Amino acid dipepetide frequency for Sinosporangium album

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.439AlaAla: 20.439 ± 0.17	1.148AlaCys: 1.148 ± 0.029	8.21AlaAsp: 8.21 ± 0.08	8.576AlaGlu: 8.576 ± 0.083	3.646AlaPhe: 3.646 ± 0.044	12.692AlaGly: 12.692 ± 0.124	2.789AlaHis: 2.789 ± 0.044	4.113AlaIle: 4.113 ± 0.058	2.925AlaLys: 2.925 ± 0.052	14.049AlaLeu: 14.049 ± 0.11	2.676AlaMet: 2.676 ± 0.04	1.974AlaAsn: 1.974 ± 0.035	6.729AlaPro: 6.729 ± 0.08	3.448AlaGln: 3.448 ± 0.046	9.974AlaArg: 9.974 ± 0.091	6.033AlaSer: 6.033 ± 0.066	6.682AlaThr: 6.682 ± 0.072	12.404AlaVal: 12.404 ± 0.115	1.911AlaTrp: 1.911 ± 0.037	2.562AlaTyr: 2.562 ± 0.038	0.0AlaXaa: 0.0 ± 0.001
Cys	1.032CysAla: 1.032 ± 0.024	0.081CysCys: 0.081 ± 0.006	0.528CysAsp: 0.528 ± 0.015	0.443CysGlu: 0.443 ± 0.014	0.214CysPhe: 0.214 ± 0.011	1.006CysGly: 1.006 ± 0.024	0.217CysHis: 0.217 ± 0.011	0.168CysIle: 0.168 ± 0.009	0.13CysLys: 0.13 ± 0.009	0.742CysLeu: 0.742 ± 0.021	0.143CysMet: 0.143 ± 0.009	0.13CysAsn: 0.13 ± 0.007	0.517CysPro: 0.517 ± 0.017	0.165CysGln: 0.165 ± 0.009	0.655CysArg: 0.655 ± 0.019	0.471CysSer: 0.471 ± 0.014	0.425CysThr: 0.425 ± 0.014	0.644CysVal: 0.644 ± 0.015	0.105CysTrp: 0.105 ± 0.008	0.175CysTyr: 0.175 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.876AspAla: 6.876 ± 0.072	0.37AspCys: 0.37 ± 0.013	3.516AspAsp: 3.516 ± 0.049	3.707AspGlu: 3.707 ± 0.049	1.547AspPhe: 1.547 ± 0.028	5.731AspGly: 5.731 ± 0.069	1.469AspHis: 1.469 ± 0.028	2.15AspIle: 2.15 ± 0.036	1.183AspLys: 1.183 ± 0.03	6.736AspLeu: 6.736 ± 0.065	0.953AspMet: 0.953 ± 0.023	0.95AspAsn: 0.95 ± 0.023	4.424AspPro: 4.424 ± 0.049	1.532AspGln: 1.532 ± 0.029	4.978AspArg: 4.978 ± 0.052	2.453AspSer: 2.453 ± 0.037	2.985AspThr: 2.985 ± 0.045	4.721AspVal: 4.721 ± 0.048	0.897AspTrp: 0.897 ± 0.018	1.282AspTyr: 1.282 ± 0.027	0.0AspXaa: 0.0 ± 0.0
Glu	7.184GluAla: 7.184 ± 0.072	0.4GluCys: 0.4 ± 0.015	2.448GluAsp: 2.448 ± 0.039	3.369GluGlu: 3.369 ± 0.052	1.545GluPhe: 1.545 ± 0.031	4.317GluGly: 4.317 ± 0.053	1.54GluHis: 1.54 ± 0.031	2.61GluIle: 2.61 ± 0.041	1.273GluLys: 1.273 ± 0.028	6.525GluLeu: 6.525 ± 0.067	0.966GluMet: 0.966 ± 0.023	1.02GluAsn: 1.02 ± 0.023	3.264GluPro: 3.264 ± 0.046	2.057GluGln: 2.057 ± 0.039	5.773GluArg: 5.773 ± 0.06	2.698GluSer: 2.698 ± 0.041	2.828GluThr: 2.828 ± 0.038	4.763GluVal: 4.763 ± 0.057	0.825GluTrp: 0.825 ± 0.021	0.991GluTyr: 0.991 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.722PheAla: 3.722 ± 0.047	0.245PheCys: 0.245 ± 0.012	2.085PheAsp: 2.085 ± 0.036	1.455PheGlu: 1.455 ± 0.026	0.819PhePhe: 0.819 ± 0.022	2.873PheGly: 2.873 ± 0.041	0.665PheHis: 0.665 ± 0.018	0.873PheIle: 0.873 ± 0.024	0.548PheLys: 0.548 ± 0.018	2.547PheLeu: 2.547 ± 0.04	0.435PheMet: 0.435 ± 0.016	0.602PheAsn: 0.602 ± 0.017	1.451PhePro: 1.451 ± 0.028	0.703PheGln: 0.703 ± 0.019	1.844PheArg: 1.844 ± 0.031	1.568PheSer: 1.568 ± 0.036	2.062PheThr: 2.062 ± 0.037	2.194PheVal: 2.194 ± 0.034	0.405PheTrp: 0.405 ± 0.013	0.597PheTyr: 0.597 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	10.471GlyAla: 10.471 ± 0.089	0.815GlyCys: 0.815 ± 0.02	5.404GlyAsp: 5.404 ± 0.06	5.323GlyGlu: 5.323 ± 0.06	2.868GlyPhe: 2.868 ± 0.037	9.054GlyGly: 9.054 ± 0.109	2.361GlyHis: 2.361 ± 0.04	3.345GlyIle: 3.345 ± 0.043	2.325GlyLys: 2.325 ± 0.043	9.414GlyLeu: 9.414 ± 0.082	2.03GlyMet: 2.03 ± 0.033	1.645GlyAsn: 1.645 ± 0.035	5.001GlyPro: 5.001 ± 0.064	2.672GlyGln: 2.672 ± 0.049	8.019GlyArg: 8.019 ± 0.068	5.035GlySer: 5.035 ± 0.068	5.711GlyThr: 5.711 ± 0.07	8.048GlyVal: 8.048 ± 0.087	1.575GlyTrp: 1.575 ± 0.03	2.164GlyTyr: 2.164 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.804HisAla: 2.804 ± 0.042	0.214HisCys: 0.214 ± 0.01	1.416HisAsp: 1.416 ± 0.03	1.23HisGlu: 1.23 ± 0.023	0.587HisPhe: 0.587 ± 0.02	2.328HisGly: 2.328 ± 0.044	0.697HisHis: 0.697 ± 0.023	0.792HisIle: 0.792 ± 0.021	0.357HisLys: 0.357 ± 0.013	2.556HisLeu: 2.556 ± 0.038	0.402HisMet: 0.402 ± 0.014	0.415HisAsn: 0.415 ± 0.015	1.764HisPro: 1.764 ± 0.036	0.595HisGln: 0.595 ± 0.019	2.035HisArg: 2.035 ± 0.036	1.061HisSer: 1.061 ± 0.024	1.268HisThr: 1.268 ± 0.028	1.893HisVal: 1.893 ± 0.037	0.339HisTrp: 0.339 ± 0.013	0.49HisTyr: 0.49 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.34IleAla: 5.34 ± 0.064	0.328IleCys: 0.328 ± 0.015	2.541IleAsp: 2.541 ± 0.046	2.239IleGlu: 2.239 ± 0.035	0.838IlePhe: 0.838 ± 0.026	3.792IleGly: 3.792 ± 0.057	0.694IleHis: 0.694 ± 0.02	1.09IleIle: 1.09 ± 0.026	0.863IleLys: 0.863 ± 0.023	2.718IleLeu: 2.718 ± 0.041	0.6IleMet: 0.6 ± 0.021	0.791IleAsn: 0.791 ± 0.022	2.015IlePro: 2.015 ± 0.033	0.822IleGln: 0.822 ± 0.024	2.623IleArg: 2.623 ± 0.041	1.999IleSer: 1.999 ± 0.036	2.469IleThr: 2.469 ± 0.044	3.236IleVal: 3.236 ± 0.046	0.457IleTrp: 0.457 ± 0.016	0.696IleTyr: 0.696 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.915LysAla: 2.915 ± 0.045	0.116LysCys: 0.116 ± 0.008	1.201LysAsp: 1.201 ± 0.025	1.176LysGlu: 1.176 ± 0.03	0.45LysPhe: 0.45 ± 0.014	1.794LysGly: 1.794 ± 0.041	0.488LysHis: 0.488 ± 0.015	0.975LysIle: 0.975 ± 0.026	0.712LysLys: 0.712 ± 0.024	1.98LysLeu: 1.98 ± 0.04	0.37LysMet: 0.37 ± 0.014	0.478LysAsn: 0.478 ± 0.018	1.49LysPro: 1.49 ± 0.035	0.627LysGln: 0.627 ± 0.018	1.646LysArg: 1.646 ± 0.029	1.231LysSer: 1.231 ± 0.028	1.265LysThr: 1.265 ± 0.028	1.974LysVal: 1.974 ± 0.039	0.241LysTrp: 0.241 ± 0.01	0.424LysTyr: 0.424 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	15.308LeuAla: 15.308 ± 0.114	0.778LeuCys: 0.778 ± 0.019	6.387LeuAsp: 6.387 ± 0.053	4.475LeuGlu: 4.475 ± 0.053	2.685LeuPhe: 2.685 ± 0.041	9.099LeuGly: 9.099 ± 0.082	2.229LeuHis: 2.229 ± 0.035	3.979LeuIle: 3.979 ± 0.058	2.059LeuLys: 2.059 ± 0.038	10.599LeuLeu: 10.599 ± 0.099	1.725LeuMet: 1.725 ± 0.031	1.867LeuAsn: 1.867 ± 0.032	6.517LeuPro: 6.517 ± 0.064	2.051LeuGln: 2.051 ± 0.035	8.85LeuArg: 8.85 ± 0.083	5.879LeuSer: 5.879 ± 0.056	6.546LeuThr: 6.546 ± 0.064	8.551LeuVal: 8.551 ± 0.073	1.314LeuTrp: 1.314 ± 0.026	1.766LeuTyr: 1.766 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.457MetAla: 2.457 ± 0.036	0.146MetCys: 0.146 ± 0.009	0.902MetAsp: 0.902 ± 0.023	0.803MetGlu: 0.803 ± 0.021	0.536MetPhe: 0.536 ± 0.019	1.345MetGly: 1.345 ± 0.022	0.372MetHis: 0.372 ± 0.012	0.786MetIle: 0.786 ± 0.021	0.452MetLys: 0.452 ± 0.016	2.03MetLeu: 2.03 ± 0.039	0.341MetMet: 0.341 ± 0.012	0.458MetAsn: 0.458 ± 0.018	1.254MetPro: 1.254 ± 0.025	0.43MetGln: 0.43 ± 0.016	1.731MetArg: 1.731 ± 0.029	1.443MetSer: 1.443 ± 0.031	1.468MetThr: 1.468 ± 0.029	1.432MetVal: 1.432 ± 0.026	0.235MetTrp: 0.235 ± 0.01	0.305MetTyr: 0.305 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.272AsnAla: 2.272 ± 0.036	0.155AsnCys: 0.155 ± 0.009	0.966AsnAsp: 0.966 ± 0.024	0.837AsnGlu: 0.837 ± 0.021	0.458AsnPhe: 0.458 ± 0.016	1.792AsnGly: 1.792 ± 0.032	0.402AsnHis: 0.402 ± 0.017	0.693AsnIle: 0.693 ± 0.019	0.377AsnLys: 0.377 ± 0.015	1.869AsnLeu: 1.869 ± 0.033	0.31AsnMet: 0.31 ± 0.013	0.391AsnAsn: 0.391 ± 0.015	1.488AsnPro: 1.488 ± 0.033	0.486AsnGln: 0.486 ± 0.016	1.384AsnArg: 1.384 ± 0.027	0.86AsnSer: 0.86 ± 0.022	1.023AsnThr: 1.023 ± 0.025	1.451AsnVal: 1.451 ± 0.028	0.261AsnTrp: 0.261 ± 0.012	0.424AsnTyr: 0.424 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.258ProAla: 8.258 ± 0.094	0.386ProCys: 0.386 ± 0.013	4.286ProAsp: 4.286 ± 0.051	4.105ProGlu: 4.105 ± 0.048	1.582ProPhe: 1.582 ± 0.024	6.706ProGly: 6.706 ± 0.085	1.453ProHis: 1.453 ± 0.033	1.83ProIle: 1.83 ± 0.037	1.302ProLys: 1.302 ± 0.029	5.342ProLeu: 5.342 ± 0.059	1.136ProMet: 1.136 ± 0.022	0.992ProAsn: 0.992 ± 0.022	4.025ProPro: 4.025 ± 0.08	1.588ProGln: 1.588 ± 0.028	4.249ProArg: 4.249 ± 0.049	3.53ProSer: 3.53 ± 0.052	3.344ProThr: 3.344 ± 0.051	5.164ProVal: 5.164 ± 0.059	0.941ProTrp: 0.941 ± 0.021	1.486ProTyr: 1.486 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.805GlnAla: 3.805 ± 0.056	0.174GlnCys: 0.174 ± 0.008	1.147GlnAsp: 1.147 ± 0.023	1.378GlnGlu: 1.378 ± 0.027	0.661GlnPhe: 0.661 ± 0.019	2.221GlnGly: 2.221 ± 0.045	0.559GlnHis: 0.559 ± 0.017	1.243GlnIle: 1.243 ± 0.029	0.506GlnLys: 0.506 ± 0.017	2.41GlnLeu: 2.41 ± 0.042	0.533GlnMet: 0.533 ± 0.019	0.431GlnAsn: 0.431 ± 0.017	1.611GlnPro: 1.611 ± 0.037	0.949GlnGln: 0.949 ± 0.031	2.419GlnArg: 2.419 ± 0.034	1.243GlnSer: 1.243 ± 0.029	1.347GlnThr: 1.347 ± 0.028	2.446GlnVal: 2.446 ± 0.037	0.419GlnTrp: 0.419 ± 0.013	0.468GlnTyr: 0.468 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.706ArgAla: 9.706 ± 0.087	0.663ArgCys: 0.663 ± 0.018	4.69ArgAsp: 4.69 ± 0.054	4.899ArgGlu: 4.899 ± 0.057	2.512ArgPhe: 2.512 ± 0.034	6.189ArgGly: 6.189 ± 0.06	2.274ArgHis: 2.274 ± 0.039	3.216ArgIle: 3.216 ± 0.04	1.75ArgLys: 1.75 ± 0.035	9.45ArgLeu: 9.45 ± 0.072	1.912ArgMet: 1.912 ± 0.034	1.365ArgAsn: 1.365 ± 0.025	5.211ArgPro: 5.211 ± 0.058	2.294ArgGln: 2.294 ± 0.038	8.262ArgArg: 8.262 ± 0.093	4.198ArgSer: 4.198 ± 0.046	4.734ArgThr: 4.734 ± 0.049	6.501ArgVal: 6.501 ± 0.055	1.374ArgTrp: 1.374 ± 0.027	1.826ArgTyr: 1.826 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	7.088SerAla: 7.088 ± 0.068	0.413SerCys: 0.413 ± 0.015	2.713SerAsp: 2.713 ± 0.035	2.641SerGlu: 2.641 ± 0.038	1.517SerPhe: 1.517 ± 0.029	6.075SerGly: 6.075 ± 0.069	1.099SerHis: 1.099 ± 0.025	1.743SerIle: 1.743 ± 0.034	1.053SerLys: 1.053 ± 0.029	5.029SerLeu: 5.029 ± 0.05	1.13SerMet: 1.13 ± 0.024	0.875SerAsn: 0.875 ± 0.019	3.601SerPro: 3.601 ± 0.048	1.251SerGln: 1.251 ± 0.028	4.114SerArg: 4.114 ± 0.044	2.955SerSer: 2.955 ± 0.047	3.024SerThr: 3.024 ± 0.046	4.218SerVal: 4.218 ± 0.043	0.869SerTrp: 0.869 ± 0.021	1.124SerTyr: 1.124 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.188ThrAla: 8.188 ± 0.072	0.479ThrCys: 0.479 ± 0.019	2.98ThrAsp: 2.98 ± 0.044	2.706ThrGlu: 2.706 ± 0.033	1.612ThrPhe: 1.612 ± 0.029	6.126ThrGly: 6.126 ± 0.067	1.239ThrHis: 1.239 ± 0.025	1.964ThrIle: 1.964 ± 0.04	1.071ThrLys: 1.071 ± 0.028	5.729ThrLeu: 5.729 ± 0.057	1.1ThrMet: 1.1 ± 0.024	0.909ThrAsn: 0.909 ± 0.024	4.169ThrPro: 4.169 ± 0.057	1.305ThrGln: 1.305 ± 0.029	4.154ThrArg: 4.154 ± 0.046	3.215ThrSer: 3.215 ± 0.047	3.498ThrThr: 3.498 ± 0.055	5.528ThrVal: 5.528 ± 0.063	0.959ThrTrp: 0.959 ± 0.027	1.294ThrTyr: 1.294 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.143ValAla: 11.143 ± 0.081	0.73ValCys: 0.73 ± 0.018	4.915ValAsp: 4.915 ± 0.055	5.138ValGlu: 5.138 ± 0.063	2.519ValPhe: 2.519 ± 0.04	6.719ValGly: 6.719 ± 0.063	1.884ValHis: 1.884 ± 0.035	3.339ValIle: 3.339 ± 0.044	1.932ValLys: 1.932 ± 0.031	9.109ValLeu: 9.109 ± 0.08	1.539ValMet: 1.539 ± 0.03	1.79ValAsn: 1.79 ± 0.03	5.19ValPro: 5.19 ± 0.057	1.924ValGln: 1.924 ± 0.032	7.034ValArg: 7.034 ± 0.065	4.709ValSer: 4.709 ± 0.058	5.468ValThr: 5.468 ± 0.065	8.079ValVal: 8.079 ± 0.082	1.157ValTrp: 1.157 ± 0.025	1.599ValTyr: 1.599 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.535TrpAla: 1.535 ± 0.032	0.154TrpCys: 0.154 ± 0.007	0.798TrpAsp: 0.798 ± 0.025	0.784TrpGlu: 0.784 ± 0.023	0.483TrpPhe: 0.483 ± 0.014	1.019TrpGly: 1.019 ± 0.025	0.396TrpHis: 0.396 ± 0.016	0.621TrpIle: 0.621 ± 0.018	0.373TrpLys: 0.373 ± 0.014	1.727TrpLeu: 1.727 ± 0.031	0.326TrpMet: 0.326 ± 0.014	0.4TrpAsn: 0.4 ± 0.014	0.878TrpPro: 0.878 ± 0.024	0.489TrpGln: 0.489 ± 0.016	1.463TrpArg: 1.463 ± 0.025	0.941TrpSer: 0.941 ± 0.025	0.885TrpThr: 0.885 ± 0.022	1.032TrpVal: 1.032 ± 0.021	0.35TrpTrp: 0.35 ± 0.015	0.317TrpTyr: 0.317 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.436TyrAla: 2.436 ± 0.033	0.194TyrCys: 0.194 ± 0.01	1.329TyrAsp: 1.329 ± 0.027	1.112TyrGlu: 1.112 ± 0.023	0.617TyrPhe: 0.617 ± 0.017	2.399TyrGly: 2.399 ± 0.047	0.414TyrHis: 0.414 ± 0.016	0.619TyrIle: 0.619 ± 0.019	0.366TyrLys: 0.366 ± 0.012	2.106TyrLeu: 2.106 ± 0.04	0.301TyrMet: 0.301 ± 0.012	0.418TyrAsn: 0.418 ± 0.014	1.105TyrPro: 1.105 ± 0.025	0.582TyrGln: 0.582 ± 0.018	1.817TyrArg: 1.817 ± 0.036	1.01TyrSer: 1.01 ± 0.021	1.193TyrThr: 1.193 ± 0.028	1.636TyrVal: 1.636 ± 0.032	0.338TyrTrp: 0.338 ± 0.013	0.427TyrTyr: 0.427 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 6239 proteins (2028968 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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