Amino acid dipepetide frequency for Belnapia rosea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.7AlaAla: 24.7 ± 0.224
1.381AlaCys: 1.381 ± 0.035
6.53AlaAsp: 6.53 ± 0.065
10.374AlaGlu: 10.374 ± 0.097
4.234AlaPhe: 4.234 ± 0.052
13.944AlaGly: 13.944 ± 0.117
2.329AlaHis: 2.329 ± 0.037
5.787AlaIle: 5.787 ± 0.065
2.795AlaLys: 2.795 ± 0.053
17.076AlaLeu: 17.076 ± 0.143
4.233AlaMet: 4.233 ± 0.052
2.475AlaAsn: 2.475 ± 0.047
8.003AlaPro: 8.003 ± 0.09
4.343AlaGln: 4.343 ± 0.06
12.011AlaArg: 12.011 ± 0.115
5.978AlaSer: 5.978 ± 0.062
6.591AlaThr: 6.591 ± 0.059
9.864AlaVal: 9.864 ± 0.08
2.233AlaTrp: 2.233 ± 0.04
2.203AlaTyr: 2.203 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
1.108CysAla: 1.108 ± 0.027
0.134CysCys: 0.134 ± 0.009
0.5CysAsp: 0.5 ± 0.016
0.388CysGlu: 0.388 ± 0.013
0.327CysPhe: 0.327 ± 0.015
1.043CysGly: 1.043 ± 0.03
0.235CysHis: 0.235 ± 0.013
0.391CysIle: 0.391 ± 0.018
0.116CysLys: 0.116 ± 0.008
0.904CysLeu: 0.904 ± 0.024
0.157CysMet: 0.157 ± 0.009
0.183CysAsn: 0.183 ± 0.01
0.534CysPro: 0.534 ± 0.02
0.216CysGln: 0.216 ± 0.012
0.774CysArg: 0.774 ± 0.022
0.389CysSer: 0.389 ± 0.016
0.469CysThr: 0.469 ± 0.019
0.569CysVal: 0.569 ± 0.019
0.142CysTrp: 0.142 ± 0.009
0.18CysTyr: 0.18 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.833AspAla: 6.833 ± 0.069
0.469AspCys: 0.469 ± 0.018
2.069AspAsp: 2.069 ± 0.045
2.513AspGlu: 2.513 ± 0.045
1.753AspPhe: 1.753 ± 0.031
4.959AspGly: 4.959 ± 0.066
1.048AspHis: 1.048 ± 0.027
2.159AspIle: 2.159 ± 0.038
0.817AspLys: 0.817 ± 0.022
5.407AspLeu: 5.407 ± 0.055
1.061AspMet: 1.061 ± 0.026
0.801AspAsn: 0.801 ± 0.023
3.798AspPro: 3.798 ± 0.043
1.412AspGln: 1.412 ± 0.026
4.468AspArg: 4.468 ± 0.057
1.79AspSer: 1.79 ± 0.037
2.172AspThr: 2.172 ± 0.041
3.185AspVal: 3.185 ± 0.041
1.06AspTrp: 1.06 ± 0.025
1.177AspTyr: 1.177 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
10.388GluAla: 10.388 ± 0.115
0.358GluCys: 0.358 ± 0.014
2.578GluAsp: 2.578 ± 0.04
3.407GluGlu: 3.407 ± 0.055
1.618GluPhe: 1.618 ± 0.031
5.238GluGly: 5.238 ± 0.059
1.069GluHis: 1.069 ± 0.028
2.541GluIle: 2.541 ± 0.042
1.124GluLys: 1.124 ± 0.031
5.028GluLeu: 5.028 ± 0.053
1.452GluMet: 1.452 ± 0.029
1.043GluAsn: 1.043 ± 0.026
3.03GluPro: 3.03 ± 0.04
1.993GluGln: 1.993 ± 0.03
5.527GluArg: 5.527 ± 0.059
2.0GluSer: 2.0 ± 0.038
2.983GluThr: 2.983 ± 0.042
4.322GluVal: 4.322 ± 0.052
0.742GluTrp: 0.742 ± 0.022
0.834GluTyr: 0.834 ± 0.023
0.0GluXaa: 0.0 ± 0.0
Phe
4.44PheAla: 4.44 ± 0.045
0.373PheCys: 0.373 ± 0.014
2.035PheAsp: 2.035 ± 0.038
1.714PheGlu: 1.714 ± 0.03
1.078PhePhe: 1.078 ± 0.032
3.577PheGly: 3.577 ± 0.045
0.701PheHis: 0.701 ± 0.019
1.184PheIle: 1.184 ± 0.023
0.508PheLys: 0.508 ± 0.018
3.314PheLeu: 3.314 ± 0.043
0.59PheMet: 0.59 ± 0.019
0.773PheAsn: 0.773 ± 0.02
1.664PhePro: 1.664 ± 0.032
0.873PheGln: 0.873 ± 0.024
2.455PheArg: 2.455 ± 0.037
1.61PheSer: 1.61 ± 0.028
1.79PheThr: 1.79 ± 0.027
2.177PheVal: 2.177 ± 0.036
0.499PheTrp: 0.499 ± 0.018
0.616PheTyr: 0.616 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
11.623GlyAla: 11.623 ± 0.101
0.95GlyCys: 0.95 ± 0.022
3.945GlyAsp: 3.945 ± 0.055
5.005GlyGlu: 5.005 ± 0.058
3.807GlyPhe: 3.807 ± 0.054
9.033GlyGly: 9.033 ± 0.122
2.02GlyHis: 2.02 ± 0.04
4.416GlyIle: 4.416 ± 0.052
2.109GlyLys: 2.109 ± 0.043
11.081GlyLeu: 11.081 ± 0.096
2.739GlyMet: 2.739 ± 0.039
1.874GlyAsn: 1.874 ± 0.046
4.939GlyPro: 4.939 ± 0.061
3.314GlyGln: 3.314 ± 0.046
8.107GlyArg: 8.107 ± 0.083
4.487GlySer: 4.487 ± 0.064
5.171GlyThr: 5.171 ± 0.064
6.156GlyVal: 6.156 ± 0.068
1.895GlyTrp: 1.895 ± 0.037
2.049GlyTyr: 2.049 ± 0.035
0.0GlyXaa: 0.0 ± 0.0
His
2.731HisAla: 2.731 ± 0.046
0.232HisCys: 0.232 ± 0.011
1.016HisAsp: 1.016 ± 0.028
0.893HisGlu: 0.893 ± 0.019
0.688HisPhe: 0.688 ± 0.021
2.157HisGly: 2.157 ± 0.034
0.575HisHis: 0.575 ± 0.022
0.709HisIle: 0.709 ± 0.022
0.297HisLys: 0.297 ± 0.013
2.187HisLeu: 2.187 ± 0.035
0.414HisMet: 0.414 ± 0.015
0.365HisAsn: 0.365 ± 0.015
1.566HisPro: 1.566 ± 0.035
0.555HisGln: 0.555 ± 0.02
1.723HisArg: 1.723 ± 0.033
0.802HisSer: 0.802 ± 0.023
0.732HisThr: 0.732 ± 0.022
1.496HisVal: 1.496 ± 0.034
0.411HisTrp: 0.411 ± 0.015
0.485HisTyr: 0.485 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
6.54IleAla: 6.54 ± 0.064
0.397IleCys: 0.397 ± 0.016
2.292IleAsp: 2.292 ± 0.04
2.847IleGlu: 2.847 ± 0.045
1.13IlePhe: 1.13 ± 0.03
4.766IleGly: 4.766 ± 0.064
0.834IleHis: 0.834 ± 0.02
1.452IleIle: 1.452 ± 0.031
0.689IleLys: 0.689 ± 0.022
3.956IleLeu: 3.956 ± 0.05
0.654IleMet: 0.654 ± 0.02
0.892IleAsn: 0.892 ± 0.023
2.333IlePro: 2.333 ± 0.037
1.01IleGln: 1.01 ± 0.023
3.402IleArg: 3.402 ± 0.047
1.773IleSer: 1.773 ± 0.033
2.142IleThr: 2.142 ± 0.037
2.744IleVal: 2.744 ± 0.042
0.486IleTrp: 0.486 ± 0.017
0.711IleTyr: 0.711 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
2.631LysAla: 2.631 ± 0.048
0.09LysCys: 0.09 ± 0.007
0.901LysAsp: 0.901 ± 0.027
0.955LysGlu: 0.955 ± 0.025
0.444LysPhe: 0.444 ± 0.016
1.648LysGly: 1.648 ± 0.037
0.377LysHis: 0.377 ± 0.015
0.761LysIle: 0.761 ± 0.02
0.481LysLys: 0.481 ± 0.019
2.174LysLeu: 2.174 ± 0.042
0.37LysMet: 0.37 ± 0.015
0.369LysAsn: 0.369 ± 0.015
1.52LysPro: 1.52 ± 0.029
0.632LysGln: 0.632 ± 0.019
1.636LysArg: 1.636 ± 0.038
0.884LysSer: 0.884 ± 0.025
0.998LysThr: 0.998 ± 0.026
1.645LysVal: 1.645 ± 0.04
0.194LysTrp: 0.194 ± 0.01
0.335LysTyr: 0.335 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
18.254LeuAla: 18.254 ± 0.138
1.003LeuCys: 1.003 ± 0.027
5.964LeuAsp: 5.964 ± 0.065
5.451LeuGlu: 5.451 ± 0.06
3.084LeuPhe: 3.084 ± 0.046
10.271LeuGly: 10.271 ± 0.095
2.185LeuHis: 2.185 ± 0.037
3.774LeuIle: 3.774 ± 0.054
2.215LeuLys: 2.215 ± 0.04
12.373LeuLeu: 12.373 ± 0.132
2.142LeuMet: 2.142 ± 0.038
2.079LeuAsn: 2.079 ± 0.033
7.6LeuPro: 7.6 ± 0.081
2.996LeuGln: 2.996 ± 0.044
9.804LeuArg: 9.804 ± 0.085
5.26LeuSer: 5.26 ± 0.059
5.232LeuThr: 5.232 ± 0.054
8.145LeuVal: 8.145 ± 0.064
1.383LeuTrp: 1.383 ± 0.033
1.799LeuTyr: 1.799 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
3.585MetAla: 3.585 ± 0.048
0.137MetCys: 0.137 ± 0.008
1.071MetAsp: 1.071 ± 0.027
1.148MetGlu: 1.148 ± 0.026
0.542MetPhe: 0.542 ± 0.019
1.835MetGly: 1.835 ± 0.033
0.416MetHis: 0.416 ± 0.014
0.921MetIle: 0.921 ± 0.022
0.552MetLys: 0.552 ± 0.019
2.802MetLeu: 2.802 ± 0.047
0.545MetMet: 0.545 ± 0.018
0.548MetAsn: 0.548 ± 0.019
1.871MetPro: 1.871 ± 0.029
0.877MetGln: 0.877 ± 0.023
2.02MetArg: 2.02 ± 0.036
1.235MetSer: 1.235 ± 0.029
1.503MetThr: 1.503 ± 0.026
1.695MetVal: 1.695 ± 0.033
0.176MetTrp: 0.176 ± 0.01
0.234MetTyr: 0.234 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.658AsnAla: 2.658 ± 0.039
0.184AsnCys: 0.184 ± 0.01
0.95AsnAsp: 0.95 ± 0.029
0.86AsnGlu: 0.86 ± 0.025
0.654AsnPhe: 0.654 ± 0.018
1.897AsnGly: 1.897 ± 0.047
0.42AsnHis: 0.42 ± 0.017
0.944AsnIle: 0.944 ± 0.023
0.364AsnLys: 0.364 ± 0.015
2.194AsnLeu: 2.194 ± 0.035
0.411AsnMet: 0.411 ± 0.018
0.506AsnAsn: 0.506 ± 0.017
1.709AsnPro: 1.709 ± 0.032
0.581AsnGln: 0.581 ± 0.018
1.722AsnArg: 1.722 ± 0.033
0.848AsnSer: 0.848 ± 0.02
0.994AsnThr: 0.994 ± 0.024
1.225AsnVal: 1.225 ± 0.029
0.33AsnTrp: 0.33 ± 0.013
0.447AsnTyr: 0.447 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
9.243ProAla: 9.243 ± 0.087
0.437ProCys: 0.437 ± 0.016
3.84ProAsp: 3.84 ± 0.049
4.73ProGlu: 4.73 ± 0.05
2.0ProPhe: 2.0 ± 0.035
6.805ProGly: 6.805 ± 0.073
1.2ProHis: 1.2 ± 0.026
2.125ProIle: 2.125 ± 0.036
1.173ProLys: 1.173 ± 0.03
5.92ProLeu: 5.92 ± 0.055
1.459ProMet: 1.459 ± 0.029
1.302ProAsn: 1.302 ± 0.024
4.545ProPro: 4.545 ± 0.071
1.785ProGln: 1.785 ± 0.037
4.374ProArg: 4.374 ± 0.061
2.762ProSer: 2.762 ± 0.039
2.578ProThr: 2.578 ± 0.041
5.015ProVal: 5.015 ± 0.062
0.966ProTrp: 0.966 ± 0.028
1.162ProTyr: 1.162 ± 0.024
0.0ProXaa: 0.0 ± 0.0
Gln
5.048GlnAla: 5.048 ± 0.053
0.188GlnCys: 0.188 ± 0.011
1.463GlnAsp: 1.463 ± 0.031
1.565GlnGlu: 1.565 ± 0.034
0.82GlnPhe: 0.82 ± 0.021
2.85GlnGly: 2.85 ± 0.042
0.614GlnHis: 0.614 ± 0.018
1.258GlnIle: 1.258 ± 0.03
0.59GlnLys: 0.59 ± 0.02
2.786GlnLeu: 2.786 ± 0.042
0.751GlnMet: 0.751 ± 0.02
0.578GlnAsn: 0.578 ± 0.02
2.197GlnPro: 2.197 ± 0.039
1.253GlnGln: 1.253 ± 0.038
2.814GlnArg: 2.814 ± 0.047
1.36GlnSer: 1.36 ± 0.029
1.339GlnThr: 1.339 ± 0.026
2.446GlnVal: 2.446 ± 0.037
0.389GlnTrp: 0.389 ± 0.015
0.479GlnTyr: 0.479 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
10.808ArgAla: 10.808 ± 0.094
0.7ArgCys: 0.7 ± 0.021
4.22ArgAsp: 4.22 ± 0.055
4.631ArgGlu: 4.631 ± 0.057
3.164ArgPhe: 3.164 ± 0.046
6.49ArgGly: 6.49 ± 0.071
2.069ArgHis: 2.069 ± 0.036
4.133ArgIle: 4.133 ± 0.052
1.496ArgLys: 1.496 ± 0.035
10.703ArgLeu: 10.703 ± 0.103
2.175ArgMet: 2.175 ± 0.035
1.773ArgAsn: 1.773 ± 0.031
5.269ArgPro: 5.269 ± 0.071
2.998ArgGln: 2.998 ± 0.045
8.427ArgArg: 8.427 ± 0.078
3.643ArgSer: 3.643 ± 0.047
3.551ArgThr: 3.551 ± 0.047
5.491ArgVal: 5.491 ± 0.052
1.467ArgTrp: 1.467 ± 0.032
1.598ArgTyr: 1.598 ± 0.029
0.0ArgXaa: 0.0 ± 0.0
Ser
5.71SerAla: 5.71 ± 0.053
0.385SerCys: 0.385 ± 0.016
1.975SerAsp: 1.975 ± 0.037
2.016SerGlu: 2.016 ± 0.036
1.697SerPhe: 1.697 ± 0.033
4.791SerGly: 4.791 ± 0.063
0.917SerHis: 0.917 ± 0.026
1.993SerIle: 1.993 ± 0.038
0.794SerLys: 0.794 ± 0.021
5.138SerLeu: 5.138 ± 0.061
1.057SerMet: 1.057 ± 0.023
0.882SerAsn: 0.882 ± 0.02
2.868SerPro: 2.868 ± 0.038
1.231SerGln: 1.231 ± 0.025
3.405SerArg: 3.405 ± 0.038
2.034SerSer: 2.034 ± 0.038
2.154SerThr: 2.154 ± 0.038
3.119SerVal: 3.119 ± 0.04
0.754SerTrp: 0.754 ± 0.021
0.956SerTyr: 0.956 ± 0.024
0.0SerXaa: 0.0 ± 0.0
Thr
6.448ThrAla: 6.448 ± 0.065
0.371ThrCys: 0.371 ± 0.014
2.477ThrAsp: 2.477 ± 0.039
2.719ThrGlu: 2.719 ± 0.041
1.405ThrPhe: 1.405 ± 0.029
5.308ThrGly: 5.308 ± 0.061
0.971ThrHis: 0.971 ± 0.022
2.266ThrIle: 2.266 ± 0.036
0.847ThrLys: 0.847 ± 0.021
5.754ThrLeu: 5.754 ± 0.071
1.07ThrMet: 1.07 ± 0.024
0.996ThrAsn: 0.996 ± 0.025
3.466ThrPro: 3.466 ± 0.049
1.27ThrGln: 1.27 ± 0.029
3.515ThrArg: 3.515 ± 0.039
2.144ThrSer: 2.144 ± 0.033
2.605ThrThr: 2.605 ± 0.05
3.834ThrVal: 3.834 ± 0.045
0.64ThrTrp: 0.64 ± 0.016
0.935ThrTyr: 0.935 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
10.159ValAla: 10.159 ± 0.089
0.58ValCys: 0.58 ± 0.019
3.298ValAsp: 3.298 ± 0.049
4.456ValGlu: 4.456 ± 0.046
2.368ValPhe: 2.368 ± 0.041
5.168ValGly: 5.168 ± 0.06
1.292ValHis: 1.292 ± 0.028
3.06ValIle: 3.06 ± 0.045
1.45ValLys: 1.45 ± 0.032
8.392ValLeu: 8.392 ± 0.078
1.722ValMet: 1.722 ± 0.033
1.644ValAsn: 1.644 ± 0.036
4.599ValPro: 4.599 ± 0.05
2.244ValGln: 2.244 ± 0.042
5.193ValArg: 5.193 ± 0.059
3.27ValSer: 3.27 ± 0.045
4.411ValThr: 4.411 ± 0.044
6.025ValVal: 6.025 ± 0.061
0.915ValTrp: 0.915 ± 0.026
1.071ValTyr: 1.071 ± 0.022
0.0ValXaa: 0.0 ± 0.0
Trp
1.683TrpAla: 1.683 ± 0.034
0.165TrpCys: 0.165 ± 0.01
0.716TrpAsp: 0.716 ± 0.022
0.668TrpGlu: 0.668 ± 0.02
0.551TrpPhe: 0.551 ± 0.019
1.094TrpGly: 1.094 ± 0.026
0.385TrpHis: 0.385 ± 0.017
0.582TrpIle: 0.582 ± 0.018
0.28TrpLys: 0.28 ± 0.013
1.997TrpLeu: 1.997 ± 0.038
0.382TrpMet: 0.382 ± 0.015
0.398TrpAsn: 0.398 ± 0.016
0.942TrpPro: 0.942 ± 0.024
0.654TrpGln: 0.654 ± 0.018
1.691TrpArg: 1.691 ± 0.034
0.773TrpSer: 0.773 ± 0.022
0.801TrpThr: 0.801 ± 0.02
0.929TrpVal: 0.929 ± 0.024
0.274TrpTrp: 0.274 ± 0.014
0.307TrpTyr: 0.307 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.494TyrAla: 2.494 ± 0.043
0.228TyrCys: 0.228 ± 0.01
1.111TyrAsp: 1.111 ± 0.027
0.937TyrGlu: 0.937 ± 0.025
0.609TyrPhe: 0.609 ± 0.021
1.845TyrGly: 1.845 ± 0.036
0.376TyrHis: 0.376 ± 0.016
0.596TyrIle: 0.596 ± 0.021
0.348TyrLys: 0.348 ± 0.013
1.827TyrLeu: 1.827 ± 0.032
0.325TyrMet: 0.325 ± 0.014
0.417TyrAsn: 0.417 ± 0.017
0.966TyrPro: 0.966 ± 0.024
0.552TyrGln: 0.552 ± 0.022
1.737TyrArg: 1.737 ± 0.031
0.832TyrSer: 0.832 ± 0.02
0.824TyrThr: 0.824 ± 0.02
1.234TyrVal: 1.234 ± 0.028
0.316TyrTrp: 0.316 ± 0.012
0.395TyrTyr: 0.395 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5712 proteins (1791141 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski