Amino acid dipepetide frequency for Streptohalobacillus salinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.262AlaAla: 5.262 ± 0.12
0.53AlaCys: 0.53 ± 0.026
3.836AlaAsp: 3.836 ± 0.076
4.931AlaGlu: 4.931 ± 0.093
3.511AlaPhe: 3.511 ± 0.076
4.938AlaGly: 4.938 ± 0.097
1.415AlaHis: 1.415 ± 0.045
6.567AlaIle: 6.567 ± 0.102
4.361AlaLys: 4.361 ± 0.097
8.475AlaLeu: 8.475 ± 0.11
2.316AlaMet: 2.316 ± 0.061
2.813AlaAsn: 2.813 ± 0.06
2.158AlaPro: 2.158 ± 0.052
2.262AlaGln: 2.262 ± 0.05
2.844AlaArg: 2.844 ± 0.064
4.269AlaSer: 4.269 ± 0.075
4.454AlaThr: 4.454 ± 0.082
5.618AlaVal: 5.618 ± 0.103
0.592AlaTrp: 0.592 ± 0.032
2.617AlaTyr: 2.617 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
0.309CysAla: 0.309 ± 0.021
0.048CysCys: 0.048 ± 0.008
0.36CysAsp: 0.36 ± 0.025
0.319CysGlu: 0.319 ± 0.021
0.232CysPhe: 0.232 ± 0.02
0.522CysGly: 0.522 ± 0.024
0.191CysHis: 0.191 ± 0.017
0.322CysIle: 0.322 ± 0.024
0.239CysLys: 0.239 ± 0.02
0.481CysLeu: 0.481 ± 0.024
0.122CysMet: 0.122 ± 0.013
0.221CysAsn: 0.221 ± 0.018
0.298CysPro: 0.298 ± 0.021
0.232CysGln: 0.232 ± 0.02
0.215CysArg: 0.215 ± 0.018
0.293CysSer: 0.293 ± 0.023
0.261CysThr: 0.261 ± 0.019
0.347CysVal: 0.347 ± 0.021
0.029CysTrp: 0.029 ± 0.006
0.207CysTyr: 0.207 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.26AspAla: 4.26 ± 0.089
0.302AspCys: 0.302 ± 0.022
3.575AspAsp: 3.575 ± 0.088
5.047AspGlu: 5.047 ± 0.088
2.621AspPhe: 2.621 ± 0.066
3.596AspGly: 3.596 ± 0.08
1.486AspHis: 1.486 ± 0.054
4.28AspIle: 4.28 ± 0.076
3.165AspLys: 3.165 ± 0.067
5.907AspLeu: 5.907 ± 0.097
1.468AspMet: 1.468 ± 0.05
1.995AspAsn: 1.995 ± 0.056
2.191AspPro: 2.191 ± 0.052
3.415AspGln: 3.415 ± 0.085
2.621AspArg: 2.621 ± 0.062
2.554AspSer: 2.554 ± 0.064
3.162AspThr: 3.162 ± 0.061
4.871AspVal: 4.871 ± 0.087
0.674AspTrp: 0.674 ± 0.037
2.64AspTyr: 2.64 ± 0.057
0.0AspXaa: 0.0 ± 0.0
Glu
7.136GluAla: 7.136 ± 0.112
0.221GluCys: 0.221 ± 0.018
4.318GluAsp: 4.318 ± 0.086
6.305GluGlu: 6.305 ± 0.124
1.85GluPhe: 1.85 ± 0.059
4.312GluGly: 4.312 ± 0.086
1.628GluHis: 1.628 ± 0.052
4.892GluIle: 4.892 ± 0.088
5.427GluLys: 5.427 ± 0.114
6.468GluLeu: 6.468 ± 0.103
2.345GluMet: 2.345 ± 0.056
3.143GluAsn: 3.143 ± 0.069
2.226GluPro: 2.226 ± 0.062
3.749GluGln: 3.749 ± 0.086
3.854GluArg: 3.854 ± 0.074
3.275GluSer: 3.275 ± 0.068
5.084GluThr: 5.084 ± 0.087
5.294GluVal: 5.294 ± 0.09
0.637GluTrp: 0.637 ± 0.032
1.708GluTyr: 1.708 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
2.622PheAla: 2.622 ± 0.059
0.247PheCys: 0.247 ± 0.019
2.872PheAsp: 2.872 ± 0.055
3.065PheGlu: 3.065 ± 0.063
2.186PhePhe: 2.186 ± 0.068
3.076PheGly: 3.076 ± 0.079
0.931PheHis: 0.931 ± 0.043
3.694PheIle: 3.694 ± 0.091
2.774PheLys: 2.774 ± 0.057
4.039PheLeu: 4.039 ± 0.086
1.113PheMet: 1.113 ± 0.043
2.258PheAsn: 2.258 ± 0.059
1.373PhePro: 1.373 ± 0.042
1.523PheGln: 1.523 ± 0.047
1.476PheArg: 1.476 ± 0.049
3.042PheSer: 3.042 ± 0.071
2.641PheThr: 2.641 ± 0.064
3.197PheVal: 3.197 ± 0.087
0.381PheTrp: 0.381 ± 0.025
1.704PheTyr: 1.704 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.66GlyAla: 4.66 ± 0.091
0.469GlyCys: 0.469 ± 0.024
3.52GlyAsp: 3.52 ± 0.079
4.536GlyGlu: 4.536 ± 0.092
3.467GlyPhe: 3.467 ± 0.069
4.105GlyGly: 4.105 ± 0.104
1.464GlyHis: 1.464 ± 0.046
5.112GlyIle: 5.112 ± 0.088
3.948GlyLys: 3.948 ± 0.08
6.437GlyLeu: 6.437 ± 0.111
1.936GlyMet: 1.936 ± 0.062
2.285GlyAsn: 2.285 ± 0.06
1.625GlyPro: 1.625 ± 0.057
2.265GlyGln: 2.265 ± 0.059
2.593GlyArg: 2.593 ± 0.062
3.451GlySer: 3.451 ± 0.069
3.652GlyThr: 3.652 ± 0.086
5.128GlyVal: 5.128 ± 0.097
0.631GlyTrp: 0.631 ± 0.03
2.815GlyTyr: 2.815 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
1.801HisAla: 1.801 ± 0.055
0.164HisCys: 0.164 ± 0.016
1.331HisAsp: 1.331 ± 0.045
1.39HisGlu: 1.39 ± 0.039
1.187HisPhe: 1.187 ± 0.041
1.473HisGly: 1.473 ± 0.051
0.859HisHis: 0.859 ± 0.038
1.464HisIle: 1.464 ± 0.043
0.993HisLys: 0.993 ± 0.034
2.61HisLeu: 2.61 ± 0.067
0.534HisMet: 0.534 ± 0.026
0.765HisAsn: 0.765 ± 0.038
1.178HisPro: 1.178 ± 0.042
1.247HisGln: 1.247 ± 0.037
1.026HisArg: 1.026 ± 0.039
0.985HisSer: 0.985 ± 0.036
1.193HisThr: 1.193 ± 0.041
1.727HisVal: 1.727 ± 0.052
0.21HisTrp: 0.21 ± 0.016
1.089HisTyr: 1.089 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.837IleAla: 5.837 ± 0.107
0.435IleCys: 0.435 ± 0.024
5.678IleAsp: 5.678 ± 0.095
6.399IleGlu: 6.399 ± 0.104
3.129IlePhe: 3.129 ± 0.082
5.515IleGly: 5.515 ± 0.113
1.598IleHis: 1.598 ± 0.054
5.625IleIle: 5.625 ± 0.103
4.743IleLys: 4.743 ± 0.09
6.247IleLeu: 6.247 ± 0.1
1.549IleMet: 1.549 ± 0.047
3.652IleAsn: 3.652 ± 0.076
2.836IlePro: 2.836 ± 0.069
2.679IleGln: 2.679 ± 0.061
2.88IleArg: 2.88 ± 0.069
4.421IleSer: 4.421 ± 0.084
4.35IleThr: 4.35 ± 0.078
5.181IleVal: 5.181 ± 0.096
0.519IleTrp: 0.519 ± 0.028
2.496IleTyr: 2.496 ± 0.066
0.0IleXaa: 0.0 ± 0.0
Lys
5.044LysAla: 5.044 ± 0.08
0.236LysCys: 0.236 ± 0.02
4.002LysAsp: 4.002 ± 0.079
5.48LysGlu: 5.48 ± 0.113
1.493LysPhe: 1.493 ± 0.052
3.585LysGly: 3.585 ± 0.07
1.6LysHis: 1.6 ± 0.038
3.815LysIle: 3.815 ± 0.078
4.837LysLys: 4.837 ± 0.089
4.877LysLeu: 4.877 ± 0.095
1.749LysMet: 1.749 ± 0.051
2.635LysAsn: 2.635 ± 0.069
1.957LysPro: 1.957 ± 0.04
3.687LysGln: 3.687 ± 0.091
3.48LysArg: 3.48 ± 0.075
2.93LysSer: 2.93 ± 0.065
3.852LysThr: 3.852 ± 0.076
4.013LysVal: 4.013 ± 0.086
0.489LysTrp: 0.489 ± 0.024
1.685LysTyr: 1.685 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
7.666LeuAla: 7.666 ± 0.111
0.367LeuCys: 0.367 ± 0.022
5.722LeuAsp: 5.722 ± 0.101
6.498LeuGlu: 6.498 ± 0.102
4.49LeuPhe: 4.49 ± 0.095
5.91LeuGly: 5.91 ± 0.123
1.86LeuHis: 1.86 ± 0.053
7.77LeuIle: 7.77 ± 0.128
6.488LeuLys: 6.488 ± 0.114
9.577LeuLeu: 9.577 ± 0.145
2.666LeuMet: 2.666 ± 0.062
4.543LeuAsn: 4.543 ± 0.078
3.747LeuPro: 3.747 ± 0.071
2.976LeuGln: 2.976 ± 0.068
3.605LeuArg: 3.605 ± 0.08
7.038LeuSer: 7.038 ± 0.11
6.979LeuThr: 6.979 ± 0.107
6.741LeuVal: 6.741 ± 0.098
0.649LeuTrp: 0.649 ± 0.03
3.15LeuTyr: 3.15 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
1.979MetAla: 1.979 ± 0.057
0.119MetCys: 0.119 ± 0.014
1.332MetAsp: 1.332 ± 0.045
1.6MetGlu: 1.6 ± 0.05
1.009MetPhe: 1.009 ± 0.043
1.563MetGly: 1.563 ± 0.045
0.635MetHis: 0.635 ± 0.03
2.36MetIle: 2.36 ± 0.053
1.999MetLys: 1.999 ± 0.054
2.528MetLeu: 2.528 ± 0.065
0.933MetMet: 0.933 ± 0.036
1.397MetAsn: 1.397 ± 0.047
0.991MetPro: 0.991 ± 0.037
1.067MetGln: 1.067 ± 0.042
1.316MetArg: 1.316 ± 0.039
1.606MetSer: 1.606 ± 0.049
1.904MetThr: 1.904 ± 0.052
1.918MetVal: 1.918 ± 0.052
0.151MetTrp: 0.151 ± 0.015
0.779MetTyr: 0.779 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.673AsnAla: 2.673 ± 0.067
0.237AsnCys: 0.237 ± 0.023
2.789AsnAsp: 2.789 ± 0.064
3.293AsnGlu: 3.293 ± 0.072
1.592AsnPhe: 1.592 ± 0.049
2.73AsnGly: 2.73 ± 0.076
1.255AsnHis: 1.255 ± 0.044
2.857AsnIle: 2.857 ± 0.067
2.669AsnLys: 2.669 ± 0.062
3.388AsnLeu: 3.388 ± 0.065
1.095AsnMet: 1.095 ± 0.036
1.767AsnAsn: 1.767 ± 0.054
1.848AsnPro: 1.848 ± 0.048
2.749AsnGln: 2.749 ± 0.067
2.075AsnArg: 2.075 ± 0.056
1.649AsnSer: 1.649 ± 0.049
2.031AsnThr: 2.031 ± 0.055
2.797AsnVal: 2.797 ± 0.052
0.456AsnTrp: 0.456 ± 0.025
1.704AsnTyr: 1.704 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
2.111ProAla: 2.111 ± 0.059
0.189ProCys: 0.189 ± 0.017
2.059ProAsp: 2.059 ± 0.058
2.847ProGlu: 2.847 ± 0.062
1.882ProPhe: 1.882 ± 0.054
2.166ProGly: 2.166 ± 0.061
0.82ProHis: 0.82 ± 0.036
2.838ProIle: 2.838 ± 0.07
1.899ProLys: 1.899 ± 0.054
3.438ProLeu: 3.438 ± 0.072
0.811ProMet: 0.811 ± 0.036
1.563ProAsn: 1.563 ± 0.043
0.753ProPro: 0.753 ± 0.032
0.946ProGln: 0.946 ± 0.037
1.092ProArg: 1.092 ± 0.037
1.995ProSer: 1.995 ± 0.049
2.031ProThr: 2.031 ± 0.054
2.855ProVal: 2.855 ± 0.064
0.291ProTrp: 0.291 ± 0.021
1.464ProTyr: 1.464 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
3.921GlnAla: 3.921 ± 0.084
0.145GlnCys: 0.145 ± 0.014
1.799GlnAsp: 1.799 ± 0.056
2.659GlnGlu: 2.659 ± 0.063
1.87GlnPhe: 1.87 ± 0.055
2.314GlnGly: 2.314 ± 0.058
0.921GlnHis: 0.921 ± 0.033
2.733GlnIle: 2.733 ± 0.073
2.292GlnLys: 2.292 ± 0.061
5.21GlnLeu: 5.21 ± 0.093
1.323GlnMet: 1.323 ± 0.044
1.321GlnAsn: 1.321 ± 0.05
1.436GlnPro: 1.436 ± 0.042
2.173GlnGln: 2.173 ± 0.063
1.69GlnArg: 1.69 ± 0.052
2.611GlnSer: 2.611 ± 0.068
2.803GlnThr: 2.803 ± 0.067
2.803GlnVal: 2.803 ± 0.063
0.4GlnTrp: 0.4 ± 0.026
1.366GlnTyr: 1.366 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.777ArgAla: 2.777 ± 0.061
0.209ArgCys: 0.209 ± 0.018
2.353ArgAsp: 2.353 ± 0.064
3.148ArgGlu: 3.148 ± 0.073
2.236ArgPhe: 2.236 ± 0.059
2.436ArgGly: 2.436 ± 0.062
1.009ArgHis: 1.009 ± 0.039
3.081ArgIle: 3.081 ± 0.061
2.63ArgLys: 2.63 ± 0.072
4.695ArgLeu: 4.695 ± 0.087
1.268ArgMet: 1.268 ± 0.044
1.511ArgAsn: 1.511 ± 0.042
1.33ArgPro: 1.33 ± 0.044
1.854ArgGln: 1.854 ± 0.052
1.901ArgArg: 1.901 ± 0.052
2.074ArgSer: 2.074 ± 0.054
2.265ArgThr: 2.265 ± 0.065
2.849ArgVal: 2.849 ± 0.068
0.36ArgTrp: 0.36 ± 0.026
1.922ArgTyr: 1.922 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
3.521SerAla: 3.521 ± 0.073
0.257SerCys: 0.257 ± 0.017
3.388SerAsp: 3.388 ± 0.075
4.019SerGlu: 4.019 ± 0.084
3.065SerPhe: 3.065 ± 0.068
4.207SerGly: 4.207 ± 0.077
1.291SerHis: 1.291 ± 0.045
4.483SerIle: 4.483 ± 0.078
3.096SerLys: 3.096 ± 0.063
5.607SerLeu: 5.607 ± 0.109
1.48SerMet: 1.48 ± 0.044
2.161SerAsn: 2.161 ± 0.054
1.694SerPro: 1.694 ± 0.047
1.966SerGln: 1.966 ± 0.055
2.242SerArg: 2.242 ± 0.054
3.132SerSer: 3.132 ± 0.067
3.07SerThr: 3.07 ± 0.069
4.209SerVal: 4.209 ± 0.071
0.461SerTrp: 0.461 ± 0.024
2.354SerTyr: 2.354 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
4.405ThrAla: 4.405 ± 0.083
0.344ThrCys: 0.344 ± 0.024
3.709ThrAsp: 3.709 ± 0.072
4.381ThrGlu: 4.381 ± 0.08
2.851ThrPhe: 2.851 ± 0.061
4.267ThrGly: 4.267 ± 0.09
1.477ThrHis: 1.477 ± 0.049
4.924ThrIle: 4.924 ± 0.087
3.285ThrLys: 3.285 ± 0.075
6.263ThrLeu: 6.263 ± 0.099
1.408ThrMet: 1.408 ± 0.042
2.527ThrAsn: 2.527 ± 0.057
2.158ThrPro: 2.158 ± 0.051
1.805ThrGln: 1.805 ± 0.044
2.176ThrArg: 2.176 ± 0.051
3.438ThrSer: 3.438 ± 0.074
3.565ThrThr: 3.565 ± 0.074
4.7ThrVal: 4.7 ± 0.085
0.464ThrTrp: 0.464 ± 0.024
2.252ThrTyr: 2.252 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
5.178ValAla: 5.178 ± 0.093
0.454ValCys: 0.454 ± 0.027
4.597ValAsp: 4.597 ± 0.08
5.34ValGlu: 5.34 ± 0.101
3.18ValPhe: 3.18 ± 0.07
4.587ValGly: 4.587 ± 0.093
1.395ValHis: 1.395 ± 0.046
6.069ValIle: 6.069 ± 0.104
4.558ValLys: 4.558 ± 0.094
7.031ValLeu: 7.031 ± 0.107
1.995ValMet: 1.995 ± 0.052
3.288ValAsn: 3.288 ± 0.067
2.452ValPro: 2.452 ± 0.055
2.129ValGln: 2.129 ± 0.06
2.618ValArg: 2.618 ± 0.063
4.648ValSer: 4.648 ± 0.079
4.784ValThr: 4.784 ± 0.092
5.548ValVal: 5.548 ± 0.104
0.5ValTrp: 0.5 ± 0.028
2.4ValTyr: 2.4 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.46TrpAla: 0.46 ± 0.027
0.047TrpCys: 0.047 ± 0.008
0.44TrpAsp: 0.44 ± 0.03
0.511TrpGlu: 0.511 ± 0.032
0.486TrpPhe: 0.486 ± 0.028
0.501TrpGly: 0.501 ± 0.026
0.199TrpHis: 0.199 ± 0.017
0.61TrpIle: 0.61 ± 0.03
0.428TrpLys: 0.428 ± 0.025
1.044TrpLeu: 1.044 ± 0.041
0.266TrpMet: 0.266 ± 0.02
0.36TrpAsn: 0.36 ± 0.021
0.24TrpPro: 0.24 ± 0.021
0.403TrpGln: 0.403 ± 0.021
0.369TrpArg: 0.369 ± 0.021
0.503TrpSer: 0.503 ± 0.03
0.423TrpThr: 0.423 ± 0.025
0.605TrpVal: 0.605 ± 0.029
0.105TrpTrp: 0.105 ± 0.014
0.33TrpTyr: 0.33 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.149TyrAla: 2.149 ± 0.055
0.225TyrCys: 0.225 ± 0.017
2.15TyrAsp: 2.15 ± 0.06
2.102TyrGlu: 2.102 ± 0.058
1.875TyrPhe: 1.875 ± 0.049
2.296TyrGly: 2.296 ± 0.064
1.193TyrHis: 1.193 ± 0.048
2.274TyrIle: 2.274 ± 0.055
1.614TyrLys: 1.614 ± 0.048
4.12TyrLeu: 4.12 ± 0.078
0.809TyrMet: 0.809 ± 0.029
1.451TyrAsn: 1.451 ± 0.055
1.559TyrPro: 1.559 ± 0.044
2.665TyrGln: 2.665 ± 0.067
1.831TyrArg: 1.831 ± 0.056
1.792TyrSer: 1.792 ± 0.059
1.896TyrThr: 1.896 ± 0.049
2.349TyrVal: 2.349 ± 0.051
0.331TyrTrp: 0.331 ± 0.021
1.631TyrTyr: 1.631 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2307 proteins (724221 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski