Amino acid dipepetide frequency for Paracoccus mutanolyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.997AlaAla: 18.997 ± 0.252	1.316AlaCys: 1.316 ± 0.051	7.147AlaAsp: 7.147 ± 0.115	8.682AlaGlu: 8.682 ± 0.152	3.947AlaPhe: 3.947 ± 0.089	12.344AlaGly: 12.344 ± 0.159	2.467AlaHis: 2.467 ± 0.068	5.834AlaIle: 5.834 ± 0.103	3.061AlaLys: 3.061 ± 0.077	15.044AlaLeu: 15.044 ± 0.193	3.905AlaMet: 3.905 ± 0.093	2.348AlaAsn: 2.348 ± 0.067	7.087AlaPro: 7.087 ± 0.146	4.863AlaGln: 4.863 ± 0.104	11.862AlaArg: 11.862 ± 0.162	5.742AlaSer: 5.742 ± 0.083	5.893AlaThr: 5.893 ± 0.115	8.788AlaVal: 8.788 ± 0.136	1.781AlaTrp: 1.781 ± 0.066	2.294AlaTyr: 2.294 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.254CysAla: 1.254 ± 0.051	0.224CysCys: 0.224 ± 0.019	0.602CysAsp: 0.602 ± 0.031	0.403CysGlu: 0.403 ± 0.028	0.319CysPhe: 0.319 ± 0.027	1.074CysGly: 1.074 ± 0.048	0.281CysHis: 0.281 ± 0.023	0.419CysIle: 0.419 ± 0.034	0.193CysLys: 0.193 ± 0.016	0.888CysLeu: 0.888 ± 0.038	0.197CysMet: 0.197 ± 0.022	0.197CysAsn: 0.197 ± 0.018	0.655CysPro: 0.655 ± 0.032	0.303CysGln: 0.303 ± 0.02	0.959CysArg: 0.959 ± 0.048	0.554CysSer: 0.554 ± 0.038	0.45CysThr: 0.45 ± 0.026	0.613CysVal: 0.613 ± 0.032	0.222CysTrp: 0.222 ± 0.023	0.184CysTyr: 0.184 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	7.335AspAla: 7.335 ± 0.123	0.512AspCys: 0.512 ± 0.03	3.163AspAsp: 3.163 ± 0.1	3.267AspGlu: 3.267 ± 0.088	2.235AspPhe: 2.235 ± 0.06	5.278AspGly: 5.278 ± 0.127	1.559AspHis: 1.559 ± 0.055	2.569AspIle: 2.569 ± 0.078	1.346AspLys: 1.346 ± 0.05	6.522AspLeu: 6.522 ± 0.113	1.386AspMet: 1.386 ± 0.049	0.981AspAsn: 0.981 ± 0.042	4.201AspPro: 4.201 ± 0.082	1.962AspGln: 1.962 ± 0.057	5.277AspArg: 5.277 ± 0.09	2.17AspSer: 2.17 ± 0.067	2.358AspThr: 2.358 ± 0.069	3.422AspVal: 3.422 ± 0.087	1.276AspTrp: 1.276 ± 0.054	1.537AspTyr: 1.537 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	7.619GluAla: 7.619 ± 0.14	0.335GluCys: 0.335 ± 0.029	2.784GluAsp: 2.784 ± 0.075	2.655GluGlu: 2.655 ± 0.086	1.637GluPhe: 1.637 ± 0.058	4.491GluGly: 4.491 ± 0.094	1.054GluHis: 1.054 ± 0.043	3.05GluIle: 3.05 ± 0.077	1.714GluLys: 1.714 ± 0.067	4.828GluLeu: 4.828 ± 0.104	1.542GluMet: 1.542 ± 0.056	1.377GluAsn: 1.377 ± 0.047	2.819GluPro: 2.819 ± 0.079	1.707GluGln: 1.707 ± 0.061	4.411GluArg: 4.411 ± 0.089	2.131GluSer: 2.131 ± 0.065	3.131GluThr: 3.131 ± 0.076	3.758GluVal: 3.758 ± 0.091	0.753GluTrp: 0.753 ± 0.037	0.997GluTyr: 0.997 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.237PheAla: 4.237 ± 0.094	0.419PheCys: 0.419 ± 0.029	2.359PheAsp: 2.359 ± 0.062	1.614PheGlu: 1.614 ± 0.052	1.269PhePhe: 1.269 ± 0.048	3.267PheGly: 3.267 ± 0.08	0.779PheHis: 0.779 ± 0.042	1.377PheIle: 1.377 ± 0.059	0.696PheLys: 0.696 ± 0.037	3.291PheLeu: 3.291 ± 0.091	0.791PheMet: 0.791 ± 0.037	0.824PheAsn: 0.824 ± 0.043	1.577PhePro: 1.577 ± 0.045	1.016PheGln: 1.016 ± 0.041	2.456PheArg: 2.456 ± 0.061	1.873PheSer: 1.873 ± 0.059	1.727PheThr: 1.727 ± 0.057	2.398PheVal: 2.398 ± 0.067	0.509PheTrp: 0.509 ± 0.025	0.859PheTyr: 0.859 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	10.832GlyAla: 10.832 ± 0.16	1.037GlyCys: 1.037 ± 0.048	4.675GlyAsp: 4.675 ± 0.108	4.161GlyGlu: 4.161 ± 0.084	3.528GlyPhe: 3.528 ± 0.088	7.621GlyGly: 7.621 ± 0.176	2.283GlyHis: 2.283 ± 0.072	4.392GlyIle: 4.392 ± 0.09	2.906GlyLys: 2.906 ± 0.077	9.549GlyLeu: 9.549 ± 0.156	2.657GlyMet: 2.657 ± 0.06	2.004GlyAsn: 2.004 ± 0.072	4.438GlyPro: 4.438 ± 0.094	3.419GlyGln: 3.419 ± 0.084	7.782GlyArg: 7.782 ± 0.143	4.268GlySer: 4.268 ± 0.099	4.575GlyThr: 4.575 ± 0.098	6.081GlyVal: 6.081 ± 0.119	1.772GlyTrp: 1.772 ± 0.065	2.058GlyTyr: 2.058 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	2.686HisAla: 2.686 ± 0.07	0.275HisCys: 0.275 ± 0.023	1.47HisAsp: 1.47 ± 0.056	1.076HisGlu: 1.076 ± 0.044	0.813HisPhe: 0.813 ± 0.039	2.197HisGly: 2.197 ± 0.074	0.585HisHis: 0.585 ± 0.039	0.839HisIle: 0.839 ± 0.036	0.396HisLys: 0.396 ± 0.026	2.345HisLeu: 2.345 ± 0.081	0.593HisMet: 0.593 ± 0.031	0.379HisAsn: 0.379 ± 0.026	1.668HisPro: 1.668 ± 0.058	0.607HisGln: 0.607 ± 0.032	1.935HisArg: 1.935 ± 0.063	0.93HisSer: 0.93 ± 0.04	0.682HisThr: 0.682 ± 0.035	1.65HisVal: 1.65 ± 0.047	0.401HisTrp: 0.401 ± 0.027	0.489HisTyr: 0.489 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.794IleAla: 6.794 ± 0.122	0.56IleCys: 0.56 ± 0.035	3.183IleAsp: 3.183 ± 0.082	3.034IleGlu: 3.034 ± 0.079	1.528IlePhe: 1.528 ± 0.051	4.571IleGly: 4.571 ± 0.107	0.934IleHis: 0.934 ± 0.041	1.694IleIle: 1.694 ± 0.075	1.063IleLys: 1.063 ± 0.045	4.454IleLeu: 4.454 ± 0.095	1.056IleMet: 1.056 ± 0.046	1.061IleAsn: 1.061 ± 0.045	2.403IlePro: 2.403 ± 0.07	1.167IleGln: 1.167 ± 0.048	3.621IleArg: 3.621 ± 0.085	2.556IleSer: 2.556 ± 0.066	2.261IleThr: 2.261 ± 0.069	3.437IleVal: 3.437 ± 0.078	0.649IleTrp: 0.649 ± 0.035	0.89IleTyr: 0.89 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.53LysAla: 3.53 ± 0.093	0.137LysCys: 0.137 ± 0.018	1.384LysAsp: 1.384 ± 0.057	1.109LysGlu: 1.109 ± 0.048	0.671LysPhe: 0.671 ± 0.036	2.409LysGly: 2.409 ± 0.067	0.538LysHis: 0.538 ± 0.03	1.227LysIle: 1.227 ± 0.044	0.917LysLys: 0.917 ± 0.046	2.379LysLeu: 2.379 ± 0.079	0.638LysMet: 0.638 ± 0.033	0.609LysAsn: 0.609 ± 0.033	1.708LysPro: 1.708 ± 0.055	0.727LysGln: 0.727 ± 0.038	1.967LysArg: 1.967 ± 0.061	1.428LysSer: 1.428 ± 0.057	1.504LysThr: 1.504 ± 0.053	1.92LysVal: 1.92 ± 0.06	0.326LysTrp: 0.326 ± 0.026	0.516LysTyr: 0.516 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	15.35LeuAla: 15.35 ± 0.212	1.034LeuCys: 1.034 ± 0.044	6.234LeuAsp: 6.234 ± 0.106	4.668LeuGlu: 4.668 ± 0.092	3.189LeuPhe: 3.189 ± 0.087	8.719LeuGly: 8.719 ± 0.143	2.08LeuHis: 2.08 ± 0.067	4.731LeuIle: 4.731 ± 0.095	2.602LeuLys: 2.602 ± 0.072	8.852LeuLeu: 8.852 ± 0.178	2.631LeuMet: 2.631 ± 0.079	2.275LeuAsn: 2.275 ± 0.068	6.352LeuPro: 6.352 ± 0.101	2.605LeuGln: 2.605 ± 0.06	8.187LeuArg: 8.187 ± 0.143	5.913LeuSer: 5.913 ± 0.115	5.776LeuThr: 5.776 ± 0.106	7.18LeuVal: 7.18 ± 0.127	1.424LeuTrp: 1.424 ± 0.058	1.887LeuTyr: 1.887 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	3.738MetAla: 3.738 ± 0.1	0.166MetCys: 0.166 ± 0.016	1.369MetAsp: 1.369 ± 0.05	1.088MetGlu: 1.088 ± 0.049	0.676MetPhe: 0.676 ± 0.032	2.119MetGly: 2.119 ± 0.063	0.423MetHis: 0.423 ± 0.022	1.477MetIle: 1.477 ± 0.055	0.921MetLys: 0.921 ± 0.042	2.66MetLeu: 2.66 ± 0.077	0.645MetMet: 0.645 ± 0.033	0.808MetAsn: 0.808 ± 0.033	1.665MetPro: 1.665 ± 0.058	1.001MetGln: 1.001 ± 0.045	2.234MetArg: 2.234 ± 0.069	1.426MetSer: 1.426 ± 0.053	2.007MetThr: 2.007 ± 0.057	1.842MetVal: 1.842 ± 0.054	0.232MetTrp: 0.232 ± 0.017	0.292MetTyr: 0.292 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.806AsnAla: 2.806 ± 0.068	0.23AsnCys: 0.23 ± 0.021	1.227AsnAsp: 1.227 ± 0.059	0.897AsnGlu: 0.897 ± 0.044	0.704AsnPhe: 0.704 ± 0.035	1.956AsnGly: 1.956 ± 0.064	0.516AsnHis: 0.516 ± 0.036	1.098AsnIle: 1.098 ± 0.045	0.512AsnLys: 0.512 ± 0.028	2.237AsnLeu: 2.237 ± 0.058	0.554AsnMet: 0.554 ± 0.034	0.516AsnAsn: 0.516 ± 0.034	1.829AsnPro: 1.829 ± 0.064	0.627AsnGln: 0.627 ± 0.038	1.88AsnArg: 1.88 ± 0.051	0.963AsnSer: 0.963 ± 0.044	0.977AsnThr: 0.977 ± 0.048	1.482AsnVal: 1.482 ± 0.053	0.343AsnTrp: 0.343 ± 0.026	0.498AsnTyr: 0.498 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	8.278ProAla: 8.278 ± 0.187	0.583ProCys: 0.583 ± 0.034	4.204ProAsp: 4.204 ± 0.104	4.401ProGlu: 4.401 ± 0.109	1.911ProPhe: 1.911 ± 0.071	5.893ProGly: 5.893 ± 0.11	1.178ProHis: 1.178 ± 0.047	2.057ProIle: 2.057 ± 0.053	1.322ProLys: 1.322 ± 0.05	5.007ProLeu: 5.007 ± 0.108	1.522ProMet: 1.522 ± 0.059	1.245ProAsn: 1.245 ± 0.045	3.111ProPro: 3.111 ± 0.094	2.126ProGln: 2.126 ± 0.065	4.239ProArg: 4.239 ± 0.108	2.658ProSer: 2.658 ± 0.077	2.33ProThr: 2.33 ± 0.059	4.73ProVal: 4.73 ± 0.099	0.872ProTrp: 0.872 ± 0.038	1.076ProTyr: 1.076 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.68GlnAla: 4.68 ± 0.076	0.213GlnCys: 0.213 ± 0.02	1.809GlnAsp: 1.809 ± 0.054	1.353GlnGlu: 1.353 ± 0.055	1.025GlnPhe: 1.025 ± 0.044	3.42GlnGly: 3.42 ± 0.087	0.735GlnHis: 0.735 ± 0.041	1.976GlnIle: 1.976 ± 0.065	0.959GlnLys: 0.959 ± 0.046	2.662GlnLeu: 2.662 ± 0.074	1.025GlnMet: 1.025 ± 0.04	0.857GlnAsn: 0.857 ± 0.04	2.06GlnPro: 2.06 ± 0.065	1.076GlnGln: 1.076 ± 0.045	2.512GlnArg: 2.512 ± 0.072	1.532GlnSer: 1.532 ± 0.048	1.656GlnThr: 1.656 ± 0.05	2.467GlnVal: 2.467 ± 0.065	0.366GlnTrp: 0.366 ± 0.029	0.514GlnTyr: 0.514 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	10.373ArgAla: 10.373 ± 0.148	0.822ArgCys: 0.822 ± 0.043	5.193ArgAsp: 5.193 ± 0.1	4.011ArgGlu: 4.011 ± 0.092	2.788ArgPhe: 2.788 ± 0.075	6.223ArgGly: 6.223 ± 0.125	2.193ArgHis: 2.193 ± 0.064	4.478ArgIle: 4.478 ± 0.084	2.192ArgLys: 2.192 ± 0.065	9.182ArgLeu: 9.182 ± 0.152	2.445ArgMet: 2.445 ± 0.067	1.705ArgAsn: 1.705 ± 0.055	4.994ArgPro: 4.994 ± 0.105	3.163ArgGln: 3.163 ± 0.078	7.784ArgArg: 7.784 ± 0.173	3.953ArgSer: 3.953 ± 0.09	3.307ArgThr: 3.307 ± 0.088	5.164ArgVal: 5.164 ± 0.101	1.429ArgTrp: 1.429 ± 0.051	1.532ArgTyr: 1.532 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	5.867SerAla: 5.867 ± 0.117	0.596SerCys: 0.596 ± 0.038	2.863SerAsp: 2.863 ± 0.077	2.108SerGlu: 2.108 ± 0.065	1.858SerPhe: 1.858 ± 0.058	5.209SerGly: 5.209 ± 0.123	1.09SerHis: 1.09 ± 0.045	2.017SerIle: 2.017 ± 0.06	1.107SerLys: 1.107 ± 0.048	4.658SerLeu: 4.658 ± 0.097	1.274SerMet: 1.274 ± 0.048	1.017SerAsn: 1.017 ± 0.051	2.855SerPro: 2.855 ± 0.086	1.57SerGln: 1.57 ± 0.054	4.035SerArg: 4.035 ± 0.1	2.398SerSer: 2.398 ± 0.074	2.374SerThr: 2.374 ± 0.063	3.377SerVal: 3.377 ± 0.097	0.779SerTrp: 0.779 ± 0.035	1.03SerTyr: 1.03 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.88ThrAla: 5.88 ± 0.118	0.56ThrCys: 0.56 ± 0.035	2.739ThrAsp: 2.739 ± 0.078	2.483ThrGlu: 2.483 ± 0.072	1.603ThrPhe: 1.603 ± 0.051	5.078ThrGly: 5.078 ± 0.115	1.043ThrHis: 1.043 ± 0.041	2.392ThrIle: 2.392 ± 0.074	1.061ThrLys: 1.061 ± 0.044	5.426ThrLeu: 5.426 ± 0.102	1.156ThrMet: 1.156 ± 0.044	1.019ThrAsn: 1.019 ± 0.045	3.517ThrPro: 3.517 ± 0.083	1.395ThrGln: 1.395 ± 0.05	3.878ThrArg: 3.878 ± 0.091	2.155ThrSer: 2.155 ± 0.068	2.469ThrThr: 2.469 ± 0.082	3.842ThrVal: 3.842 ± 0.093	0.706ThrTrp: 0.706 ± 0.037	1.063ThrTyr: 1.063 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.153ValAla: 9.153 ± 0.148	0.565ValCys: 0.565 ± 0.035	3.701ValAsp: 3.701 ± 0.079	4.186ValGlu: 4.186 ± 0.098	2.356ValPhe: 2.356 ± 0.077	5.114ValGly: 5.114 ± 0.106	1.371ValHis: 1.371 ± 0.052	3.862ValIle: 3.862 ± 0.089	1.774ValLys: 1.774 ± 0.061	7.587ValLeu: 7.587 ± 0.131	1.965ValMet: 1.965 ± 0.069	1.681ValAsn: 1.681 ± 0.06	3.9ValPro: 3.9 ± 0.068	2.162ValGln: 2.162 ± 0.064	4.762ValArg: 4.762 ± 0.097	3.674ValSer: 3.674 ± 0.077	4.29ValThr: 4.29 ± 0.099	5.477ValVal: 5.477 ± 0.107	1.063ValTrp: 1.063 ± 0.047	1.212ValTyr: 1.212 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.656TrpAla: 1.656 ± 0.066	0.171TrpCys: 0.171 ± 0.018	0.797TrpAsp: 0.797 ± 0.042	0.552TrpGlu: 0.552 ± 0.034	0.563TrpPhe: 0.563 ± 0.034	1.099TrpGly: 1.099 ± 0.049	0.394TrpHis: 0.394 ± 0.028	0.709TrpIle: 0.709 ± 0.039	0.425TrpLys: 0.425 ± 0.031	2.002TrpLeu: 2.002 ± 0.061	0.445TrpMet: 0.445 ± 0.027	0.459TrpAsn: 0.459 ± 0.031	0.928TrpPro: 0.928 ± 0.047	0.704TrpGln: 0.704 ± 0.032	1.539TrpArg: 1.539 ± 0.054	0.839TrpSer: 0.839 ± 0.042	0.841TrpThr: 0.841 ± 0.046	0.844TrpVal: 0.844 ± 0.036	0.263TrpTrp: 0.263 ± 0.023	0.268TrpTyr: 0.268 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.339TyrAla: 2.339 ± 0.068	0.233TyrCys: 0.233 ± 0.022	1.453TyrAsp: 1.453 ± 0.052	1.045TyrGlu: 1.045 ± 0.04	0.717TyrPhe: 0.717 ± 0.04	1.955TyrGly: 1.955 ± 0.067	0.512TyrHis: 0.512 ± 0.028	0.717TyrIle: 0.717 ± 0.04	0.478TyrLys: 0.478 ± 0.026	2.117TyrLeu: 2.117 ± 0.07	0.357TyrMet: 0.357 ± 0.027	0.489TyrAsn: 0.489 ± 0.03	0.975TyrPro: 0.975 ± 0.037	0.698TyrGln: 0.698 ± 0.035	1.612TyrArg: 1.612 ± 0.056	0.923TyrSer: 0.923 ± 0.042	0.857TyrThr: 0.857 ± 0.037	1.388TyrVal: 1.388 ± 0.051	0.332TyrTrp: 0.332 ± 0.026	0.512TyrTyr: 0.512 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2325 proteins (548463 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---