Amino acid dipepetide frequency for Polaribacter atrinae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.121AlaAla: 4.121 ± 0.092	0.49AlaCys: 0.49 ± 0.023	3.37AlaAsp: 3.37 ± 0.062	3.719AlaGlu: 3.719 ± 0.067	3.172AlaPhe: 3.172 ± 0.054	3.837AlaGly: 3.837 ± 0.069	1.001AlaHis: 1.001 ± 0.031	5.563AlaIle: 5.563 ± 0.077	4.841AlaLys: 4.841 ± 0.072	5.51AlaLeu: 5.51 ± 0.081	1.328AlaMet: 1.328 ± 0.039	3.528AlaAsn: 3.528 ± 0.068	1.705AlaPro: 1.705 ± 0.042	2.049AlaGln: 2.049 ± 0.041	1.742AlaArg: 1.742 ± 0.039	4.013AlaSer: 4.013 ± 0.072	3.823AlaThr: 3.823 ± 0.067	3.843AlaVal: 3.843 ± 0.075	0.549AlaTrp: 0.549 ± 0.02	2.231AlaTyr: 2.231 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.407CysAla: 0.407 ± 0.018	0.086CysCys: 0.086 ± 0.008	0.384CysAsp: 0.384 ± 0.022	0.392CysGlu: 0.392 ± 0.021	0.407CysPhe: 0.407 ± 0.019	0.522CysGly: 0.522 ± 0.023	0.166CysHis: 0.166 ± 0.015	0.521CysIle: 0.521 ± 0.024	0.506CysLys: 0.506 ± 0.023	0.581CysLeu: 0.581 ± 0.025	0.118CysMet: 0.118 ± 0.01	0.405CysAsn: 0.405 ± 0.02	0.273CysPro: 0.273 ± 0.018	0.175CysGln: 0.175 ± 0.013	0.16CysArg: 0.16 ± 0.013	0.469CysSer: 0.469 ± 0.023	0.384CysThr: 0.384 ± 0.021	0.397CysVal: 0.397 ± 0.018	0.058CysTrp: 0.058 ± 0.006	0.251CysTyr: 0.251 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.801AspAla: 3.801 ± 0.061	0.398AspCys: 0.398 ± 0.02	3.017AspAsp: 3.017 ± 0.069	3.738AspGlu: 3.738 ± 0.057	3.825AspPhe: 3.825 ± 0.057	3.515AspGly: 3.515 ± 0.084	0.74AspHis: 0.74 ± 0.025	4.493AspIle: 4.493 ± 0.067	4.685AspLys: 4.685 ± 0.073	5.389AspLeu: 5.389 ± 0.075	0.933AspMet: 0.933 ± 0.029	3.412AspAsn: 3.412 ± 0.066	1.313AspPro: 1.313 ± 0.038	1.295AspGln: 1.295 ± 0.032	1.642AspArg: 1.642 ± 0.04	3.133AspSer: 3.133 ± 0.058	2.839AspThr: 2.839 ± 0.055	3.867AspVal: 3.867 ± 0.071	0.719AspTrp: 0.719 ± 0.023	2.596AspTyr: 2.596 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	4.048GluAla: 4.048 ± 0.07	0.319GluCys: 0.319 ± 0.018	3.513GluAsp: 3.513 ± 0.061	4.95GluGlu: 4.95 ± 0.082	3.175GluPhe: 3.175 ± 0.053	3.508GluGly: 3.508 ± 0.057	1.083GluHis: 1.083 ± 0.034	6.115GluIle: 6.115 ± 0.084	6.52GluLys: 6.52 ± 0.083	6.183GluLeu: 6.183 ± 0.074	1.569GluMet: 1.569 ± 0.038	5.417GluAsn: 5.417 ± 0.086	1.331GluPro: 1.331 ± 0.031	2.032GluGln: 2.032 ± 0.049	2.266GluArg: 2.266 ± 0.05	3.388GluSer: 3.388 ± 0.056	3.883GluThr: 3.883 ± 0.063	4.426GluVal: 4.426 ± 0.069	0.566GluTrp: 0.566 ± 0.026	2.558GluTyr: 2.558 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	2.825PheAla: 2.825 ± 0.055	0.399PheCys: 0.399 ± 0.021	3.314PheAsp: 3.314 ± 0.059	3.229PheGlu: 3.229 ± 0.059	2.875PhePhe: 2.875 ± 0.053	3.7PheGly: 3.7 ± 0.058	0.796PheHis: 0.796 ± 0.027	4.461PheIle: 4.461 ± 0.072	4.465PheLys: 4.465 ± 0.077	5.093PheLeu: 5.093 ± 0.081	1.07PheMet: 1.07 ± 0.029	3.716PheAsn: 3.716 ± 0.062	1.679PhePro: 1.679 ± 0.038	1.41PheGln: 1.41 ± 0.033	1.419PheArg: 1.419 ± 0.043	4.373PheSer: 4.373 ± 0.058	3.365PheThr: 3.365 ± 0.062	3.148PheVal: 3.148 ± 0.051	0.61PheTrp: 0.61 ± 0.022	2.351PheTyr: 2.351 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.943GlyAla: 3.943 ± 0.065	0.497GlyCys: 0.497 ± 0.025	3.274GlyAsp: 3.274 ± 0.058	3.461GlyGlu: 3.461 ± 0.063	3.786GlyPhe: 3.786 ± 0.06	4.372GlyGly: 4.372 ± 0.09	0.971GlyHis: 0.971 ± 0.031	5.389GlyIle: 5.389 ± 0.079	5.024GlyLys: 5.024 ± 0.064	5.426GlyLeu: 5.426 ± 0.075	1.4GlyMet: 1.4 ± 0.039	3.695GlyAsn: 3.695 ± 0.073	1.095GlyPro: 1.095 ± 0.033	1.645GlyGln: 1.645 ± 0.038	1.882GlyArg: 1.882 ± 0.047	3.925GlySer: 3.925 ± 0.071	3.913GlyThr: 3.913 ± 0.074	4.392GlyVal: 4.392 ± 0.075	0.68GlyTrp: 0.68 ± 0.026	2.661GlyTyr: 2.661 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.9HisAla: 0.9 ± 0.028	0.127HisCys: 0.127 ± 0.011	0.714HisAsp: 0.714 ± 0.027	0.863HisGlu: 0.863 ± 0.029	1.071HisPhe: 1.071 ± 0.034	0.898HisGly: 0.898 ± 0.029	0.45HisHis: 0.45 ± 0.022	1.328HisIle: 1.328 ± 0.036	1.378HisLys: 1.378 ± 0.036	1.748HisLeu: 1.748 ± 0.046	0.256HisMet: 0.256 ± 0.015	0.916HisAsn: 0.916 ± 0.03	0.802HisPro: 0.802 ± 0.028	0.76HisGln: 0.76 ± 0.026	0.572HisArg: 0.572 ± 0.022	0.951HisSer: 0.951 ± 0.031	0.939HisThr: 0.939 ± 0.028	0.827HisVal: 0.827 ± 0.032	0.181HisTrp: 0.181 ± 0.015	0.723HisTyr: 0.723 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.567IleAla: 5.567 ± 0.081	0.612IleCys: 0.612 ± 0.026	5.271IleAsp: 5.271 ± 0.072	5.789IleGlu: 5.789 ± 0.079	3.851IlePhe: 3.851 ± 0.06	5.123IleGly: 5.123 ± 0.077	1.358IleHis: 1.358 ± 0.037	6.735IleIle: 6.735 ± 0.102	6.924IleLys: 6.924 ± 0.095	7.427IleLeu: 7.427 ± 0.099	1.299IleMet: 1.299 ± 0.039	5.205IleAsn: 5.205 ± 0.084	3.227IlePro: 3.227 ± 0.054	2.55IleGln: 2.55 ± 0.049	2.439IleArg: 2.439 ± 0.051	6.314IleSer: 6.314 ± 0.082	5.253IleThr: 5.253 ± 0.077	4.861IleVal: 4.861 ± 0.069	0.712IleTrp: 0.712 ± 0.029	2.965IleTyr: 2.965 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.887LysAla: 4.887 ± 0.084	0.341LysCys: 0.341 ± 0.02	4.891LysAsp: 4.891 ± 0.067	7.733LysGlu: 7.733 ± 0.105	3.299LysPhe: 3.299 ± 0.061	4.941LysGly: 4.941 ± 0.067	1.394LysHis: 1.394 ± 0.04	7.338LysIle: 7.338 ± 0.102	8.322LysLys: 8.322 ± 0.134	6.936LysLeu: 6.936 ± 0.085	2.189LysMet: 2.189 ± 0.043	6.406LysAsn: 6.406 ± 0.09	2.452LysPro: 2.452 ± 0.046	2.782LysGln: 2.782 ± 0.052	2.908LysArg: 2.908 ± 0.062	5.014LysSer: 5.014 ± 0.076	5.337LysThr: 5.337 ± 0.075	5.241LysVal: 5.241 ± 0.073	0.841LysTrp: 0.841 ± 0.027	3.394LysTyr: 3.394 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.29LeuAla: 5.29 ± 0.081	0.557LeuCys: 0.557 ± 0.021	4.998LeuAsp: 4.998 ± 0.068	6.48LeuGlu: 6.48 ± 0.093	5.162LeuPhe: 5.162 ± 0.081	5.678LeuGly: 5.678 ± 0.079	1.47LeuHis: 1.47 ± 0.039	7.231LeuIle: 7.231 ± 0.092	8.562LeuLys: 8.562 ± 0.107	8.595LeuLeu: 8.595 ± 0.125	1.907LeuMet: 1.907 ± 0.044	5.946LeuAsn: 5.946 ± 0.092	3.241LeuPro: 3.241 ± 0.055	3.175LeuGln: 3.175 ± 0.059	2.817LeuArg: 2.817 ± 0.051	6.6LeuSer: 6.6 ± 0.092	5.16LeuThr: 5.16 ± 0.077	5.127LeuVal: 5.127 ± 0.071	0.78LeuTrp: 0.78 ± 0.032	3.054LeuTyr: 3.054 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.389MetAla: 1.389 ± 0.039	0.124MetCys: 0.124 ± 0.012	1.007MetAsp: 1.007 ± 0.03	1.141MetGlu: 1.141 ± 0.027	0.878MetPhe: 0.878 ± 0.03	1.203MetGly: 1.203 ± 0.037	0.379MetHis: 0.379 ± 0.022	1.561MetIle: 1.561 ± 0.043	2.096MetLys: 2.096 ± 0.042	1.797MetLeu: 1.797 ± 0.043	0.536MetMet: 0.536 ± 0.024	1.305MetAsn: 1.305 ± 0.033	0.721MetPro: 0.721 ± 0.023	0.73MetGln: 0.73 ± 0.029	0.708MetArg: 0.708 ± 0.023	1.351MetSer: 1.351 ± 0.037	1.018MetThr: 1.018 ± 0.032	1.221MetVal: 1.221 ± 0.036	0.145MetTrp: 0.145 ± 0.011	0.707MetTyr: 0.707 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.798AsnAla: 3.798 ± 0.067	0.433AsnCys: 0.433 ± 0.023	3.367AsnAsp: 3.367 ± 0.073	3.926AsnGlu: 3.926 ± 0.063	3.492AsnPhe: 3.492 ± 0.067	4.016AsnGly: 4.016 ± 0.089	1.106AsnHis: 1.106 ± 0.031	5.442AsnIle: 5.442 ± 0.073	5.412AsnLys: 5.412 ± 0.078	6.039AsnLeu: 6.039 ± 0.081	1.119AsnMet: 1.119 ± 0.029	4.619AsnAsn: 4.619 ± 0.079	2.669AsnPro: 2.669 ± 0.059	2.248AsnGln: 2.248 ± 0.046	1.983AsnArg: 1.983 ± 0.041	4.386AsnSer: 4.386 ± 0.077	4.166AsnThr: 4.166 ± 0.062	3.734AsnVal: 3.734 ± 0.059	0.864AsnTrp: 0.864 ± 0.031	3.102AsnTyr: 3.102 ± 0.068	0.0AsnXaa: 0.0 ± 0.0
Pro	1.612ProAla: 1.612 ± 0.045	0.171ProCys: 0.171 ± 0.014	1.61ProAsp: 1.61 ± 0.044	2.459ProGlu: 2.459 ± 0.044	1.819ProPhe: 1.819 ± 0.042	1.583ProGly: 1.583 ± 0.043	0.511ProHis: 0.511 ± 0.024	2.758ProIle: 2.758 ± 0.047	2.716ProLys: 2.716 ± 0.051	2.741ProLeu: 2.741 ± 0.05	0.59ProMet: 0.59 ± 0.022	2.165ProAsn: 2.165 ± 0.048	0.65ProPro: 0.65 ± 0.026	0.92ProGln: 0.92 ± 0.025	0.851ProArg: 0.851 ± 0.03	1.936ProSer: 1.936 ± 0.042	2.117ProThr: 2.117 ± 0.045	1.99ProVal: 1.99 ± 0.043	0.334ProTrp: 0.334 ± 0.021	1.278ProTyr: 1.278 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	1.627GlnAla: 1.627 ± 0.042	0.151GlnCys: 0.151 ± 0.012	1.543GlnAsp: 1.543 ± 0.038	2.329GlnGlu: 2.329 ± 0.048	1.738GlnPhe: 1.738 ± 0.039	1.582GlnGly: 1.582 ± 0.038	0.545GlnHis: 0.545 ± 0.021	2.56GlnIle: 2.56 ± 0.049	2.995GlnLys: 2.995 ± 0.058	3.17GlnLeu: 3.17 ± 0.059	0.69GlnMet: 0.69 ± 0.026	2.127GlnAsn: 2.127 ± 0.046	0.937GlnPro: 0.937 ± 0.029	1.287GlnGln: 1.287 ± 0.032	1.089GlnArg: 1.089 ± 0.032	1.73GlnSer: 1.73 ± 0.044	1.795GlnThr: 1.795 ± 0.045	1.824GlnVal: 1.824 ± 0.036	0.272GlnTrp: 0.272 ± 0.015	1.217GlnTyr: 1.217 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.832ArgAla: 1.832 ± 0.045	0.17ArgCys: 0.17 ± 0.013	1.547ArgAsp: 1.547 ± 0.038	1.954ArgGlu: 1.954 ± 0.046	1.772ArgPhe: 1.772 ± 0.044	1.783ArgGly: 1.783 ± 0.043	0.515ArgHis: 0.515 ± 0.021	2.67ArgIle: 2.67 ± 0.048	2.854ArgLys: 2.854 ± 0.054	2.831ArgLeu: 2.831 ± 0.059	0.755ArgMet: 0.755 ± 0.025	2.025ArgAsn: 2.025 ± 0.048	0.948ArgPro: 0.948 ± 0.031	0.921ArgGln: 0.921 ± 0.031	1.163ArgArg: 1.163 ± 0.039	1.713ArgSer: 1.713 ± 0.046	1.742ArgThr: 1.742 ± 0.041	1.859ArgVal: 1.859 ± 0.036	0.328ArgTrp: 0.328 ± 0.02	1.336ArgTyr: 1.336 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.611SerAla: 3.611 ± 0.064	0.606SerCys: 0.606 ± 0.024	3.528SerAsp: 3.528 ± 0.065	4.263SerGlu: 4.263 ± 0.069	4.168SerPhe: 4.168 ± 0.066	4.353SerGly: 4.353 ± 0.068	0.985SerHis: 0.985 ± 0.03	5.602SerIle: 5.602 ± 0.075	5.644SerLys: 5.644 ± 0.079	6.208SerLeu: 6.208 ± 0.084	1.2SerMet: 1.2 ± 0.028	4.14SerAsn: 4.14 ± 0.07	1.921SerPro: 1.921 ± 0.042	1.851SerGln: 1.851 ± 0.039	1.893SerArg: 1.893 ± 0.043	4.469SerSer: 4.469 ± 0.076	3.795SerThr: 3.795 ± 0.068	4.082SerVal: 4.082 ± 0.056	0.74SerTrp: 0.74 ± 0.028	2.89SerTyr: 2.89 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	3.682ThrAla: 3.682 ± 0.055	0.354ThrCys: 0.354 ± 0.019	3.527ThrAsp: 3.527 ± 0.075	3.834ThrGlu: 3.834 ± 0.063	3.228ThrPhe: 3.228 ± 0.057	3.85ThrGly: 3.85 ± 0.072	0.978ThrHis: 0.978 ± 0.033	5.306ThrIle: 5.306 ± 0.079	4.653ThrLys: 4.653 ± 0.065	5.372ThrLeu: 5.372 ± 0.064	0.948ThrMet: 0.948 ± 0.031	3.688ThrAsn: 3.688 ± 0.08	2.35ThrPro: 2.35 ± 0.048	1.771ThrGln: 1.771 ± 0.045	1.552ThrArg: 1.552 ± 0.041	4.188ThrSer: 4.188 ± 0.072	3.908ThrThr: 3.908 ± 0.08	3.783ThrVal: 3.783 ± 0.057	0.585ThrTrp: 0.585 ± 0.027	2.422ThrTyr: 2.422 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.149ValAla: 4.149 ± 0.074	0.432ValCys: 0.432 ± 0.02	3.705ValAsp: 3.705 ± 0.053	3.773ValGlu: 3.773 ± 0.069	3.495ValPhe: 3.495 ± 0.053	3.83ValGly: 3.83 ± 0.064	1.009ValHis: 1.009 ± 0.033	4.844ValIle: 4.844 ± 0.07	4.633ValLys: 4.633 ± 0.068	6.112ValLeu: 6.112 ± 0.083	1.152ValMet: 1.152 ± 0.037	3.637ValAsn: 3.637 ± 0.059	1.919ValPro: 1.919 ± 0.038	1.664ValGln: 1.664 ± 0.045	1.869ValArg: 1.869 ± 0.044	4.591ValSer: 4.591 ± 0.066	3.61ValThr: 3.61 ± 0.061	4.189ValVal: 4.189 ± 0.069	0.625ValTrp: 0.625 ± 0.025	2.319ValTyr: 2.319 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.568TrpAla: 0.568 ± 0.024	0.1TrpCys: 0.1 ± 0.011	0.559TrpAsp: 0.559 ± 0.024	0.669TrpGlu: 0.669 ± 0.027	0.598TrpPhe: 0.598 ± 0.026	0.651TrpGly: 0.651 ± 0.027	0.191TrpHis: 0.191 ± 0.013	0.755TrpIle: 0.755 ± 0.027	0.812TrpLys: 0.812 ± 0.026	0.923TrpLeu: 0.923 ± 0.03	0.293TrpMet: 0.293 ± 0.015	0.724TrpAsn: 0.724 ± 0.023	0.197TrpPro: 0.197 ± 0.015	0.381TrpGln: 0.381 ± 0.022	0.38TrpArg: 0.38 ± 0.02	0.676TrpSer: 0.676 ± 0.028	0.517TrpThr: 0.517 ± 0.023	0.651TrpVal: 0.651 ± 0.029	0.148TrpTrp: 0.148 ± 0.013	0.406TrpTyr: 0.406 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.377TyrAla: 2.377 ± 0.051	0.295TyrCys: 0.295 ± 0.016	2.211TyrAsp: 2.211 ± 0.049	2.145TyrGlu: 2.145 ± 0.047	2.488TyrPhe: 2.488 ± 0.055	2.484TyrGly: 2.484 ± 0.052	0.756TyrHis: 0.756 ± 0.028	2.811TyrIle: 2.811 ± 0.052	3.606TyrLys: 3.606 ± 0.066	3.749TyrLeu: 3.749 ± 0.069	0.665TyrMet: 0.665 ± 0.023	2.848TyrAsn: 2.848 ± 0.06	1.383TyrPro: 1.383 ± 0.036	1.56TyrGln: 1.56 ± 0.04	1.382TyrArg: 1.382 ± 0.04	2.727TyrSer: 2.727 ± 0.06	2.415TyrThr: 2.415 ± 0.05	2.094TyrVal: 2.094 ± 0.044	0.466TyrTrp: 0.466 ± 0.024	1.786TyrTyr: 1.786 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3258 proteins (1114503 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---