Amino acid dipepetide frequency for Candidatus Nesciobacter abundans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.348AlaAla: 2.348 ± 0.152
0.739AlaCys: 0.739 ± 0.082
2.051AlaAsp: 2.051 ± 0.121
3.105AlaGlu: 3.105 ± 0.15
2.343AlaPhe: 2.343 ± 0.123
2.549AlaGly: 2.549 ± 0.122
0.699AlaHis: 0.699 ± 0.067
3.7AlaIle: 3.7 ± 0.141
4.153AlaLys: 4.153 ± 0.167
4.737AlaLeu: 4.737 ± 0.18
1.317AlaMet: 1.317 ± 0.098
2.537AlaAsn: 2.537 ± 0.121
1.128AlaPro: 1.128 ± 0.084
1.277AlaGln: 1.277 ± 0.079
1.919AlaArg: 1.919 ± 0.124
3.54AlaSer: 3.54 ± 0.152
1.547AlaThr: 1.547 ± 0.101
2.652AlaVal: 2.652 ± 0.154
0.332AlaTrp: 0.332 ± 0.043
1.764AlaTyr: 1.764 ± 0.103
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.062
0.183CysCys: 0.183 ± 0.029
0.785CysAsp: 0.785 ± 0.067
0.808CysGlu: 0.808 ± 0.06
1.014CysPhe: 1.014 ± 0.078
0.79CysGly: 0.79 ± 0.079
0.206CysHis: 0.206 ± 0.039
1.272CysIle: 1.272 ± 0.103
1.398CysLys: 1.398 ± 0.105
1.266CysLeu: 1.266 ± 0.093
0.407CysMet: 0.407 ± 0.049
0.773CysAsn: 0.773 ± 0.07
0.344CysPro: 0.344 ± 0.046
0.223CysGln: 0.223 ± 0.036
0.458CysArg: 0.458 ± 0.05
1.272CysSer: 1.272 ± 0.108
0.636CysThr: 0.636 ± 0.058
0.894CysVal: 0.894 ± 0.077
0.103CysTrp: 0.103 ± 0.024
0.349CysTyr: 0.349 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
1.988AspAla: 1.988 ± 0.101
0.819AspCys: 0.819 ± 0.067
1.862AspAsp: 1.862 ± 0.113
3.328AspGlu: 3.328 ± 0.166
3.614AspPhe: 3.614 ± 0.15
2.526AspGly: 2.526 ± 0.17
1.02AspHis: 1.02 ± 0.086
4.714AspIle: 4.714 ± 0.148
5.195AspLys: 5.195 ± 0.18
6.507AspLeu: 6.507 ± 0.215
1.157AspMet: 1.157 ± 0.097
2.572AspAsn: 2.572 ± 0.145
1.695AspPro: 1.695 ± 0.104
1.472AspGln: 1.472 ± 0.093
1.758AspArg: 1.758 ± 0.139
5.338AspSer: 5.338 ± 0.164
1.919AspThr: 1.919 ± 0.107
2.91AspVal: 2.91 ± 0.138
0.458AspTrp: 0.458 ± 0.054
2.137AspTyr: 2.137 ± 0.114
0.0AspXaa: 0.0 ± 0.0
Glu
3.064GluAla: 3.064 ± 0.147
0.865GluCys: 0.865 ± 0.065
3.689GluAsp: 3.689 ± 0.159
5.665GluGlu: 5.665 ± 0.269
3.213GluPhe: 3.213 ± 0.139
2.904GluGly: 2.904 ± 0.15
1.358GluHis: 1.358 ± 0.099
7.269GluIle: 7.269 ± 0.254
8.867GluLys: 8.867 ± 0.288
5.602GluLeu: 5.602 ± 0.252
1.816GluMet: 1.816 ± 0.109
5.779GluAsn: 5.779 ± 0.214
1.226GluPro: 1.226 ± 0.095
1.799GluGln: 1.799 ± 0.113
2.423GluArg: 2.423 ± 0.138
6.851GluSer: 6.851 ± 0.207
2.818GluThr: 2.818 ± 0.123
3.987GluVal: 3.987 ± 0.162
0.458GluTrp: 0.458 ± 0.053
2.308GluTyr: 2.308 ± 0.131
0.0GluXaa: 0.0 ± 0.0
Phe
2.612PheAla: 2.612 ± 0.132
1.042PheCys: 1.042 ± 0.083
2.893PheAsp: 2.893 ± 0.117
3.122PheGlu: 3.122 ± 0.166
3.5PhePhe: 3.5 ± 0.223
3.133PheGly: 3.133 ± 0.192
0.687PheHis: 0.687 ± 0.064
4.462PheIle: 4.462 ± 0.234
4.032PheLys: 4.032 ± 0.145
5.814PheLeu: 5.814 ± 0.28
1.369PheMet: 1.369 ± 0.089
2.875PheAsn: 2.875 ± 0.172
1.461PhePro: 1.461 ± 0.095
1.071PheGln: 1.071 ± 0.082
1.707PheArg: 1.707 ± 0.107
5.493PheSer: 5.493 ± 0.224
1.953PheThr: 1.953 ± 0.096
3.442PheVal: 3.442 ± 0.146
0.51PheTrp: 0.51 ± 0.056
2.131PheTyr: 2.131 ± 0.117
0.0PheXaa: 0.0 ± 0.0
Gly
2.663GlyAla: 2.663 ± 0.147
0.768GlyCys: 0.768 ± 0.073
2.795GlyAsp: 2.795 ± 0.214
2.83GlyGlu: 2.83 ± 0.138
3.105GlyPhe: 3.105 ± 0.155
2.927GlyGly: 2.927 ± 0.185
1.117GlyHis: 1.117 ± 0.086
4.857GlyIle: 4.857 ± 0.168
5.482GlyLys: 5.482 ± 0.192
5.098GlyLeu: 5.098 ± 0.197
1.627GlyMet: 1.627 ± 0.101
3.024GlyAsn: 3.024 ± 0.14
1.186GlyPro: 1.186 ± 0.081
1.317GlyGln: 1.317 ± 0.085
2.016GlyArg: 2.016 ± 0.132
4.955GlySer: 4.955 ± 0.175
2.411GlyThr: 2.411 ± 0.102
3.185GlyVal: 3.185 ± 0.167
0.435GlyTrp: 0.435 ± 0.053
2.2GlyTyr: 2.2 ± 0.108
0.0GlyXaa: 0.0 ± 0.0
His
0.951HisAla: 0.951 ± 0.079
0.258HisCys: 0.258 ± 0.041
0.922HisAsp: 0.922 ± 0.068
1.231HisGlu: 1.231 ± 0.084
0.79HisPhe: 0.79 ± 0.068
1.266HisGly: 1.266 ± 0.093
0.332HisHis: 0.332 ± 0.045
1.644HisIle: 1.644 ± 0.099
1.81HisLys: 1.81 ± 0.111
1.438HisLeu: 1.438 ± 0.11
0.372HisMet: 0.372 ± 0.046
1.1HisAsn: 1.1 ± 0.076
0.693HisPro: 0.693 ± 0.057
0.384HisGln: 0.384 ± 0.047
0.659HisArg: 0.659 ± 0.062
1.352HisSer: 1.352 ± 0.084
0.716HisThr: 0.716 ± 0.065
1.048HisVal: 1.048 ± 0.084
0.12HisTrp: 0.12 ± 0.027
0.601HisTyr: 0.601 ± 0.058
0.0HisXaa: 0.0 ± 0.0
Ile
4.084IleAla: 4.084 ± 0.183
1.489IleCys: 1.489 ± 0.106
4.903IleAsp: 4.903 ± 0.196
6.112IleGlu: 6.112 ± 0.217
4.903IlePhe: 4.903 ± 0.235
4.685IleGly: 4.685 ± 0.184
1.432IleHis: 1.432 ± 0.09
6.69IleIle: 6.69 ± 0.239
9.262IleLys: 9.262 ± 0.257
7.95IleLeu: 7.95 ± 0.24
2.177IleMet: 2.177 ± 0.114
6.054IleAsn: 6.054 ± 0.213
3.15IlePro: 3.15 ± 0.161
1.907IleGln: 1.907 ± 0.1
3.19IleArg: 3.19 ± 0.131
8.609IleSer: 8.609 ± 0.259
3.838IleThr: 3.838 ± 0.154
4.485IleVal: 4.485 ± 0.155
0.705IleTrp: 0.705 ± 0.075
2.744IleTyr: 2.744 ± 0.138
0.0IleXaa: 0.0 ± 0.0
Lys
4.29LysAla: 4.29 ± 0.181
0.934LysCys: 0.934 ± 0.072
5.688LysAsp: 5.688 ± 0.215
8.168LysGlu: 8.168 ± 0.278
4.204LysPhe: 4.204 ± 0.174
4.41LysGly: 4.41 ± 0.196
1.93LysHis: 1.93 ± 0.092
10.201LysIle: 10.201 ± 0.252
10.161LysLys: 10.161 ± 0.291
7.916LysLeu: 7.916 ± 0.248
2.6LysMet: 2.6 ± 0.131
8.517LysAsn: 8.517 ± 0.237
2.457LysPro: 2.457 ± 0.11
2.984LysGln: 2.984 ± 0.139
3.294LysArg: 3.294 ± 0.17
9.027LysSer: 9.027 ± 0.247
5.189LysThr: 5.189 ± 0.192
5.241LysVal: 5.241 ± 0.179
0.945LysTrp: 0.945 ± 0.078
3.706LysTyr: 3.706 ± 0.148
0.0LysXaa: 0.0 ± 0.0
Leu
3.752LeuAla: 3.752 ± 0.174
1.358LeuCys: 1.358 ± 0.081
5.43LeuAsp: 5.43 ± 0.223
7.555LeuGlu: 7.555 ± 0.262
4.697LeuPhe: 4.697 ± 0.241
5.671LeuGly: 5.671 ± 0.187
1.747LeuHis: 1.747 ± 0.103
6.684LeuIle: 6.684 ± 0.226
9.039LeuLys: 9.039 ± 0.256
6.816LeuLeu: 6.816 ± 0.229
1.976LeuMet: 1.976 ± 0.115
5.991LeuAsn: 5.991 ± 0.225
2.268LeuPro: 2.268 ± 0.138
2.629LeuGln: 2.629 ± 0.137
3.316LeuArg: 3.316 ± 0.151
9.004LeuSer: 9.004 ± 0.278
3.345LeuThr: 3.345 ± 0.159
4.571LeuVal: 4.571 ± 0.173
0.693LeuTrp: 0.693 ± 0.074
2.572LeuTyr: 2.572 ± 0.132
0.0LeuXaa: 0.0 ± 0.0
Met
0.922MetAla: 0.922 ± 0.072
0.349MetCys: 0.349 ± 0.049
1.369MetAsp: 1.369 ± 0.087
1.552MetGlu: 1.552 ± 0.114
1.421MetPhe: 1.421 ± 0.098
1.157MetGly: 1.157 ± 0.08
0.699MetHis: 0.699 ± 0.064
2.142MetIle: 2.142 ± 0.126
2.446MetLys: 2.446 ± 0.135
2.102MetLeu: 2.102 ± 0.115
0.487MetMet: 0.487 ± 0.055
1.982MetAsn: 1.982 ± 0.102
0.848MetPro: 0.848 ± 0.065
0.882MetGln: 0.882 ± 0.07
0.985MetArg: 0.985 ± 0.075
2.297MetSer: 2.297 ± 0.133
1.031MetThr: 1.031 ± 0.084
1.231MetVal: 1.231 ± 0.089
0.109MetTrp: 0.109 ± 0.025
0.836MetTyr: 0.836 ± 0.066
0.0MetXaa: 0.0 ± 0.0
Asn
2.904AsnAla: 2.904 ± 0.161
0.682AsnCys: 0.682 ± 0.06
3.013AsnAsp: 3.013 ± 0.135
4.456AsnGlu: 4.456 ± 0.179
3.099AsnPhe: 3.099 ± 0.142
3.053AsnGly: 3.053 ± 0.129
1.22AsnHis: 1.22 ± 0.086
6.553AsnIle: 6.553 ± 0.223
7.24AsnLys: 7.24 ± 0.204
6.61AsnLeu: 6.61 ± 0.212
1.632AsnMet: 1.632 ± 0.095
4.422AsnAsn: 4.422 ± 0.204
2.503AsnPro: 2.503 ± 0.125
1.862AsnGln: 1.862 ± 0.104
2.045AsnArg: 2.045 ± 0.141
5.779AsnSer: 5.779 ± 0.207
2.898AsnThr: 2.898 ± 0.156
3.66AsnVal: 3.66 ± 0.144
0.601AsnTrp: 0.601 ± 0.056
2.257AsnTyr: 2.257 ± 0.119
0.0AsnXaa: 0.0 ± 0.0
Pro
1.22ProAla: 1.22 ± 0.093
0.424ProCys: 0.424 ± 0.053
1.449ProAsp: 1.449 ± 0.108
2.36ProGlu: 2.36 ± 0.141
1.627ProPhe: 1.627 ± 0.109
1.73ProGly: 1.73 ± 0.123
0.544ProHis: 0.544 ± 0.053
2.377ProIle: 2.377 ± 0.123
2.474ProLys: 2.474 ± 0.115
2.068ProLeu: 2.068 ± 0.121
0.653ProMet: 0.653 ± 0.064
1.564ProAsn: 1.564 ± 0.085
0.475ProPro: 0.475 ± 0.057
0.745ProGln: 0.745 ± 0.063
0.859ProArg: 0.859 ± 0.071
2.377ProSer: 2.377 ± 0.123
1.077ProThr: 1.077 ± 0.075
1.89ProVal: 1.89 ± 0.126
0.246ProTrp: 0.246 ± 0.037
1.146ProTyr: 1.146 ± 0.087
0.0ProXaa: 0.0 ± 0.0
Gln
1.226GlnAla: 1.226 ± 0.096
0.275GlnCys: 0.275 ± 0.037
1.358GlnAsp: 1.358 ± 0.094
2.245GlnGlu: 2.245 ± 0.129
0.945GlnPhe: 0.945 ± 0.078
1.3GlnGly: 1.3 ± 0.086
0.435GlnHis: 0.435 ± 0.05
2.394GlnIle: 2.394 ± 0.126
3.053GlnLys: 3.053 ± 0.132
1.426GlnLeu: 1.426 ± 0.095
0.636GlnMet: 0.636 ± 0.063
2.463GlnAsn: 2.463 ± 0.117
0.573GlnPro: 0.573 ± 0.061
0.579GlnGln: 0.579 ± 0.064
0.991GlnArg: 0.991 ± 0.083
2.217GlnSer: 2.217 ± 0.118
1.26GlnThr: 1.26 ± 0.076
1.432GlnVal: 1.432 ± 0.096
0.212GlnTrp: 0.212 ± 0.044
0.974GlnTyr: 0.974 ± 0.082
0.0GlnXaa: 0.0 ± 0.0
Arg
1.661ArgAla: 1.661 ± 0.101
0.361ArgCys: 0.361 ± 0.04
1.793ArgAsp: 1.793 ± 0.104
2.228ArgGlu: 2.228 ± 0.127
1.953ArgPhe: 1.953 ± 0.164
1.781ArgGly: 1.781 ± 0.106
0.579ArgHis: 0.579 ± 0.06
3.248ArgIle: 3.248 ± 0.139
3.906ArgLys: 3.906 ± 0.159
2.612ArgLeu: 2.612 ± 0.113
0.842ArgMet: 0.842 ± 0.067
2.698ArgAsn: 2.698 ± 0.127
0.945ArgPro: 0.945 ± 0.101
0.831ArgGln: 0.831 ± 0.071
1.466ArgArg: 1.466 ± 0.097
2.99ArgSer: 2.99 ± 0.168
1.484ArgThr: 1.484 ± 0.081
2.119ArgVal: 2.119 ± 0.131
0.246ArgTrp: 0.246 ± 0.036
1.111ArgTyr: 1.111 ± 0.089
0.0ArgXaa: 0.0 ± 0.0
Ser
4.181SerAla: 4.181 ± 0.159
1.306SerCys: 1.306 ± 0.097
5.424SerAsp: 5.424 ± 0.213
7.143SerGlu: 7.143 ± 0.219
4.909SerPhe: 4.909 ± 0.205
5.653SerGly: 5.653 ± 0.222
1.363SerHis: 1.363 ± 0.099
8.036SerIle: 8.036 ± 0.224
9.766SerLys: 9.766 ± 0.251
7.945SerLeu: 7.945 ± 0.241
2.509SerMet: 2.509 ± 0.121
5.51SerAsn: 5.51 ± 0.193
1.919SerPro: 1.919 ± 0.113
2.257SerGln: 2.257 ± 0.14
3.082SerArg: 3.082 ± 0.139
8.134SerSer: 8.134 ± 0.294
3.66SerThr: 3.66 ± 0.147
5.378SerVal: 5.378 ± 0.213
0.705SerTrp: 0.705 ± 0.067
3.511SerTyr: 3.511 ± 0.175
0.0SerXaa: 0.0 ± 0.0
Thr
1.713ThrAla: 1.713 ± 0.108
0.493ThrCys: 0.493 ± 0.059
2.068ThrAsp: 2.068 ± 0.104
3.316ThrGlu: 3.316 ± 0.174
2.085ThrPhe: 2.085 ± 0.11
2.778ThrGly: 2.778 ± 0.136
0.67ThrHis: 0.67 ± 0.063
3.265ThrIle: 3.265 ± 0.158
4.376ThrLys: 4.376 ± 0.183
3.987ThrLeu: 3.987 ± 0.161
0.894ThrMet: 0.894 ± 0.07
2.83ThrAsn: 2.83 ± 0.137
1.415ThrPro: 1.415 ± 0.084
1.168ThrGln: 1.168 ± 0.083
1.1ThrArg: 1.1 ± 0.084
3.448ThrSer: 3.448 ± 0.122
1.81ThrThr: 1.81 ± 0.124
2.159ThrVal: 2.159 ± 0.1
0.372ThrTrp: 0.372 ± 0.042
1.535ThrTyr: 1.535 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
2.337ValAla: 2.337 ± 0.122
0.939ValCys: 0.939 ± 0.062
3.213ValAsp: 3.213 ± 0.153
3.752ValGlu: 3.752 ± 0.189
3.798ValPhe: 3.798 ± 0.176
3.19ValGly: 3.19 ± 0.129
1.031ValHis: 1.031 ± 0.101
4.634ValIle: 4.634 ± 0.166
4.714ValLys: 4.714 ± 0.175
5.184ValLeu: 5.184 ± 0.215
1.398ValMet: 1.398 ± 0.09
3.179ValAsn: 3.179 ± 0.137
1.81ValPro: 1.81 ± 0.116
1.569ValGln: 1.569 ± 0.109
2.039ValArg: 2.039 ± 0.113
5.751ValSer: 5.751 ± 0.208
2.194ValThr: 2.194 ± 0.113
3.414ValVal: 3.414 ± 0.203
0.47ValTrp: 0.47 ± 0.052
1.644ValTyr: 1.644 ± 0.103
0.0ValXaa: 0.0 ± 0.0
Trp
0.315TrpAla: 0.315 ± 0.043
0.103TrpCys: 0.103 ± 0.026
0.498TrpAsp: 0.498 ± 0.054
0.389TrpGlu: 0.389 ± 0.051
0.412TrpPhe: 0.412 ± 0.051
0.384TrpGly: 0.384 ± 0.051
0.149TrpHis: 0.149 ± 0.03
0.894TrpIle: 0.894 ± 0.08
0.842TrpLys: 0.842 ± 0.072
0.682TrpLeu: 0.682 ± 0.066
0.212TrpMet: 0.212 ± 0.029
0.693TrpAsn: 0.693 ± 0.07
0.189TrpPro: 0.189 ± 0.032
0.183TrpGln: 0.183 ± 0.031
0.269TrpArg: 0.269 ± 0.041
0.659TrpSer: 0.659 ± 0.065
0.389TrpThr: 0.389 ± 0.057
0.475TrpVal: 0.475 ± 0.055
0.052TrpTrp: 0.052 ± 0.019
0.258TrpTyr: 0.258 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.621TyrAla: 1.621 ± 0.107
0.378TyrCys: 0.378 ± 0.05
1.787TyrAsp: 1.787 ± 0.116
2.595TyrGlu: 2.595 ± 0.151
1.678TyrPhe: 1.678 ± 0.108
2.108TyrGly: 2.108 ± 0.112
0.47TyrHis: 0.47 ± 0.052
3.339TyrIle: 3.339 ± 0.166
3.649TyrLys: 3.649 ± 0.162
3.357TyrLeu: 3.357 ± 0.15
0.762TyrMet: 0.762 ± 0.066
1.925TyrAsn: 1.925 ± 0.11
1.02TyrPro: 1.02 ± 0.086
0.853TyrGln: 0.853 ± 0.063
1.277TyrArg: 1.277 ± 0.091
3.299TyrSer: 3.299 ± 0.146
1.306TyrThr: 1.306 ± 0.091
2.085TyrVal: 2.085 ± 0.108
0.275TyrTrp: 0.275 ± 0.04
1.054TyrTyr: 1.054 ± 0.093
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 501 proteins (174585 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski