Amino acid dipepetide frequency for Streptococcus phage Javan220

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.565AlaAla: 5.565 ± 1.292
0.818AlaCys: 0.818 ± 0.337
5.074AlaAsp: 5.074 ± 0.861
4.501AlaGlu: 4.501 ± 0.505
1.882AlaPhe: 1.882 ± 0.392
6.056AlaGly: 6.056 ± 0.748
0.818AlaHis: 0.818 ± 0.243
4.91AlaIle: 4.91 ± 0.601
6.547AlaLys: 6.547 ± 0.833
6.138AlaLeu: 6.138 ± 0.893
1.8AlaMet: 1.8 ± 0.514
5.483AlaAsn: 5.483 ± 1.007
2.21AlaPro: 2.21 ± 0.354
3.355AlaGln: 3.355 ± 0.543
2.946AlaArg: 2.946 ± 0.562
5.729AlaSer: 5.729 ± 0.679
5.238AlaThr: 5.238 ± 0.844
5.238AlaVal: 5.238 ± 0.898
0.491AlaTrp: 0.491 ± 0.164
2.128AlaTyr: 2.128 ± 0.456
0.0AlaXaa: 0.0 ± 0.0
Cys
0.573CysAla: 0.573 ± 0.185
0.0CysCys: 0.0 ± 0.0
0.246CysAsp: 0.246 ± 0.153
1.146CysGlu: 1.146 ± 0.244
0.327CysPhe: 0.327 ± 0.175
0.164CysGly: 0.164 ± 0.12
0.246CysHis: 0.246 ± 0.177
0.491CysIle: 0.491 ± 0.197
0.655CysLys: 0.655 ± 0.246
0.327CysLeu: 0.327 ± 0.158
0.164CysMet: 0.164 ± 0.141
0.409CysAsn: 0.409 ± 0.164
0.164CysPro: 0.164 ± 0.129
0.573CysGln: 0.573 ± 0.192
0.246CysArg: 0.246 ± 0.146
0.327CysSer: 0.327 ± 0.177
0.409CysThr: 0.409 ± 0.169
0.491CysVal: 0.491 ± 0.216
0.164CysTrp: 0.164 ± 0.118
0.409CysTyr: 0.409 ± 0.172
0.0CysXaa: 0.0 ± 0.0
Asp
4.092AspAla: 4.092 ± 0.48
0.246AspCys: 0.246 ± 0.142
4.829AspAsp: 4.829 ± 0.987
5.811AspGlu: 5.811 ± 0.809
3.192AspPhe: 3.192 ± 0.67
5.565AspGly: 5.565 ± 0.938
0.9AspHis: 0.9 ± 0.283
3.192AspIle: 3.192 ± 0.473
4.01AspLys: 4.01 ± 0.522
5.156AspLeu: 5.156 ± 0.546
2.128AspMet: 2.128 ± 0.584
3.765AspAsn: 3.765 ± 0.596
1.228AspPro: 1.228 ± 0.287
1.882AspGln: 1.882 ± 0.578
2.21AspArg: 2.21 ± 0.48
3.355AspSer: 3.355 ± 0.488
2.701AspThr: 2.701 ± 0.435
4.092AspVal: 4.092 ± 0.491
1.309AspTrp: 1.309 ± 0.351
4.256AspTyr: 4.256 ± 0.661
0.0AspXaa: 0.0 ± 0.0
Glu
4.665GluAla: 4.665 ± 0.726
0.409GluCys: 0.409 ± 0.187
4.256GluAsp: 4.256 ± 0.562
5.074GluGlu: 5.074 ± 0.845
2.537GluPhe: 2.537 ± 0.392
2.537GluGly: 2.537 ± 0.51
1.064GluHis: 1.064 ± 0.328
6.302GluIle: 6.302 ± 0.967
6.138GluLys: 6.138 ± 0.797
8.593GluLeu: 8.593 ± 1.024
1.309GluMet: 1.309 ± 0.277
3.437GluAsn: 3.437 ± 0.445
1.882GluPro: 1.882 ± 0.44
2.292GluGln: 2.292 ± 0.522
2.864GluArg: 2.864 ± 0.467
3.274GluSer: 3.274 ± 0.563
5.647GluThr: 5.647 ± 0.607
4.829GluVal: 4.829 ± 0.934
1.228GluTrp: 1.228 ± 0.289
2.537GluTyr: 2.537 ± 0.445
0.0GluXaa: 0.0 ± 0.0
Phe
2.537PheAla: 2.537 ± 0.349
0.246PheCys: 0.246 ± 0.122
3.355PheAsp: 3.355 ± 0.532
3.683PheGlu: 3.683 ± 0.529
2.046PhePhe: 2.046 ± 0.584
3.437PheGly: 3.437 ± 0.706
0.409PheHis: 0.409 ± 0.194
2.21PheIle: 2.21 ± 0.348
3.519PheLys: 3.519 ± 0.626
2.619PheLeu: 2.619 ± 0.556
0.655PheMet: 0.655 ± 0.232
1.555PheAsn: 1.555 ± 0.336
1.228PhePro: 1.228 ± 0.28
0.982PheGln: 0.982 ± 0.356
1.146PheArg: 1.146 ± 0.313
2.783PheSer: 2.783 ± 0.533
2.619PheThr: 2.619 ± 0.443
1.8PheVal: 1.8 ± 0.435
0.491PheTrp: 0.491 ± 0.206
1.882PheTyr: 1.882 ± 0.508
0.0PheXaa: 0.0 ± 0.0
Gly
4.092GlyAla: 4.092 ± 0.637
0.409GlyCys: 0.409 ± 0.21
2.619GlyAsp: 2.619 ± 0.489
3.601GlyGlu: 3.601 ± 0.541
2.537GlyPhe: 2.537 ± 0.49
5.401GlyGly: 5.401 ± 0.696
0.737GlyHis: 0.737 ± 0.247
4.665GlyIle: 4.665 ± 0.521
7.447GlyLys: 7.447 ± 0.755
6.711GlyLeu: 6.711 ± 0.905
1.8GlyMet: 1.8 ± 0.285
4.338GlyAsn: 4.338 ± 0.597
0.655GlyPro: 0.655 ± 0.317
2.373GlyGln: 2.373 ± 0.566
3.11GlyArg: 3.11 ± 0.417
3.601GlySer: 3.601 ± 0.485
3.928GlyThr: 3.928 ± 0.613
4.01GlyVal: 4.01 ± 0.444
1.146GlyTrp: 1.146 ± 0.238
2.783GlyTyr: 2.783 ± 0.505
0.0GlyXaa: 0.0 ± 0.0
His
0.655HisAla: 0.655 ± 0.203
0.164HisCys: 0.164 ± 0.115
0.737HisAsp: 0.737 ± 0.256
0.737HisGlu: 0.737 ± 0.26
0.491HisPhe: 0.491 ± 0.244
0.982HisGly: 0.982 ± 0.29
0.327HisHis: 0.327 ± 0.158
0.818HisIle: 0.818 ± 0.231
0.655HisLys: 0.655 ± 0.215
1.064HisLeu: 1.064 ± 0.335
0.246HisMet: 0.246 ± 0.163
0.655HisAsn: 0.655 ± 0.194
0.409HisPro: 0.409 ± 0.15
0.164HisGln: 0.164 ± 0.115
0.327HisArg: 0.327 ± 0.171
1.146HisSer: 1.146 ± 0.412
0.655HisThr: 0.655 ± 0.234
0.737HisVal: 0.737 ± 0.24
0.164HisTrp: 0.164 ± 0.12
0.655HisTyr: 0.655 ± 0.162
0.0HisXaa: 0.0 ± 0.0
Ile
5.32IleAla: 5.32 ± 0.546
0.409IleCys: 0.409 ± 0.177
5.729IleAsp: 5.729 ± 0.523
5.565IleGlu: 5.565 ± 0.763
1.719IlePhe: 1.719 ± 0.408
3.028IleGly: 3.028 ± 0.598
0.737IleHis: 0.737 ± 0.204
4.092IleIle: 4.092 ± 0.779
5.647IleLys: 5.647 ± 0.628
5.156IleLeu: 5.156 ± 0.76
1.309IleMet: 1.309 ± 0.41
3.437IleAsn: 3.437 ± 0.511
2.373IlePro: 2.373 ± 0.364
2.21IleGln: 2.21 ± 0.443
2.046IleArg: 2.046 ± 0.477
3.846IleSer: 3.846 ± 0.613
3.846IleThr: 3.846 ± 0.528
3.028IleVal: 3.028 ± 0.496
0.655IleTrp: 0.655 ± 0.178
2.701IleTyr: 2.701 ± 0.541
0.0IleXaa: 0.0 ± 0.0
Lys
7.284LysAla: 7.284 ± 0.961
0.655LysCys: 0.655 ± 0.284
4.092LysAsp: 4.092 ± 0.653
7.611LysGlu: 7.611 ± 1.016
3.192LysPhe: 3.192 ± 0.572
4.829LysGly: 4.829 ± 0.49
0.818LysHis: 0.818 ± 0.235
4.338LysIle: 4.338 ± 0.496
7.366LysLys: 7.366 ± 1.259
5.32LysLeu: 5.32 ± 0.652
1.964LysMet: 1.964 ± 0.409
5.647LysAsn: 5.647 ± 0.674
2.128LysPro: 2.128 ± 0.543
4.338LysGln: 4.338 ± 0.588
3.846LysArg: 3.846 ± 0.623
3.437LysSer: 3.437 ± 0.568
7.202LysThr: 7.202 ± 0.711
5.811LysVal: 5.811 ± 0.643
0.818LysTrp: 0.818 ± 0.267
3.274LysTyr: 3.274 ± 0.453
0.0LysXaa: 0.0 ± 0.0
Leu
5.974LeuAla: 5.974 ± 0.816
0.491LeuCys: 0.491 ± 0.196
5.32LeuAsp: 5.32 ± 0.6
6.547LeuGlu: 6.547 ± 0.952
2.292LeuPhe: 2.292 ± 0.475
5.156LeuGly: 5.156 ± 0.696
0.9LeuHis: 0.9 ± 0.26
4.419LeuIle: 4.419 ± 0.746
8.675LeuLys: 8.675 ± 1.041
6.302LeuLeu: 6.302 ± 0.594
1.555LeuMet: 1.555 ± 0.315
4.338LeuAsn: 4.338 ± 0.697
2.946LeuPro: 2.946 ± 0.564
3.683LeuGln: 3.683 ± 0.69
3.519LeuArg: 3.519 ± 0.561
5.32LeuSer: 5.32 ± 0.543
5.483LeuThr: 5.483 ± 0.793
5.074LeuVal: 5.074 ± 0.674
0.818LeuTrp: 0.818 ± 0.273
1.964LeuTyr: 1.964 ± 0.469
0.0LeuXaa: 0.0 ± 0.0
Met
1.882MetAla: 1.882 ± 0.422
0.082MetCys: 0.082 ± 0.091
1.555MetAsp: 1.555 ± 0.321
0.818MetGlu: 0.818 ± 0.201
0.655MetPhe: 0.655 ± 0.252
0.9MetGly: 0.9 ± 0.365
0.327MetHis: 0.327 ± 0.207
2.292MetIle: 2.292 ± 0.372
1.882MetLys: 1.882 ± 0.383
1.637MetLeu: 1.637 ± 0.365
0.409MetMet: 0.409 ± 0.152
1.309MetAsn: 1.309 ± 0.297
0.818MetPro: 0.818 ± 0.211
0.737MetGln: 0.737 ± 0.27
0.982MetArg: 0.982 ± 0.259
1.555MetSer: 1.555 ± 0.447
1.8MetThr: 1.8 ± 0.478
1.309MetVal: 1.309 ± 0.441
0.246MetTrp: 0.246 ± 0.135
0.9MetTyr: 0.9 ± 0.264
0.0MetXaa: 0.0 ± 0.0
Asn
3.846AsnAla: 3.846 ± 0.624
0.491AsnCys: 0.491 ± 0.218
3.683AsnAsp: 3.683 ± 0.559
4.419AsnGlu: 4.419 ± 0.609
1.964AsnPhe: 1.964 ± 0.401
5.729AsnGly: 5.729 ± 0.664
0.982AsnHis: 0.982 ± 0.296
2.537AsnIle: 2.537 ± 0.436
4.01AsnLys: 4.01 ± 0.584
5.32AsnLeu: 5.32 ± 1.229
1.473AsnMet: 1.473 ± 0.392
3.846AsnAsn: 3.846 ± 0.597
2.373AsnPro: 2.373 ± 0.408
2.373AsnGln: 2.373 ± 0.394
1.637AsnArg: 1.637 ± 0.321
4.256AsnSer: 4.256 ± 0.608
3.601AsnThr: 3.601 ± 0.696
4.91AsnVal: 4.91 ± 0.445
0.655AsnTrp: 0.655 ± 0.245
2.373AsnTyr: 2.373 ± 0.303
0.0AsnXaa: 0.0 ± 0.0
Pro
2.864ProAla: 2.864 ± 0.439
0.082ProCys: 0.082 ± 0.074
2.783ProAsp: 2.783 ± 0.46
2.619ProGlu: 2.619 ± 0.423
1.473ProPhe: 1.473 ± 0.316
0.655ProGly: 0.655 ± 0.194
0.164ProHis: 0.164 ± 0.097
1.473ProIle: 1.473 ± 0.309
2.128ProLys: 2.128 ± 0.457
2.128ProLeu: 2.128 ± 0.476
0.164ProMet: 0.164 ± 0.102
2.373ProAsn: 2.373 ± 0.549
0.573ProPro: 0.573 ± 0.244
1.064ProGln: 1.064 ± 0.23
0.9ProArg: 0.9 ± 0.308
1.8ProSer: 1.8 ± 0.403
1.8ProThr: 1.8 ± 0.537
1.309ProVal: 1.309 ± 0.319
0.164ProTrp: 0.164 ± 0.119
1.064ProTyr: 1.064 ± 0.34
0.0ProXaa: 0.0 ± 0.0
Gln
3.519GlnAla: 3.519 ± 0.731
0.246GlnCys: 0.246 ± 0.132
1.391GlnAsp: 1.391 ± 0.416
2.046GlnGlu: 2.046 ± 0.404
2.292GlnPhe: 2.292 ± 0.389
2.619GlnGly: 2.619 ± 0.433
0.246GlnHis: 0.246 ± 0.131
2.864GlnIle: 2.864 ± 0.537
2.373GlnLys: 2.373 ± 0.612
3.192GlnLeu: 3.192 ± 0.537
0.982GlnMet: 0.982 ± 0.323
2.128GlnAsn: 2.128 ± 0.495
0.573GlnPro: 0.573 ± 0.219
1.391GlnGln: 1.391 ± 0.32
1.473GlnArg: 1.473 ± 0.298
3.765GlnSer: 3.765 ± 0.626
3.274GlnThr: 3.274 ± 0.651
2.619GlnVal: 2.619 ± 0.587
0.327GlnTrp: 0.327 ± 0.15
1.473GlnTyr: 1.473 ± 0.294
0.0GlnXaa: 0.0 ± 0.0
Arg
2.537ArgAla: 2.537 ± 0.486
0.164ArgCys: 0.164 ± 0.104
2.046ArgAsp: 2.046 ± 0.483
2.292ArgGlu: 2.292 ± 0.529
2.292ArgPhe: 2.292 ± 0.437
1.964ArgGly: 1.964 ± 0.372
1.064ArgHis: 1.064 ± 0.302
4.01ArgIle: 4.01 ± 0.622
2.864ArgLys: 2.864 ± 0.527
2.864ArgLeu: 2.864 ± 0.36
0.655ArgMet: 0.655 ± 0.2
2.373ArgAsn: 2.373 ± 0.505
0.818ArgPro: 0.818 ± 0.161
1.309ArgGln: 1.309 ± 0.283
2.046ArgArg: 2.046 ± 0.475
1.228ArgSer: 1.228 ± 0.289
2.21ArgThr: 2.21 ± 0.528
2.537ArgVal: 2.537 ± 0.455
0.491ArgTrp: 0.491 ± 0.183
1.882ArgTyr: 1.882 ± 0.415
0.0ArgXaa: 0.0 ± 0.0
Ser
5.238SerAla: 5.238 ± 1.133
0.818SerCys: 0.818 ± 0.272
4.665SerAsp: 4.665 ± 0.826
3.765SerGlu: 3.765 ± 0.521
2.864SerPhe: 2.864 ± 0.411
5.238SerGly: 5.238 ± 0.555
0.409SerHis: 0.409 ± 0.164
3.601SerIle: 3.601 ± 0.388
4.174SerLys: 4.174 ± 0.599
4.583SerLeu: 4.583 ± 0.733
0.737SerMet: 0.737 ± 0.225
4.338SerAsn: 4.338 ± 0.697
1.555SerPro: 1.555 ± 0.413
3.028SerGln: 3.028 ± 0.56
1.309SerArg: 1.309 ± 0.303
4.419SerSer: 4.419 ± 1.081
4.092SerThr: 4.092 ± 0.916
4.583SerVal: 4.583 ± 0.456
0.737SerTrp: 0.737 ± 0.195
3.028SerTyr: 3.028 ± 0.599
0.0SerXaa: 0.0 ± 0.0
Thr
7.611ThrAla: 7.611 ± 1.674
0.491ThrCys: 0.491 ± 0.212
3.437ThrAsp: 3.437 ± 0.517
2.946ThrGlu: 2.946 ± 0.428
2.783ThrPhe: 2.783 ± 0.554
4.829ThrGly: 4.829 ± 0.592
0.737ThrHis: 0.737 ± 0.21
4.01ThrIle: 4.01 ± 0.642
5.647ThrLys: 5.647 ± 0.572
4.829ThrLeu: 4.829 ± 0.573
1.964ThrMet: 1.964 ± 0.459
3.928ThrAsn: 3.928 ± 0.727
2.864ThrPro: 2.864 ± 0.543
2.619ThrGln: 2.619 ± 0.442
2.21ThrArg: 2.21 ± 0.403
4.338ThrSer: 4.338 ± 0.732
5.892ThrThr: 5.892 ± 1.057
4.174ThrVal: 4.174 ± 0.557
0.573ThrTrp: 0.573 ± 0.205
3.355ThrTyr: 3.355 ± 0.368
0.0ThrXaa: 0.0 ± 0.0
Val
5.565ValAla: 5.565 ± 0.932
0.655ValCys: 0.655 ± 0.273
4.256ValAsp: 4.256 ± 0.697
4.01ValGlu: 4.01 ± 0.586
2.701ValPhe: 2.701 ± 0.633
3.601ValGly: 3.601 ± 0.556
0.409ValHis: 0.409 ± 0.171
3.683ValIle: 3.683 ± 0.495
6.547ValLys: 6.547 ± 0.649
5.238ValLeu: 5.238 ± 0.847
0.982ValMet: 0.982 ± 0.283
4.501ValAsn: 4.501 ± 0.565
1.309ValPro: 1.309 ± 0.343
1.637ValGln: 1.637 ± 0.246
2.701ValArg: 2.701 ± 0.502
5.238ValSer: 5.238 ± 0.645
4.583ValThr: 4.583 ± 0.686
3.519ValVal: 3.519 ± 0.717
0.655ValTrp: 0.655 ± 0.226
2.21ValTyr: 2.21 ± 0.377
0.0ValXaa: 0.0 ± 0.0
Trp
0.573TrpAla: 0.573 ± 0.195
0.246TrpCys: 0.246 ± 0.119
0.737TrpAsp: 0.737 ± 0.248
0.818TrpGlu: 0.818 ± 0.245
0.491TrpPhe: 0.491 ± 0.201
0.327TrpGly: 0.327 ± 0.132
0.082TrpHis: 0.082 ± 0.09
0.9TrpIle: 0.9 ± 0.247
0.9TrpLys: 0.9 ± 0.252
0.9TrpLeu: 0.9 ± 0.357
0.246TrpMet: 0.246 ± 0.16
0.655TrpAsn: 0.655 ± 0.325
0.0TrpPro: 0.0 ± 0.0
0.573TrpGln: 0.573 ± 0.194
0.737TrpArg: 0.737 ± 0.285
0.9TrpSer: 0.9 ± 0.303
0.982TrpThr: 0.982 ± 0.351
0.737TrpVal: 0.737 ± 0.23
0.246TrpTrp: 0.246 ± 0.119
0.982TrpTyr: 0.982 ± 0.264
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.537TyrAla: 2.537 ± 0.454
0.409TyrCys: 0.409 ± 0.188
3.11TyrAsp: 3.11 ± 0.556
2.864TyrGlu: 2.864 ± 0.483
1.473TyrPhe: 1.473 ± 0.403
2.946TyrGly: 2.946 ± 0.531
0.409TyrHis: 0.409 ± 0.168
2.046TyrIle: 2.046 ± 0.416
2.783TyrLys: 2.783 ± 0.494
2.701TyrLeu: 2.701 ± 0.478
1.473TyrMet: 1.473 ± 0.291
2.046TyrAsn: 2.046 ± 0.439
1.473TyrPro: 1.473 ± 0.342
2.21TyrGln: 2.21 ± 0.464
1.391TyrArg: 1.391 ± 0.464
2.864TyrSer: 2.864 ± 0.663
3.274TyrThr: 3.274 ± 0.686
3.192TyrVal: 3.192 ± 0.571
0.655TyrTrp: 0.655 ± 0.253
1.309TyrTyr: 1.309 ± 0.312
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (12220 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski