Amino acid dipepetide frequency for Candidatus Paracaedibacter acanthamoebae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.269AlaAla: 7.269 ± 0.155
0.925AlaCys: 0.925 ± 0.045
4.021AlaAsp: 4.021 ± 0.092
4.715AlaGlu: 4.715 ± 0.111
3.176AlaPhe: 3.176 ± 0.078
5.166AlaGly: 5.166 ± 0.125
1.771AlaHis: 1.771 ± 0.05
5.427AlaIle: 5.427 ± 0.113
4.713AlaLys: 4.713 ± 0.116
8.537AlaLeu: 8.537 ± 0.15
2.229AlaMet: 2.229 ± 0.07
2.939AlaAsn: 2.939 ± 0.082
2.941AlaPro: 2.941 ± 0.081
3.472AlaGln: 3.472 ± 0.088
3.583AlaArg: 3.583 ± 0.084
4.908AlaSer: 4.908 ± 0.094
4.512AlaThr: 4.512 ± 0.112
4.693AlaVal: 4.693 ± 0.11
0.785AlaTrp: 0.785 ± 0.04
2.271AlaTyr: 2.271 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
0.639CysAla: 0.639 ± 0.036
0.173CysCys: 0.173 ± 0.021
0.564CysAsp: 0.564 ± 0.034
0.54CysGlu: 0.54 ± 0.032
0.504CysPhe: 0.504 ± 0.027
0.803CysGly: 0.803 ± 0.043
0.354CysHis: 0.354 ± 0.029
0.608CysIle: 0.608 ± 0.033
0.46CysLys: 0.46 ± 0.029
1.146CysLeu: 1.146 ± 0.047
0.21CysMet: 0.21 ± 0.018
0.376CysAsn: 0.376 ± 0.023
0.52CysPro: 0.52 ± 0.031
0.577CysGln: 0.577 ± 0.038
0.54CysArg: 0.54 ± 0.034
0.717CysSer: 0.717 ± 0.035
0.456CysThr: 0.456 ± 0.031
0.559CysVal: 0.559 ± 0.034
0.13CysTrp: 0.13 ± 0.013
0.303CysTyr: 0.303 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.576AspAla: 3.576 ± 0.084
0.526AspCys: 0.526 ± 0.032
2.451AspAsp: 2.451 ± 0.077
3.045AspGlu: 3.045 ± 0.084
2.415AspPhe: 2.415 ± 0.076
2.992AspGly: 2.992 ± 0.083
1.506AspHis: 1.506 ± 0.052
3.941AspIle: 3.941 ± 0.089
3.251AspLys: 3.251 ± 0.08
5.923AspLeu: 5.923 ± 0.102
1.199AspMet: 1.199 ± 0.045
2.035AspAsn: 2.035 ± 0.069
2.424AspPro: 2.424 ± 0.074
2.367AspGln: 2.367 ± 0.062
2.568AspArg: 2.568 ± 0.073
2.999AspSer: 2.999 ± 0.073
2.433AspThr: 2.433 ± 0.065
3.079AspVal: 3.079 ± 0.09
0.675AspTrp: 0.675 ± 0.037
2.048AspTyr: 2.048 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
5.392GluAla: 5.392 ± 0.125
0.433GluCys: 0.433 ± 0.026
3.019GluAsp: 3.019 ± 0.077
4.866GluGlu: 4.866 ± 0.143
2.294GluPhe: 2.294 ± 0.067
3.777GluGly: 3.777 ± 0.088
1.135GluHis: 1.135 ± 0.041
4.823GluIle: 4.823 ± 0.108
4.93GluLys: 4.93 ± 0.104
5.516GluLeu: 5.516 ± 0.111
1.533GluMet: 1.533 ± 0.055
2.813GluAsn: 2.813 ± 0.072
1.703GluPro: 1.703 ± 0.058
2.716GluGln: 2.716 ± 0.085
3.143GluArg: 3.143 ± 0.087
3.58GluSer: 3.58 ± 0.084
3.523GluThr: 3.523 ± 0.078
3.676GluVal: 3.676 ± 0.099
0.697GluTrp: 0.697 ± 0.032
1.471GluTyr: 1.471 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.016PheAla: 3.016 ± 0.089
0.584PheCys: 0.584 ± 0.03
2.351PheAsp: 2.351 ± 0.067
2.293PheGlu: 2.293 ± 0.073
2.085PhePhe: 2.085 ± 0.069
2.82PheGly: 2.82 ± 0.091
0.893PheHis: 0.893 ± 0.041
3.322PheIle: 3.322 ± 0.085
2.587PheLys: 2.587 ± 0.071
4.427PheLeu: 4.427 ± 0.103
1.166PheMet: 1.166 ± 0.043
2.074PheAsn: 2.074 ± 0.073
1.619PhePro: 1.619 ± 0.059
1.433PheGln: 1.433 ± 0.05
1.59PheArg: 1.59 ± 0.051
3.419PheSer: 3.419 ± 0.093
2.296PheThr: 2.296 ± 0.069
2.402PheVal: 2.402 ± 0.064
0.555PheTrp: 0.555 ± 0.032
1.581PheTyr: 1.581 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
4.664GlyAla: 4.664 ± 0.112
0.79GlyCys: 0.79 ± 0.041
3.277GlyAsp: 3.277 ± 0.082
3.727GlyGlu: 3.727 ± 0.077
2.891GlyPhe: 2.891 ± 0.069
4.773GlyGly: 4.773 ± 0.163
1.517GlyHis: 1.517 ± 0.049
5.135GlyIle: 5.135 ± 0.112
4.18GlyLys: 4.18 ± 0.102
6.487GlyLeu: 6.487 ± 0.126
1.794GlyMet: 1.794 ± 0.069
2.55GlyAsn: 2.55 ± 0.094
1.557GlyPro: 1.557 ± 0.056
2.565GlyGln: 2.565 ± 0.068
3.282GlyArg: 3.282 ± 0.093
4.16GlySer: 4.16 ± 0.104
3.669GlyThr: 3.669 ± 0.098
4.302GlyVal: 4.302 ± 0.097
0.865GlyTrp: 0.865 ± 0.048
2.466GlyTyr: 2.466 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.65HisAla: 1.65 ± 0.054
0.268HisCys: 0.268 ± 0.021
1.057HisAsp: 1.057 ± 0.041
1.177HisGlu: 1.177 ± 0.046
0.98HisPhe: 0.98 ± 0.042
1.615HisGly: 1.615 ± 0.06
0.847HisHis: 0.847 ± 0.041
1.499HisIle: 1.499 ± 0.056
1.376HisLys: 1.376 ± 0.059
2.775HisLeu: 2.775 ± 0.087
0.486HisMet: 0.486 ± 0.028
1.064HisAsn: 1.064 ± 0.048
1.351HisPro: 1.351 ± 0.052
1.309HisGln: 1.309 ± 0.055
1.199HisArg: 1.199 ± 0.053
1.369HisSer: 1.369 ± 0.051
1.263HisThr: 1.263 ± 0.047
1.181HisVal: 1.181 ± 0.043
0.274HisTrp: 0.274 ± 0.023
0.951HisTyr: 0.951 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
5.655IleAla: 5.655 ± 0.105
0.785IleCys: 0.785 ± 0.035
4.153IleAsp: 4.153 ± 0.09
4.54IleGlu: 4.54 ± 0.109
2.99IlePhe: 2.99 ± 0.092
4.775IleGly: 4.775 ± 0.1
1.676IleHis: 1.676 ± 0.059
5.138IleIle: 5.138 ± 0.11
4.702IleLys: 4.702 ± 0.11
7.128IleLeu: 7.128 ± 0.136
1.535IleMet: 1.535 ± 0.053
3.587IleAsn: 3.587 ± 0.092
3.329IlePro: 3.329 ± 0.081
2.937IleGln: 2.937 ± 0.073
3.118IleArg: 3.118 ± 0.081
5.138IleSer: 5.138 ± 0.097
4.175IleThr: 4.175 ± 0.104
4.036IleVal: 4.036 ± 0.096
0.619IleTrp: 0.619 ± 0.036
2.214IleTyr: 2.214 ± 0.071
0.0IleXaa: 0.0 ± 0.0
Lys
5.116LysAla: 5.116 ± 0.127
0.434LysCys: 0.434 ± 0.029
3.592LysAsp: 3.592 ± 0.09
4.536LysGlu: 4.536 ± 0.095
2.209LysPhe: 2.209 ± 0.065
3.842LysGly: 3.842 ± 0.102
1.247LysHis: 1.247 ± 0.048
5.155LysIle: 5.155 ± 0.092
4.881LysLys: 4.881 ± 0.123
6.119LysLeu: 6.119 ± 0.104
1.617LysMet: 1.617 ± 0.056
3.302LysAsn: 3.302 ± 0.087
2.148LysPro: 2.148 ± 0.063
2.408LysGln: 2.408 ± 0.071
3.136LysArg: 3.136 ± 0.084
3.899LysSer: 3.899 ± 0.088
3.753LysThr: 3.753 ± 0.087
3.793LysVal: 3.793 ± 0.096
0.579LysTrp: 0.579 ± 0.033
1.772LysTyr: 1.772 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
8.205LeuAla: 8.205 ± 0.136
1.093LeuCys: 1.093 ± 0.049
5.297LeuAsp: 5.297 ± 0.114
6.646LeuGlu: 6.646 ± 0.137
4.176LeuPhe: 4.176 ± 0.102
6.622LeuGly: 6.622 ± 0.135
2.074LeuHis: 2.074 ± 0.062
7.227LeuIle: 7.227 ± 0.117
7.393LeuLys: 7.393 ± 0.115
9.746LeuLeu: 9.746 ± 0.181
2.674LeuMet: 2.674 ± 0.07
4.797LeuAsn: 4.797 ± 0.101
4.947LeuPro: 4.947 ± 0.11
4.266LeuGln: 4.266 ± 0.102
4.678LeuArg: 4.678 ± 0.11
8.568LeuSer: 8.568 ± 0.131
6.75LeuThr: 6.75 ± 0.128
5.482LeuVal: 5.482 ± 0.121
1.112LeuTrp: 1.112 ± 0.045
3.101LeuTyr: 3.101 ± 0.08
0.0LeuXaa: 0.0 ± 0.0
Met
2.298MetAla: 2.298 ± 0.069
0.188MetCys: 0.188 ± 0.019
1.228MetAsp: 1.228 ± 0.044
1.311MetGlu: 1.311 ± 0.05
0.668MetPhe: 0.668 ± 0.035
1.842MetGly: 1.842 ± 0.065
0.482MetHis: 0.482 ± 0.029
1.809MetIle: 1.809 ± 0.063
1.541MetLys: 1.541 ± 0.057
2.22MetLeu: 2.22 ± 0.067
0.717MetMet: 0.717 ± 0.034
1.044MetAsn: 1.044 ± 0.044
1.112MetPro: 1.112 ± 0.049
0.909MetGln: 0.909 ± 0.039
1.256MetArg: 1.256 ± 0.046
1.548MetSer: 1.548 ± 0.054
1.668MetThr: 1.668 ± 0.053
1.769MetVal: 1.769 ± 0.063
0.186MetTrp: 0.186 ± 0.017
0.489MetTyr: 0.489 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.008AsnAla: 3.008 ± 0.08
0.455AsnCys: 0.455 ± 0.032
1.898AsnAsp: 1.898 ± 0.065
2.123AsnGlu: 2.123 ± 0.068
2.252AsnPhe: 2.252 ± 0.069
2.649AsnGly: 2.649 ± 0.092
1.081AsnHis: 1.081 ± 0.043
3.194AsnIle: 3.194 ± 0.077
2.649AsnLys: 2.649 ± 0.073
4.952AsnLeu: 4.952 ± 0.106
0.904AsnMet: 0.904 ± 0.043
2.138AsnAsn: 2.138 ± 0.078
2.49AsnPro: 2.49 ± 0.071
2.008AsnGln: 2.008 ± 0.062
2.265AsnArg: 2.265 ± 0.069
2.698AsnSer: 2.698 ± 0.09
2.247AsnThr: 2.247 ± 0.071
2.291AsnVal: 2.291 ± 0.076
0.577AsnTrp: 0.577 ± 0.03
1.672AsnTyr: 1.672 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
3.141ProAla: 3.141 ± 0.089
0.352ProCys: 0.352 ± 0.025
2.196ProAsp: 2.196 ± 0.055
2.939ProGlu: 2.939 ± 0.067
1.855ProPhe: 1.855 ± 0.061
2.346ProGly: 2.346 ± 0.072
1.143ProHis: 1.143 ± 0.046
2.764ProIle: 2.764 ± 0.065
2.32ProLys: 2.32 ± 0.062
4.894ProLeu: 4.894 ± 0.11
0.825ProMet: 0.825 ± 0.041
1.688ProAsn: 1.688 ± 0.066
1.767ProPro: 1.767 ± 0.083
2.043ProGln: 2.043 ± 0.074
1.537ProArg: 1.537 ± 0.057
3.147ProSer: 3.147 ± 0.093
2.663ProThr: 2.663 ± 0.076
2.627ProVal: 2.627 ± 0.069
0.434ProTrp: 0.434 ± 0.031
1.484ProTyr: 1.484 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
3.921GlnAla: 3.921 ± 0.09
0.308GlnCys: 0.308 ± 0.023
2.234GlnAsp: 2.234 ± 0.067
2.977GlnGlu: 2.977 ± 0.084
1.573GlnPhe: 1.573 ± 0.055
2.733GlnGly: 2.733 ± 0.083
1.13GlnHis: 1.13 ± 0.048
2.89GlnIle: 2.89 ± 0.083
2.972GlnLys: 2.972 ± 0.085
4.377GlnLeu: 4.377 ± 0.087
0.958GlnMet: 0.958 ± 0.042
1.909GlnAsn: 1.909 ± 0.065
1.849GlnPro: 1.849 ± 0.073
2.481GlnGln: 2.481 ± 0.114
2.247GlnArg: 2.247 ± 0.067
2.811GlnSer: 2.811 ± 0.079
2.384GlnThr: 2.384 ± 0.075
2.419GlnVal: 2.419 ± 0.065
0.458GlnTrp: 0.458 ± 0.028
1.154GlnTyr: 1.154 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.324ArgAla: 3.324 ± 0.076
0.455ArgCys: 0.455 ± 0.026
2.448ArgAsp: 2.448 ± 0.078
2.999ArgGlu: 2.999 ± 0.084
2.028ArgPhe: 2.028 ± 0.067
2.871ArgGly: 2.871 ± 0.076
1.3ArgHis: 1.3 ± 0.053
3.204ArgIle: 3.204 ± 0.077
2.733ArgLys: 2.733 ± 0.078
5.461ArgLeu: 5.461 ± 0.124
1.077ArgMet: 1.077 ± 0.049
1.847ArgAsn: 1.847 ± 0.059
1.853ArgPro: 1.853 ± 0.058
2.718ArgGln: 2.718 ± 0.079
2.8ArgArg: 2.8 ± 0.098
2.784ArgSer: 2.784 ± 0.075
2.271ArgThr: 2.271 ± 0.069
2.838ArgVal: 2.838 ± 0.075
0.582ArgTrp: 0.582 ± 0.035
1.696ArgTyr: 1.696 ± 0.059
0.0ArgXaa: 0.0 ± 0.0
Ser
4.686SerAla: 4.686 ± 0.101
0.726SerCys: 0.726 ± 0.033
3.198SerAsp: 3.198 ± 0.077
3.629SerGlu: 3.629 ± 0.098
3.379SerPhe: 3.379 ± 0.088
4.207SerGly: 4.207 ± 0.095
1.736SerHis: 1.736 ± 0.067
4.755SerIle: 4.755 ± 0.091
3.806SerLys: 3.806 ± 0.108
8.046SerLeu: 8.046 ± 0.147
1.696SerMet: 1.696 ± 0.053
2.712SerAsn: 2.712 ± 0.087
3.205SerPro: 3.205 ± 0.084
2.986SerGln: 2.986 ± 0.092
2.886SerArg: 2.886 ± 0.075
5.19SerSer: 5.19 ± 0.145
3.658SerThr: 3.658 ± 0.105
3.782SerVal: 3.782 ± 0.083
0.772SerTrp: 0.772 ± 0.041
2.473SerTyr: 2.473 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
4.509ThrAla: 4.509 ± 0.107
0.504ThrCys: 0.504 ± 0.031
2.842ThrAsp: 2.842 ± 0.075
2.953ThrGlu: 2.953 ± 0.079
2.481ThrPhe: 2.481 ± 0.065
3.676ThrGly: 3.676 ± 0.085
1.477ThrHis: 1.477 ± 0.054
4.273ThrIle: 4.273 ± 0.089
2.866ThrLys: 2.866 ± 0.079
6.692ThrLeu: 6.692 ± 0.128
1.163ThrMet: 1.163 ± 0.052
2.218ThrAsn: 2.218 ± 0.068
3.083ThrPro: 3.083 ± 0.09
2.441ThrGln: 2.441 ± 0.075
2.183ThrArg: 2.183 ± 0.069
3.819ThrSer: 3.819 ± 0.097
3.346ThrThr: 3.346 ± 0.097
3.872ThrVal: 3.872 ± 0.087
0.604ThrTrp: 0.604 ± 0.032
1.893ThrTyr: 1.893 ± 0.064
0.0ThrXaa: 0.0 ± 0.0
Val
4.863ValAla: 4.863 ± 0.103
0.688ValCys: 0.688 ± 0.033
3.371ValAsp: 3.371 ± 0.087
3.601ValGlu: 3.601 ± 0.085
2.461ValPhe: 2.461 ± 0.073
4.067ValGly: 4.067 ± 0.103
1.201ValHis: 1.201 ± 0.051
4.374ValIle: 4.374 ± 0.091
3.623ValLys: 3.623 ± 0.088
5.569ValLeu: 5.569 ± 0.102
1.504ValMet: 1.504 ± 0.053
2.559ValAsn: 2.559 ± 0.076
2.464ValPro: 2.464 ± 0.068
1.959ValGln: 1.959 ± 0.062
2.855ValArg: 2.855 ± 0.075
4.06ValSer: 4.06 ± 0.083
3.614ValThr: 3.614 ± 0.083
3.775ValVal: 3.775 ± 0.107
0.57ValTrp: 0.57 ± 0.031
1.718ValTyr: 1.718 ± 0.055
0.0ValXaa: 0.0 ± 0.0
Trp
0.752TrpAla: 0.752 ± 0.037
0.117TrpCys: 0.117 ± 0.015
0.546TrpAsp: 0.546 ± 0.031
0.582TrpGlu: 0.582 ± 0.031
0.528TrpPhe: 0.528 ± 0.029
0.741TrpGly: 0.741 ± 0.036
0.296TrpHis: 0.296 ± 0.023
0.726TrpIle: 0.726 ± 0.038
0.63TrpLys: 0.63 ± 0.035
1.265TrpLeu: 1.265 ± 0.053
0.279TrpMet: 0.279 ± 0.022
0.451TrpAsn: 0.451 ± 0.029
0.409TrpPro: 0.409 ± 0.026
0.639TrpGln: 0.639 ± 0.036
0.668TrpArg: 0.668 ± 0.04
0.641TrpSer: 0.641 ± 0.039
0.522TrpThr: 0.522 ± 0.027
0.644TrpVal: 0.644 ± 0.03
0.173TrpTrp: 0.173 ± 0.018
0.42TrpTyr: 0.42 ± 0.03
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.369TyrAla: 2.369 ± 0.073
0.374TyrCys: 0.374 ± 0.027
1.71TyrAsp: 1.71 ± 0.063
1.842TyrGlu: 1.842 ± 0.057
1.566TyrPhe: 1.566 ± 0.056
2.335TyrGly: 2.335 ± 0.078
0.829TyrHis: 0.829 ± 0.047
1.968TyrIle: 1.968 ± 0.068
1.928TyrLys: 1.928 ± 0.074
3.574TyrLeu: 3.574 ± 0.086
0.716TyrMet: 0.716 ± 0.034
1.448TyrAsn: 1.448 ± 0.055
1.393TyrPro: 1.393 ± 0.055
1.553TyrGln: 1.553 ± 0.054
1.752TyrArg: 1.752 ± 0.052
2.075TyrSer: 2.075 ± 0.069
1.688TyrThr: 1.688 ± 0.055
1.676TyrVal: 1.676 ± 0.056
0.382TyrTrp: 0.382 ± 0.026
1.197TyrTyr: 1.197 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1803 proteins (547837 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski