Amino acid dipepetide frequency for Staphylococcus virus PH15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.992AlaAla: 1.992 ± 0.331
0.295AlaCys: 0.295 ± 0.156
2.287AlaAsp: 2.287 ± 0.388
3.909AlaGlu: 3.909 ± 0.638
2.213AlaPhe: 2.213 ± 0.652
3.246AlaGly: 3.246 ± 0.482
1.328AlaHis: 1.328 ± 0.321
4.795AlaIle: 4.795 ± 0.84
5.237AlaLys: 5.237 ± 0.775
5.09AlaLeu: 5.09 ± 0.774
1.77AlaMet: 1.77 ± 0.332
4.131AlaAsn: 4.131 ± 0.567
1.328AlaPro: 1.328 ± 0.249
2.434AlaGln: 2.434 ± 0.438
1.623AlaArg: 1.623 ± 0.33
3.762AlaSer: 3.762 ± 0.678
2.877AlaThr: 2.877 ± 0.478
2.803AlaVal: 2.803 ± 0.627
0.738AlaTrp: 0.738 ± 0.213
2.213AlaTyr: 2.213 ± 0.443
0.0AlaXaa: 0.0 ± 0.0
Cys
0.443CysAla: 0.443 ± 0.161
0.0CysCys: 0.0 ± 0.0
0.148CysAsp: 0.148 ± 0.12
0.148CysGlu: 0.148 ± 0.104
0.221CysPhe: 0.221 ± 0.12
0.59CysGly: 0.59 ± 0.194
0.074CysHis: 0.074 ± 0.07
0.443CysIle: 0.443 ± 0.181
0.516CysLys: 0.516 ± 0.238
0.295CysLeu: 0.295 ± 0.159
0.0CysMet: 0.0 ± 0.0
0.885CysAsn: 0.885 ± 0.259
0.295CysPro: 0.295 ± 0.144
0.074CysGln: 0.074 ± 0.068
0.295CysArg: 0.295 ± 0.196
0.295CysSer: 0.295 ± 0.148
0.148CysThr: 0.148 ± 0.103
0.369CysVal: 0.369 ± 0.17
0.148CysTrp: 0.148 ± 0.095
0.369CysTyr: 0.369 ± 0.196
0.0CysXaa: 0.0 ± 0.0
Asp
2.877AspAla: 2.877 ± 0.557
0.295AspCys: 0.295 ± 0.166
4.573AspAsp: 4.573 ± 0.702
6.196AspGlu: 6.196 ± 0.785
2.582AspPhe: 2.582 ± 0.397
3.688AspGly: 3.688 ± 0.454
0.59AspHis: 0.59 ± 0.212
4.795AspIle: 4.795 ± 0.626
5.901AspLys: 5.901 ± 0.54
6.122AspLeu: 6.122 ± 0.638
1.697AspMet: 1.697 ± 0.505
4.942AspAsn: 4.942 ± 0.777
1.401AspPro: 1.401 ± 0.292
1.033AspGln: 1.033 ± 0.275
2.139AspArg: 2.139 ± 0.386
3.393AspSer: 3.393 ± 0.415
3.836AspThr: 3.836 ± 0.614
3.467AspVal: 3.467 ± 0.565
0.959AspTrp: 0.959 ± 0.232
3.246AspTyr: 3.246 ± 0.492
0.0AspXaa: 0.0 ± 0.0
Glu
3.172GluAla: 3.172 ± 0.656
0.295GluCys: 0.295 ± 0.155
3.393GluAsp: 3.393 ± 0.496
5.532GluGlu: 5.532 ± 0.916
2.951GluPhe: 2.951 ± 0.506
1.77GluGly: 1.77 ± 0.405
1.475GluHis: 1.475 ± 0.341
5.237GluIle: 5.237 ± 0.7
6.344GluLys: 6.344 ± 0.7
7.671GluLeu: 7.671 ± 0.934
2.213GluMet: 2.213 ± 0.46
4.942GluAsn: 4.942 ± 0.645
1.992GluPro: 1.992 ± 0.417
3.836GluGln: 3.836 ± 0.645
4.721GluArg: 4.721 ± 0.706
3.983GluSer: 3.983 ± 0.462
4.426GluThr: 4.426 ± 0.646
5.532GluVal: 5.532 ± 0.738
1.328GluTrp: 1.328 ± 0.298
3.983GluTyr: 3.983 ± 0.46
0.0GluXaa: 0.0 ± 0.0
Phe
1.77PheAla: 1.77 ± 0.411
0.074PheCys: 0.074 ± 0.068
2.951PheAsp: 2.951 ± 0.462
2.065PheGlu: 2.065 ± 0.509
1.401PhePhe: 1.401 ± 0.336
2.213PheGly: 2.213 ± 0.665
0.664PheHis: 0.664 ± 0.225
2.877PheIle: 2.877 ± 0.495
2.951PheLys: 2.951 ± 0.373
1.549PheLeu: 1.549 ± 0.283
1.401PheMet: 1.401 ± 0.322
3.467PheAsn: 3.467 ± 0.4
0.516PhePro: 0.516 ± 0.202
1.254PheGln: 1.254 ± 0.388
1.623PheArg: 1.623 ± 0.379
1.77PheSer: 1.77 ± 0.34
2.434PheThr: 2.434 ± 0.379
2.582PheVal: 2.582 ± 0.502
0.369PheTrp: 0.369 ± 0.201
1.992PheTyr: 1.992 ± 0.424
0.0PheXaa: 0.0 ± 0.0
Gly
3.541GlyAla: 3.541 ± 0.618
0.664GlyCys: 0.664 ± 0.186
2.877GlyAsp: 2.877 ± 0.609
3.541GlyGlu: 3.541 ± 0.606
1.992GlyPhe: 1.992 ± 0.4
3.688GlyGly: 3.688 ± 0.706
1.401GlyHis: 1.401 ± 0.379
5.016GlyIle: 5.016 ± 0.733
5.311GlyLys: 5.311 ± 0.777
4.278GlyLeu: 4.278 ± 0.675
1.697GlyMet: 1.697 ± 0.337
3.246GlyAsn: 3.246 ± 0.597
0.664GlyPro: 0.664 ± 0.18
3.024GlyGln: 3.024 ± 0.464
2.877GlyArg: 2.877 ± 0.31
2.877GlySer: 2.877 ± 0.774
4.057GlyThr: 4.057 ± 0.59
4.131GlyVal: 4.131 ± 0.715
0.885GlyTrp: 0.885 ± 0.336
3.688GlyTyr: 3.688 ± 0.684
0.0GlyXaa: 0.0 ± 0.0
His
1.328HisAla: 1.328 ± 0.324
0.148HisCys: 0.148 ± 0.104
1.106HisAsp: 1.106 ± 0.336
1.033HisGlu: 1.033 ± 0.242
0.59HisPhe: 0.59 ± 0.231
1.106HisGly: 1.106 ± 0.266
0.738HisHis: 0.738 ± 0.253
0.811HisIle: 0.811 ± 0.253
1.254HisLys: 1.254 ± 0.346
1.106HisLeu: 1.106 ± 0.272
0.295HisMet: 0.295 ± 0.161
1.328HisAsn: 1.328 ± 0.322
0.811HisPro: 0.811 ± 0.227
0.738HisGln: 0.738 ± 0.252
0.738HisArg: 0.738 ± 0.231
1.106HisSer: 1.106 ± 0.279
1.549HisThr: 1.549 ± 0.3
1.106HisVal: 1.106 ± 0.293
0.148HisTrp: 0.148 ± 0.111
0.738HisTyr: 0.738 ± 0.21
0.0HisXaa: 0.0 ± 0.0
Ile
5.532IleAla: 5.532 ± 0.651
0.221IleCys: 0.221 ± 0.127
5.311IleAsp: 5.311 ± 0.604
7.081IleGlu: 7.081 ± 0.836
1.844IlePhe: 1.844 ± 0.337
5.68IleGly: 5.68 ± 0.753
0.443IleHis: 0.443 ± 0.199
4.057IleIle: 4.057 ± 0.646
8.114IleLys: 8.114 ± 0.777
3.983IleLeu: 3.983 ± 0.622
1.475IleMet: 1.475 ± 0.403
4.573IleAsn: 4.573 ± 0.483
2.434IlePro: 2.434 ± 0.337
2.139IleGln: 2.139 ± 0.298
2.36IleArg: 2.36 ± 0.357
4.5IleSer: 4.5 ± 0.703
5.237IleThr: 5.237 ± 0.58
3.909IleVal: 3.909 ± 0.721
0.885IleTrp: 0.885 ± 0.31
2.582IleTyr: 2.582 ± 0.42
0.0IleXaa: 0.0 ± 0.0
Lys
4.721LysAla: 4.721 ± 0.621
0.443LysCys: 0.443 ± 0.187
6.344LysAsp: 6.344 ± 0.57
9.073LysGlu: 9.073 ± 1.235
2.877LysPhe: 2.877 ± 0.425
5.163LysGly: 5.163 ± 0.524
1.623LysHis: 1.623 ± 0.329
6.417LysIle: 6.417 ± 0.855
7.155LysLys: 7.155 ± 0.929
8.04LysLeu: 8.04 ± 0.729
2.729LysMet: 2.729 ± 0.491
5.016LysAsn: 5.016 ± 0.676
2.803LysPro: 2.803 ± 0.592
5.458LysGln: 5.458 ± 0.733
5.237LysArg: 5.237 ± 0.675
5.09LysSer: 5.09 ± 0.633
6.049LysThr: 6.049 ± 0.851
5.385LysVal: 5.385 ± 0.549
1.18LysTrp: 1.18 ± 0.251
4.131LysTyr: 4.131 ± 0.73
0.0LysXaa: 0.0 ± 0.0
Leu
4.131LeuAla: 4.131 ± 0.693
0.221LeuCys: 0.221 ± 0.158
5.606LeuAsp: 5.606 ± 0.486
6.049LeuGlu: 6.049 ± 0.747
3.098LeuPhe: 3.098 ± 0.512
4.278LeuGly: 4.278 ± 0.728
1.254LeuHis: 1.254 ± 0.313
5.606LeuIle: 5.606 ± 0.674
7.376LeuLys: 7.376 ± 0.905
5.311LeuLeu: 5.311 ± 0.761
1.623LeuMet: 1.623 ± 0.342
5.68LeuAsn: 5.68 ± 0.499
2.434LeuPro: 2.434 ± 0.4
3.541LeuGln: 3.541 ± 0.608
3.762LeuArg: 3.762 ± 0.653
4.573LeuSer: 4.573 ± 0.513
4.204LeuThr: 4.204 ± 0.504
3.319LeuVal: 3.319 ± 0.431
1.401LeuTrp: 1.401 ± 0.316
3.172LeuTyr: 3.172 ± 0.58
0.0LeuXaa: 0.0 ± 0.0
Met
1.77MetAla: 1.77 ± 0.516
0.148MetCys: 0.148 ± 0.118
1.106MetAsp: 1.106 ± 0.263
1.623MetGlu: 1.623 ± 0.378
0.811MetPhe: 0.811 ± 0.307
0.885MetGly: 0.885 ± 0.216
0.295MetHis: 0.295 ± 0.147
1.475MetIle: 1.475 ± 0.299
3.246MetLys: 3.246 ± 0.437
2.655MetLeu: 2.655 ± 0.519
0.811MetMet: 0.811 ± 0.265
1.623MetAsn: 1.623 ± 0.322
1.033MetPro: 1.033 ± 0.236
0.885MetGln: 0.885 ± 0.254
1.106MetArg: 1.106 ± 0.292
1.918MetSer: 1.918 ± 0.356
1.77MetThr: 1.77 ± 0.38
0.959MetVal: 0.959 ± 0.261
0.516MetTrp: 0.516 ± 0.211
1.475MetTyr: 1.475 ± 0.347
0.0MetXaa: 0.0 ± 0.0
Asn
3.836AsnAla: 3.836 ± 0.58
0.811AsnCys: 0.811 ± 0.389
5.163AsnAsp: 5.163 ± 0.803
4.131AsnGlu: 4.131 ± 0.592
2.508AsnPhe: 2.508 ± 0.373
5.163AsnGly: 5.163 ± 0.81
1.106AsnHis: 1.106 ± 0.302
4.868AsnIle: 4.868 ± 0.8
6.786AsnLys: 6.786 ± 0.728
3.983AsnLeu: 3.983 ± 0.577
1.033AsnMet: 1.033 ± 0.292
4.795AsnAsn: 4.795 ± 0.709
2.582AsnPro: 2.582 ± 0.402
3.172AsnGln: 3.172 ± 0.735
3.393AsnArg: 3.393 ± 0.503
3.983AsnSer: 3.983 ± 0.586
3.467AsnThr: 3.467 ± 0.591
4.426AsnVal: 4.426 ± 0.612
0.664AsnTrp: 0.664 ± 0.209
2.36AsnTyr: 2.36 ± 0.483
0.0AsnXaa: 0.0 ± 0.0
Pro
1.106ProAla: 1.106 ± 0.299
0.074ProCys: 0.074 ± 0.077
1.844ProAsp: 1.844 ± 0.39
1.844ProGlu: 1.844 ± 0.307
1.549ProPhe: 1.549 ± 0.413
1.254ProGly: 1.254 ± 0.37
0.516ProHis: 0.516 ± 0.197
2.803ProIle: 2.803 ± 0.534
2.951ProLys: 2.951 ± 0.462
1.328ProLeu: 1.328 ± 0.335
0.738ProMet: 0.738 ± 0.251
1.918ProAsn: 1.918 ± 0.395
1.106ProPro: 1.106 ± 0.3
0.811ProGln: 0.811 ± 0.259
1.77ProArg: 1.77 ± 0.443
2.065ProSer: 2.065 ± 0.451
1.328ProThr: 1.328 ± 0.311
1.844ProVal: 1.844 ± 0.385
0.148ProTrp: 0.148 ± 0.095
1.18ProTyr: 1.18 ± 0.284
0.0ProXaa: 0.0 ± 0.0
Gln
2.508GlnAla: 2.508 ± 0.479
0.221GlnCys: 0.221 ± 0.102
2.065GlnAsp: 2.065 ± 0.414
2.655GlnGlu: 2.655 ± 0.415
1.106GlnPhe: 1.106 ± 0.245
2.139GlnGly: 2.139 ± 0.365
0.959GlnHis: 0.959 ± 0.316
3.098GlnIle: 3.098 ± 0.429
4.352GlnLys: 4.352 ± 0.684
3.172GlnLeu: 3.172 ± 0.455
1.033GlnMet: 1.033 ± 0.267
3.688GlnAsn: 3.688 ± 0.513
1.254GlnPro: 1.254 ± 0.336
1.918GlnGln: 1.918 ± 0.415
2.065GlnArg: 2.065 ± 0.331
2.065GlnSer: 2.065 ± 0.428
2.213GlnThr: 2.213 ± 0.549
1.844GlnVal: 1.844 ± 0.458
0.369GlnTrp: 0.369 ± 0.151
1.475GlnTyr: 1.475 ± 0.338
0.0GlnXaa: 0.0 ± 0.0
Arg
2.655ArgAla: 2.655 ± 0.585
0.443ArgCys: 0.443 ± 0.172
3.098ArgAsp: 3.098 ± 0.453
3.172ArgGlu: 3.172 ± 0.478
1.475ArgPhe: 1.475 ± 0.289
2.508ArgGly: 2.508 ± 0.482
1.033ArgHis: 1.033 ± 0.275
2.803ArgIle: 2.803 ± 0.471
4.721ArgLys: 4.721 ± 0.767
3.762ArgLeu: 3.762 ± 0.508
1.77ArgMet: 1.77 ± 0.334
3.098ArgAsn: 3.098 ± 0.496
1.18ArgPro: 1.18 ± 0.283
1.254ArgGln: 1.254 ± 0.309
2.287ArgArg: 2.287 ± 0.521
2.434ArgSer: 2.434 ± 0.522
1.697ArgThr: 1.697 ± 0.345
3.246ArgVal: 3.246 ± 0.448
0.885ArgTrp: 0.885 ± 0.252
2.729ArgTyr: 2.729 ± 0.474
0.0ArgXaa: 0.0 ± 0.0
Ser
3.098SerAla: 3.098 ± 0.588
0.148SerCys: 0.148 ± 0.108
3.762SerAsp: 3.762 ± 0.618
3.688SerGlu: 3.688 ± 0.494
2.213SerPhe: 2.213 ± 0.4
4.426SerGly: 4.426 ± 0.658
1.254SerHis: 1.254 ± 0.335
3.614SerIle: 3.614 ± 0.519
5.09SerLys: 5.09 ± 0.572
5.09SerLeu: 5.09 ± 0.562
1.549SerMet: 1.549 ± 0.255
4.573SerAsn: 4.573 ± 0.855
1.18SerPro: 1.18 ± 0.292
2.508SerGln: 2.508 ± 0.518
2.508SerArg: 2.508 ± 0.461
2.508SerSer: 2.508 ± 0.392
3.467SerThr: 3.467 ± 0.548
3.614SerVal: 3.614 ± 0.475
1.033SerTrp: 1.033 ± 0.284
2.36SerTyr: 2.36 ± 0.357
0.0SerXaa: 0.0 ± 0.0
Thr
3.319ThrAla: 3.319 ± 0.587
0.221ThrCys: 0.221 ± 0.119
3.688ThrAsp: 3.688 ± 0.543
2.729ThrGlu: 2.729 ± 0.629
2.655ThrPhe: 2.655 ± 0.473
3.909ThrGly: 3.909 ± 0.572
1.18ThrHis: 1.18 ± 0.235
5.311ThrIle: 5.311 ± 0.502
6.86ThrLys: 6.86 ± 0.814
4.352ThrLeu: 4.352 ± 0.533
1.18ThrMet: 1.18 ± 0.227
3.172ThrAsn: 3.172 ± 0.532
2.139ThrPro: 2.139 ± 0.42
2.655ThrGln: 2.655 ± 0.405
2.287ThrArg: 2.287 ± 0.461
3.393ThrSer: 3.393 ± 0.494
4.868ThrThr: 4.868 ± 0.726
3.541ThrVal: 3.541 ± 0.769
0.443ThrTrp: 0.443 ± 0.156
2.065ThrTyr: 2.065 ± 0.433
0.0ThrXaa: 0.0 ± 0.0
Val
3.688ValAla: 3.688 ± 0.749
0.443ValCys: 0.443 ± 0.276
4.942ValAsp: 4.942 ± 0.504
4.868ValGlu: 4.868 ± 0.644
2.139ValPhe: 2.139 ± 0.479
3.614ValGly: 3.614 ± 0.453
0.59ValHis: 0.59 ± 0.227
3.614ValIle: 3.614 ± 0.478
6.049ValLys: 6.049 ± 0.696
4.057ValLeu: 4.057 ± 0.565
1.401ValMet: 1.401 ± 0.284
3.098ValAsn: 3.098 ± 0.478
1.77ValPro: 1.77 ± 0.385
1.697ValGln: 1.697 ± 0.407
2.951ValArg: 2.951 ± 0.359
4.942ValSer: 4.942 ± 0.506
3.393ValThr: 3.393 ± 0.511
4.573ValVal: 4.573 ± 0.489
0.295ValTrp: 0.295 ± 0.214
2.287ValTyr: 2.287 ± 0.492
0.0ValXaa: 0.0 ± 0.0
Trp
0.811TrpAla: 0.811 ± 0.257
0.148TrpCys: 0.148 ± 0.111
0.443TrpAsp: 0.443 ± 0.182
1.475TrpGlu: 1.475 ± 0.36
0.369TrpPhe: 0.369 ± 0.173
0.738TrpGly: 0.738 ± 0.322
0.148TrpHis: 0.148 ± 0.105
1.033TrpIle: 1.033 ± 0.265
0.885TrpLys: 0.885 ± 0.285
1.18TrpLeu: 1.18 ± 0.333
0.0TrpMet: 0.0 ± 0.0
0.738TrpAsn: 0.738 ± 0.323
0.148TrpPro: 0.148 ± 0.093
0.369TrpGln: 0.369 ± 0.146
0.59TrpArg: 0.59 ± 0.209
0.738TrpSer: 0.738 ± 0.212
1.328TrpThr: 1.328 ± 0.277
1.328TrpVal: 1.328 ± 0.315
0.295TrpTrp: 0.295 ± 0.166
0.59TrpTyr: 0.59 ± 0.201
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.77TyrAla: 1.77 ± 0.347
0.443TyrCys: 0.443 ± 0.178
3.024TyrAsp: 3.024 ± 0.51
3.983TyrGlu: 3.983 ± 0.628
1.328TyrPhe: 1.328 ± 0.345
3.393TyrGly: 3.393 ± 0.762
1.106TyrHis: 1.106 ± 0.298
3.688TyrIle: 3.688 ± 0.544
3.836TyrLys: 3.836 ± 0.557
3.614TyrLeu: 3.614 ± 0.605
1.623TyrMet: 1.623 ± 0.352
3.319TyrAsn: 3.319 ± 0.505
1.106TyrPro: 1.106 ± 0.298
1.401TyrGln: 1.401 ± 0.265
1.918TyrArg: 1.918 ± 0.427
2.287TyrSer: 2.287 ± 0.432
1.623TyrThr: 1.623 ± 0.334
2.508TyrVal: 2.508 ± 0.344
0.664TyrTrp: 0.664 ± 0.242
1.549TyrTyr: 1.549 ± 0.442
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (13558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski