Amino acid dipepetide frequency for Micromonospora craterilacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.672AlaAla: 22.672 ± 0.182
0.948AlaCys: 0.948 ± 0.023
8.873AlaAsp: 8.873 ± 0.068
8.497AlaGlu: 8.497 ± 0.082
3.255AlaPhe: 3.255 ± 0.044
14.571AlaGly: 14.571 ± 0.11
2.473AlaHis: 2.473 ± 0.035
4.048AlaIle: 4.048 ± 0.05
2.229AlaLys: 2.229 ± 0.049
14.141AlaLeu: 14.141 ± 0.125
2.396AlaMet: 2.396 ± 0.038
2.329AlaAsn: 2.329 ± 0.038
6.87AlaPro: 6.87 ± 0.065
3.668AlaGln: 3.668 ± 0.051
10.389AlaArg: 10.389 ± 0.079
5.617AlaSer: 5.617 ± 0.06
8.256AlaThr: 8.256 ± 0.08
12.777AlaVal: 12.777 ± 0.097
1.996AlaTrp: 1.996 ± 0.036
2.835AlaTyr: 2.835 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
0.97CysAla: 0.97 ± 0.021
0.102CysCys: 0.102 ± 0.007
0.492CysAsp: 0.492 ± 0.016
0.337CysGlu: 0.337 ± 0.014
0.207CysPhe: 0.207 ± 0.01
0.916CysGly: 0.916 ± 0.024
0.198CysHis: 0.198 ± 0.01
0.152CysIle: 0.152 ± 0.008
0.081CysLys: 0.081 ± 0.007
0.745CysLeu: 0.745 ± 0.02
0.088CysMet: 0.088 ± 0.006
0.144CysAsn: 0.144 ± 0.008
0.497CysPro: 0.497 ± 0.018
0.206CysGln: 0.206 ± 0.01
0.642CysArg: 0.642 ± 0.021
0.362CysSer: 0.362 ± 0.015
0.45CysThr: 0.45 ± 0.016
0.648CysVal: 0.648 ± 0.019
0.133CysTrp: 0.133 ± 0.008
0.175CysTyr: 0.175 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.506AspAla: 7.506 ± 0.062
0.428AspCys: 0.428 ± 0.013
3.71AspAsp: 3.71 ± 0.047
3.671AspGlu: 3.671 ± 0.047
1.487AspPhe: 1.487 ± 0.027
6.492AspGly: 6.492 ± 0.067
1.324AspHis: 1.324 ± 0.029
1.712AspIle: 1.712 ± 0.029
0.882AspLys: 0.882 ± 0.025
6.726AspLeu: 6.726 ± 0.06
0.729AspMet: 0.729 ± 0.019
1.037AspAsn: 1.037 ± 0.023
4.869AspPro: 4.869 ± 0.049
1.808AspGln: 1.808 ± 0.032
5.585AspArg: 5.585 ± 0.053
2.321AspSer: 2.321 ± 0.033
2.921AspThr: 2.921 ± 0.039
4.808AspVal: 4.808 ± 0.047
1.031AspTrp: 1.031 ± 0.022
1.166AspTyr: 1.166 ± 0.023
0.0AspXaa: 0.0 ± 0.0
Glu
6.33GluAla: 6.33 ± 0.066
0.343GluCys: 0.343 ± 0.013
1.987GluAsp: 1.987 ± 0.035
2.423GluGlu: 2.423 ± 0.046
1.452GluPhe: 1.452 ± 0.026
3.076GluGly: 3.076 ± 0.044
1.336GluHis: 1.336 ± 0.024
2.203GluIle: 2.203 ± 0.042
0.958GluLys: 0.958 ± 0.027
6.388GluLeu: 6.388 ± 0.072
0.847GluMet: 0.847 ± 0.024
0.829GluAsn: 0.829 ± 0.021
3.505GluPro: 3.505 ± 0.044
2.279GluGln: 2.279 ± 0.038
4.897GluArg: 4.897 ± 0.065
2.187GluSer: 2.187 ± 0.032
2.457GluThr: 2.457 ± 0.036
4.753GluVal: 4.753 ± 0.05
0.737GluTrp: 0.737 ± 0.019
1.082GluTyr: 1.082 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
3.75PheAla: 3.75 ± 0.047
0.234PheCys: 0.234 ± 0.012
1.987PheAsp: 1.987 ± 0.031
1.202PheGlu: 1.202 ± 0.024
0.85PhePhe: 0.85 ± 0.022
2.943PheGly: 2.943 ± 0.041
0.572PheHis: 0.572 ± 0.016
0.738PheIle: 0.738 ± 0.019
0.422PheLys: 0.422 ± 0.015
2.479PheLeu: 2.479 ± 0.038
0.339PheMet: 0.339 ± 0.013
0.625PheAsn: 0.625 ± 0.02
1.33PhePro: 1.33 ± 0.025
0.639PheGln: 0.639 ± 0.019
1.843PheArg: 1.843 ± 0.03
1.284PheSer: 1.284 ± 0.028
1.926PheThr: 1.926 ± 0.028
2.436PheVal: 2.436 ± 0.038
0.446PheTrp: 0.446 ± 0.017
0.615PheTyr: 0.615 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
10.627GlyAla: 10.627 ± 0.08
0.859GlyCys: 0.859 ± 0.022
5.287GlyAsp: 5.287 ± 0.052
4.665GlyGlu: 4.665 ± 0.052
2.736GlyPhe: 2.736 ± 0.037
8.838GlyGly: 8.838 ± 0.103
2.157GlyHis: 2.157 ± 0.036
3.233GlyIle: 3.233 ± 0.04
1.883GlyLys: 1.883 ± 0.034
9.395GlyLeu: 9.395 ± 0.079
1.852GlyMet: 1.852 ± 0.03
1.96GlyAsn: 1.96 ± 0.042
5.277GlyPro: 5.277 ± 0.056
2.99GlyGln: 2.99 ± 0.046
8.191GlyArg: 8.191 ± 0.075
4.835GlySer: 4.835 ± 0.054
5.95GlyThr: 5.95 ± 0.064
8.006GlyVal: 8.006 ± 0.065
1.983GlyTrp: 1.983 ± 0.037
2.481GlyTyr: 2.481 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
2.491HisAla: 2.491 ± 0.034
0.182HisCys: 0.182 ± 0.009
1.342HisAsp: 1.342 ± 0.027
1.044HisGlu: 1.044 ± 0.024
0.555HisPhe: 0.555 ± 0.017
2.188HisGly: 2.188 ± 0.036
0.662HisHis: 0.662 ± 0.018
0.58HisIle: 0.58 ± 0.016
0.254HisLys: 0.254 ± 0.012
2.521HisLeu: 2.521 ± 0.04
0.279HisMet: 0.279 ± 0.01
0.379HisAsn: 0.379 ± 0.014
1.679HisPro: 1.679 ± 0.035
0.661HisGln: 0.661 ± 0.018
2.229HisArg: 2.229 ± 0.038
0.874HisSer: 0.874 ± 0.018
1.154HisThr: 1.154 ± 0.023
1.636HisVal: 1.636 ± 0.033
0.354HisTrp: 0.354 ± 0.012
0.468HisTyr: 0.468 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.821IleAla: 4.821 ± 0.051
0.28IleCys: 0.28 ± 0.012
2.401IleAsp: 2.401 ± 0.038
1.973IleGlu: 1.973 ± 0.037
0.89IlePhe: 0.89 ± 0.021
3.608IleGly: 3.608 ± 0.044
0.568IleHis: 0.568 ± 0.016
0.968IleIle: 0.968 ± 0.024
0.635IleLys: 0.635 ± 0.018
2.5IleLeu: 2.5 ± 0.038
0.445IleMet: 0.445 ± 0.014
0.787IleAsn: 0.787 ± 0.019
1.681IlePro: 1.681 ± 0.031
0.752IleGln: 0.752 ± 0.023
2.541IleArg: 2.541 ± 0.041
1.701IleSer: 1.701 ± 0.031
2.178IleThr: 2.178 ± 0.034
2.867IleVal: 2.867 ± 0.043
0.451IleTrp: 0.451 ± 0.013
0.606IleTyr: 0.606 ± 0.016
0.0IleXaa: 0.0 ± 0.0
Lys
2.062LysAla: 2.062 ± 0.042
0.097LysCys: 0.097 ± 0.007
0.786LysAsp: 0.786 ± 0.022
0.739LysGlu: 0.739 ± 0.023
0.38LysPhe: 0.38 ± 0.017
1.211LysGly: 1.211 ± 0.031
0.323LysHis: 0.323 ± 0.014
0.761LysIle: 0.761 ± 0.019
0.5LysLys: 0.5 ± 0.024
1.759LysLeu: 1.759 ± 0.033
0.289LysMet: 0.289 ± 0.013
0.384LysAsn: 0.384 ± 0.017
1.085LysPro: 1.085 ± 0.027
0.607LysGln: 0.607 ± 0.021
1.228LysArg: 1.228 ± 0.029
0.852LysSer: 0.852 ± 0.022
1.017LysThr: 1.017 ± 0.024
1.535LysVal: 1.535 ± 0.033
0.222LysTrp: 0.222 ± 0.01
0.363LysTyr: 0.363 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
16.907LeuAla: 16.907 ± 0.133
0.758LeuCys: 0.758 ± 0.021
6.885LeuAsp: 6.885 ± 0.069
3.684LeuGlu: 3.684 ± 0.052
2.605LeuPhe: 2.605 ± 0.037
9.161LeuGly: 9.161 ± 0.078
2.293LeuHis: 2.293 ± 0.041
3.317LeuIle: 3.317 ± 0.045
1.373LeuLys: 1.373 ± 0.029
11.895LeuLeu: 11.895 ± 0.116
1.378LeuMet: 1.378 ± 0.026
1.733LeuAsn: 1.733 ± 0.03
6.749LeuPro: 6.749 ± 0.074
1.946LeuGln: 1.946 ± 0.027
9.352LeuArg: 9.352 ± 0.081
4.916LeuSer: 4.916 ± 0.049
7.123LeuThr: 7.123 ± 0.065
9.995LeuVal: 9.995 ± 0.086
1.342LeuTrp: 1.342 ± 0.026
1.704LeuTyr: 1.704 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
2.164MetAla: 2.164 ± 0.032
0.115MetCys: 0.115 ± 0.008
0.723MetAsp: 0.723 ± 0.018
0.584MetGlu: 0.584 ± 0.018
0.451MetPhe: 0.451 ± 0.015
1.072MetGly: 1.072 ± 0.023
0.303MetHis: 0.303 ± 0.012
0.68MetIle: 0.68 ± 0.017
0.318MetLys: 0.318 ± 0.011
1.761MetLeu: 1.761 ± 0.03
0.28MetMet: 0.28 ± 0.012
0.362MetAsn: 0.362 ± 0.012
1.091MetPro: 1.091 ± 0.024
0.423MetGln: 0.423 ± 0.016
1.377MetArg: 1.377 ± 0.03
1.202MetSer: 1.202 ± 0.024
1.501MetThr: 1.501 ± 0.027
1.339MetVal: 1.339 ± 0.023
0.217MetTrp: 0.217 ± 0.011
0.289MetTyr: 0.289 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.261AsnAla: 2.261 ± 0.036
0.166AsnCys: 0.166 ± 0.01
1.005AsnAsp: 1.005 ± 0.023
0.823AsnGlu: 0.823 ± 0.022
0.56AsnPhe: 0.56 ± 0.016
2.05AsnGly: 2.05 ± 0.043
0.402AsnHis: 0.402 ± 0.014
0.626AsnIle: 0.626 ± 0.019
0.342AsnLys: 0.342 ± 0.013
1.998AsnLeu: 1.998 ± 0.033
0.297AsnMet: 0.297 ± 0.013
0.575AsnAsn: 0.575 ± 0.021
1.546AsnPro: 1.546 ± 0.031
0.652AsnGln: 0.652 ± 0.019
1.434AsnArg: 1.434 ± 0.031
0.966AsnSer: 0.966 ± 0.025
1.143AsnThr: 1.143 ± 0.031
1.479AsnVal: 1.479 ± 0.032
0.346AsnTrp: 0.346 ± 0.015
0.477AsnTyr: 0.477 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
9.796ProAla: 9.796 ± 0.081
0.328ProCys: 0.328 ± 0.013
4.714ProAsp: 4.714 ± 0.052
3.74ProGlu: 3.74 ± 0.047
1.416ProPhe: 1.416 ± 0.028
6.543ProGly: 6.543 ± 0.062
1.246ProHis: 1.246 ± 0.028
1.67ProIle: 1.67 ± 0.033
0.961ProLys: 0.961 ± 0.025
5.221ProLeu: 5.221 ± 0.052
1.03ProMet: 1.03 ± 0.02
1.114ProAsn: 1.114 ± 0.023
4.259ProPro: 4.259 ± 0.072
1.712ProGln: 1.712 ± 0.03
3.941ProArg: 3.941 ± 0.05
2.951ProSer: 2.951 ± 0.039
4.07ProThr: 4.07 ± 0.06
5.919ProVal: 5.919 ± 0.066
0.974ProTrp: 0.974 ± 0.02
1.312ProTyr: 1.312 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.743GlnAla: 3.743 ± 0.047
0.165GlnCys: 0.165 ± 0.009
1.101GlnAsp: 1.101 ± 0.024
1.177GlnGlu: 1.177 ± 0.026
0.808GlnPhe: 0.808 ± 0.018
1.964GlnGly: 1.964 ± 0.035
0.703GlnHis: 0.703 ± 0.019
1.139GlnIle: 1.139 ± 0.026
0.422GlnLys: 0.422 ± 0.016
3.546GlnLeu: 3.546 ± 0.039
0.473GlnMet: 0.473 ± 0.017
0.52GlnAsn: 0.52 ± 0.016
2.082GlnPro: 2.082 ± 0.04
1.253GlnGln: 1.253 ± 0.028
2.851GlnArg: 2.851 ± 0.044
1.222GlnSer: 1.222 ± 0.026
1.46GlnThr: 1.46 ± 0.027
2.966GlnVal: 2.966 ± 0.039
0.525GlnTrp: 0.525 ± 0.018
0.545GlnTyr: 0.545 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
10.202ArgAla: 10.202 ± 0.084
0.65ArgCys: 0.65 ± 0.018
4.651ArgAsp: 4.651 ± 0.053
4.189ArgGlu: 4.189 ± 0.054
2.458ArgPhe: 2.458 ± 0.036
5.723ArgGly: 5.723 ± 0.059
2.256ArgHis: 2.256 ± 0.037
3.218ArgIle: 3.218 ± 0.042
1.287ArgLys: 1.287 ± 0.03
9.636ArgLeu: 9.636 ± 0.096
1.88ArgMet: 1.88 ± 0.028
1.504ArgAsn: 1.504 ± 0.028
5.492ArgPro: 5.492 ± 0.057
2.947ArgGln: 2.947 ± 0.043
8.863ArgArg: 8.863 ± 0.104
4.057ArgSer: 4.057 ± 0.047
4.933ArgThr: 4.933 ± 0.053
6.474ArgVal: 6.474 ± 0.056
1.755ArgTrp: 1.755 ± 0.03
2.079ArgTyr: 2.079 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.243SerAla: 6.243 ± 0.056
0.387SerCys: 0.387 ± 0.014
2.378SerAsp: 2.378 ± 0.033
1.938SerGlu: 1.938 ± 0.038
1.414SerPhe: 1.414 ± 0.028
5.388SerGly: 5.388 ± 0.066
0.898SerHis: 0.898 ± 0.02
1.585SerIle: 1.585 ± 0.029
0.756SerLys: 0.756 ± 0.021
4.218SerLeu: 4.218 ± 0.048
0.962SerMet: 0.962 ± 0.024
0.944SerAsn: 0.944 ± 0.026
3.096SerPro: 3.096 ± 0.041
1.212SerGln: 1.212 ± 0.027
3.755SerArg: 3.755 ± 0.044
2.436SerSer: 2.436 ± 0.042
3.158SerThr: 3.158 ± 0.048
4.076SerVal: 4.076 ± 0.045
0.983SerTrp: 0.983 ± 0.024
1.234SerTyr: 1.234 ± 0.029
0.0SerXaa: 0.0 ± 0.0
Thr
8.82ThrAla: 8.82 ± 0.077
0.437ThrCys: 0.437 ± 0.014
3.71ThrAsp: 3.71 ± 0.044
3.028ThrGlu: 3.028 ± 0.043
1.66ThrPhe: 1.66 ± 0.027
6.709ThrGly: 6.709 ± 0.061
1.065ThrHis: 1.065 ± 0.023
2.048ThrIle: 2.048 ± 0.032
0.938ThrLys: 0.938 ± 0.026
5.903ThrLeu: 5.903 ± 0.059
1.016ThrMet: 1.016 ± 0.025
1.219ThrAsn: 1.219 ± 0.03
4.205ThrPro: 4.205 ± 0.048
1.331ThrGln: 1.331 ± 0.031
4.174ThrArg: 4.174 ± 0.042
3.037ThrSer: 3.037 ± 0.041
3.895ThrThr: 3.895 ± 0.05
6.501ThrVal: 6.501 ± 0.059
1.003ThrTrp: 1.003 ± 0.023
1.335ThrTyr: 1.335 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
12.841ValAla: 12.841 ± 0.107
0.708ValCys: 0.708 ± 0.019
5.937ValAsp: 5.937 ± 0.055
4.687ValGlu: 4.687 ± 0.063
2.305ValPhe: 2.305 ± 0.04
7.581ValGly: 7.581 ± 0.068
1.818ValHis: 1.818 ± 0.029
2.971ValIle: 2.971 ± 0.046
1.391ValLys: 1.391 ± 0.027
9.811ValLeu: 9.811 ± 0.084
1.193ValMet: 1.193 ± 0.029
1.844ValAsn: 1.844 ± 0.034
5.4ValPro: 5.4 ± 0.054
2.115ValGln: 2.115 ± 0.032
7.26ValArg: 7.26 ± 0.061
4.267ValSer: 4.267 ± 0.048
6.224ValThr: 6.224 ± 0.07
8.891ValVal: 8.891 ± 0.078
1.161ValTrp: 1.161 ± 0.024
1.563ValTyr: 1.563 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.755TrpAla: 1.755 ± 0.036
0.171TrpCys: 0.171 ± 0.008
0.802TrpAsp: 0.802 ± 0.021
0.64TrpGlu: 0.64 ± 0.019
0.523TrpPhe: 0.523 ± 0.016
1.009TrpGly: 1.009 ± 0.023
0.428TrpHis: 0.428 ± 0.015
0.578TrpIle: 0.578 ± 0.018
0.276TrpLys: 0.276 ± 0.012
2.091TrpLeu: 2.091 ± 0.04
0.293TrpMet: 0.293 ± 0.013
0.429TrpAsn: 0.429 ± 0.017
0.966TrpPro: 0.966 ± 0.024
0.72TrpGln: 0.72 ± 0.019
1.688TrpArg: 1.688 ± 0.033
1.06TrpSer: 1.06 ± 0.025
1.046TrpThr: 1.046 ± 0.025
1.152TrpVal: 1.152 ± 0.024
0.442TrpTrp: 0.442 ± 0.016
0.411TrpTyr: 0.411 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.879TyrAla: 2.879 ± 0.038
0.186TyrCys: 0.186 ± 0.011
1.441TyrAsp: 1.441 ± 0.03
1.03TyrGlu: 1.03 ± 0.024
0.649TyrPhe: 0.649 ± 0.019
2.158TyrGly: 2.158 ± 0.038
0.505TyrHis: 0.505 ± 0.016
0.425TyrIle: 0.425 ± 0.013
0.292TyrLys: 0.292 ± 0.013
2.384TyrLeu: 2.384 ± 0.034
0.185TyrMet: 0.185 ± 0.01
0.432TyrAsn: 0.432 ± 0.018
1.241TyrPro: 1.241 ± 0.024
0.742TyrGln: 0.742 ± 0.022
2.015TyrArg: 2.015 ± 0.034
0.915TyrSer: 0.915 ± 0.022
1.171TyrThr: 1.171 ± 0.029
1.711TyrVal: 1.711 ± 0.029
0.379TyrTrp: 0.379 ± 0.015
0.45TyrTyr: 0.45 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6519 proteins (2067831 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski