Amino acid dipepetide frequency for Coraliomargarita akajimensis (strain DSM 45221 / IAM 15411 / JCM 23193 / KCTC 12865 / 04OKA010-24)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.671AlaAla: 9.671 ± 0.119	1.08AlaCys: 1.08 ± 0.036	5.59AlaAsp: 5.59 ± 0.094	6.72AlaGlu: 6.72 ± 0.102	3.581AlaPhe: 3.581 ± 0.062	7.413AlaGly: 7.413 ± 0.157	1.826AlaHis: 1.826 ± 0.053	5.407AlaIle: 5.407 ± 0.082	4.242AlaLys: 4.242 ± 0.096	9.541AlaLeu: 9.541 ± 0.11	2.189AlaMet: 2.189 ± 0.061	3.305AlaAsn: 3.305 ± 0.066	3.699AlaPro: 3.699 ± 0.065	3.627AlaGln: 3.627 ± 0.058	4.731AlaArg: 4.731 ± 0.089	6.023AlaSer: 6.023 ± 0.089	4.892AlaThr: 4.892 ± 0.103	6.396AlaVal: 6.396 ± 0.079	1.165AlaTrp: 1.165 ± 0.039	2.963AlaTyr: 2.963 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.077CysAla: 1.077 ± 0.04	0.2CysCys: 0.2 ± 0.013	0.584CysAsp: 0.584 ± 0.027	0.665CysGlu: 0.665 ± 0.031	0.471CysPhe: 0.471 ± 0.022	0.946CysGly: 0.946 ± 0.035	0.3CysHis: 0.3 ± 0.019	0.642CysIle: 0.642 ± 0.029	0.351CysLys: 0.351 ± 0.019	1.133CysLeu: 1.133 ± 0.041	0.249CysMet: 0.249 ± 0.015	0.316CysAsn: 0.316 ± 0.02	0.524CysPro: 0.524 ± 0.025	0.348CysGln: 0.348 ± 0.02	0.595CysArg: 0.595 ± 0.028	0.758CysSer: 0.758 ± 0.035	0.504CysThr: 0.504 ± 0.022	0.735CysVal: 0.735 ± 0.03	0.163CysTrp: 0.163 ± 0.012	0.324CysTyr: 0.324 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.941AspAla: 5.941 ± 0.091	0.683AspCys: 0.683 ± 0.03	3.119AspAsp: 3.119 ± 0.089	3.896AspGlu: 3.896 ± 0.066	2.895AspPhe: 2.895 ± 0.062	5.132AspGly: 5.132 ± 0.14	1.178AspHis: 1.178 ± 0.037	3.089AspIle: 3.089 ± 0.074	2.026AspLys: 2.026 ± 0.055	5.958AspLeu: 5.958 ± 0.084	1.195AspMet: 1.195 ± 0.035	1.815AspAsn: 1.815 ± 0.057	3.175AspPro: 3.175 ± 0.066	2.166AspGln: 2.166 ± 0.044	3.125AspArg: 3.125 ± 0.053	3.79AspSer: 3.79 ± 0.08	2.858AspThr: 2.858 ± 0.085	3.713AspVal: 3.713 ± 0.082	1.163AspTrp: 1.163 ± 0.034	2.304AspTyr: 2.304 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	6.977GluAla: 6.977 ± 0.1	0.533GluCys: 0.533 ± 0.024	3.455GluAsp: 3.455 ± 0.053	3.71GluGlu: 3.71 ± 0.072	2.519GluPhe: 2.519 ± 0.046	4.404GluGly: 4.404 ± 0.078	1.542GluHis: 1.542 ± 0.044	3.866GluIle: 3.866 ± 0.073	2.748GluLys: 2.748 ± 0.064	7.537GluLeu: 7.537 ± 0.088	1.618GluMet: 1.618 ± 0.046	2.175GluAsn: 2.175 ± 0.044	2.554GluPro: 2.554 ± 0.061	3.162GluGln: 3.162 ± 0.062	4.409GluArg: 4.409 ± 0.09	4.255GluSer: 4.255 ± 0.071	3.601GluThr: 3.601 ± 0.057	4.546GluVal: 4.546 ± 0.067	1.027GluTrp: 1.027 ± 0.031	1.793GluTyr: 1.793 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.611PheAla: 3.611 ± 0.062	0.577PheCys: 0.577 ± 0.027	2.86PheAsp: 2.86 ± 0.054	2.914PheGlu: 2.914 ± 0.054	1.886PhePhe: 1.886 ± 0.049	3.366PheGly: 3.366 ± 0.065	0.815PheHis: 0.815 ± 0.033	2.254PheIle: 2.254 ± 0.047	1.743PheLys: 1.743 ± 0.039	3.579PheLeu: 3.579 ± 0.081	0.899PheMet: 0.899 ± 0.026	1.726PheAsn: 1.726 ± 0.038	1.651PhePro: 1.651 ± 0.044	1.232PheGln: 1.232 ± 0.034	2.072PheArg: 2.072 ± 0.048	2.984PheSer: 2.984 ± 0.068	2.398PheThr: 2.398 ± 0.061	2.685PheVal: 2.685 ± 0.052	0.617PheTrp: 0.617 ± 0.024	1.341PheTyr: 1.341 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	6.489GlyAla: 6.489 ± 0.103	0.926GlyCys: 0.926 ± 0.032	4.496GlyAsp: 4.496 ± 0.15	4.677GlyGlu: 4.677 ± 0.082	3.43GlyPhe: 3.43 ± 0.057	5.914GlyGly: 5.914 ± 0.128	1.636GlyHis: 1.636 ± 0.043	4.571GlyIle: 4.571 ± 0.075	3.572GlyLys: 3.572 ± 0.078	7.504GlyLeu: 7.504 ± 0.106	1.986GlyMet: 1.986 ± 0.052	2.707GlyAsn: 2.707 ± 0.082	2.618GlyPro: 2.618 ± 0.056	2.825GlyGln: 2.825 ± 0.056	4.07GlyArg: 4.07 ± 0.076	5.111GlySer: 5.111 ± 0.123	4.505GlyThr: 4.505 ± 0.146	5.393GlyVal: 5.393 ± 0.071	1.198GlyTrp: 1.198 ± 0.039	2.65GlyTyr: 2.65 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.931HisAla: 1.931 ± 0.045	0.317HisCys: 0.317 ± 0.017	1.087HisAsp: 1.087 ± 0.034	1.248HisGlu: 1.248 ± 0.037	1.135HisPhe: 1.135 ± 0.037	1.644HisGly: 1.644 ± 0.05	0.604HisHis: 0.604 ± 0.03	1.093HisIle: 1.093 ± 0.035	0.692HisLys: 0.692 ± 0.027	2.132HisLeu: 2.132 ± 0.055	0.49HisMet: 0.49 ± 0.021	0.71HisAsn: 0.71 ± 0.028	1.316HisPro: 1.316 ± 0.038	0.787HisGln: 0.787 ± 0.024	1.228HisArg: 1.228 ± 0.036	1.397HisSer: 1.397 ± 0.041	1.052HisThr: 1.052 ± 0.031	1.301HisVal: 1.301 ± 0.036	0.43HisTrp: 0.43 ± 0.023	0.839HisTyr: 0.839 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.735IleAla: 5.735 ± 0.081	0.705IleCys: 0.705 ± 0.026	3.862IleAsp: 3.862 ± 0.073	4.671IleGlu: 4.671 ± 0.08	1.978IlePhe: 1.978 ± 0.048	4.536IleGly: 4.536 ± 0.08	1.26IleHis: 1.26 ± 0.038	2.77IleIle: 2.77 ± 0.057	1.979IleLys: 1.979 ± 0.045	5.198IleLeu: 5.198 ± 0.087	0.902IleMet: 0.902 ± 0.027	2.033IleAsn: 2.033 ± 0.068	2.717IlePro: 2.717 ± 0.054	2.245IleGln: 2.245 ± 0.047	3.364IleArg: 3.364 ± 0.056	3.423IleSer: 3.423 ± 0.066	3.163IleThr: 3.163 ± 0.099	3.745IleVal: 3.745 ± 0.06	0.647IleTrp: 0.647 ± 0.027	1.691IleTyr: 1.691 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.242LysAla: 4.242 ± 0.094	0.282LysCys: 0.282 ± 0.019	2.419LysAsp: 2.419 ± 0.056	2.72LysGlu: 2.72 ± 0.07	1.333LysPhe: 1.333 ± 0.037	2.972LysGly: 2.972 ± 0.065	0.987LysHis: 0.987 ± 0.037	2.173LysIle: 2.173 ± 0.051	2.171LysLys: 2.171 ± 0.084	4.207LysLeu: 4.207 ± 0.078	0.945LysMet: 0.945 ± 0.028	1.368LysAsn: 1.368 ± 0.037	2.188LysPro: 2.188 ± 0.052	2.005LysGln: 2.005 ± 0.053	2.638LysArg: 2.638 ± 0.059	2.394LysSer: 2.394 ± 0.06	2.361LysThr: 2.361 ± 0.051	2.822LysVal: 2.822 ± 0.063	0.56LysTrp: 0.56 ± 0.024	1.159LysTyr: 1.159 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	9.19LeuAla: 9.19 ± 0.111	1.302LeuCys: 1.302 ± 0.046	5.963LeuAsp: 5.963 ± 0.085	6.727LeuGlu: 6.727 ± 0.071	3.916LeuPhe: 3.916 ± 0.066	7.271LeuGly: 7.271 ± 0.094	1.982LeuHis: 1.982 ± 0.044	5.677LeuIle: 5.677 ± 0.07	4.661LeuLys: 4.661 ± 0.095	10.046LeuLeu: 10.046 ± 0.179	2.162LeuMet: 2.162 ± 0.055	3.941LeuAsn: 3.941 ± 0.069	4.821LeuPro: 4.821 ± 0.068	3.759LeuGln: 3.759 ± 0.068	5.55LeuArg: 5.55 ± 0.089	7.526LeuSer: 7.526 ± 0.096	5.393LeuThr: 5.393 ± 0.121	6.26LeuVal: 6.26 ± 0.092	1.178LeuTrp: 1.178 ± 0.038	2.629LeuTyr: 2.629 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.005MetAla: 2.005 ± 0.045	0.19MetCys: 0.19 ± 0.012	1.317MetAsp: 1.317 ± 0.036	1.389MetGlu: 1.389 ± 0.035	0.646MetPhe: 0.646 ± 0.027	1.642MetGly: 1.642 ± 0.048	0.503MetHis: 0.503 ± 0.025	1.239MetIle: 1.239 ± 0.037	1.321MetLys: 1.321 ± 0.038	2.173MetLeu: 2.173 ± 0.056	0.55MetMet: 0.55 ± 0.027	1.02MetAsn: 1.02 ± 0.029	1.15MetPro: 1.15 ± 0.036	1.0MetGln: 1.0 ± 0.03	1.4MetArg: 1.4 ± 0.037	1.519MetSer: 1.519 ± 0.042	1.251MetThr: 1.251 ± 0.032	1.41MetVal: 1.41 ± 0.042	0.195MetTrp: 0.195 ± 0.014	0.434MetTyr: 0.434 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.238AsnAla: 3.238 ± 0.062	0.41AsnCys: 0.41 ± 0.022	1.934AsnAsp: 1.934 ± 0.061	2.158AsnGlu: 2.158 ± 0.045	1.564AsnPhe: 1.564 ± 0.05	3.144AsnGly: 3.144 ± 0.097	0.758AsnHis: 0.758 ± 0.025	1.728AsnIle: 1.728 ± 0.047	1.209AsnLys: 1.209 ± 0.037	3.49AsnLeu: 3.49 ± 0.067	0.699AsnMet: 0.699 ± 0.026	1.306AsnAsn: 1.306 ± 0.053	2.372AsnPro: 2.372 ± 0.048	1.484AsnGln: 1.484 ± 0.037	1.959AsnArg: 1.959 ± 0.046	2.232AsnSer: 2.232 ± 0.059	1.996AsnThr: 1.996 ± 0.072	2.114AsnVal: 2.114 ± 0.055	0.722AsnTrp: 0.722 ± 0.027	1.342AsnTyr: 1.342 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	4.052ProAla: 4.052 ± 0.076	0.324ProCys: 0.324 ± 0.018	3.081ProAsp: 3.081 ± 0.058	3.996ProGlu: 3.996 ± 0.066	1.824ProPhe: 1.824 ± 0.042	3.251ProGly: 3.251 ± 0.059	0.98ProHis: 0.98 ± 0.034	2.458ProIle: 2.458 ± 0.048	2.123ProLys: 2.123 ± 0.056	4.013ProLeu: 4.013 ± 0.075	0.981ProMet: 0.981 ± 0.033	1.861ProAsn: 1.861 ± 0.043	1.636ProPro: 1.636 ± 0.057	1.659ProGln: 1.659 ± 0.037	1.956ProArg: 1.956 ± 0.052	2.908ProSer: 2.908 ± 0.051	2.511ProThr: 2.511 ± 0.051	3.415ProVal: 3.415 ± 0.058	0.65ProTrp: 0.65 ± 0.026	1.328ProTyr: 1.328 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.099GlnAla: 4.099 ± 0.065	0.305GlnCys: 0.305 ± 0.016	1.822GlnAsp: 1.822 ± 0.035	2.053GlnGlu: 2.053 ± 0.046	1.544GlnPhe: 1.544 ± 0.038	2.479GlnGly: 2.479 ± 0.052	0.923GlnHis: 0.923 ± 0.029	2.313GlnIle: 2.313 ± 0.04	1.479GlnLys: 1.479 ± 0.046	4.462GlnLeu: 4.462 ± 0.083	0.994GlnMet: 0.994 ± 0.034	1.233GlnAsn: 1.233 ± 0.035	1.718GlnPro: 1.718 ± 0.045	2.073GlnGln: 2.073 ± 0.058	2.472GlnArg: 2.472 ± 0.056	2.614GlnSer: 2.614 ± 0.064	2.183GlnThr: 2.183 ± 0.05	2.639GlnVal: 2.639 ± 0.053	0.589GlnTrp: 0.589 ± 0.025	1.059GlnTyr: 1.059 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.58ArgAla: 4.58 ± 0.089	0.551ArgCys: 0.551 ± 0.025	2.899ArgAsp: 2.899 ± 0.058	3.814ArgGlu: 3.814 ± 0.077	2.706ArgPhe: 2.706 ± 0.058	3.351ArgGly: 3.351 ± 0.053	1.161ArgHis: 1.161 ± 0.038	3.719ArgIle: 3.719 ± 0.06	2.473ArgLys: 2.473 ± 0.055	5.639ArgLeu: 5.639 ± 0.096	1.566ArgMet: 1.566 ± 0.047	1.952ArgAsn: 1.952 ± 0.041	2.215ArgPro: 2.215 ± 0.05	2.109ArgGln: 2.109 ± 0.059	3.292ArgArg: 3.292 ± 0.077	3.545ArgSer: 3.545 ± 0.077	2.799ArgThr: 2.799 ± 0.049	3.967ArgVal: 3.967 ± 0.06	0.815ArgTrp: 0.815 ± 0.034	2.088ArgTyr: 2.088 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.914SerAla: 5.914 ± 0.096	0.673SerCys: 0.673 ± 0.027	3.908SerAsp: 3.908 ± 0.079	4.054SerGlu: 4.054 ± 0.077	2.87SerPhe: 2.87 ± 0.054	5.892SerGly: 5.892 ± 0.127	1.249SerHis: 1.249 ± 0.037	4.144SerIle: 4.144 ± 0.074	2.789SerLys: 2.789 ± 0.062	6.573SerLeu: 6.573 ± 0.088	1.593SerMet: 1.593 ± 0.039	2.35SerAsn: 2.35 ± 0.055	2.841SerPro: 2.841 ± 0.057	2.195SerGln: 2.195 ± 0.052	3.185SerArg: 3.185 ± 0.063	4.607SerSer: 4.607 ± 0.084	3.816SerThr: 3.816 ± 0.092	4.546SerVal: 4.546 ± 0.077	0.867SerTrp: 0.867 ± 0.029	2.047SerTyr: 2.047 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.324ThrAla: 5.324 ± 0.115	0.496ThrCys: 0.496 ± 0.026	3.41ThrAsp: 3.41 ± 0.092	3.441ThrGlu: 3.441 ± 0.065	2.087ThrPhe: 2.087 ± 0.069	4.673ThrGly: 4.673 ± 0.14	1.161ThrHis: 1.161 ± 0.032	3.31ThrIle: 3.31 ± 0.102	2.004ThrLys: 2.004 ± 0.042	5.544ThrLeu: 5.544 ± 0.126	0.989ThrMet: 0.989 ± 0.033	1.853ThrAsn: 1.853 ± 0.064	2.882ThrPro: 2.882 ± 0.053	1.978ThrGln: 1.978 ± 0.044	2.582ThrArg: 2.582 ± 0.047	3.322ThrSer: 3.322 ± 0.082	3.205ThrThr: 3.205 ± 0.091	4.403ThrVal: 4.403 ± 0.117	0.748ThrTrp: 0.748 ± 0.029	1.649ThrTyr: 1.649 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	6.16ValAla: 6.16 ± 0.085	0.796ValCys: 0.796 ± 0.033	4.549ValAsp: 4.549 ± 0.079	4.931ValGlu: 4.931 ± 0.075	2.815ValPhe: 2.815 ± 0.06	4.836ValGly: 4.836 ± 0.085	1.481ValHis: 1.481 ± 0.043	3.805ValIle: 3.805 ± 0.072	2.551ValLys: 2.551 ± 0.057	6.548ValLeu: 6.548 ± 0.093	1.349ValMet: 1.349 ± 0.037	2.478ValAsn: 2.478 ± 0.066	2.977ValPro: 2.977 ± 0.049	2.392ValGln: 2.392 ± 0.048	3.755ValArg: 3.755 ± 0.064	4.741ValSer: 4.741 ± 0.09	3.831ValThr: 3.831 ± 0.12	4.913ValVal: 4.913 ± 0.077	0.833ValTrp: 0.833 ± 0.031	2.021ValTyr: 2.021 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.085TrpAla: 1.085 ± 0.036	0.16TrpCys: 0.16 ± 0.012	0.812TrpAsp: 0.812 ± 0.028	0.746TrpGlu: 0.746 ± 0.027	0.61TrpPhe: 0.61 ± 0.025	0.971TrpGly: 0.971 ± 0.036	0.377TrpHis: 0.377 ± 0.022	0.87TrpIle: 0.87 ± 0.032	0.692TrpLys: 0.692 ± 0.028	1.556TrpLeu: 1.556 ± 0.049	0.404TrpMet: 0.404 ± 0.02	0.641TrpAsn: 0.641 ± 0.023	0.578TrpPro: 0.578 ± 0.025	0.636TrpGln: 0.636 ± 0.028	0.794TrpArg: 0.794 ± 0.028	0.907TrpSer: 0.907 ± 0.033	0.909TrpThr: 0.909 ± 0.033	0.901TrpVal: 0.901 ± 0.034	0.262TrpTrp: 0.262 ± 0.017	0.421TrpTyr: 0.421 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.739TyrAla: 2.739 ± 0.055	0.376TyrCys: 0.376 ± 0.021	2.055TyrAsp: 2.055 ± 0.059	1.902TyrGlu: 1.902 ± 0.045	1.4TyrPhe: 1.4 ± 0.036	2.442TyrGly: 2.442 ± 0.052	0.711TyrHis: 0.711 ± 0.026	1.495TyrIle: 1.495 ± 0.037	1.119TyrLys: 1.119 ± 0.035	3.12TyrLeu: 3.12 ± 0.063	0.592TyrMet: 0.592 ± 0.026	1.069TyrAsn: 1.069 ± 0.035	1.37TyrPro: 1.37 ± 0.045	1.373TyrGln: 1.373 ± 0.039	2.065TyrArg: 2.065 ± 0.047	2.061TyrSer: 2.061 ± 0.043	1.832TyrThr: 1.832 ± 0.048	1.859TyrVal: 1.859 ± 0.044	0.501TyrTrp: 0.501 ± 0.023	1.104TyrTyr: 1.104 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3110 proteins (1118454 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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