Amino acid dipepetide frequency for Mannheimia phage vB_MhS_587AP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.959AlaAla: 5.959 ± 1.11
0.203AlaCys: 0.203 ± 0.095
5.079AlaAsp: 5.079 ± 0.562
6.975AlaGlu: 6.975 ± 0.899
2.506AlaPhe: 2.506 ± 0.477
4.469AlaGly: 4.469 ± 0.467
1.422AlaHis: 1.422 ± 0.356
5.485AlaIle: 5.485 ± 0.82
6.84AlaLys: 6.84 ± 1.048
5.959AlaLeu: 5.959 ± 0.634
1.964AlaMet: 1.964 ± 0.412
4.74AlaAsn: 4.74 ± 0.747
2.641AlaPro: 2.641 ± 0.441
3.928AlaGln: 3.928 ± 0.671
3.792AlaArg: 3.792 ± 0.638
3.725AlaSer: 3.725 ± 0.688
4.605AlaThr: 4.605 ± 0.686
6.636AlaVal: 6.636 ± 0.705
1.219AlaTrp: 1.219 ± 0.302
2.776AlaTyr: 2.776 ± 0.412
0.0AlaXaa: 0.0 ± 0.0
Cys
0.677CysAla: 0.677 ± 0.267
0.339CysCys: 0.339 ± 0.243
0.677CysAsp: 0.677 ± 0.215
0.677CysGlu: 0.677 ± 0.232
0.203CysPhe: 0.203 ± 0.132
0.88CysGly: 0.88 ± 0.303
0.203CysHis: 0.203 ± 0.091
0.677CysIle: 0.677 ± 0.202
0.677CysLys: 0.677 ± 0.217
1.151CysLeu: 1.151 ± 0.339
0.135CysMet: 0.135 ± 0.094
0.813CysAsn: 0.813 ± 0.22
0.406CysPro: 0.406 ± 0.17
0.203CysGln: 0.203 ± 0.124
0.068CysArg: 0.068 ± 0.065
1.151CysSer: 1.151 ± 0.312
0.474CysThr: 0.474 ± 0.163
0.474CysVal: 0.474 ± 0.227
0.339CysTrp: 0.339 ± 0.14
0.203CysTyr: 0.203 ± 0.121
0.0CysXaa: 0.0 ± 0.0
Asp
2.709AspAla: 2.709 ± 0.659
0.813AspCys: 0.813 ± 0.322
3.25AspAsp: 3.25 ± 0.553
4.199AspGlu: 4.199 ± 0.511
2.506AspPhe: 2.506 ± 0.504
5.011AspGly: 5.011 ± 0.502
0.677AspHis: 0.677 ± 0.197
2.573AspIle: 2.573 ± 0.434
4.199AspLys: 4.199 ± 0.584
5.011AspLeu: 5.011 ± 0.57
0.745AspMet: 0.745 ± 0.231
2.912AspAsn: 2.912 ± 0.544
1.964AspPro: 1.964 ± 0.308
1.49AspGln: 1.49 ± 0.291
2.235AspArg: 2.235 ± 0.411
3.183AspSer: 3.183 ± 0.625
2.709AspThr: 2.709 ± 0.395
3.657AspVal: 3.657 ± 0.518
1.219AspTrp: 1.219 ± 0.275
1.761AspTyr: 1.761 ± 0.412
0.0AspXaa: 0.0 ± 0.0
Glu
5.892GluAla: 5.892 ± 0.77
0.948GluCys: 0.948 ± 0.324
2.641GluAsp: 2.641 ± 0.433
4.537GluGlu: 4.537 ± 0.642
3.928GluPhe: 3.928 ± 0.531
2.37GluGly: 2.37 ± 0.55
0.677GluHis: 0.677 ± 0.194
5.756GluIle: 5.756 ± 0.552
4.876GluLys: 4.876 ± 0.547
5.892GluLeu: 5.892 ± 0.705
1.625GluMet: 1.625 ± 0.41
3.792GluAsn: 3.792 ± 0.584
2.167GluPro: 2.167 ± 0.483
5.079GluGln: 5.079 ± 0.708
3.183GluArg: 3.183 ± 0.436
4.063GluSer: 4.063 ± 0.417
3.928GluThr: 3.928 ± 0.639
4.943GluVal: 4.943 ± 0.801
1.422GluTrp: 1.422 ± 0.369
2.167GluTyr: 2.167 ± 0.431
0.0GluXaa: 0.0 ± 0.0
Phe
3.454PheAla: 3.454 ± 0.43
0.203PheCys: 0.203 ± 0.117
3.589PheAsp: 3.589 ± 0.429
2.776PheGlu: 2.776 ± 0.442
1.49PhePhe: 1.49 ± 0.412
2.573PheGly: 2.573 ± 0.446
0.745PheHis: 0.745 ± 0.198
2.573PheIle: 2.573 ± 0.433
2.438PheLys: 2.438 ± 0.441
2.641PheLeu: 2.641 ± 0.565
0.948PheMet: 0.948 ± 0.252
2.776PheAsn: 2.776 ± 0.442
1.219PhePro: 1.219 ± 0.356
1.016PheGln: 1.016 ± 0.272
2.167PheArg: 2.167 ± 0.445
3.25PheSer: 3.25 ± 0.669
2.844PheThr: 2.844 ± 0.371
2.506PheVal: 2.506 ± 0.44
0.406PheTrp: 0.406 ± 0.138
1.151PheTyr: 1.151 ± 0.277
0.0PheXaa: 0.0 ± 0.0
Gly
3.792GlyAla: 3.792 ± 0.613
1.083GlyCys: 1.083 ± 0.284
2.776GlyAsp: 2.776 ± 0.429
4.605GlyGlu: 4.605 ± 0.71
2.844GlyPhe: 2.844 ± 0.519
4.334GlyGly: 4.334 ± 0.639
0.609GlyHis: 0.609 ± 0.189
2.98GlyIle: 2.98 ± 0.46
6.23GlyLys: 6.23 ± 0.682
5.282GlyLeu: 5.282 ± 0.563
1.693GlyMet: 1.693 ± 0.325
3.995GlyAsn: 3.995 ± 0.667
0.542GlyPro: 0.542 ± 0.19
2.438GlyGln: 2.438 ± 0.4
3.047GlyArg: 3.047 ± 0.402
3.86GlySer: 3.86 ± 0.515
3.25GlyThr: 3.25 ± 0.565
3.995GlyVal: 3.995 ± 0.54
1.083GlyTrp: 1.083 ± 0.228
4.402GlyTyr: 4.402 ± 0.607
0.0GlyXaa: 0.0 ± 0.0
His
0.813HisAla: 0.813 ± 0.22
0.406HisCys: 0.406 ± 0.175
0.813HisAsp: 0.813 ± 0.288
0.677HisGlu: 0.677 ± 0.265
0.948HisPhe: 0.948 ± 0.218
1.083HisGly: 1.083 ± 0.272
0.406HisHis: 0.406 ± 0.141
1.49HisIle: 1.49 ± 0.33
0.88HisLys: 0.88 ± 0.318
1.422HisLeu: 1.422 ± 0.312
0.203HisMet: 0.203 ± 0.13
1.354HisAsn: 1.354 ± 0.32
0.474HisPro: 0.474 ± 0.156
1.151HisGln: 1.151 ± 0.277
0.948HisArg: 0.948 ± 0.261
1.422HisSer: 1.422 ± 0.342
1.083HisThr: 1.083 ± 0.327
0.406HisVal: 0.406 ± 0.194
0.271HisTrp: 0.271 ± 0.153
0.813HisTyr: 0.813 ± 0.301
0.0HisXaa: 0.0 ± 0.0
Ile
5.485IleAla: 5.485 ± 0.577
0.745IleCys: 0.745 ± 0.31
3.725IleAsp: 3.725 ± 0.544
5.485IleGlu: 5.485 ± 0.598
1.964IlePhe: 1.964 ± 0.302
4.469IleGly: 4.469 ± 0.596
1.151IleHis: 1.151 ± 0.297
3.928IleIle: 3.928 ± 0.492
5.621IleLys: 5.621 ± 0.68
5.35IleLeu: 5.35 ± 0.75
1.151IleMet: 1.151 ± 0.305
4.199IleAsn: 4.199 ± 0.684
1.761IlePro: 1.761 ± 0.308
3.725IleGln: 3.725 ± 0.497
3.657IleArg: 3.657 ± 0.627
4.74IleSer: 4.74 ± 0.571
5.214IleThr: 5.214 ± 0.746
3.521IleVal: 3.521 ± 0.456
0.948IleTrp: 0.948 ± 0.299
2.438IleTyr: 2.438 ± 0.371
0.0IleXaa: 0.0 ± 0.0
Lys
7.517LysAla: 7.517 ± 0.877
0.474LysCys: 0.474 ± 0.176
3.115LysAsp: 3.115 ± 0.572
3.928LysGlu: 3.928 ± 0.561
2.099LysPhe: 2.099 ± 0.446
4.605LysGly: 4.605 ± 0.576
1.49LysHis: 1.49 ± 0.311
4.605LysIle: 4.605 ± 0.588
4.943LysLys: 4.943 ± 0.536
6.84LysLeu: 6.84 ± 0.639
2.235LysMet: 2.235 ± 0.386
3.792LysAsn: 3.792 ± 0.515
2.302LysPro: 2.302 ± 0.465
3.86LysGln: 3.86 ± 0.686
3.86LysArg: 3.86 ± 0.599
4.402LysSer: 4.402 ± 0.613
4.402LysThr: 4.402 ± 0.463
3.995LysVal: 3.995 ± 0.55
0.745LysTrp: 0.745 ± 0.18
2.844LysTyr: 2.844 ± 0.48
0.0LysXaa: 0.0 ± 0.0
Leu
7.314LeuAla: 7.314 ± 0.742
1.016LeuCys: 1.016 ± 0.247
4.402LeuAsp: 4.402 ± 0.655
5.147LeuGlu: 5.147 ± 0.499
3.047LeuPhe: 3.047 ± 0.543
4.808LeuGly: 4.808 ± 0.528
1.49LeuHis: 1.49 ± 0.38
6.027LeuIle: 6.027 ± 0.734
4.266LeuLys: 4.266 ± 0.618
6.569LeuLeu: 6.569 ± 0.742
1.693LeuMet: 1.693 ± 0.315
6.162LeuAsn: 6.162 ± 0.629
3.25LeuPro: 3.25 ± 0.53
3.047LeuGln: 3.047 ± 0.46
4.199LeuArg: 4.199 ± 0.597
5.892LeuSer: 5.892 ± 0.585
5.282LeuThr: 5.282 ± 0.613
4.402LeuVal: 4.402 ± 0.533
0.88LeuTrp: 0.88 ± 0.283
2.776LeuTyr: 2.776 ± 0.327
0.0LeuXaa: 0.0 ± 0.0
Met
1.828MetAla: 1.828 ± 0.41
0.339MetCys: 0.339 ± 0.16
0.542MetAsp: 0.542 ± 0.222
1.354MetGlu: 1.354 ± 0.285
0.948MetPhe: 0.948 ± 0.284
1.422MetGly: 1.422 ± 0.281
0.203MetHis: 0.203 ± 0.09
1.354MetIle: 1.354 ± 0.36
1.896MetLys: 1.896 ± 0.331
1.828MetLeu: 1.828 ± 0.344
0.406MetMet: 0.406 ± 0.193
1.016MetAsn: 1.016 ± 0.249
1.016MetPro: 1.016 ± 0.289
1.083MetGln: 1.083 ± 0.339
1.219MetArg: 1.219 ± 0.29
1.964MetSer: 1.964 ± 0.37
1.49MetThr: 1.49 ± 0.375
1.083MetVal: 1.083 ± 0.259
0.339MetTrp: 0.339 ± 0.196
0.542MetTyr: 0.542 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
6.975AsnAla: 6.975 ± 1.056
0.203AsnCys: 0.203 ± 0.101
2.506AsnAsp: 2.506 ± 0.33
3.521AsnGlu: 3.521 ± 0.532
2.235AsnPhe: 2.235 ± 0.464
5.35AsnGly: 5.35 ± 0.585
1.287AsnHis: 1.287 ± 0.234
3.589AsnIle: 3.589 ± 0.61
3.725AsnLys: 3.725 ± 0.41
4.673AsnLeu: 4.673 ± 0.531
1.151AsnMet: 1.151 ± 0.267
4.199AsnAsn: 4.199 ± 0.532
2.302AsnPro: 2.302 ± 0.475
3.318AsnGln: 3.318 ± 0.539
3.047AsnArg: 3.047 ± 0.404
3.86AsnSer: 3.86 ± 0.503
2.235AsnThr: 2.235 ± 0.415
3.454AsnVal: 3.454 ± 0.766
0.406AsnTrp: 0.406 ± 0.192
1.625AsnTyr: 1.625 ± 0.392
0.0AsnXaa: 0.0 ± 0.0
Pro
1.896ProAla: 1.896 ± 0.301
0.609ProCys: 0.609 ± 0.232
1.693ProAsp: 1.693 ± 0.323
3.386ProGlu: 3.386 ± 0.532
1.49ProPhe: 1.49 ± 0.317
0.745ProGly: 0.745 ± 0.205
0.406ProHis: 0.406 ± 0.194
2.912ProIle: 2.912 ± 0.432
2.235ProLys: 2.235 ± 0.44
2.641ProLeu: 2.641 ± 0.516
0.745ProMet: 0.745 ± 0.217
2.167ProAsn: 2.167 ± 0.382
1.49ProPro: 1.49 ± 0.449
1.693ProGln: 1.693 ± 0.318
1.287ProArg: 1.287 ± 0.327
2.167ProSer: 2.167 ± 0.374
2.099ProThr: 2.099 ± 0.434
2.235ProVal: 2.235 ± 0.361
0.406ProTrp: 0.406 ± 0.145
0.677ProTyr: 0.677 ± 0.205
0.0ProXaa: 0.0 ± 0.0
Gln
5.282GlnAla: 5.282 ± 0.671
0.135GlnCys: 0.135 ± 0.112
2.641GlnAsp: 2.641 ± 0.388
2.912GlnGlu: 2.912 ± 0.531
1.828GlnPhe: 1.828 ± 0.321
2.709GlnGly: 2.709 ± 0.455
0.406GlnHis: 0.406 ± 0.167
4.74GlnIle: 4.74 ± 0.506
3.115GlnLys: 3.115 ± 0.577
3.792GlnLeu: 3.792 ± 0.434
1.693GlnMet: 1.693 ± 0.481
3.115GlnAsn: 3.115 ± 0.423
1.016GlnPro: 1.016 ± 0.279
3.115GlnGln: 3.115 ± 0.448
2.302GlnArg: 2.302 ± 0.34
3.183GlnSer: 3.183 ± 0.445
2.641GlnThr: 2.641 ± 0.323
2.167GlnVal: 2.167 ± 0.318
1.083GlnTrp: 1.083 ± 0.273
1.422GlnTyr: 1.422 ± 0.287
0.0GlnXaa: 0.0 ± 0.0
Arg
2.506ArgAla: 2.506 ± 0.422
0.406ArgCys: 0.406 ± 0.164
2.099ArgAsp: 2.099 ± 0.415
3.521ArgGlu: 3.521 ± 0.521
2.167ArgPhe: 2.167 ± 0.353
2.167ArgGly: 2.167 ± 0.42
1.49ArgHis: 1.49 ± 0.311
3.86ArgIle: 3.86 ± 0.573
4.402ArgLys: 4.402 ± 0.531
4.537ArgLeu: 4.537 ± 0.637
1.016ArgMet: 1.016 ± 0.27
3.25ArgAsn: 3.25 ± 0.372
2.032ArgPro: 2.032 ± 0.407
2.573ArgGln: 2.573 ± 0.421
1.693ArgArg: 1.693 ± 0.382
1.896ArgSer: 1.896 ± 0.354
2.98ArgThr: 2.98 ± 0.428
1.558ArgVal: 1.558 ± 0.391
0.406ArgTrp: 0.406 ± 0.171
1.693ArgTyr: 1.693 ± 0.351
0.0ArgXaa: 0.0 ± 0.0
Ser
5.824SerAla: 5.824 ± 0.822
0.88SerCys: 0.88 ± 0.31
4.131SerAsp: 4.131 ± 0.504
4.605SerGlu: 4.605 ± 0.533
2.641SerPhe: 2.641 ± 0.494
4.334SerGly: 4.334 ± 0.492
1.287SerHis: 1.287 ± 0.238
3.928SerIle: 3.928 ± 0.49
3.725SerLys: 3.725 ± 0.472
4.469SerLeu: 4.469 ± 0.478
1.422SerMet: 1.422 ± 0.368
3.454SerAsn: 3.454 ± 0.504
1.896SerPro: 1.896 ± 0.451
3.386SerGln: 3.386 ± 0.552
2.302SerArg: 2.302 ± 0.346
3.183SerSer: 3.183 ± 0.597
3.386SerThr: 3.386 ± 0.476
5.282SerVal: 5.282 ± 0.66
0.609SerTrp: 0.609 ± 0.18
2.844SerTyr: 2.844 ± 0.522
0.0SerXaa: 0.0 ± 0.0
Thr
5.417ThrAla: 5.417 ± 0.873
0.474ThrCys: 0.474 ± 0.182
3.454ThrAsp: 3.454 ± 0.377
4.74ThrGlu: 4.74 ± 0.628
2.302ThrPhe: 2.302 ± 0.434
3.995ThrGly: 3.995 ± 0.651
1.219ThrHis: 1.219 ± 0.278
3.86ThrIle: 3.86 ± 0.575
4.199ThrLys: 4.199 ± 0.46
4.402ThrLeu: 4.402 ± 0.461
0.813ThrMet: 0.813 ± 0.246
3.183ThrAsn: 3.183 ± 0.698
2.709ThrPro: 2.709 ± 0.421
3.115ThrGln: 3.115 ± 0.5
1.625ThrArg: 1.625 ± 0.313
3.454ThrSer: 3.454 ± 0.475
1.964ThrThr: 1.964 ± 0.367
3.995ThrVal: 3.995 ± 0.584
0.609ThrTrp: 0.609 ± 0.192
1.422ThrTyr: 1.422 ± 0.351
0.0ThrXaa: 0.0 ± 0.0
Val
4.537ValAla: 4.537 ± 0.512
0.609ValCys: 0.609 ± 0.212
2.844ValAsp: 2.844 ± 0.478
4.537ValGlu: 4.537 ± 0.606
2.912ValPhe: 2.912 ± 0.499
3.792ValGly: 3.792 ± 0.544
0.88ValHis: 0.88 ± 0.252
4.605ValIle: 4.605 ± 0.625
4.402ValLys: 4.402 ± 0.553
4.673ValLeu: 4.673 ± 0.493
1.354ValMet: 1.354 ± 0.268
2.641ValAsn: 2.641 ± 0.578
2.099ValPro: 2.099 ± 0.342
2.099ValGln: 2.099 ± 0.338
2.844ValArg: 2.844 ± 0.485
4.199ValSer: 4.199 ± 0.501
3.995ValThr: 3.995 ± 0.651
4.808ValVal: 4.808 ± 0.541
1.354ValTrp: 1.354 ± 0.397
2.37ValTyr: 2.37 ± 0.8
0.0ValXaa: 0.0 ± 0.0
Trp
1.016TrpAla: 1.016 ± 0.265
0.271TrpCys: 0.271 ± 0.151
0.609TrpAsp: 0.609 ± 0.224
0.88TrpGlu: 0.88 ± 0.226
0.948TrpPhe: 0.948 ± 0.223
0.745TrpGly: 0.745 ± 0.351
0.474TrpHis: 0.474 ± 0.187
1.49TrpIle: 1.49 ± 0.29
1.151TrpLys: 1.151 ± 0.266
1.625TrpLeu: 1.625 ± 0.351
0.135TrpMet: 0.135 ± 0.094
0.677TrpAsn: 0.677 ± 0.254
0.068TrpPro: 0.068 ± 0.063
1.219TrpGln: 1.219 ± 0.298
0.745TrpArg: 0.745 ± 0.203
0.745TrpSer: 0.745 ± 0.182
0.677TrpThr: 0.677 ± 0.257
0.948TrpVal: 0.948 ± 0.233
0.339TrpTrp: 0.339 ± 0.18
0.271TrpTyr: 0.271 ± 0.146
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.032TyrAla: 2.032 ± 0.38
0.271TyrCys: 0.271 ± 0.152
2.235TyrAsp: 2.235 ± 0.459
1.422TyrGlu: 1.422 ± 0.331
1.761TyrPhe: 1.761 ± 0.381
3.047TyrGly: 3.047 ± 0.61
0.542TyrHis: 0.542 ± 0.202
2.844TyrIle: 2.844 ± 0.406
2.235TyrLys: 2.235 ± 0.406
2.912TyrLeu: 2.912 ± 0.452
0.677TyrMet: 0.677 ± 0.219
1.422TyrAsn: 1.422 ± 0.332
1.625TyrPro: 1.625 ± 0.328
1.761TyrGln: 1.761 ± 0.384
2.032TyrArg: 2.032 ± 0.324
3.25TyrSer: 3.25 ± 0.553
1.693TyrThr: 1.693 ± 0.349
1.49TyrVal: 1.49 ± 0.361
0.948TyrTrp: 0.948 ± 0.229
0.88TyrTyr: 0.88 ± 0.209
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (14768 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski