Amino acid dipepetide frequency for Streptomyces spongiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.326AlaAla: 19.326 ± 0.12	1.044AlaCys: 1.044 ± 0.018	8.146AlaAsp: 8.146 ± 0.063	8.464AlaGlu: 8.464 ± 0.063	3.51AlaPhe: 3.51 ± 0.035	12.068AlaGly: 12.068 ± 0.081	2.813AlaHis: 2.813 ± 0.031	3.465AlaIle: 3.465 ± 0.039	2.833AlaLys: 2.833 ± 0.038	14.164AlaLeu: 14.164 ± 0.095	2.423AlaMet: 2.423 ± 0.03	1.978AlaAsn: 1.978 ± 0.03	6.675AlaPro: 6.675 ± 0.053	3.665AlaGln: 3.665 ± 0.039	9.84AlaArg: 9.84 ± 0.076	6.087AlaSer: 6.087 ± 0.048	7.03AlaThr: 7.03 ± 0.051	12.077AlaVal: 12.077 ± 0.07	1.844AlaTrp: 1.844 ± 0.028	2.758AlaTyr: 2.758 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.04CysAla: 1.04 ± 0.019	0.092CysCys: 0.092 ± 0.006	0.486CysAsp: 0.486 ± 0.013	0.418CysGlu: 0.418 ± 0.01	0.219CysPhe: 0.219 ± 0.007	0.927CysGly: 0.927 ± 0.018	0.189CysHis: 0.189 ± 0.008	0.153CysIle: 0.153 ± 0.008	0.108CysLys: 0.108 ± 0.005	0.733CysLeu: 0.733 ± 0.017	0.112CysMet: 0.112 ± 0.005	0.121CysAsn: 0.121 ± 0.007	0.462CysPro: 0.462 ± 0.013	0.171CysGln: 0.171 ± 0.007	0.618CysArg: 0.618 ± 0.014	0.433CysSer: 0.433 ± 0.01	0.503CysThr: 0.503 ± 0.014	0.688CysVal: 0.688 ± 0.016	0.123CysTrp: 0.123 ± 0.007	0.153CysTyr: 0.153 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.509AspAla: 7.509 ± 0.05	0.427AspCys: 0.427 ± 0.013	3.757AspAsp: 3.757 ± 0.043	3.94AspGlu: 3.94 ± 0.037	1.729AspPhe: 1.729 ± 0.026	6.463AspGly: 6.463 ± 0.057	1.531AspHis: 1.531 ± 0.024	2.01AspIle: 2.01 ± 0.024	1.259AspLys: 1.259 ± 0.028	6.326AspLeu: 6.326 ± 0.048	0.849AspMet: 0.849 ± 0.017	1.064AspAsn: 1.064 ± 0.017	4.458AspPro: 4.458 ± 0.039	1.632AspGln: 1.632 ± 0.022	4.878AspArg: 4.878 ± 0.042	2.759AspSer: 2.759 ± 0.036	3.464AspThr: 3.464 ± 0.034	4.882AspVal: 4.882 ± 0.043	1.079AspTrp: 1.079 ± 0.021	1.151AspTyr: 1.151 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	7.261GluAla: 7.261 ± 0.057	0.367GluCys: 0.367 ± 0.011	2.938GluAsp: 2.938 ± 0.031	3.62GluGlu: 3.62 ± 0.042	1.53GluPhe: 1.53 ± 0.02	4.413GluGly: 4.413 ± 0.035	1.53GluHis: 1.53 ± 0.025	2.263GluIle: 2.263 ± 0.031	1.488GluLys: 1.488 ± 0.029	6.75GluLeu: 6.75 ± 0.056	0.891GluMet: 0.891 ± 0.017	1.088GluAsn: 1.088 ± 0.02	3.436GluPro: 3.436 ± 0.039	2.264GluGln: 2.264 ± 0.029	5.436GluArg: 5.436 ± 0.048	2.695GluSer: 2.695 ± 0.032	2.961GluThr: 2.961 ± 0.03	4.389GluVal: 4.389 ± 0.043	0.808GluTrp: 0.808 ± 0.017	1.184GluTyr: 1.184 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.572PheAla: 3.572 ± 0.033	0.253PheCys: 0.253 ± 0.009	1.998PheAsp: 1.998 ± 0.027	1.475PheGlu: 1.475 ± 0.025	0.888PhePhe: 0.888 ± 0.021	3.019PheGly: 3.019 ± 0.034	0.645PheHis: 0.645 ± 0.014	0.724PheIle: 0.724 ± 0.015	0.531PheLys: 0.531 ± 0.014	2.709PheLeu: 2.709 ± 0.034	0.424PheMet: 0.424 ± 0.013	0.608PheAsn: 0.608 ± 0.013	1.403PhePro: 1.403 ± 0.022	0.749PheGln: 0.749 ± 0.014	1.874PheArg: 1.874 ± 0.025	1.537PheSer: 1.537 ± 0.023	2.056PheThr: 2.056 ± 0.027	2.307PheVal: 2.307 ± 0.033	0.442PheTrp: 0.442 ± 0.012	0.601PheTyr: 0.601 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.604GlyAla: 10.604 ± 0.076	0.795GlyCys: 0.795 ± 0.016	5.267GlyAsp: 5.267 ± 0.044	5.123GlyGlu: 5.123 ± 0.047	2.903GlyPhe: 2.903 ± 0.032	8.634GlyGly: 8.634 ± 0.073	2.354GlyHis: 2.354 ± 0.03	3.477GlyIle: 3.477 ± 0.036	2.458GlyLys: 2.458 ± 0.035	9.353GlyLeu: 9.353 ± 0.061	2.0GlyMet: 2.0 ± 0.028	1.813GlyAsn: 1.813 ± 0.025	5.009GlyPro: 5.009 ± 0.048	2.698GlyGln: 2.698 ± 0.029	7.484GlyArg: 7.484 ± 0.053	5.555GlySer: 5.555 ± 0.048	6.57GlyThr: 6.57 ± 0.055	7.554GlyVal: 7.554 ± 0.051	1.707GlyTrp: 1.707 ± 0.024	2.262GlyTyr: 2.262 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.66HisAla: 2.66 ± 0.037	0.21HisCys: 0.21 ± 0.009	1.385HisAsp: 1.385 ± 0.023	1.251HisGlu: 1.251 ± 0.021	0.673HisPhe: 0.673 ± 0.015	2.429HisGly: 2.429 ± 0.03	0.717HisHis: 0.717 ± 0.017	0.71HisIle: 0.71 ± 0.014	0.362HisLys: 0.362 ± 0.011	2.485HisLeu: 2.485 ± 0.03	0.347HisMet: 0.347 ± 0.01	0.37HisAsn: 0.37 ± 0.012	1.779HisPro: 1.779 ± 0.025	0.673HisGln: 0.673 ± 0.014	2.136HisArg: 2.136 ± 0.029	1.073HisSer: 1.073 ± 0.019	1.401HisThr: 1.401 ± 0.023	1.773HisVal: 1.773 ± 0.025	0.384HisTrp: 0.384 ± 0.013	0.491HisTyr: 0.491 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.69IleAla: 4.69 ± 0.044	0.277IleCys: 0.277 ± 0.009	2.273IleAsp: 2.273 ± 0.028	1.943IleGlu: 1.943 ± 0.026	0.718IlePhe: 0.718 ± 0.017	3.509IleGly: 3.509 ± 0.035	0.64IleHis: 0.64 ± 0.015	0.853IleIle: 0.853 ± 0.018	0.778IleLys: 0.778 ± 0.017	2.442IleLeu: 2.442 ± 0.03	0.454IleMet: 0.454 ± 0.012	0.718IleAsn: 0.718 ± 0.017	1.839IlePro: 1.839 ± 0.025	0.746IleGln: 0.746 ± 0.017	2.256IleArg: 2.256 ± 0.024	1.751IleSer: 1.751 ± 0.028	2.274IleThr: 2.274 ± 0.026	2.742IleVal: 2.742 ± 0.032	0.395IleTrp: 0.395 ± 0.012	0.528IleTyr: 0.528 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.004LysAla: 3.004 ± 0.042	0.115LysCys: 0.115 ± 0.006	1.429LysAsp: 1.429 ± 0.03	1.261LysGlu: 1.261 ± 0.024	0.464LysPhe: 0.464 ± 0.015	1.916LysGly: 1.916 ± 0.029	0.425LysHis: 0.425 ± 0.013	0.85LysIle: 0.85 ± 0.018	0.919LysLys: 0.919 ± 0.029	2.084LysLeu: 2.084 ± 0.026	0.38LysMet: 0.38 ± 0.012	0.561LysAsn: 0.561 ± 0.015	1.4LysPro: 1.4 ± 0.027	0.715LysGln: 0.715 ± 0.017	1.448LysArg: 1.448 ± 0.025	1.256LysSer: 1.256 ± 0.026	1.326LysThr: 1.326 ± 0.028	1.959LysVal: 1.959 ± 0.032	0.307LysTrp: 0.307 ± 0.01	0.493LysTyr: 0.493 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	14.601LeuAla: 14.601 ± 0.094	0.857LeuCys: 0.857 ± 0.018	6.807LeuAsp: 6.807 ± 0.048	4.622LeuGlu: 4.622 ± 0.043	2.671LeuPhe: 2.671 ± 0.033	9.215LeuGly: 9.215 ± 0.063	2.316LeuHis: 2.316 ± 0.035	3.254LeuIle: 3.254 ± 0.037	2.124LeuLys: 2.124 ± 0.028	11.096LeuLeu: 11.096 ± 0.089	1.652LeuMet: 1.652 ± 0.023	1.79LeuAsn: 1.79 ± 0.027	6.435LeuPro: 6.435 ± 0.058	2.205LeuGln: 2.205 ± 0.026	8.618LeuArg: 8.618 ± 0.064	5.617LeuSer: 5.617 ± 0.043	7.094LeuThr: 7.094 ± 0.051	8.885LeuVal: 8.885 ± 0.064	1.338LeuTrp: 1.338 ± 0.023	1.927LeuTyr: 1.927 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.252MetAla: 2.252 ± 0.026	0.131MetCys: 0.131 ± 0.006	0.889MetAsp: 0.889 ± 0.017	0.748MetGlu: 0.748 ± 0.014	0.458MetPhe: 0.458 ± 0.013	1.36MetGly: 1.36 ± 0.024	0.35MetHis: 0.35 ± 0.011	0.647MetIle: 0.647 ± 0.015	0.449MetLys: 0.449 ± 0.012	1.652MetLeu: 1.652 ± 0.022	0.298MetMet: 0.298 ± 0.009	0.44MetAsn: 0.44 ± 0.013	1.088MetPro: 1.088 ± 0.018	0.418MetGln: 0.418 ± 0.011	1.436MetArg: 1.436 ± 0.022	1.313MetSer: 1.313 ± 0.019	1.585MetThr: 1.585 ± 0.022	1.323MetVal: 1.323 ± 0.022	0.221MetTrp: 0.221 ± 0.007	0.34MetTyr: 0.34 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.261AsnAla: 2.261 ± 0.031	0.181AsnCys: 0.181 ± 0.007	1.028AsnAsp: 1.028 ± 0.019	0.876AsnGlu: 0.876 ± 0.016	0.519AsnPhe: 0.519 ± 0.013	2.005AsnGly: 2.005 ± 0.031	0.393AsnHis: 0.393 ± 0.012	0.678AsnIle: 0.678 ± 0.016	0.432AsnLys: 0.432 ± 0.014	1.736AsnLeu: 1.736 ± 0.023	0.298AsnMet: 0.298 ± 0.011	0.479AsnAsn: 0.479 ± 0.012	1.419AsnPro: 1.419 ± 0.022	0.559AsnGln: 0.559 ± 0.014	1.316AsnArg: 1.316 ± 0.023	1.032AsnSer: 1.032 ± 0.022	1.223AsnThr: 1.223 ± 0.024	1.439AsnVal: 1.439 ± 0.022	0.322AsnTrp: 0.322 ± 0.011	0.455AsnTyr: 0.455 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.711ProAla: 7.711 ± 0.051	0.321ProCys: 0.321 ± 0.011	4.591ProAsp: 4.591 ± 0.044	4.384ProGlu: 4.384 ± 0.043	1.556ProPhe: 1.556 ± 0.021	6.325ProGly: 6.325 ± 0.057	1.451ProHis: 1.451 ± 0.023	1.287ProIle: 1.287 ± 0.019	1.267ProLys: 1.267 ± 0.025	5.373ProLeu: 5.373 ± 0.047	1.011ProMet: 1.011 ± 0.015	0.98ProAsn: 0.98 ± 0.018	3.296ProPro: 3.296 ± 0.041	1.704ProGln: 1.704 ± 0.025	3.893ProArg: 3.893 ± 0.041	3.346ProSer: 3.346 ± 0.039	3.376ProThr: 3.376 ± 0.032	5.453ProVal: 5.453 ± 0.044	0.951ProTrp: 0.951 ± 0.017	1.418ProTyr: 1.418 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.621GlnAla: 3.621 ± 0.038	0.171GlnCys: 0.171 ± 0.007	1.504GlnAsp: 1.504 ± 0.024	1.524GlnGlu: 1.524 ± 0.024	0.688GlnPhe: 0.688 ± 0.015	2.365GlnGly: 2.365 ± 0.029	0.685GlnHis: 0.685 ± 0.015	1.067GlnIle: 1.067 ± 0.02	0.65GlnLys: 0.65 ± 0.016	3.085GlnLeu: 3.085 ± 0.031	0.477GlnMet: 0.477 ± 0.013	0.533GlnAsn: 0.533 ± 0.016	1.636GlnPro: 1.636 ± 0.024	1.249GlnGln: 1.249 ± 0.025	2.365GlnArg: 2.365 ± 0.024	1.33GlnSer: 1.33 ± 0.023	1.374GlnThr: 1.374 ± 0.022	2.388GlnVal: 2.388 ± 0.034	0.496GlnTrp: 0.496 ± 0.013	0.652GlnTyr: 0.652 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.379ArgAla: 9.379 ± 0.074	0.607ArgCys: 0.607 ± 0.015	4.31ArgAsp: 4.31 ± 0.04	4.68ArgGlu: 4.68 ± 0.038	2.348ArgPhe: 2.348 ± 0.029	5.779ArgGly: 5.779 ± 0.041	2.135ArgHis: 2.135 ± 0.028	3.154ArgIle: 3.154 ± 0.032	1.649ArgLys: 1.649 ± 0.028	8.731ArgLeu: 8.731 ± 0.068	1.684ArgMet: 1.684 ± 0.022	1.362ArgAsn: 1.362 ± 0.025	4.794ArgPro: 4.794 ± 0.046	2.358ArgGln: 2.358 ± 0.027	7.484ArgArg: 7.484 ± 0.069	4.112ArgSer: 4.112 ± 0.039	5.437ArgThr: 5.437 ± 0.042	6.049ArgVal: 6.049 ± 0.043	1.337ArgTrp: 1.337 ± 0.022	1.769ArgTyr: 1.769 ± 0.022	0.0ArgXaa: 0.0 ± 0.0
Ser	6.852SerAla: 6.852 ± 0.049	0.402SerCys: 0.402 ± 0.013	2.913SerAsp: 2.913 ± 0.029	2.647SerGlu: 2.647 ± 0.032	1.548SerPhe: 1.548 ± 0.023	6.312SerGly: 6.312 ± 0.055	1.104SerHis: 1.104 ± 0.019	1.493SerIle: 1.493 ± 0.025	1.132SerLys: 1.132 ± 0.026	5.067SerLeu: 5.067 ± 0.044	1.094SerMet: 1.094 ± 0.019	0.948SerAsn: 0.948 ± 0.02	3.263SerPro: 3.263 ± 0.039	1.312SerGln: 1.312 ± 0.023	3.736SerArg: 3.736 ± 0.039	3.205SerSer: 3.205 ± 0.046	3.34SerThr: 3.34 ± 0.036	4.444SerVal: 4.444 ± 0.034	0.956SerTrp: 0.956 ± 0.019	1.282SerTyr: 1.282 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.939ThrAla: 8.939 ± 0.057	0.441ThrCys: 0.441 ± 0.013	3.831ThrAsp: 3.831 ± 0.038	3.47ThrGlu: 3.47 ± 0.037	1.685ThrPhe: 1.685 ± 0.027	6.796ThrGly: 6.796 ± 0.061	1.277ThrHis: 1.277 ± 0.023	1.756ThrIle: 1.756 ± 0.027	1.273ThrLys: 1.273 ± 0.023	5.861ThrLeu: 5.861 ± 0.053	0.963ThrMet: 0.963 ± 0.019	1.121ThrAsn: 1.121 ± 0.02	4.175ThrPro: 4.175 ± 0.045	1.388ThrGln: 1.388 ± 0.023	4.038ThrArg: 4.038 ± 0.039	3.473ThrSer: 3.473 ± 0.038	4.152ThrThr: 4.152 ± 0.052	6.206ThrVal: 6.206 ± 0.043	0.977ThrTrp: 0.977 ± 0.018	1.491ThrTyr: 1.491 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.498ValAla: 10.498 ± 0.07	0.729ValCys: 0.729 ± 0.016	5.13ValAsp: 5.13 ± 0.039	4.78ValGlu: 4.78 ± 0.04	2.513ValPhe: 2.513 ± 0.027	6.612ValGly: 6.612 ± 0.048	1.966ValHis: 1.966 ± 0.028	2.914ValIle: 2.914 ± 0.035	1.766ValLys: 1.766 ± 0.028	9.652ValLeu: 9.652 ± 0.063	1.459ValMet: 1.459 ± 0.022	1.759ValAsn: 1.759 ± 0.03	5.235ValPro: 5.235 ± 0.038	2.077ValGln: 2.077 ± 0.028	7.192ValArg: 7.192 ± 0.053	4.5ValSer: 4.5 ± 0.038	5.794ValThr: 5.794 ± 0.048	8.016ValVal: 8.016 ± 0.063	1.17ValTrp: 1.17 ± 0.02	1.614ValTyr: 1.614 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.633TrpAla: 1.633 ± 0.024	0.151TrpCys: 0.151 ± 0.007	0.879TrpAsp: 0.879 ± 0.018	0.749TrpGlu: 0.749 ± 0.015	0.523TrpPhe: 0.523 ± 0.014	1.143TrpGly: 1.143 ± 0.021	0.396TrpHis: 0.396 ± 0.011	0.56TrpIle: 0.56 ± 0.015	0.402TrpLys: 0.402 ± 0.012	1.755TrpLeu: 1.755 ± 0.027	0.3TrpMet: 0.3 ± 0.011	0.461TrpAsn: 0.461 ± 0.013	0.824TrpPro: 0.824 ± 0.017	0.663TrpGln: 0.663 ± 0.014	1.328TrpArg: 1.328 ± 0.021	0.992TrpSer: 0.992 ± 0.02	1.081TrpThr: 1.081 ± 0.02	1.023TrpVal: 1.023 ± 0.021	0.339TrpTrp: 0.339 ± 0.011	0.391TrpTyr: 0.391 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.797TyrAla: 2.797 ± 0.029	0.177TyrCys: 0.177 ± 0.008	1.606TyrAsp: 1.606 ± 0.026	1.337TyrGlu: 1.337 ± 0.02	0.673TyrPhe: 0.673 ± 0.016	2.33TyrGly: 2.33 ± 0.026	0.393TyrHis: 0.393 ± 0.011	0.51TyrIle: 0.51 ± 0.012	0.433TyrLys: 0.433 ± 0.013	2.07TyrLeu: 2.07 ± 0.025	0.283TyrMet: 0.283 ± 0.009	0.454TyrAsn: 0.454 ± 0.012	1.069TyrPro: 1.069 ± 0.019	0.612TyrGln: 0.612 ± 0.012	1.784TyrArg: 1.784 ± 0.027	0.985TyrSer: 0.985 ± 0.019	1.273TyrThr: 1.273 ± 0.021	1.781TyrVal: 1.781 ± 0.027	0.397TyrTrp: 0.397 ± 0.01	0.504TyrTyr: 0.504 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9455 proteins (3197008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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