Amino acid dipepetide frequency for Citricoccus sp. SGAir0253

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.735AlaAla: 22.735 ± 0.278
0.859AlaCys: 0.859 ± 0.03
7.622AlaAsp: 7.622 ± 0.091
9.403AlaGlu: 9.403 ± 0.128
3.372AlaPhe: 3.372 ± 0.065
16.375AlaGly: 16.375 ± 0.187
2.644AlaHis: 2.644 ± 0.055
3.972AlaIle: 3.972 ± 0.076
2.093AlaLys: 2.093 ± 0.061
13.856AlaLeu: 13.856 ± 0.167
2.718AlaMet: 2.718 ± 0.05
1.989AlaAsn: 1.989 ± 0.045
8.005AlaPro: 8.005 ± 0.113
3.646AlaGln: 3.646 ± 0.073
10.378AlaArg: 10.378 ± 0.138
6.207AlaSer: 6.207 ± 0.084
7.433AlaThr: 7.433 ± 0.108
12.56AlaVal: 12.56 ± 0.134
2.052AlaTrp: 2.052 ± 0.049
2.257AlaTyr: 2.257 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.789CysAla: 0.789 ± 0.031
0.062CysCys: 0.062 ± 0.009
0.283CysAsp: 0.283 ± 0.018
0.265CysGlu: 0.265 ± 0.018
0.185CysPhe: 0.185 ± 0.014
0.712CysGly: 0.712 ± 0.027
0.161CysHis: 0.161 ± 0.014
0.217CysIle: 0.217 ± 0.017
0.062CysLys: 0.062 ± 0.007
0.557CysLeu: 0.557 ± 0.024
0.099CysMet: 0.099 ± 0.009
0.101CysAsn: 0.101 ± 0.011
0.375CysPro: 0.375 ± 0.02
0.161CysGln: 0.161 ± 0.013
0.487CysArg: 0.487 ± 0.022
0.317CysSer: 0.317 ± 0.018
0.403CysThr: 0.403 ± 0.02
0.488CysVal: 0.488 ± 0.024
0.092CysTrp: 0.092 ± 0.01
0.128CysTyr: 0.128 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.732AspAla: 7.732 ± 0.1
0.306AspCys: 0.306 ± 0.016
2.92AspAsp: 2.92 ± 0.068
3.717AspGlu: 3.717 ± 0.076
1.565AspPhe: 1.565 ± 0.045
6.152AspGly: 6.152 ± 0.084
1.454AspHis: 1.454 ± 0.039
1.713AspIle: 1.713 ± 0.044
0.834AspLys: 0.834 ± 0.035
6.305AspLeu: 6.305 ± 0.096
0.862AspMet: 0.862 ± 0.029
0.781AspAsn: 0.781 ± 0.032
4.998AspPro: 4.998 ± 0.081
1.564AspGln: 1.564 ± 0.046
5.154AspArg: 5.154 ± 0.078
2.213AspSer: 2.213 ± 0.048
2.871AspThr: 2.871 ± 0.054
4.989AspVal: 4.989 ± 0.07
1.054AspTrp: 1.054 ± 0.035
1.234AspTyr: 1.234 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
8.57GluAla: 8.57 ± 0.107
0.306GluCys: 0.306 ± 0.017
4.118GluAsp: 4.118 ± 0.067
3.882GluGlu: 3.882 ± 0.066
1.523GluPhe: 1.523 ± 0.039
4.842GluGly: 4.842 ± 0.072
1.735GluHis: 1.735 ± 0.045
2.054GluIle: 2.054 ± 0.051
1.118GluLys: 1.118 ± 0.043
6.241GluLeu: 6.241 ± 0.081
0.976GluMet: 0.976 ± 0.031
1.039GluAsn: 1.039 ± 0.034
3.198GluPro: 3.198 ± 0.064
2.341GluGln: 2.341 ± 0.052
5.39GluArg: 5.39 ± 0.091
2.624GluSer: 2.624 ± 0.052
2.876GluThr: 2.876 ± 0.057
4.919GluVal: 4.919 ± 0.079
0.856GluTrp: 0.856 ± 0.028
1.186GluTyr: 1.186 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.492PheAla: 3.492 ± 0.067
0.207PheCys: 0.207 ± 0.015
1.704PheAsp: 1.704 ± 0.044
1.566PheGlu: 1.566 ± 0.042
0.897PhePhe: 0.897 ± 0.034
3.039PheGly: 3.039 ± 0.065
0.628PheHis: 0.628 ± 0.026
0.948PheIle: 0.948 ± 0.037
0.388PheLys: 0.388 ± 0.018
2.72PheLeu: 2.72 ± 0.062
0.485PheMet: 0.485 ± 0.024
0.592PheAsn: 0.592 ± 0.027
1.341PhePro: 1.341 ± 0.037
0.677PheGln: 0.677 ± 0.025
1.846PheArg: 1.846 ± 0.045
1.561PheSer: 1.561 ± 0.042
2.005PheThr: 2.005 ± 0.051
2.266PheVal: 2.266 ± 0.056
0.429PheTrp: 0.429 ± 0.026
0.594PheTyr: 0.594 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
12.474GlyAla: 12.474 ± 0.148
0.62GlyCys: 0.62 ± 0.027
4.83GlyAsp: 4.83 ± 0.077
5.285GlyGlu: 5.285 ± 0.069
2.935GlyPhe: 2.935 ± 0.057
9.023GlyGly: 9.023 ± 0.126
2.475GlyHis: 2.475 ± 0.056
3.94GlyIle: 3.94 ± 0.071
1.766GlyLys: 1.766 ± 0.049
10.046GlyLeu: 10.046 ± 0.126
2.192GlyMet: 2.192 ± 0.048
1.639GlyAsn: 1.639 ± 0.042
6.26GlyPro: 6.26 ± 0.101
2.943GlyGln: 2.943 ± 0.052
8.467GlyArg: 8.467 ± 0.116
5.332GlySer: 5.332 ± 0.089
7.177GlyThr: 7.177 ± 0.098
7.58GlyVal: 7.58 ± 0.1
1.799GlyTrp: 1.799 ± 0.048
2.247GlyTyr: 2.247 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.779HisAla: 2.779 ± 0.063
0.16HisCys: 0.16 ± 0.014
1.226HisAsp: 1.226 ± 0.039
1.295HisGlu: 1.295 ± 0.039
0.579HisPhe: 0.579 ± 0.024
2.481HisGly: 2.481 ± 0.061
0.752HisHis: 0.752 ± 0.034
0.505HisIle: 0.505 ± 0.022
0.268HisLys: 0.268 ± 0.018
2.418HisLeu: 2.418 ± 0.051
0.302HisMet: 0.302 ± 0.017
0.337HisAsn: 0.337 ± 0.017
1.865HisPro: 1.865 ± 0.046
0.652HisGln: 0.652 ± 0.028
2.21HisArg: 2.21 ± 0.051
0.911HisSer: 0.911 ± 0.032
1.031HisThr: 1.031 ± 0.033
1.973HisVal: 1.973 ± 0.046
0.372HisTrp: 0.372 ± 0.02
0.443HisTyr: 0.443 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
4.706IleAla: 4.706 ± 0.078
0.211IleCys: 0.211 ± 0.013
2.123IleAsp: 2.123 ± 0.053
1.954IleGlu: 1.954 ± 0.054
0.767IlePhe: 0.767 ± 0.03
3.504IleGly: 3.504 ± 0.066
0.668IleHis: 0.668 ± 0.026
1.208IleIle: 1.208 ± 0.035
0.635IleLys: 0.635 ± 0.028
2.816IleLeu: 2.816 ± 0.061
0.572IleMet: 0.572 ± 0.029
0.724IleAsn: 0.724 ± 0.027
1.938IlePro: 1.938 ± 0.047
0.805IleGln: 0.805 ± 0.036
2.196IleArg: 2.196 ± 0.047
1.645IleSer: 1.645 ± 0.044
2.35IleThr: 2.35 ± 0.048
2.99IleVal: 2.99 ± 0.057
0.336IleTrp: 0.336 ± 0.017
0.548IleTyr: 0.548 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
2.174LysAla: 2.174 ± 0.062
0.074LysCys: 0.074 ± 0.008
1.141LysAsp: 1.141 ± 0.04
0.879LysGlu: 0.879 ± 0.033
0.364LysPhe: 0.364 ± 0.022
1.379LysGly: 1.379 ± 0.047
0.345LysHis: 0.345 ± 0.019
0.65LysIle: 0.65 ± 0.031
0.516LysLys: 0.516 ± 0.027
1.32LysLeu: 1.32 ± 0.041
0.36LysMet: 0.36 ± 0.02
0.388LysAsn: 0.388 ± 0.025
0.859LysPro: 0.859 ± 0.035
0.439LysGln: 0.439 ± 0.022
1.148LysArg: 1.148 ± 0.039
0.861LysSer: 0.861 ± 0.033
1.04LysThr: 1.04 ± 0.034
1.565LysVal: 1.565 ± 0.047
0.167LysTrp: 0.167 ± 0.014
0.379LysTyr: 0.379 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
15.782LeuAla: 15.782 ± 0.163
0.61LeuCys: 0.61 ± 0.026
6.602LeuAsp: 6.602 ± 0.086
6.12LeuGlu: 6.12 ± 0.08
2.613LeuPhe: 2.613 ± 0.065
9.624LeuGly: 9.624 ± 0.105
2.092LeuHis: 2.092 ± 0.045
2.754LeuIle: 2.754 ± 0.069
1.599LeuLys: 1.599 ± 0.048
10.133LeuLeu: 10.133 ± 0.16
1.802LeuMet: 1.802 ± 0.043
1.737LeuAsn: 1.737 ± 0.044
5.984LeuPro: 5.984 ± 0.083
2.593LeuGln: 2.593 ± 0.05
7.52LeuArg: 7.52 ± 0.099
5.207LeuSer: 5.207 ± 0.075
5.69LeuThr: 5.69 ± 0.083
9.8LeuVal: 9.8 ± 0.123
1.247LeuTrp: 1.247 ± 0.041
1.618LeuTyr: 1.618 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.559MetAla: 2.559 ± 0.055
0.101MetCys: 0.101 ± 0.01
1.158MetAsp: 1.158 ± 0.035
0.936MetGlu: 0.936 ± 0.033
0.51MetPhe: 0.51 ± 0.025
1.539MetGly: 1.539 ± 0.038
0.356MetHis: 0.356 ± 0.021
0.717MetIle: 0.717 ± 0.026
0.374MetLys: 0.374 ± 0.018
1.769MetLeu: 1.769 ± 0.046
0.385MetMet: 0.385 ± 0.02
0.412MetAsn: 0.412 ± 0.02
1.092MetPro: 1.092 ± 0.037
0.445MetGln: 0.445 ± 0.023
1.263MetArg: 1.263 ± 0.038
1.32MetSer: 1.32 ± 0.034
1.704MetThr: 1.704 ± 0.044
1.685MetVal: 1.685 ± 0.04
0.193MetTrp: 0.193 ± 0.014
0.286MetTyr: 0.286 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.191AsnAla: 2.191 ± 0.053
0.126AsnCys: 0.126 ± 0.01
0.907AsnAsp: 0.907 ± 0.029
0.815AsnGlu: 0.815 ± 0.027
0.482AsnPhe: 0.482 ± 0.022
1.612AsnGly: 1.612 ± 0.044
0.39AsnHis: 0.39 ± 0.019
0.689AsnIle: 0.689 ± 0.028
0.293AsnLys: 0.293 ± 0.018
1.745AsnLeu: 1.745 ± 0.052
0.31AsnMet: 0.31 ± 0.019
0.408AsnAsn: 0.408 ± 0.023
1.341AsnPro: 1.341 ± 0.041
0.514AsnGln: 0.514 ± 0.024
1.3AsnArg: 1.3 ± 0.036
0.728AsnSer: 0.728 ± 0.032
1.072AsnThr: 1.072 ± 0.038
1.424AsnVal: 1.424 ± 0.036
0.28AsnTrp: 0.28 ± 0.016
0.379AsnTyr: 0.379 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
10.11ProAla: 10.11 ± 0.148
0.243ProCys: 0.243 ± 0.014
4.4ProAsp: 4.4 ± 0.073
4.785ProGlu: 4.785 ± 0.076
1.612ProPhe: 1.612 ± 0.04
7.644ProGly: 7.644 ± 0.114
1.214ProHis: 1.214 ± 0.032
1.334ProIle: 1.334 ± 0.045
0.786ProLys: 0.786 ± 0.032
5.021ProLeu: 5.021 ± 0.075
1.031ProMet: 1.031 ± 0.036
0.816ProAsn: 0.816 ± 0.028
2.792ProPro: 2.792 ± 0.071
1.601ProGln: 1.601 ± 0.035
4.2ProArg: 4.2 ± 0.07
3.043ProSer: 3.043 ± 0.064
3.207ProThr: 3.207 ± 0.065
5.922ProVal: 5.922 ± 0.088
0.973ProTrp: 0.973 ± 0.034
1.043ProTyr: 1.043 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.835GlnAla: 3.835 ± 0.069
0.143GlnCys: 0.143 ± 0.012
1.932GlnAsp: 1.932 ± 0.046
1.604GlnGlu: 1.604 ± 0.047
0.719GlnPhe: 0.719 ± 0.024
2.232GlnGly: 2.232 ± 0.047
0.694GlnHis: 0.694 ± 0.027
0.85GlnIle: 0.85 ± 0.029
0.513GlnLys: 0.513 ± 0.026
2.938GlnLeu: 2.938 ± 0.055
0.537GlnMet: 0.537 ± 0.023
0.531GlnAsn: 0.531 ± 0.022
1.472GlnPro: 1.472 ± 0.046
1.132GlnGln: 1.132 ± 0.041
2.375GlnArg: 2.375 ± 0.05
1.346GlnSer: 1.346 ± 0.038
1.154GlnThr: 1.154 ± 0.037
2.782GlnVal: 2.782 ± 0.052
0.525GlnTrp: 0.525 ± 0.025
0.619GlnTyr: 0.619 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
9.638ArgAla: 9.638 ± 0.129
0.408ArgCys: 0.408 ± 0.023
4.498ArgAsp: 4.498 ± 0.066
4.815ArgGlu: 4.815 ± 0.07
2.304ArgPhe: 2.304 ± 0.045
6.077ArgGly: 6.077 ± 0.094
2.13ArgHis: 2.13 ± 0.052
3.104ArgIle: 3.104 ± 0.063
1.254ArgLys: 1.254 ± 0.04
8.208ArgLeu: 8.208 ± 0.116
1.818ArgMet: 1.818 ± 0.042
1.329ArgAsn: 1.329 ± 0.04
5.226ArgPro: 5.226 ± 0.074
2.581ArgGln: 2.581 ± 0.058
8.017ArgArg: 8.017 ± 0.121
4.054ArgSer: 4.054 ± 0.068
4.885ArgThr: 4.885 ± 0.081
5.826ArgVal: 5.826 ± 0.09
1.375ArgTrp: 1.375 ± 0.039
1.685ArgTyr: 1.685 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.595SerAla: 6.595 ± 0.084
0.298SerCys: 0.298 ± 0.019
2.061SerAsp: 2.061 ± 0.05
2.284SerGlu: 2.284 ± 0.053
1.546SerPhe: 1.546 ± 0.043
5.683SerGly: 5.683 ± 0.086
0.926SerHis: 0.926 ± 0.029
1.709SerIle: 1.709 ± 0.042
0.756SerLys: 0.756 ± 0.029
4.919SerLeu: 4.919 ± 0.07
1.11SerMet: 1.11 ± 0.034
0.833SerAsn: 0.833 ± 0.03
3.236SerPro: 3.236 ± 0.064
1.192SerGln: 1.192 ± 0.034
3.759SerArg: 3.759 ± 0.055
2.875SerSer: 2.875 ± 0.063
3.26SerThr: 3.26 ± 0.055
4.273SerVal: 4.273 ± 0.066
0.858SerTrp: 0.858 ± 0.029
1.028SerTyr: 1.028 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
8.561ThrAla: 8.561 ± 0.117
0.336ThrCys: 0.336 ± 0.017
3.312ThrAsp: 3.312 ± 0.061
3.3ThrGlu: 3.3 ± 0.057
1.586ThrPhe: 1.586 ± 0.04
7.047ThrGly: 7.047 ± 0.09
1.157ThrHis: 1.157 ± 0.032
2.005ThrIle: 2.005 ± 0.049
0.844ThrLys: 0.844 ± 0.032
5.511ThrLeu: 5.511 ± 0.073
0.966ThrMet: 0.966 ± 0.033
0.937ThrAsn: 0.937 ± 0.031
4.112ThrPro: 4.112 ± 0.074
1.296ThrGln: 1.296 ± 0.038
3.72ThrArg: 3.72 ± 0.069
2.852ThrSer: 2.852 ± 0.057
3.958ThrThr: 3.958 ± 0.067
6.164ThrVal: 6.164 ± 0.08
0.838ThrTrp: 0.838 ± 0.03
1.212ThrTyr: 1.212 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
11.37ValAla: 11.37 ± 0.135
0.615ValCys: 0.615 ± 0.025
5.519ValAsp: 5.519 ± 0.084
5.059ValGlu: 5.059 ± 0.073
2.631ValPhe: 2.631 ± 0.053
6.915ValGly: 6.915 ± 0.092
2.07ValHis: 2.07 ± 0.048
3.181ValIle: 3.181 ± 0.065
1.395ValLys: 1.395 ± 0.039
10.672ValLeu: 10.672 ± 0.143
1.647ValMet: 1.647 ± 0.046
1.705ValAsn: 1.705 ± 0.048
5.88ValPro: 5.88 ± 0.081
2.27ValGln: 2.27 ± 0.052
6.738ValArg: 6.738 ± 0.08
4.241ValSer: 4.241 ± 0.067
5.505ValThr: 5.505 ± 0.079
9.077ValVal: 9.077 ± 0.115
0.951ValTrp: 0.951 ± 0.034
1.508ValTyr: 1.508 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.709TrpAla: 1.709 ± 0.047
0.114TrpCys: 0.114 ± 0.012
0.914TrpAsp: 0.914 ± 0.029
0.717TrpGlu: 0.717 ± 0.026
0.553TrpPhe: 0.553 ± 0.027
1.124TrpGly: 1.124 ± 0.042
0.318TrpHis: 0.318 ± 0.017
0.618TrpIle: 0.618 ± 0.029
0.257TrpLys: 0.257 ± 0.017
1.802TrpLeu: 1.802 ± 0.044
0.353TrpMet: 0.353 ± 0.018
0.351TrpAsn: 0.351 ± 0.021
0.734TrpPro: 0.734 ± 0.031
0.497TrpGln: 0.497 ± 0.022
1.296TrpArg: 1.296 ± 0.042
0.877TrpSer: 0.877 ± 0.031
1.021TrpThr: 1.021 ± 0.032
1.172TrpVal: 1.172 ± 0.031
0.353TrpTrp: 0.353 ± 0.02
0.305TrpTyr: 0.305 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.373TyrAla: 2.373 ± 0.043
0.146TyrCys: 0.146 ± 0.013
1.149TyrAsp: 1.149 ± 0.032
1.113TyrGlu: 1.113 ± 0.04
0.644TyrPhe: 0.644 ± 0.028
2.025TyrGly: 2.025 ± 0.048
0.351TyrHis: 0.351 ± 0.02
0.527TyrIle: 0.527 ± 0.027
0.297TyrLys: 0.297 ± 0.016
2.132TyrLeu: 2.132 ± 0.05
0.28TyrMet: 0.28 ± 0.018
0.356TyrAsn: 0.356 ± 0.016
1.068TyrPro: 1.068 ± 0.033
0.583TyrGln: 0.583 ± 0.024
1.766TyrArg: 1.766 ± 0.043
0.985TyrSer: 0.985 ± 0.032
1.073TyrThr: 1.073 ± 0.038
1.492TyrVal: 1.492 ± 0.035
0.337TyrTrp: 0.337 ± 0.018
0.427TyrTyr: 0.427 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2944 proteins (1013340 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski