Amino acid dipepetide frequency for Defluviimonas aquaemixtae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.185AlaAla: 18.185 ± 0.192	1.099AlaCys: 1.099 ± 0.034	7.109AlaAsp: 7.109 ± 0.078	9.465AlaGlu: 9.465 ± 0.119	4.596AlaPhe: 4.596 ± 0.071	11.306AlaGly: 11.306 ± 0.11	2.359AlaHis: 2.359 ± 0.043	6.045AlaIle: 6.045 ± 0.069	3.865AlaLys: 3.865 ± 0.064	14.03AlaLeu: 14.03 ± 0.144	3.768AlaMet: 3.768 ± 0.051	2.695AlaAsn: 2.695 ± 0.051	6.11AlaPro: 6.11 ± 0.089	3.568AlaGln: 3.568 ± 0.057	9.709AlaArg: 9.709 ± 0.134	5.608AlaSer: 5.608 ± 0.066	6.145AlaThr: 6.145 ± 0.079	8.732AlaVal: 8.732 ± 0.093	1.542AlaTrp: 1.542 ± 0.038	2.554AlaTyr: 2.554 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.09CysAla: 1.09 ± 0.028	0.106CysCys: 0.106 ± 0.009	0.616CysAsp: 0.616 ± 0.022	0.468CysGlu: 0.468 ± 0.02	0.34CysPhe: 0.34 ± 0.015	1.018CysGly: 1.018 ± 0.032	0.285CysHis: 0.285 ± 0.015	0.375CysIle: 0.375 ± 0.02	0.199CysLys: 0.199 ± 0.014	0.909CysLeu: 0.909 ± 0.03	0.167CysMet: 0.167 ± 0.012	0.239CysAsn: 0.239 ± 0.013	0.543CysPro: 0.543 ± 0.023	0.211CysGln: 0.211 ± 0.013	0.64CysArg: 0.64 ± 0.024	0.442CysSer: 0.442 ± 0.018	0.444CysThr: 0.444 ± 0.019	0.62CysVal: 0.62 ± 0.022	0.112CysTrp: 0.112 ± 0.009	0.238CysTyr: 0.238 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.262AspAla: 7.262 ± 0.074	0.6AspCys: 0.6 ± 0.026	3.268AspAsp: 3.268 ± 0.061	3.69AspGlu: 3.69 ± 0.073	2.317AspPhe: 2.317 ± 0.047	5.492AspGly: 5.492 ± 0.075	1.339AspHis: 1.339 ± 0.038	3.075AspIle: 3.075 ± 0.046	1.584AspLys: 1.584 ± 0.044	6.14AspLeu: 6.14 ± 0.08	1.47AspMet: 1.47 ± 0.033	1.215AspAsn: 1.215 ± 0.052	3.907AspPro: 3.907 ± 0.061	1.563AspGln: 1.563 ± 0.039	4.732AspArg: 4.732 ± 0.066	2.049AspSer: 2.049 ± 0.046	2.627AspThr: 2.627 ± 0.059	4.089AspVal: 4.089 ± 0.056	1.233AspTrp: 1.233 ± 0.031	1.582AspTyr: 1.582 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.891GluAla: 8.891 ± 0.109	0.428GluCys: 0.428 ± 0.017	3.375GluAsp: 3.375 ± 0.061	3.833GluGlu: 3.833 ± 0.066	1.961GluPhe: 1.961 ± 0.042	5.299GluGly: 5.299 ± 0.071	1.177GluHis: 1.177 ± 0.032	3.817GluIle: 3.817 ± 0.061	2.151GluLys: 2.151 ± 0.054	5.434GluLeu: 5.434 ± 0.08	1.824GluMet: 1.824 ± 0.042	1.577GluAsn: 1.577 ± 0.038	2.896GluPro: 2.896 ± 0.066	1.631GluGln: 1.631 ± 0.038	4.966GluArg: 4.966 ± 0.073	2.396GluSer: 2.396 ± 0.044	3.839GluThr: 3.839 ± 0.054	4.534GluVal: 4.534 ± 0.073	0.763GluTrp: 0.763 ± 0.028	1.034GluTyr: 1.034 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.848PheAla: 4.848 ± 0.072	0.414PheCys: 0.414 ± 0.016	2.82PheAsp: 2.82 ± 0.049	2.19PheGlu: 2.19 ± 0.046	1.428PhePhe: 1.428 ± 0.036	3.716PheGly: 3.716 ± 0.061	0.745PheHis: 0.745 ± 0.025	1.558PheIle: 1.558 ± 0.033	0.829PheLys: 0.829 ± 0.026	3.483PheLeu: 3.483 ± 0.063	0.751PheMet: 0.751 ± 0.026	0.944PheAsn: 0.944 ± 0.029	1.592PhePro: 1.592 ± 0.037	0.951PheGln: 0.951 ± 0.028	2.448PheArg: 2.448 ± 0.046	2.017PheSer: 2.017 ± 0.041	2.032PheThr: 2.032 ± 0.039	2.846PheVal: 2.846 ± 0.054	0.629PheTrp: 0.629 ± 0.025	0.916PheTyr: 0.916 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.601GlyAla: 10.601 ± 0.11	0.92GlyCys: 0.92 ± 0.032	4.794GlyAsp: 4.794 ± 0.083	5.145GlyGlu: 5.145 ± 0.072	3.688GlyPhe: 3.688 ± 0.054	7.852GlyGly: 7.852 ± 0.12	1.997GlyHis: 1.997 ± 0.038	4.569GlyIle: 4.569 ± 0.064	3.099GlyLys: 3.099 ± 0.065	9.19GlyLeu: 9.19 ± 0.093	2.608GlyMet: 2.608 ± 0.049	2.078GlyAsn: 2.078 ± 0.062	4.005GlyPro: 4.005 ± 0.057	2.892GlyGln: 2.892 ± 0.051	6.663GlyArg: 6.663 ± 0.075	4.226GlySer: 4.226 ± 0.064	4.657GlyThr: 4.657 ± 0.067	6.226GlyVal: 6.226 ± 0.083	1.587GlyTrp: 1.587 ± 0.035	2.282GlyTyr: 2.282 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.444HisAla: 2.444 ± 0.049	0.272HisCys: 0.272 ± 0.015	1.27HisAsp: 1.27 ± 0.032	1.153HisGlu: 1.153 ± 0.029	0.842HisPhe: 0.842 ± 0.025	2.001HisGly: 2.001 ± 0.043	0.569HisHis: 0.569 ± 0.024	0.902HisIle: 0.902 ± 0.027	0.482HisLys: 0.482 ± 0.019	2.1HisLeu: 2.1 ± 0.047	0.52HisMet: 0.52 ± 0.021	0.417HisAsn: 0.417 ± 0.017	1.365HisPro: 1.365 ± 0.036	0.524HisGln: 0.524 ± 0.021	1.49HisArg: 1.49 ± 0.032	0.941HisSer: 0.941 ± 0.031	0.771HisThr: 0.771 ± 0.028	1.643HisVal: 1.643 ± 0.038	0.372HisTrp: 0.372 ± 0.017	0.545HisTyr: 0.545 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.289IleAla: 7.289 ± 0.079	0.581IleCys: 0.581 ± 0.023	3.547IleAsp: 3.547 ± 0.063	3.554IleGlu: 3.554 ± 0.06	1.733IlePhe: 1.733 ± 0.037	4.981IleGly: 4.981 ± 0.071	0.969IleHis: 0.969 ± 0.031	1.946IleIle: 1.946 ± 0.05	1.2IleLys: 1.2 ± 0.032	4.744IleLeu: 4.744 ± 0.067	1.019IleMet: 1.019 ± 0.031	1.19IleAsn: 1.19 ± 0.036	2.251IlePro: 2.251 ± 0.049	1.048IleGln: 1.048 ± 0.028	3.501IleArg: 3.501 ± 0.055	2.665IleSer: 2.665 ± 0.054	2.563IleThr: 2.563 ± 0.05	4.154IleVal: 4.154 ± 0.069	0.718IleTrp: 0.718 ± 0.022	1.154IleTyr: 1.154 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.866LysAla: 3.866 ± 0.061	0.189LysCys: 0.189 ± 0.013	1.697LysAsp: 1.697 ± 0.044	1.581LysGlu: 1.581 ± 0.042	0.858LysPhe: 0.858 ± 0.024	2.78LysGly: 2.78 ± 0.056	0.609LysHis: 0.609 ± 0.023	1.609LysIle: 1.609 ± 0.035	1.207LysLys: 1.207 ± 0.04	2.935LysLeu: 2.935 ± 0.046	0.771LysMet: 0.771 ± 0.025	0.723LysAsn: 0.723 ± 0.028	1.779LysPro: 1.779 ± 0.046	0.768LysGln: 0.768 ± 0.025	2.244LysArg: 2.244 ± 0.047	1.721LysSer: 1.721 ± 0.043	1.792LysThr: 1.792 ± 0.041	2.31LysVal: 2.31 ± 0.049	0.403LysTrp: 0.403 ± 0.017	0.538LysTyr: 0.538 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	13.514LeuAla: 13.514 ± 0.145	0.944LeuCys: 0.944 ± 0.027	5.944LeuAsp: 5.944 ± 0.067	5.118LeuGlu: 5.118 ± 0.064	3.454LeuPhe: 3.454 ± 0.066	8.564LeuGly: 8.564 ± 0.086	1.847LeuHis: 1.847 ± 0.037	5.204LeuIle: 5.204 ± 0.081	3.334LeuLys: 3.334 ± 0.057	8.508LeuLeu: 8.508 ± 0.12	2.511LeuMet: 2.511 ± 0.043	2.547LeuAsn: 2.547 ± 0.046	5.689LeuPro: 5.689 ± 0.084	2.278LeuGln: 2.278 ± 0.043	6.989LeuArg: 6.989 ± 0.094	6.502LeuSer: 6.502 ± 0.081	5.812LeuThr: 5.812 ± 0.079	6.933LeuVal: 6.933 ± 0.084	1.416LeuTrp: 1.416 ± 0.032	1.985LeuTyr: 1.985 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.309MetAla: 3.309 ± 0.049	0.172MetCys: 0.172 ± 0.01	1.237MetAsp: 1.237 ± 0.034	1.401MetGlu: 1.401 ± 0.038	0.75MetPhe: 0.75 ± 0.028	2.149MetGly: 2.149 ± 0.044	0.483MetHis: 0.483 ± 0.02	1.52MetIle: 1.52 ± 0.037	1.035MetLys: 1.035 ± 0.029	2.459MetLeu: 2.459 ± 0.05	0.686MetMet: 0.686 ± 0.024	0.813MetAsn: 0.813 ± 0.024	1.486MetPro: 1.486 ± 0.036	0.818MetGln: 0.818 ± 0.026	1.979MetArg: 1.979 ± 0.044	1.677MetSer: 1.677 ± 0.039	2.019MetThr: 2.019 ± 0.038	1.715MetVal: 1.715 ± 0.037	0.243MetTrp: 0.243 ± 0.014	0.318MetTyr: 0.318 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.939AsnAla: 2.939 ± 0.051	0.267AsnCys: 0.267 ± 0.015	1.316AsnAsp: 1.316 ± 0.045	1.161AsnGlu: 1.161 ± 0.031	0.928AsnPhe: 0.928 ± 0.028	2.355AsnGly: 2.355 ± 0.059	0.496AsnHis: 0.496 ± 0.023	1.22AsnIle: 1.22 ± 0.035	0.566AsnLys: 0.566 ± 0.022	2.373AsnLeu: 2.373 ± 0.043	0.65AsnMet: 0.65 ± 0.025	0.597AsnAsn: 0.597 ± 0.027	1.759AsnPro: 1.759 ± 0.037	0.632AsnGln: 0.632 ± 0.021	1.747AsnArg: 1.747 ± 0.038	1.102AsnSer: 1.102 ± 0.036	1.158AsnThr: 1.158 ± 0.037	1.812AsnVal: 1.812 ± 0.049	0.424AsnTrp: 0.424 ± 0.021	0.623AsnTyr: 0.623 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.26ProAla: 6.26 ± 0.083	0.371ProCys: 0.371 ± 0.015	4.065ProAsp: 4.065 ± 0.063	4.493ProGlu: 4.493 ± 0.083	1.957ProPhe: 1.957 ± 0.04	4.882ProGly: 4.882 ± 0.074	1.049ProHis: 1.049 ± 0.03	2.327ProIle: 2.327 ± 0.047	1.641ProLys: 1.641 ± 0.04	4.471ProLeu: 4.471 ± 0.072	1.341ProMet: 1.341 ± 0.036	1.331ProAsn: 1.331 ± 0.031	2.437ProPro: 2.437 ± 0.063	1.31ProGln: 1.31 ± 0.031	3.031ProArg: 3.031 ± 0.056	2.547ProSer: 2.547 ± 0.051	2.352ProThr: 2.352 ± 0.042	4.438ProVal: 4.438 ± 0.065	0.694ProTrp: 0.694 ± 0.026	1.184ProTyr: 1.184 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.337GlnAla: 3.337 ± 0.056	0.185GlnCys: 0.185 ± 0.013	1.31GlnAsp: 1.31 ± 0.033	1.361GlnGlu: 1.361 ± 0.036	0.969GlnPhe: 0.969 ± 0.028	2.229GlnGly: 2.229 ± 0.045	0.539GlnHis: 0.539 ± 0.019	1.709GlnIle: 1.709 ± 0.038	0.963GlnLys: 0.963 ± 0.029	2.402GlnLeu: 2.402 ± 0.044	0.863GlnMet: 0.863 ± 0.027	0.767GlnAsn: 0.767 ± 0.025	1.459GlnPro: 1.459 ± 0.031	0.772GlnGln: 0.772 ± 0.026	1.946GlnArg: 1.946 ± 0.045	1.636GlnSer: 1.636 ± 0.038	1.454GlnThr: 1.454 ± 0.035	2.04GlnVal: 2.04 ± 0.04	0.349GlnTrp: 0.349 ± 0.015	0.489GlnTyr: 0.489 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.06ArgAla: 9.06 ± 0.116	0.547ArgCys: 0.547 ± 0.023	4.399ArgAsp: 4.399 ± 0.067	4.226ArgGlu: 4.226 ± 0.059	2.919ArgPhe: 2.919 ± 0.056	5.004ArgGly: 5.004 ± 0.068	1.741ArgHis: 1.741 ± 0.042	4.235ArgIle: 4.235 ± 0.059	2.231ArgLys: 2.231 ± 0.047	8.121ArgLeu: 8.121 ± 0.106	2.014ArgMet: 2.014 ± 0.04	1.744ArgAsn: 1.744 ± 0.038	3.742ArgPro: 3.742 ± 0.061	2.197ArgGln: 2.197 ± 0.041	5.987ArgArg: 5.987 ± 0.084	3.494ArgSer: 3.494 ± 0.053	3.257ArgThr: 3.257 ± 0.051	5.033ArgVal: 5.033 ± 0.066	1.041ArgTrp: 1.041 ± 0.029	1.699ArgTyr: 1.699 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.053SerAla: 6.053 ± 0.07	0.452SerCys: 0.452 ± 0.02	3.182SerAsp: 3.182 ± 0.051	3.057SerGlu: 3.057 ± 0.055	2.125SerPhe: 2.125 ± 0.039	5.482SerGly: 5.482 ± 0.077	1.096SerHis: 1.096 ± 0.03	2.351SerIle: 2.351 ± 0.049	1.358SerLys: 1.358 ± 0.031	4.71SerLeu: 4.71 ± 0.067	1.263SerMet: 1.263 ± 0.031	1.218SerAsn: 1.218 ± 0.038	2.53SerPro: 2.53 ± 0.044	1.334SerGln: 1.334 ± 0.038	3.378SerArg: 3.378 ± 0.055	2.373SerSer: 2.373 ± 0.055	2.325SerThr: 2.325 ± 0.044	3.788SerVal: 3.788 ± 0.064	0.684SerTrp: 0.684 ± 0.023	1.228SerTyr: 1.228 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.092ThrAla: 6.092 ± 0.083	0.489ThrCys: 0.489 ± 0.02	3.086ThrAsp: 3.086 ± 0.049	3.225ThrGlu: 3.225 ± 0.056	1.954ThrPhe: 1.954 ± 0.038	5.442ThrGly: 5.442 ± 0.082	1.061ThrHis: 1.061 ± 0.029	2.67ThrIle: 2.67 ± 0.048	1.415ThrLys: 1.415 ± 0.038	5.686ThrLeu: 5.686 ± 0.058	1.18ThrMet: 1.18 ± 0.032	1.234ThrAsn: 1.234 ± 0.039	3.041ThrPro: 3.041 ± 0.051	1.253ThrGln: 1.253 ± 0.029	3.552ThrArg: 3.552 ± 0.055	2.52ThrSer: 2.52 ± 0.041	2.65ThrThr: 2.65 ± 0.055	4.197ThrVal: 4.197 ± 0.066	0.692ThrTrp: 0.692 ± 0.023	1.148ThrTyr: 1.148 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.45ValAla: 9.45 ± 0.1	0.65ValCys: 0.65 ± 0.025	3.852ValAsp: 3.852 ± 0.059	4.659ValGlu: 4.659 ± 0.065	2.868ValPhe: 2.868 ± 0.047	5.407ValGly: 5.407 ± 0.066	1.369ValHis: 1.369 ± 0.034	4.055ValIle: 4.055 ± 0.061	2.226ValLys: 2.226 ± 0.05	7.444ValLeu: 7.444 ± 0.092	2.006ValMet: 2.006 ± 0.044	1.851ValAsn: 1.851 ± 0.039	3.78ValPro: 3.78 ± 0.058	1.855ValGln: 1.855 ± 0.043	4.762ValArg: 4.762 ± 0.067	4.031ValSer: 4.031 ± 0.057	4.848ValThr: 4.848 ± 0.072	5.66ValVal: 5.66 ± 0.07	1.0ValTrp: 1.0 ± 0.031	1.496ValTyr: 1.496 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.461TrpAla: 1.461 ± 0.037	0.146TrpCys: 0.146 ± 0.012	0.764TrpAsp: 0.764 ± 0.026	0.697TrpGlu: 0.697 ± 0.025	0.587TrpPhe: 0.587 ± 0.021	1.048TrpGly: 1.048 ± 0.033	0.377TrpHis: 0.377 ± 0.018	0.751TrpIle: 0.751 ± 0.024	0.489TrpLys: 0.489 ± 0.02	1.722TrpLeu: 1.722 ± 0.041	0.386TrpMet: 0.386 ± 0.019	0.417TrpAsn: 0.417 ± 0.019	0.774TrpPro: 0.774 ± 0.027	0.555TrpGln: 0.555 ± 0.021	1.22TrpArg: 1.22 ± 0.038	0.829TrpSer: 0.829 ± 0.024	0.862TrpThr: 0.862 ± 0.028	0.879TrpVal: 0.879 ± 0.027	0.239TrpTrp: 0.239 ± 0.012	0.282TrpTyr: 0.282 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.541TyrAla: 2.541 ± 0.047	0.231TyrCys: 0.231 ± 0.014	1.586TyrAsp: 1.586 ± 0.039	1.347TyrGlu: 1.347 ± 0.034	0.886TyrPhe: 0.886 ± 0.029	2.071TyrGly: 2.071 ± 0.043	0.515TyrHis: 0.515 ± 0.022	0.867TyrIle: 0.867 ± 0.027	0.508TyrLys: 0.508 ± 0.021	2.231TyrLeu: 2.231 ± 0.047	0.473TyrMet: 0.473 ± 0.019	0.528TyrAsn: 0.528 ± 0.024	1.036TyrPro: 1.036 ± 0.033	0.616TyrGln: 0.616 ± 0.019	1.707TyrArg: 1.707 ± 0.037	1.208TyrSer: 1.208 ± 0.033	0.982TyrThr: 0.982 ± 0.033	1.618TyrVal: 1.618 ± 0.032	0.344TyrTrp: 0.344 ± 0.019	0.585TyrTyr: 0.585 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4129 proteins (1262290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---