Amino acid dipepetide frequency for Erwinia tracheiphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.303AlaAla: 9.303 ± 0.121	1.167AlaCys: 1.167 ± 0.031	4.788AlaAsp: 4.788 ± 0.074	5.672AlaGlu: 5.672 ± 0.086	3.286AlaPhe: 3.286 ± 0.056	7.323AlaGly: 7.323 ± 0.11	1.948AlaHis: 1.948 ± 0.048	5.329AlaIle: 5.329 ± 0.075	3.707AlaLys: 3.707 ± 0.064	10.971AlaLeu: 10.971 ± 0.12	2.882AlaMet: 2.882 ± 0.057	2.788AlaAsn: 2.788 ± 0.056	3.229AlaPro: 3.229 ± 0.065	3.83AlaGln: 3.83 ± 0.073	5.523AlaArg: 5.523 ± 0.076	5.648AlaSer: 5.648 ± 0.086	4.627AlaThr: 4.627 ± 0.061	6.577AlaVal: 6.577 ± 0.087	1.463AlaTrp: 1.463 ± 0.042	1.938AlaTyr: 1.938 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.032	0.313CysCys: 0.313 ± 0.018	0.609CysAsp: 0.609 ± 0.023	0.676CysGlu: 0.676 ± 0.026	0.518CysPhe: 0.518 ± 0.023	1.101CysGly: 1.101 ± 0.038	0.323CysHis: 0.323 ± 0.02	0.662CysIle: 0.662 ± 0.029	0.5CysLys: 0.5 ± 0.024	1.084CysLeu: 1.084 ± 0.035	0.249CysMet: 0.249 ± 0.014	0.365CysAsn: 0.365 ± 0.019	0.471CysPro: 0.471 ± 0.025	0.537CysGln: 0.537 ± 0.02	0.731CysArg: 0.731 ± 0.028	0.706CysSer: 0.706 ± 0.033	0.502CysThr: 0.502 ± 0.022	0.746CysVal: 0.746 ± 0.029	0.208CysTrp: 0.208 ± 0.012	0.355CysTyr: 0.355 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.147AspAla: 5.147 ± 0.079	0.539AspCys: 0.539 ± 0.025	3.008AspAsp: 3.008 ± 0.057	3.449AspGlu: 3.449 ± 0.064	2.151AspPhe: 2.151 ± 0.042	3.816AspGly: 3.816 ± 0.069	1.088AspHis: 1.088 ± 0.034	3.589AspIle: 3.589 ± 0.064	2.669AspLys: 2.669 ± 0.057	4.579AspLeu: 4.579 ± 0.066	1.365AspMet: 1.365 ± 0.035	2.314AspAsn: 2.314 ± 0.052	2.037AspPro: 2.037 ± 0.049	1.587AspGln: 1.587 ± 0.038	2.93AspArg: 2.93 ± 0.055	3.133AspSer: 3.133 ± 0.06	2.715AspThr: 2.715 ± 0.057	3.681AspVal: 3.681 ± 0.055	0.869AspTrp: 0.869 ± 0.032	1.804AspTyr: 1.804 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	5.008GluAla: 5.008 ± 0.071	0.513GluCys: 0.513 ± 0.024	2.338GluAsp: 2.338 ± 0.052	3.302GluGlu: 3.302 ± 0.068	1.836GluPhe: 1.836 ± 0.041	3.501GluGly: 3.501 ± 0.052	1.323GluHis: 1.323 ± 0.036	3.481GluIle: 3.481 ± 0.062	3.572GluLys: 3.572 ± 0.066	5.959GluLeu: 5.959 ± 0.087	1.9GluMet: 1.9 ± 0.04	2.609GluAsn: 2.609 ± 0.049	1.868GluPro: 1.868 ± 0.046	3.433GluGln: 3.433 ± 0.073	3.817GluArg: 3.817 ± 0.07	3.138GluSer: 3.138 ± 0.05	2.882GluThr: 2.882 ± 0.055	3.751GluVal: 3.751 ± 0.068	0.783GluTrp: 0.783 ± 0.028	1.422GluTyr: 1.422 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	3.269PheAla: 3.269 ± 0.055	0.58PheCys: 0.58 ± 0.024	2.222PheAsp: 2.222 ± 0.049	1.717PheGlu: 1.717 ± 0.042	1.683PhePhe: 1.683 ± 0.05	2.928PheGly: 2.928 ± 0.061	0.833PheHis: 0.833 ± 0.033	2.528PheIle: 2.528 ± 0.05	1.357PheLys: 1.357 ± 0.041	3.174PheLeu: 3.174 ± 0.062	0.933PheMet: 0.933 ± 0.03	1.745PheAsn: 1.745 ± 0.048	1.569PhePro: 1.569 ± 0.042	1.188PheGln: 1.188 ± 0.032	2.109PheArg: 2.109 ± 0.05	3.35PheSer: 3.35 ± 0.064	2.206PheThr: 2.206 ± 0.047	2.227PheVal: 2.227 ± 0.054	0.63PheTrp: 0.63 ± 0.028	1.403PheTyr: 1.403 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	5.529GlyAla: 5.529 ± 0.091	0.989GlyCys: 0.989 ± 0.03	3.633GlyAsp: 3.633 ± 0.071	4.379GlyGlu: 4.379 ± 0.072	3.064GlyPhe: 3.064 ± 0.061	5.192GlyGly: 5.192 ± 0.102	1.664GlyHis: 1.664 ± 0.047	4.723GlyIle: 4.723 ± 0.075	4.115GlyLys: 4.115 ± 0.07	7.095GlyLeu: 7.095 ± 0.108	2.27GlyMet: 2.27 ± 0.054	2.88GlyAsn: 2.88 ± 0.062	1.9GlyPro: 1.9 ± 0.045	2.931GlyGln: 2.931 ± 0.059	4.183GlyArg: 4.183 ± 0.061	4.34GlySer: 4.34 ± 0.082	3.593GlyThr: 3.593 ± 0.061	5.356GlyVal: 5.356 ± 0.077	1.29GlyTrp: 1.29 ± 0.038	2.564GlyTyr: 2.564 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.775HisAla: 1.775 ± 0.039	0.347HisCys: 0.347 ± 0.018	1.251HisAsp: 1.251 ± 0.034	1.099HisGlu: 1.099 ± 0.035	1.053HisPhe: 1.053 ± 0.037	1.654HisGly: 1.654 ± 0.041	0.849HisHis: 0.849 ± 0.034	1.486HisIle: 1.486 ± 0.035	0.864HisLys: 0.864 ± 0.029	2.344HisLeu: 2.344 ± 0.053	0.553HisMet: 0.553 ± 0.024	0.909HisAsn: 0.909 ± 0.031	1.329HisPro: 1.329 ± 0.04	1.141HisGln: 1.141 ± 0.035	1.432HisArg: 1.432 ± 0.036	1.324HisSer: 1.324 ± 0.037	1.073HisThr: 1.073 ± 0.037	1.401HisVal: 1.401 ± 0.045	0.44HisTrp: 0.44 ± 0.022	0.962HisTyr: 0.962 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.874IleAla: 5.874 ± 0.081	0.797IleCys: 0.797 ± 0.031	3.442IleAsp: 3.442 ± 0.064	3.331IleGlu: 3.331 ± 0.051	2.09IlePhe: 2.09 ± 0.052	4.208IleGly: 4.208 ± 0.079	1.213IleHis: 1.213 ± 0.032	3.444IleIle: 3.444 ± 0.067	2.726IleLys: 2.726 ± 0.056	4.814IleLeu: 4.814 ± 0.071	1.314IleMet: 1.314 ± 0.037	2.79IleAsn: 2.79 ± 0.063	2.54IlePro: 2.54 ± 0.053	1.984IleGln: 1.984 ± 0.044	3.271IleArg: 3.271 ± 0.057	4.34IleSer: 4.34 ± 0.08	3.598IleThr: 3.598 ± 0.062	3.779IleVal: 3.779 ± 0.069	0.715IleTrp: 0.715 ± 0.027	1.563IleTyr: 1.563 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.253LysAla: 4.253 ± 0.078	0.296LysCys: 0.296 ± 0.018	2.161LysAsp: 2.161 ± 0.051	2.658LysGlu: 2.658 ± 0.062	1.319LysPhe: 1.319 ± 0.039	3.132LysGly: 3.132 ± 0.064	0.94LysHis: 0.94 ± 0.029	2.789LysIle: 2.789 ± 0.058	3.146LysLys: 3.146 ± 0.078	4.324LysLeu: 4.324 ± 0.067	1.387LysMet: 1.387 ± 0.038	2.268LysAsn: 2.268 ± 0.061	2.095LysPro: 2.095 ± 0.044	2.057LysGln: 2.057 ± 0.05	2.888LysArg: 2.888 ± 0.057	2.794LysSer: 2.794 ± 0.056	2.955LysThr: 2.955 ± 0.053	3.256LysVal: 3.256 ± 0.057	0.561LysTrp: 0.561 ± 0.022	1.353LysTyr: 1.353 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	10.592LeuAla: 10.592 ± 0.112	1.273LeuCys: 1.273 ± 0.038	5.221LeuAsp: 5.221 ± 0.07	5.156LeuGlu: 5.156 ± 0.086	4.028LeuPhe: 4.028 ± 0.074	6.377LeuGly: 6.377 ± 0.091	2.293LeuHis: 2.293 ± 0.046	5.814LeuIle: 5.814 ± 0.095	5.078LeuLys: 5.078 ± 0.082	11.526LeuLeu: 11.526 ± 0.148	2.882LeuMet: 2.882 ± 0.06	4.788LeuAsn: 4.788 ± 0.076	5.575LeuPro: 5.575 ± 0.088	4.365LeuGln: 4.365 ± 0.072	6.404LeuArg: 6.404 ± 0.096	7.595LeuSer: 7.595 ± 0.081	6.267LeuThr: 6.267 ± 0.077	6.504LeuVal: 6.504 ± 0.099	1.344LeuTrp: 1.344 ± 0.036	2.603LeuTyr: 2.603 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.863MetAla: 2.863 ± 0.052	0.248MetCys: 0.248 ± 0.016	1.326MetAsp: 1.326 ± 0.033	1.278MetGlu: 1.278 ± 0.035	0.825MetPhe: 0.825 ± 0.028	1.699MetGly: 1.699 ± 0.046	0.57MetHis: 0.57 ± 0.024	1.478MetIle: 1.478 ± 0.038	1.508MetLys: 1.508 ± 0.04	3.142MetLeu: 3.142 ± 0.063	0.9MetMet: 0.9 ± 0.037	1.124MetAsn: 1.124 ± 0.03	1.341MetPro: 1.341 ± 0.037	1.176MetGln: 1.176 ± 0.036	1.536MetArg: 1.536 ± 0.036	2.038MetSer: 2.038 ± 0.042	1.787MetThr: 1.787 ± 0.037	1.878MetVal: 1.878 ± 0.045	0.256MetTrp: 0.256 ± 0.016	0.475MetTyr: 0.475 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.671AsnAla: 3.671 ± 0.071	0.362AsnCys: 0.362 ± 0.018	2.12AsnAsp: 2.12 ± 0.051	2.053AsnGlu: 2.053 ± 0.048	1.296AsnPhe: 1.296 ± 0.039	3.179AsnGly: 3.179 ± 0.071	0.885AsnHis: 0.885 ± 0.03	2.573AsnIle: 2.573 ± 0.056	1.826AsnLys: 1.826 ± 0.051	3.891AsnLeu: 3.891 ± 0.073	0.961AsnMet: 0.961 ± 0.028	1.884AsnAsn: 1.884 ± 0.061	2.086AsnPro: 2.086 ± 0.044	1.758AsnGln: 1.758 ± 0.046	2.276AsnArg: 2.276 ± 0.048	2.33AsnSer: 2.33 ± 0.056	2.07AsnThr: 2.07 ± 0.051	2.641AsnVal: 2.641 ± 0.051	0.612AsnTrp: 0.612 ± 0.023	1.164AsnTyr: 1.164 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	4.167ProAla: 4.167 ± 0.071	0.41ProCys: 0.41 ± 0.021	2.943ProAsp: 2.943 ± 0.058	3.384ProGlu: 3.384 ± 0.05	1.716ProPhe: 1.716 ± 0.042	3.683ProGly: 3.683 ± 0.068	1.022ProHis: 1.022 ± 0.03	1.623ProIle: 1.623 ± 0.041	1.453ProLys: 1.453 ± 0.044	4.632ProLeu: 4.632 ± 0.07	1.056ProMet: 1.056 ± 0.033	1.162ProAsn: 1.162 ± 0.03	1.744ProPro: 1.744 ± 0.046	2.162ProGln: 2.162 ± 0.053	2.103ProArg: 2.103 ± 0.051	2.122ProSer: 2.122 ± 0.049	2.029ProThr: 2.029 ± 0.048	3.832ProVal: 3.832 ± 0.073	0.662ProTrp: 0.662 ± 0.023	1.114ProTyr: 1.114 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.436GlnAla: 4.436 ± 0.071	0.388GlnCys: 0.388 ± 0.023	1.962GlnAsp: 1.962 ± 0.046	2.123GlnGlu: 2.123 ± 0.049	1.48GlnPhe: 1.48 ± 0.039	2.885GlnGly: 2.885 ± 0.061	1.349GlnHis: 1.349 ± 0.041	2.402GlnIle: 2.402 ± 0.049	1.869GlnLys: 1.869 ± 0.046	5.072GlnLeu: 5.072 ± 0.083	1.355GlnMet: 1.355 ± 0.034	1.657GlnAsn: 1.657 ± 0.049	2.166GlnPro: 2.166 ± 0.051	3.48GlnGln: 3.48 ± 0.104	3.239GlnArg: 3.239 ± 0.068	2.519GlnSer: 2.519 ± 0.054	2.264GlnThr: 2.264 ± 0.053	2.97GlnVal: 2.97 ± 0.057	0.734GlnTrp: 0.734 ± 0.025	1.207GlnTyr: 1.207 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	4.791ArgAla: 4.791 ± 0.071	0.704ArgCys: 0.704 ± 0.03	3.112ArgAsp: 3.112 ± 0.058	3.755ArgGlu: 3.755 ± 0.071	2.679ArgPhe: 2.679 ± 0.061	3.553ArgGly: 3.553 ± 0.067	1.792ArgHis: 1.792 ± 0.046	3.409ArgIle: 3.409 ± 0.055	2.985ArgLys: 2.985 ± 0.058	6.874ArgLeu: 6.874 ± 0.092	1.647ArgMet: 1.647 ± 0.042	2.304ArgAsn: 2.304 ± 0.053	2.356ArgPro: 2.356 ± 0.05	3.337ArgGln: 3.337 ± 0.063	4.028ArgArg: 4.028 ± 0.082	3.065ArgSer: 3.065 ± 0.062	2.966ArgThr: 2.966 ± 0.06	3.806ArgVal: 3.806 ± 0.061	1.087ArgTrp: 1.087 ± 0.038	2.403ArgTyr: 2.403 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.871SerAla: 5.871 ± 0.084	0.658SerCys: 0.658 ± 0.026	3.433SerAsp: 3.433 ± 0.059	3.653SerGlu: 3.653 ± 0.059	2.319SerPhe: 2.319 ± 0.052	5.537SerGly: 5.537 ± 0.085	1.479SerHis: 1.479 ± 0.041	2.991SerIle: 2.991 ± 0.06	2.661SerLys: 2.661 ± 0.059	6.859SerLeu: 6.859 ± 0.075	1.524SerMet: 1.524 ± 0.041	2.175SerAsn: 2.175 ± 0.052	2.813SerPro: 2.813 ± 0.05	2.789SerGln: 2.789 ± 0.057	3.929SerArg: 3.929 ± 0.066	4.067SerSer: 4.067 ± 0.078	3.182SerThr: 3.182 ± 0.081	4.545SerVal: 4.545 ± 0.073	1.011SerTrp: 1.011 ± 0.032	1.688SerTyr: 1.688 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	4.847ThrAla: 4.847 ± 0.077	0.568ThrCys: 0.568 ± 0.026	3.021ThrAsp: 3.021 ± 0.058	3.013ThrGlu: 3.013 ± 0.061	2.029ThrPhe: 2.029 ± 0.042	4.626ThrGly: 4.626 ± 0.067	1.217ThrHis: 1.217 ± 0.032	2.913ThrIle: 2.913 ± 0.049	1.648ThrLys: 1.648 ± 0.044	6.982ThrLeu: 6.982 ± 0.089	1.148ThrMet: 1.148 ± 0.032	1.602ThrAsn: 1.602 ± 0.037	2.914ThrPro: 2.914 ± 0.052	2.214ThrGln: 2.214 ± 0.05	3.216ThrArg: 3.216 ± 0.053	3.2ThrSer: 3.2 ± 0.07	2.858ThrThr: 2.858 ± 0.074	3.8ThrVal: 3.8 ± 0.054	0.716ThrTrp: 0.716 ± 0.028	1.1ThrTyr: 1.1 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	6.448ValAla: 6.448 ± 0.075	0.758ValCys: 0.758 ± 0.027	3.72ValAsp: 3.72 ± 0.055	3.895ValGlu: 3.895 ± 0.073	2.519ValPhe: 2.519 ± 0.056	4.397ValGly: 4.397 ± 0.072	1.259ValHis: 1.259 ± 0.032	4.452ValIle: 4.452 ± 0.082	3.294ValLys: 3.294 ± 0.065	6.873ValLeu: 6.873 ± 0.088	2.049ValMet: 2.049 ± 0.059	2.764ValAsn: 2.764 ± 0.057	2.859ValPro: 2.859 ± 0.055	2.442ValGln: 2.442 ± 0.054	3.93ValArg: 3.93 ± 0.064	4.83ValSer: 4.83 ± 0.065	4.078ValThr: 4.078 ± 0.067	5.172ValVal: 5.172 ± 0.08	0.917ValTrp: 0.917 ± 0.033	1.769ValTyr: 1.769 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.981TrpAla: 0.981 ± 0.031	0.216TrpCys: 0.216 ± 0.014	0.569TrpAsp: 0.569 ± 0.025	0.584TrpGlu: 0.584 ± 0.024	0.657TrpPhe: 0.657 ± 0.028	0.759TrpGly: 0.759 ± 0.025	0.493TrpHis: 0.493 ± 0.02	0.747TrpIle: 0.747 ± 0.029	0.572TrpLys: 0.572 ± 0.025	2.379TrpLeu: 2.379 ± 0.055	0.399TrpMet: 0.399 ± 0.017	0.498TrpAsn: 0.498 ± 0.023	0.742TrpPro: 0.742 ± 0.027	1.297TrpGln: 1.297 ± 0.04	1.091TrpArg: 1.091 ± 0.039	0.855TrpSer: 0.855 ± 0.03	0.54TrpThr: 0.54 ± 0.021	0.845TrpVal: 0.845 ± 0.03	0.242TrpTrp: 0.242 ± 0.018	0.478TrpTyr: 0.478 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.237TyrAla: 2.237 ± 0.044	0.464TyrCys: 0.464 ± 0.024	1.588TyrAsp: 1.588 ± 0.045	1.26TyrGlu: 1.26 ± 0.035	1.105TyrPhe: 1.105 ± 0.034	2.14TyrGly: 2.14 ± 0.046	0.748TyrHis: 0.748 ± 0.027	1.401TyrIle: 1.401 ± 0.042	1.083TyrLys: 1.083 ± 0.038	3.108TyrLeu: 3.108 ± 0.057	0.672TyrMet: 0.672 ± 0.024	1.01TyrAsn: 1.01 ± 0.032	1.385TyrPro: 1.385 ± 0.043	1.85TyrGln: 1.85 ± 0.046	2.019TyrArg: 2.019 ± 0.049	1.789TyrSer: 1.789 ± 0.045	1.441TyrThr: 1.441 ± 0.04	1.657TyrVal: 1.657 ± 0.04	0.403TyrTrp: 0.403 ± 0.02	0.851TyrTyr: 0.851 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3807 proteins (1026315 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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