Amino acid dipepetide frequency for Coniosporium apollinis (strain CBS 100218) (Rock-inhabiting black yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.694AlaAla: 10.694 ± 0.069	0.994AlaCys: 0.994 ± 0.014	4.709AlaAsp: 4.709 ± 0.039	6.142AlaGlu: 6.142 ± 0.044	3.233AlaPhe: 3.233 ± 0.028	6.496AlaGly: 6.496 ± 0.049	1.883AlaHis: 1.883 ± 0.022	4.088AlaIle: 4.088 ± 0.037	4.273AlaLys: 4.273 ± 0.035	8.304AlaLeu: 8.304 ± 0.047	1.974AlaMet: 1.974 ± 0.023	2.911AlaAsn: 2.911 ± 0.023	5.659AlaPro: 5.659 ± 0.049	3.729AlaGln: 3.729 ± 0.032	5.727AlaArg: 5.727 ± 0.04	7.735AlaSer: 7.735 ± 0.05	5.517AlaThr: 5.517 ± 0.043	5.964AlaVal: 5.964 ± 0.046	1.187AlaTrp: 1.187 ± 0.018	2.266AlaTyr: 2.266 ± 0.021	0.0AlaXaa: 0.0 ± 0.0
Cys	0.913CysAla: 0.913 ± 0.014	0.208CysCys: 0.208 ± 0.007	0.563CysAsp: 0.563 ± 0.012	0.568CysGlu: 0.568 ± 0.012	0.48CysPhe: 0.48 ± 0.011	0.906CysGly: 0.906 ± 0.019	0.295CysHis: 0.295 ± 0.008	0.633CysIle: 0.633 ± 0.012	0.483CysLys: 0.483 ± 0.012	1.095CysLeu: 1.095 ± 0.018	0.253CysMet: 0.253 ± 0.008	0.381CysAsn: 0.381 ± 0.009	0.616CysPro: 0.616 ± 0.014	0.376CysGln: 0.376 ± 0.009	0.697CysArg: 0.697 ± 0.014	0.769CysSer: 0.769 ± 0.014	0.605CysThr: 0.605 ± 0.012	0.757CysVal: 0.757 ± 0.014	0.18CysTrp: 0.18 ± 0.007	0.345CysTyr: 0.345 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.295AspAla: 5.295 ± 0.04	0.594AspCys: 0.594 ± 0.012	4.0AspAsp: 4.0 ± 0.04	4.705AspGlu: 4.705 ± 0.043	2.16AspPhe: 2.16 ± 0.024	4.138AspGly: 4.138 ± 0.035	1.141AspHis: 1.141 ± 0.014	2.747AspIle: 2.747 ± 0.024	2.258AspLys: 2.258 ± 0.028	4.874AspLeu: 4.874 ± 0.032	1.201AspMet: 1.201 ± 0.016	1.677AspAsn: 1.677 ± 0.017	3.398AspPro: 3.398 ± 0.027	1.746AspGln: 1.746 ± 0.021	3.164AspArg: 3.164 ± 0.033	3.848AspSer: 3.848 ± 0.034	2.952AspThr: 2.952 ± 0.027	3.878AspVal: 3.878 ± 0.031	0.886AspTrp: 0.886 ± 0.015	1.546AspTyr: 1.546 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	6.173GluAla: 6.173 ± 0.048	0.577GluCys: 0.577 ± 0.012	4.495GluAsp: 4.495 ± 0.042	6.243GluGlu: 6.243 ± 0.065	1.889GluPhe: 1.889 ± 0.023	4.441GluGly: 4.441 ± 0.037	1.443GluHis: 1.443 ± 0.021	2.864GluIle: 2.864 ± 0.025	3.81GluLys: 3.81 ± 0.039	5.448GluLeu: 5.448 ± 0.041	1.542GluMet: 1.542 ± 0.02	2.074GluAsn: 2.074 ± 0.024	2.982GluPro: 2.982 ± 0.036	2.616GluGln: 2.616 ± 0.028	4.631GluArg: 4.631 ± 0.047	4.052GluSer: 4.052 ± 0.036	3.36GluThr: 3.36 ± 0.03	3.925GluVal: 3.925 ± 0.034	0.904GluTrp: 0.904 ± 0.014	1.621GluTyr: 1.621 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.073PheAla: 3.073 ± 0.032	0.518PheCys: 0.518 ± 0.012	2.165PheAsp: 2.165 ± 0.025	2.138PheGlu: 2.138 ± 0.023	1.518PhePhe: 1.518 ± 0.021	2.819PheGly: 2.819 ± 0.03	0.859PheHis: 0.859 ± 0.015	1.588PheIle: 1.588 ± 0.022	1.426PheLys: 1.426 ± 0.02	3.287PheLeu: 3.287 ± 0.036	0.728PheMet: 0.728 ± 0.013	1.287PheAsn: 1.287 ± 0.02	1.856PhePro: 1.856 ± 0.019	1.234PheGln: 1.234 ± 0.018	1.972PheArg: 1.972 ± 0.021	2.807PheSer: 2.807 ± 0.027	2.032PheThr: 2.032 ± 0.023	2.374PheVal: 2.374 ± 0.025	0.598PheTrp: 0.598 ± 0.014	1.036PheTyr: 1.036 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	6.046GlyAla: 6.046 ± 0.048	0.842GlyCys: 0.842 ± 0.017	3.72GlyAsp: 3.72 ± 0.03	4.102GlyGlu: 4.102 ± 0.034	2.799GlyPhe: 2.799 ± 0.031	6.468GlyGly: 6.468 ± 0.071	1.625GlyHis: 1.625 ± 0.019	3.336GlyIle: 3.336 ± 0.029	3.626GlyLys: 3.626 ± 0.035	6.032GlyLeu: 6.032 ± 0.042	1.779GlyMet: 1.779 ± 0.021	2.331GlyAsn: 2.331 ± 0.027	3.365GlyPro: 3.365 ± 0.033	2.587GlyGln: 2.587 ± 0.032	4.659GlyArg: 4.659 ± 0.035	5.657GlySer: 5.657 ± 0.045	4.034GlyThr: 4.034 ± 0.034	4.596GlyVal: 4.596 ± 0.036	1.224GlyTrp: 1.224 ± 0.018	2.144GlyTyr: 2.144 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.984HisAla: 1.984 ± 0.022	0.299HisCys: 0.299 ± 0.008	1.274HisAsp: 1.274 ± 0.019	1.363HisGlu: 1.363 ± 0.018	0.885HisPhe: 0.885 ± 0.015	1.708HisGly: 1.708 ± 0.021	0.802HisHis: 0.802 ± 0.016	1.113HisIle: 1.113 ± 0.017	0.872HisLys: 0.872 ± 0.013	2.196HisLeu: 2.196 ± 0.024	0.457HisMet: 0.457 ± 0.01	0.783HisAsn: 0.783 ± 0.013	1.684HisPro: 1.684 ± 0.02	0.952HisGln: 0.952 ± 0.014	1.525HisArg: 1.525 ± 0.019	1.755HisSer: 1.755 ± 0.023	1.255HisThr: 1.255 ± 0.018	1.413HisVal: 1.413 ± 0.017	0.327HisTrp: 0.327 ± 0.009	0.666HisTyr: 0.666 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.094IleAla: 4.094 ± 0.031	0.636IleCys: 0.636 ± 0.012	2.598IleAsp: 2.598 ± 0.026	2.797IleGlu: 2.797 ± 0.026	1.723IlePhe: 1.723 ± 0.021	2.962IleGly: 2.962 ± 0.031	1.074IleHis: 1.074 ± 0.017	2.151IleIle: 2.151 ± 0.027	2.022IleLys: 2.022 ± 0.023	4.091IleLeu: 4.091 ± 0.036	0.892IleMet: 0.892 ± 0.016	1.624IleAsn: 1.624 ± 0.019	2.823IlePro: 2.823 ± 0.031	1.712IleGln: 1.712 ± 0.018	2.735IleArg: 2.735 ± 0.025	3.478IleSer: 3.478 ± 0.026	2.706IleThr: 2.706 ± 0.024	2.971IleVal: 2.971 ± 0.025	0.629IleTrp: 0.629 ± 0.013	1.256IleTyr: 1.256 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.523LysAla: 4.523 ± 0.04	0.443LysCys: 0.443 ± 0.011	2.771LysAsp: 2.771 ± 0.029	3.537LysGlu: 3.537 ± 0.036	1.328LysPhe: 1.328 ± 0.02	3.108LysGly: 3.108 ± 0.032	1.127LysHis: 1.127 ± 0.013	2.056LysIle: 2.056 ± 0.026	3.292LysLys: 3.292 ± 0.052	3.946LysLeu: 3.946 ± 0.033	0.997LysMet: 0.997 ± 0.014	1.553LysAsn: 1.553 ± 0.02	2.871LysPro: 2.871 ± 0.031	1.821LysGln: 1.821 ± 0.023	3.73LysArg: 3.73 ± 0.034	3.213LysSer: 3.213 ± 0.032	2.685LysThr: 2.685 ± 0.026	2.749LysVal: 2.749 ± 0.026	0.628LysTrp: 0.628 ± 0.011	1.267LysTyr: 1.267 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	8.112LeuAla: 8.112 ± 0.055	1.123LeuCys: 1.123 ± 0.017	5.077LeuAsp: 5.077 ± 0.03	5.649LeuGlu: 5.649 ± 0.051	3.135LeuPhe: 3.135 ± 0.033	5.929LeuGly: 5.929 ± 0.046	2.194LeuHis: 2.194 ± 0.027	3.575LeuIle: 3.575 ± 0.037	4.126LeuLys: 4.126 ± 0.035	8.291LeuLeu: 8.291 ± 0.068	1.724LeuMet: 1.724 ± 0.021	2.992LeuAsn: 2.992 ± 0.028	5.618LeuPro: 5.618 ± 0.044	3.794LeuGln: 3.794 ± 0.035	6.108LeuArg: 6.108 ± 0.046	7.076LeuSer: 7.076 ± 0.045	4.697LeuThr: 4.697 ± 0.039	5.292LeuVal: 5.292 ± 0.036	1.159LeuTrp: 1.159 ± 0.018	2.296LeuTyr: 2.296 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.217MetAla: 2.217 ± 0.023	0.224MetCys: 0.224 ± 0.007	1.222MetAsp: 1.222 ± 0.017	1.294MetGlu: 1.294 ± 0.016	0.685MetPhe: 0.685 ± 0.014	1.47MetGly: 1.47 ± 0.021	0.473MetHis: 0.473 ± 0.011	0.869MetIle: 0.869 ± 0.014	0.948MetLys: 0.948 ± 0.015	1.827MetLeu: 1.827 ± 0.024	0.519MetMet: 0.519 ± 0.011	0.749MetAsn: 0.749 ± 0.014	1.308MetPro: 1.308 ± 0.022	0.876MetGln: 0.876 ± 0.017	1.347MetArg: 1.347 ± 0.02	1.767MetSer: 1.767 ± 0.022	1.187MetThr: 1.187 ± 0.016	1.237MetVal: 1.237 ± 0.016	0.256MetTrp: 0.256 ± 0.008	0.5MetTyr: 0.5 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.109AsnAla: 3.109 ± 0.027	0.378AsnCys: 0.378 ± 0.011	1.782AsnAsp: 1.782 ± 0.02	1.886AsnGlu: 1.886 ± 0.022	1.246AsnPhe: 1.246 ± 0.017	2.99AsnGly: 2.99 ± 0.03	0.772AsnHis: 0.772 ± 0.013	1.779AsnIle: 1.779 ± 0.022	1.399AsnLys: 1.399 ± 0.019	3.021AsnLeu: 3.021 ± 0.031	0.709AsnMet: 0.709 ± 0.014	1.257AsnAsn: 1.257 ± 0.018	2.351AsnPro: 2.351 ± 0.026	1.194AsnGln: 1.194 ± 0.018	1.909AsnArg: 1.909 ± 0.022	2.369AsnSer: 2.369 ± 0.026	2.044AsnThr: 2.044 ± 0.022	2.165AsnVal: 2.165 ± 0.027	0.51AsnTrp: 0.51 ± 0.011	0.963AsnTyr: 0.963 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	6.116ProAla: 6.116 ± 0.058	0.436ProCys: 0.436 ± 0.01	3.223ProAsp: 3.223 ± 0.028	3.868ProGlu: 3.868 ± 0.041	2.007ProPhe: 2.007 ± 0.023	4.015ProGly: 4.015 ± 0.035	1.419ProHis: 1.419 ± 0.019	2.372ProIle: 2.372 ± 0.023	2.689ProLys: 2.689 ± 0.03	4.914ProLeu: 4.914 ± 0.045	1.049ProMet: 1.049 ± 0.018	2.133ProAsn: 2.133 ± 0.026	6.018ProPro: 6.018 ± 0.085	2.65ProGln: 2.65 ± 0.037	3.67ProArg: 3.67 ± 0.031	6.312ProSer: 6.312 ± 0.056	4.31ProThr: 4.31 ± 0.043	3.616ProVal: 3.616 ± 0.036	0.703ProTrp: 0.703 ± 0.013	1.539ProTyr: 1.539 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.713GlnAla: 3.713 ± 0.034	0.41GlnCys: 0.41 ± 0.01	2.075GlnAsp: 2.075 ± 0.023	2.456GlnGlu: 2.456 ± 0.029	1.136GlnPhe: 1.136 ± 0.019	2.437GlnGly: 2.437 ± 0.027	1.098GlnHis: 1.098 ± 0.017	1.716GlnIle: 1.716 ± 0.022	1.931GlnLys: 1.931 ± 0.026	3.438GlnLeu: 3.438 ± 0.034	0.827GlnMet: 0.827 ± 0.018	1.374GlnAsn: 1.374 ± 0.018	2.748GlnPro: 2.748 ± 0.041	2.574GlnGln: 2.574 ± 0.056	2.854GlnArg: 2.854 ± 0.028	2.992GlnSer: 2.992 ± 0.029	2.233GlnThr: 2.233 ± 0.025	2.048GlnVal: 2.048 ± 0.025	0.536GlnTrp: 0.536 ± 0.011	1.135GlnTyr: 1.135 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.361ArgAla: 5.361 ± 0.037	0.68ArgCys: 0.68 ± 0.014	3.508ArgAsp: 3.508 ± 0.033	4.357ArgGlu: 4.357 ± 0.043	2.171ArgPhe: 2.171 ± 0.027	4.154ArgGly: 4.154 ± 0.038	1.589ArgHis: 1.589 ± 0.019	2.976ArgIle: 2.976 ± 0.026	3.801ArgLys: 3.801 ± 0.03	5.728ArgLeu: 5.728 ± 0.039	1.44ArgMet: 1.44 ± 0.017	2.272ArgAsn: 2.272 ± 0.025	3.829ArgPro: 3.829 ± 0.04	2.794ArgGln: 2.794 ± 0.029	5.775ArgArg: 5.775 ± 0.055	4.965ArgSer: 4.965 ± 0.049	3.601ArgThr: 3.601 ± 0.029	3.516ArgVal: 3.516 ± 0.025	0.967ArgTrp: 0.967 ± 0.018	1.731ArgTyr: 1.731 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	7.358SerAla: 7.358 ± 0.05	0.742SerCys: 0.742 ± 0.015	4.04SerAsp: 4.04 ± 0.033	4.125SerGlu: 4.125 ± 0.036	2.797SerPhe: 2.797 ± 0.031	5.538SerGly: 5.538 ± 0.045	1.81SerHis: 1.81 ± 0.022	3.595SerIle: 3.595 ± 0.028	3.487SerLys: 3.487 ± 0.033	6.827SerLeu: 6.827 ± 0.046	1.579SerMet: 1.579 ± 0.023	2.765SerAsn: 2.765 ± 0.027	5.671SerPro: 5.671 ± 0.063	3.016SerGln: 3.016 ± 0.029	5.003SerArg: 5.003 ± 0.046	8.519SerSer: 8.519 ± 0.073	5.595SerThr: 5.595 ± 0.045	4.444SerVal: 4.444 ± 0.036	0.993SerTrp: 0.993 ± 0.015	1.966SerTyr: 1.966 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	5.868ThrAla: 5.868 ± 0.044	0.649ThrCys: 0.649 ± 0.013	2.805ThrAsp: 2.805 ± 0.025	3.17ThrGlu: 3.17 ± 0.029	2.149ThrPhe: 2.149 ± 0.027	4.082ThrGly: 4.082 ± 0.039	1.28ThrHis: 1.28 ± 0.018	2.813ThrIle: 2.813 ± 0.028	2.483ThrLys: 2.483 ± 0.025	5.17ThrLeu: 5.17 ± 0.039	1.092ThrMet: 1.092 ± 0.015	1.964ThrAsn: 1.964 ± 0.021	4.522ThrPro: 4.522 ± 0.046	2.082ThrGln: 2.082 ± 0.021	3.221ThrArg: 3.221 ± 0.03	5.296ThrSer: 5.296 ± 0.046	4.196ThrThr: 4.196 ± 0.045	3.707ThrVal: 3.707 ± 0.032	0.783ThrTrp: 0.783 ± 0.015	1.529ThrTyr: 1.529 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.466ValAla: 5.466 ± 0.041	0.778ValCys: 0.778 ± 0.014	3.703ValAsp: 3.703 ± 0.032	4.243ValGlu: 4.243 ± 0.032	2.348ValPhe: 2.348 ± 0.026	4.293ValGly: 4.293 ± 0.036	1.371ValHis: 1.371 ± 0.02	2.71ValIle: 2.71 ± 0.024	2.941ValLys: 2.941 ± 0.034	5.602ValLeu: 5.602 ± 0.039	1.275ValMet: 1.275 ± 0.015	2.122ValAsn: 2.122 ± 0.025	3.689ValPro: 3.689 ± 0.036	2.348ValGln: 2.348 ± 0.026	3.814ValArg: 3.814 ± 0.031	4.405ValSer: 4.405 ± 0.036	3.396ValThr: 3.396 ± 0.029	4.459ValVal: 4.459 ± 0.042	0.876ValTrp: 0.876 ± 0.016	1.699ValTyr: 1.699 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.124TrpAla: 1.124 ± 0.017	0.196TrpCys: 0.196 ± 0.007	0.855TrpAsp: 0.855 ± 0.014	0.857TrpGlu: 0.857 ± 0.014	0.494TrpPhe: 0.494 ± 0.012	0.923TrpGly: 0.923 ± 0.015	0.339TrpHis: 0.339 ± 0.009	0.714TrpIle: 0.714 ± 0.011	0.728TrpLys: 0.728 ± 0.012	1.324TrpLeu: 1.324 ± 0.02	0.363TrpMet: 0.363 ± 0.009	0.548TrpAsn: 0.548 ± 0.011	0.572TrpPro: 0.572 ± 0.013	0.571TrpGln: 0.571 ± 0.01	1.037TrpArg: 1.037 ± 0.017	0.975TrpSer: 0.975 ± 0.015	0.862TrpThr: 0.862 ± 0.013	0.847TrpVal: 0.847 ± 0.013	0.268TrpTrp: 0.268 ± 0.008	0.416TrpTyr: 0.416 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.244TyrAla: 2.244 ± 0.025	0.393TyrCys: 0.393 ± 0.009	1.622TyrAsp: 1.622 ± 0.022	1.589TyrGlu: 1.589 ± 0.021	1.133TyrPhe: 1.133 ± 0.017	2.098TyrGly: 2.098 ± 0.027	0.721TyrHis: 0.721 ± 0.013	1.28TyrIle: 1.28 ± 0.018	1.049TyrLys: 1.049 ± 0.016	2.552TyrLeu: 2.552 ± 0.025	0.573TyrMet: 0.573 ± 0.012	1.037TyrAsn: 1.037 ± 0.017	1.478TyrPro: 1.478 ± 0.019	1.058TyrGln: 1.058 ± 0.017	1.637TyrArg: 1.637 ± 0.021	1.882TyrSer: 1.882 ± 0.021	1.594TyrThr: 1.594 ± 0.021	1.582TyrVal: 1.582 ± 0.02	0.402TyrTrp: 0.402 ± 0.009	0.881TyrTyr: 0.881 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9306 proteins (4486276 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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