValGlu: 4.677 ± 2.432
2.976ValPhe: 2.976 ± 1.45
4.252ValGly: 4.252 ± 1.266
3.401ValHis: 3.401 ± 0.879
3.401ValIle: 3.401 ± 1.107
2.976ValLys: 2.976 ± 1.45
6.803ValLeu: 6.803 ± 1.248
2.126ValMet: 2.126 ± 0.539
3.401ValAsn: 3.401 ± 0.151
4.252ValPro: 4.252 ± 3.365
4.252ValGln: 4.252 ± 2.288
4.252ValArg: 4.252 ± 1.484
3.827ValSer: 3.827 ± 1.067
4.677ValThr: 4.677 ± 0.726
5.102ValVal: 5.102 ± 1.535
1.276ValTrp: 1.276 ± 0.483
2.976ValTyr: 2.976 ± 1.995
0.0ValXaa: 0.0 ± 0.0
Trp
0.85TrpAla: 0.85 ± 0.618
0.0TrpCys: 0.0 ± 0.0
1.276TrpAsp: 1.276 ± 0.529
1.276TrpGlu: 1.276 ± 0.529
1.276TrpPhe: 1.276 ± 0.621
0.425TrpGly: 0.425 ± 0.207
0.0TrpHis: 0.0 ± 0.0
0.425TrpIle: 0.425 ± 0.207
1.276TrpLys: 1.276 ± 0.483
0.85TrpLeu: 0.85 ± 0.59
0.425TrpMet: 0.425 ± 0.207
0.85TrpAsn: 0.85 ± 0.618
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.85TrpSer: 0.85 ± 0.414
0.425TrpThr: 0.425 ± 0.207
0.425TrpVal: 0.425 ± 0.709
0.0TrpTrp: 0.0 ± 0.0
0.425TrpTyr: 0.425 ± 0.207
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.276TyrAla: 1.276 ± 0.621
0.85TyrCys: 0.85 ± 0.414
1.701TyrAsp: 1.701 ± 0.828
0.0TyrGlu: 0.0 ± 0.0
1.701TyrPhe: 1.701 ± 0.828
2.126TyrGly: 2.126 ± 0.633
1.701TyrHis: 1.701 ± 0.828
2.976TyrIle: 2.976 ± 0.702
2.126TyrLys: 2.126 ± 0.438
3.827TyrLeu: 3.827 ± 0.824
1.276TyrMet: 1.276 ± 0.483
1.276TyrAsn: 1.276 ± 0.483
0.425TyrPro: 0.425 ± 0.207
1.276TyrGln: 1.276 ± 1.288
2.976TyrArg: 2.976 ± 1.45
2.976TyrSer: 2.976 ± 1.032
2.126TyrThr: 2.126 ± 1.102
1.276TyrVal: 1.276 ± 0.621
0.425TyrTrp: 0.425 ± 0.709
0.425TyrTyr: 0.425 ± 0.207
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (2353 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski