Amino acid dipepetide frequency for Microvirga subterranea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.981AlaAla: 15.981 ± 0.132	1.011AlaCys: 1.011 ± 0.027	6.386AlaAsp: 6.386 ± 0.072	7.395AlaGlu: 7.395 ± 0.088	4.568AlaPhe: 4.568 ± 0.062	10.218AlaGly: 10.218 ± 0.099	2.15AlaHis: 2.15 ± 0.037	6.086AlaIle: 6.086 ± 0.071	3.991AlaLys: 3.991 ± 0.067	13.163AlaLeu: 13.163 ± 0.122	3.258AlaMet: 3.258 ± 0.051	2.693AlaAsn: 2.693 ± 0.048	5.65AlaPro: 5.65 ± 0.07	4.044AlaGln: 4.044 ± 0.058	8.326AlaArg: 8.326 ± 0.094	6.585AlaSer: 6.585 ± 0.075	5.668AlaThr: 5.668 ± 0.069	8.995AlaVal: 8.995 ± 0.092	1.48AlaTrp: 1.48 ± 0.036	2.678AlaTyr: 2.678 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.832CysAla: 0.832 ± 0.025	0.096CysCys: 0.096 ± 0.008	0.444CysAsp: 0.444 ± 0.018	0.403CysGlu: 0.403 ± 0.017	0.27CysPhe: 0.27 ± 0.014	0.784CysGly: 0.784 ± 0.025	0.24CysHis: 0.24 ± 0.014	0.391CysIle: 0.391 ± 0.018	0.141CysLys: 0.141 ± 0.01	0.759CysLeu: 0.759 ± 0.024	0.128CysMet: 0.128 ± 0.01	0.191CysAsn: 0.191 ± 0.012	0.414CysPro: 0.414 ± 0.017	0.192CysGln: 0.192 ± 0.012	0.633CysArg: 0.633 ± 0.02	0.456CysSer: 0.456 ± 0.017	0.395CysThr: 0.395 ± 0.016	0.543CysVal: 0.543 ± 0.017	0.104CysTrp: 0.104 ± 0.009	0.168CysTyr: 0.168 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.384AspAla: 6.384 ± 0.069	0.377AspCys: 0.377 ± 0.015	3.035AspAsp: 3.035 ± 0.065	3.786AspGlu: 3.786 ± 0.06	2.102AspPhe: 2.102 ± 0.038	5.163AspGly: 5.163 ± 0.079	1.22AspHis: 1.22 ± 0.026	2.811AspIle: 2.811 ± 0.045	1.659AspLys: 1.659 ± 0.034	6.316AspLeu: 6.316 ± 0.074	1.216AspMet: 1.216 ± 0.031	1.209AspAsn: 1.209 ± 0.03	3.684AspPro: 3.684 ± 0.057	1.797AspGln: 1.797 ± 0.038	4.626AspArg: 4.626 ± 0.062	2.033AspSer: 2.033 ± 0.038	2.516AspThr: 2.516 ± 0.054	4.43AspVal: 4.43 ± 0.063	0.835AspTrp: 0.835 ± 0.023	1.32AspTyr: 1.32 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.117GluAla: 8.117 ± 0.088	0.332GluCys: 0.332 ± 0.017	2.809GluAsp: 2.809 ± 0.049	3.47GluGlu: 3.47 ± 0.06	1.681GluPhe: 1.681 ± 0.032	4.564GluGly: 4.564 ± 0.064	1.204GluHis: 1.204 ± 0.028	3.455GluIle: 3.455 ± 0.053	2.131GluLys: 2.131 ± 0.039	5.088GluLeu: 5.088 ± 0.059	1.448GluMet: 1.448 ± 0.032	1.574GluAsn: 1.574 ± 0.029	2.987GluPro: 2.987 ± 0.053	2.129GluGln: 2.129 ± 0.04	5.602GluArg: 5.602 ± 0.08	2.423GluSer: 2.423 ± 0.04	3.566GluThr: 3.566 ± 0.054	3.992GluVal: 3.992 ± 0.056	0.678GluTrp: 0.678 ± 0.02	0.929GluTyr: 0.929 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.317PheAla: 4.317 ± 0.059	0.358PheCys: 0.358 ± 0.016	2.539PheAsp: 2.539 ± 0.043	2.112PheGlu: 2.112 ± 0.041	1.433PhePhe: 1.433 ± 0.037	3.707PheGly: 3.707 ± 0.059	0.7PheHis: 0.7 ± 0.024	1.756PheIle: 1.756 ± 0.035	1.033PheLys: 1.033 ± 0.031	3.503PheLeu: 3.503 ± 0.06	0.838PheMet: 0.838 ± 0.024	0.994PheAsn: 0.994 ± 0.027	1.607PhePro: 1.607 ± 0.032	1.089PheGln: 1.089 ± 0.03	2.415PheArg: 2.415 ± 0.038	2.145PheSer: 2.145 ± 0.041	2.049PheThr: 2.049 ± 0.04	2.931PheVal: 2.931 ± 0.048	0.61PheTrp: 0.61 ± 0.021	0.898PheTyr: 0.898 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.092GlyAla: 9.092 ± 0.093	0.799GlyCys: 0.799 ± 0.024	4.424GlyAsp: 4.424 ± 0.072	4.735GlyGlu: 4.735 ± 0.068	3.708GlyPhe: 3.708 ± 0.053	7.657GlyGly: 7.657 ± 0.122	1.968GlyHis: 1.968 ± 0.04	4.661GlyIle: 4.661 ± 0.067	2.898GlyLys: 2.898 ± 0.046	9.252GlyLeu: 9.252 ± 0.094	2.126GlyMet: 2.126 ± 0.042	2.312GlyAsn: 2.312 ± 0.067	3.784GlyPro: 3.784 ± 0.059	3.008GlyGln: 3.008 ± 0.049	6.65GlyArg: 6.65 ± 0.074	5.112GlySer: 5.112 ± 0.071	4.878GlyThr: 4.878 ± 0.068	5.935GlyVal: 5.935 ± 0.07	1.332GlyTrp: 1.332 ± 0.032	2.291GlyTyr: 2.291 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.23HisAla: 2.23 ± 0.038	0.197HisCys: 0.197 ± 0.011	1.223HisAsp: 1.223 ± 0.031	1.121HisGlu: 1.121 ± 0.028	0.765HisPhe: 0.765 ± 0.021	1.934HisGly: 1.934 ± 0.037	0.565HisHis: 0.565 ± 0.021	0.818HisIle: 0.818 ± 0.026	0.48HisLys: 0.48 ± 0.017	2.157HisLeu: 2.157 ± 0.035	0.464HisMet: 0.464 ± 0.017	0.478HisAsn: 0.478 ± 0.019	1.423HisPro: 1.423 ± 0.035	0.63HisGln: 0.63 ± 0.021	1.558HisArg: 1.558 ± 0.036	0.897HisSer: 0.897 ± 0.025	0.814HisThr: 0.814 ± 0.025	1.583HisVal: 1.583 ± 0.037	0.306HisTrp: 0.306 ± 0.014	0.489HisTyr: 0.489 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.764IleAla: 6.764 ± 0.071	0.462IleCys: 0.462 ± 0.017	3.385IleAsp: 3.385 ± 0.054	3.475IleGlu: 3.475 ± 0.057	1.636IlePhe: 1.636 ± 0.038	5.051IleGly: 5.051 ± 0.068	0.935IleHis: 0.935 ± 0.025	2.144IleIle: 2.144 ± 0.045	1.398IleLys: 1.398 ± 0.036	4.917IleLeu: 4.917 ± 0.068	1.053IleMet: 1.053 ± 0.028	1.271IleAsn: 1.271 ± 0.028	2.447IlePro: 2.447 ± 0.044	1.34IleGln: 1.34 ± 0.032	3.465IleArg: 3.465 ± 0.051	2.556IleSer: 2.556 ± 0.042	2.605IleThr: 2.605 ± 0.048	4.513IleVal: 4.513 ± 0.063	0.574IleTrp: 0.574 ± 0.021	1.124IleTyr: 1.124 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.367LysAla: 4.367 ± 0.063	0.145LysCys: 0.145 ± 0.01	1.913LysAsp: 1.913 ± 0.037	1.725LysGlu: 1.725 ± 0.04	0.789LysPhe: 0.789 ± 0.028	2.806LysGly: 2.806 ± 0.047	0.582LysHis: 0.582 ± 0.02	1.547LysIle: 1.547 ± 0.036	1.216LysLys: 1.216 ± 0.038	3.075LysLeu: 3.075 ± 0.05	0.682LysMet: 0.682 ± 0.025	0.851LysAsn: 0.851 ± 0.026	2.164LysPro: 2.164 ± 0.042	0.941LysGln: 0.941 ± 0.026	2.384LysArg: 2.384 ± 0.05	1.683LysSer: 1.683 ± 0.033	1.81LysThr: 1.81 ± 0.038	2.477LysVal: 2.477 ± 0.051	0.29LysTrp: 0.29 ± 0.014	0.529LysTyr: 0.529 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.226LeuAla: 13.226 ± 0.126	0.806LeuCys: 0.806 ± 0.027	6.112LeuAsp: 6.112 ± 0.068	5.228LeuGlu: 5.228 ± 0.069	3.667LeuPhe: 3.667 ± 0.058	8.588LeuGly: 8.588 ± 0.087	1.845LeuHis: 1.845 ± 0.035	4.97LeuIle: 4.97 ± 0.063	3.72LeuLys: 3.72 ± 0.053	9.639LeuLeu: 9.639 ± 0.121	2.274LeuMet: 2.274 ± 0.039	2.61LeuAsn: 2.61 ± 0.044	5.528LeuPro: 5.528 ± 0.063	2.838LeuGln: 2.838 ± 0.046	7.089LeuArg: 7.089 ± 0.077	6.734LeuSer: 6.734 ± 0.071	5.633LeuThr: 5.633 ± 0.07	8.187LeuVal: 8.187 ± 0.079	1.201LeuTrp: 1.201 ± 0.03	2.069LeuTyr: 2.069 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	2.979MetAla: 2.979 ± 0.05	0.136MetCys: 0.136 ± 0.01	1.045MetAsp: 1.045 ± 0.024	1.084MetGlu: 1.084 ± 0.027	0.628MetPhe: 0.628 ± 0.023	1.783MetGly: 1.783 ± 0.039	0.436MetHis: 0.436 ± 0.016	1.311MetIle: 1.311 ± 0.03	0.96MetLys: 0.96 ± 0.028	2.25MetLeu: 2.25 ± 0.039	0.636MetMet: 0.636 ± 0.025	0.778MetAsn: 0.778 ± 0.024	1.417MetPro: 1.417 ± 0.032	0.763MetGln: 0.763 ± 0.023	1.832MetArg: 1.832 ± 0.033	1.57MetSer: 1.57 ± 0.031	1.833MetThr: 1.833 ± 0.036	1.625MetVal: 1.625 ± 0.035	0.205MetTrp: 0.205 ± 0.013	0.29MetTyr: 0.29 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.048AsnAla: 3.048 ± 0.054	0.186AsnCys: 0.186 ± 0.011	1.577AsnAsp: 1.577 ± 0.048	1.324AsnGlu: 1.324 ± 0.031	0.86AsnPhe: 0.86 ± 0.024	2.479AsnGly: 2.479 ± 0.052	0.467AsnHis: 0.467 ± 0.02	1.244AsnIle: 1.244 ± 0.026	0.73AsnLys: 0.73 ± 0.021	2.656AsnLeu: 2.656 ± 0.042	0.542AsnMet: 0.542 ± 0.018	0.728AsnAsn: 0.728 ± 0.023	1.913AsnPro: 1.913 ± 0.039	0.773AsnGln: 0.773 ± 0.027	1.821AsnArg: 1.821 ± 0.035	1.131AsnSer: 1.131 ± 0.032	1.273AsnThr: 1.273 ± 0.034	2.035AsnVal: 2.035 ± 0.038	0.369AsnTrp: 0.369 ± 0.015	0.644AsnTyr: 0.644 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.234ProAla: 6.234 ± 0.081	0.296ProCys: 0.296 ± 0.015	3.706ProAsp: 3.706 ± 0.05	3.832ProGlu: 3.832 ± 0.051	2.095ProPhe: 2.095 ± 0.041	4.642ProGly: 4.642 ± 0.057	1.136ProHis: 1.136 ± 0.026	2.361ProIle: 2.361 ± 0.041	1.832ProLys: 1.832 ± 0.037	4.726ProLeu: 4.726 ± 0.063	1.249ProMet: 1.249 ± 0.029	1.543ProAsn: 1.543 ± 0.037	2.688ProPro: 2.688 ± 0.055	1.752ProGln: 1.752 ± 0.036	3.06ProArg: 3.06 ± 0.051	3.108ProSer: 3.108 ± 0.052	2.634ProThr: 2.634 ± 0.042	4.544ProVal: 4.544 ± 0.06	0.721ProTrp: 0.721 ± 0.022	1.258ProTyr: 1.258 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.385GlnAla: 4.385 ± 0.062	0.156GlnCys: 0.156 ± 0.012	1.747GlnAsp: 1.747 ± 0.041	1.815GlnGlu: 1.815 ± 0.04	0.972GlnPhe: 0.972 ± 0.025	2.575GlnGly: 2.575 ± 0.045	0.655GlnHis: 0.655 ± 0.022	1.741GlnIle: 1.741 ± 0.039	1.059GlnLys: 1.059 ± 0.029	2.595GlnLeu: 2.595 ± 0.046	0.757GlnMet: 0.757 ± 0.022	0.894GlnAsn: 0.894 ± 0.026	1.846GlnPro: 1.846 ± 0.039	1.232GlnGln: 1.232 ± 0.04	2.44GlnArg: 2.44 ± 0.046	1.703GlnSer: 1.703 ± 0.037	1.719GlnThr: 1.719 ± 0.04	2.509GlnVal: 2.509 ± 0.038	0.397GlnTrp: 0.397 ± 0.016	0.592GlnTyr: 0.592 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	7.563ArgAla: 7.563 ± 0.094	0.487ArgCys: 0.487 ± 0.016	4.137ArgAsp: 4.137 ± 0.055	4.485ArgGlu: 4.485 ± 0.061	3.048ArgPhe: 3.048 ± 0.044	4.926ArgGly: 4.926 ± 0.067	1.729ArgHis: 1.729 ± 0.036	4.393ArgIle: 4.393 ± 0.059	2.223ArgLys: 2.223 ± 0.038	8.376ArgLeu: 8.376 ± 0.091	1.868ArgMet: 1.868 ± 0.037	1.929ArgAsn: 1.929 ± 0.038	3.94ArgPro: 3.94 ± 0.06	2.735ArgGln: 2.735 ± 0.044	6.283ArgArg: 6.283 ± 0.094	4.137ArgSer: 4.137 ± 0.063	3.759ArgThr: 3.759 ± 0.051	5.097ArgVal: 5.097 ± 0.059	1.005ArgTrp: 1.005 ± 0.032	1.73ArgTyr: 1.73 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.032SerAla: 6.032 ± 0.077	0.428SerCys: 0.428 ± 0.02	3.002SerAsp: 3.002 ± 0.052	2.815SerGlu: 2.815 ± 0.045	2.379SerPhe: 2.379 ± 0.042	5.58SerGly: 5.58 ± 0.078	1.133SerHis: 1.133 ± 0.03	2.777SerIle: 2.777 ± 0.045	1.548SerLys: 1.548 ± 0.037	5.905SerLeu: 5.905 ± 0.069	1.248SerMet: 1.248 ± 0.029	1.381SerAsn: 1.381 ± 0.032	3.037SerPro: 3.037 ± 0.044	1.637SerGln: 1.637 ± 0.032	3.91SerArg: 3.91 ± 0.05	3.081SerSer: 3.081 ± 0.052	2.736SerThr: 2.736 ± 0.051	4.026SerVal: 4.026 ± 0.053	0.775SerTrp: 0.775 ± 0.023	1.313SerTyr: 1.313 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.874ThrAla: 5.874 ± 0.072	0.394ThrCys: 0.394 ± 0.019	2.697ThrAsp: 2.697 ± 0.051	2.689ThrGlu: 2.689 ± 0.042	2.151ThrPhe: 2.151 ± 0.039	5.12ThrGly: 5.12 ± 0.065	1.013ThrHis: 1.013 ± 0.028	3.13ThrIle: 3.13 ± 0.046	1.571ThrLys: 1.571 ± 0.035	5.85ThrLeu: 5.85 ± 0.074	1.198ThrMet: 1.198 ± 0.029	1.313ThrAsn: 1.313 ± 0.03	3.174ThrPro: 3.174 ± 0.053	1.419ThrGln: 1.419 ± 0.033	3.378ThrArg: 3.378 ± 0.053	2.924ThrSer: 2.924 ± 0.048	2.863ThrThr: 2.863 ± 0.056	4.552ThrVal: 4.552 ± 0.069	0.72ThrTrp: 0.72 ± 0.024	1.306ThrTyr: 1.306 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.216ValAla: 9.216 ± 0.084	0.587ValCys: 0.587 ± 0.02	4.174ValAsp: 4.174 ± 0.068	4.855ValGlu: 4.855 ± 0.061	2.854ValPhe: 2.854 ± 0.048	5.931ValGly: 5.931 ± 0.077	1.377ValHis: 1.377 ± 0.029	3.947ValIle: 3.947 ± 0.061	2.368ValLys: 2.368 ± 0.051	7.955ValLeu: 7.955 ± 0.087	1.827ValMet: 1.827 ± 0.032	2.038ValAsn: 2.038 ± 0.039	3.918ValPro: 3.918 ± 0.048	2.256ValGln: 2.256 ± 0.034	5.382ValArg: 5.382 ± 0.063	4.532ValSer: 4.532 ± 0.057	4.686ValThr: 4.686 ± 0.06	6.392ValVal: 6.392 ± 0.069	0.928ValTrp: 0.928 ± 0.026	1.604ValTyr: 1.604 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.218TrpAla: 1.218 ± 0.029	0.121TrpCys: 0.121 ± 0.008	0.669TrpAsp: 0.669 ± 0.023	0.564TrpGlu: 0.564 ± 0.019	0.547TrpPhe: 0.547 ± 0.019	0.921TrpGly: 0.921 ± 0.027	0.32TrpHis: 0.32 ± 0.014	0.72TrpIle: 0.72 ± 0.024	0.41TrpLys: 0.41 ± 0.018	1.618TrpLeu: 1.618 ± 0.038	0.331TrpMet: 0.331 ± 0.015	0.44TrpAsn: 0.44 ± 0.017	0.651TrpPro: 0.651 ± 0.021	0.499TrpGln: 0.499 ± 0.02	1.151TrpArg: 1.151 ± 0.029	0.822TrpSer: 0.822 ± 0.027	0.783TrpThr: 0.783 ± 0.029	0.801TrpVal: 0.801 ± 0.024	0.224TrpTrp: 0.224 ± 0.012	0.278TrpTyr: 0.278 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.47TyrAla: 2.47 ± 0.044	0.207TyrCys: 0.207 ± 0.011	1.495TyrAsp: 1.495 ± 0.036	1.266TyrGlu: 1.266 ± 0.034	0.882TyrPhe: 0.882 ± 0.025	2.191TyrGly: 2.191 ± 0.041	0.456TyrHis: 0.456 ± 0.017	0.849TyrIle: 0.849 ± 0.029	0.608TyrLys: 0.608 ± 0.024	2.164TyrLeu: 2.164 ± 0.04	0.417TyrMet: 0.417 ± 0.017	0.573TyrAsn: 0.573 ± 0.02	1.148TyrPro: 1.148 ± 0.028	0.716TyrGln: 0.716 ± 0.023	1.845TyrArg: 1.845 ± 0.034	1.112TyrSer: 1.112 ± 0.028	1.118TyrThr: 1.118 ± 0.025	1.658TyrVal: 1.658 ± 0.036	0.333TyrTrp: 0.333 ± 0.013	0.635TyrTyr: 0.635 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4897 proteins (1507765 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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