Amino acid dipepetide frequency for Maribellus luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.602AlaAla: 5.602 ± 0.076	0.764AlaCys: 0.764 ± 0.024	3.975AlaAsp: 3.975 ± 0.061	4.895AlaGlu: 4.895 ± 0.061	3.509AlaPhe: 3.509 ± 0.046	5.603AlaGly: 5.603 ± 0.059	1.206AlaHis: 1.206 ± 0.025	4.676AlaIle: 4.676 ± 0.052	4.04AlaLys: 4.04 ± 0.058	6.405AlaLeu: 6.405 ± 0.065	1.653AlaMet: 1.653 ± 0.032	3.293AlaAsn: 3.293 ± 0.048	2.317AlaPro: 2.317 ± 0.045	2.613AlaGln: 2.613 ± 0.037	2.956AlaArg: 2.956 ± 0.047	4.324AlaSer: 4.324 ± 0.056	3.527AlaThr: 3.527 ± 0.061	4.729AlaVal: 4.729 ± 0.059	0.908AlaTrp: 0.908 ± 0.023	2.624AlaTyr: 2.624 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.548CysAla: 0.548 ± 0.018	0.12CysCys: 0.12 ± 0.009	0.542CysAsp: 0.542 ± 0.028	0.526CysGlu: 0.526 ± 0.021	0.446CysPhe: 0.446 ± 0.018	0.713CysGly: 0.713 ± 0.023	0.248CysHis: 0.248 ± 0.025	0.529CysIle: 0.529 ± 0.018	0.456CysLys: 0.456 ± 0.015	0.696CysLeu: 0.696 ± 0.019	0.19CysMet: 0.19 ± 0.011	0.453CysAsn: 0.453 ± 0.021	0.418CysPro: 0.418 ± 0.022	0.296CysGln: 0.296 ± 0.016	0.371CysArg: 0.371 ± 0.015	0.626CysSer: 0.626 ± 0.021	0.466CysThr: 0.466 ± 0.018	0.49CysVal: 0.49 ± 0.017	0.122CysTrp: 0.122 ± 0.01	0.341CysTyr: 0.341 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.815AspAla: 3.815 ± 0.053	0.483AspCys: 0.483 ± 0.023	2.848AspAsp: 2.848 ± 0.045	3.916AspGlu: 3.916 ± 0.057	3.377AspPhe: 3.377 ± 0.05	4.169AspGly: 4.169 ± 0.075	0.973AspHis: 0.973 ± 0.024	3.757AspIle: 3.757 ± 0.052	3.589AspLys: 3.589 ± 0.051	5.091AspLeu: 5.091 ± 0.057	1.234AspMet: 1.234 ± 0.028	2.791AspAsn: 2.791 ± 0.044	2.289AspPro: 2.289 ± 0.037	1.785AspGln: 1.785 ± 0.036	2.239AspArg: 2.239 ± 0.034	3.046AspSer: 3.046 ± 0.058	2.472AspThr: 2.472 ± 0.044	3.696AspVal: 3.696 ± 0.051	0.954AspTrp: 0.954 ± 0.024	2.755AspTyr: 2.755 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	4.768GluAla: 4.768 ± 0.062	0.448GluCys: 0.448 ± 0.018	3.254GluAsp: 3.254 ± 0.047	4.902GluGlu: 4.902 ± 0.067	2.916GluPhe: 2.916 ± 0.038	4.139GluGly: 4.139 ± 0.057	1.158GluHis: 1.158 ± 0.027	5.203GluIle: 5.203 ± 0.055	5.821GluLys: 5.821 ± 0.071	6.49GluLeu: 6.49 ± 0.066	1.961GluMet: 1.961 ± 0.032	4.361GluAsn: 4.361 ± 0.052	1.919GluPro: 1.919 ± 0.037	2.498GluGln: 2.498 ± 0.038	2.801GluArg: 2.801 ± 0.048	3.533GluSer: 3.533 ± 0.044	3.605GluThr: 3.605 ± 0.047	4.547GluVal: 4.547 ± 0.06	0.911GluTrp: 0.911 ± 0.025	2.586GluTyr: 2.586 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.271PheAla: 3.271 ± 0.044	0.476PheCys: 0.476 ± 0.019	3.126PheAsp: 3.126 ± 0.043	3.205PheGlu: 3.205 ± 0.046	2.656PhePhe: 2.656 ± 0.052	3.46PheGly: 3.46 ± 0.047	0.89PheHis: 0.89 ± 0.022	3.382PheIle: 3.382 ± 0.053	2.744PheLys: 2.744 ± 0.038	4.562PheLeu: 4.562 ± 0.061	1.209PheMet: 1.209 ± 0.027	2.761PheAsn: 2.761 ± 0.042	1.954PhePro: 1.954 ± 0.038	1.572PheGln: 1.572 ± 0.03	2.166PheArg: 2.166 ± 0.036	4.059PheSer: 4.059 ± 0.063	2.89PheThr: 2.89 ± 0.043	3.302PheVal: 3.302 ± 0.05	0.701PheTrp: 0.701 ± 0.022	2.133PheTyr: 2.133 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	4.609GlyAla: 4.609 ± 0.059	0.692GlyCys: 0.692 ± 0.024	3.653GlyAsp: 3.653 ± 0.049	4.432GlyGlu: 4.432 ± 0.054	3.745GlyPhe: 3.745 ± 0.046	4.846GlyGly: 4.846 ± 0.068	1.239GlyHis: 1.239 ± 0.023	5.387GlyIle: 5.387 ± 0.059	5.239GlyLys: 5.239 ± 0.05	6.072GlyLeu: 6.072 ± 0.065	1.908GlyMet: 1.908 ± 0.038	3.85GlyAsn: 3.85 ± 0.059	1.717GlyPro: 1.717 ± 0.036	2.15GlyGln: 2.15 ± 0.038	2.66GlyArg: 2.66 ± 0.039	4.222GlySer: 4.222 ± 0.062	4.171GlyThr: 4.171 ± 0.059	4.771GlyVal: 4.771 ± 0.061	1.118GlyTrp: 1.118 ± 0.027	3.092GlyTyr: 3.092 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.093HisAla: 1.093 ± 0.025	0.2HisCys: 0.2 ± 0.01	0.912HisAsp: 0.912 ± 0.029	1.048HisGlu: 1.048 ± 0.025	1.199HisPhe: 1.199 ± 0.03	1.237HisGly: 1.237 ± 0.028	0.461HisHis: 0.461 ± 0.017	1.215HisIle: 1.215 ± 0.029	0.995HisLys: 0.995 ± 0.022	1.795HisLeu: 1.795 ± 0.034	0.403HisMet: 0.403 ± 0.017	0.907HisAsn: 0.907 ± 0.02	1.062HisPro: 1.062 ± 0.027	0.649HisGln: 0.649 ± 0.02	0.826HisArg: 0.826 ± 0.02	1.228HisSer: 1.228 ± 0.027	0.923HisThr: 0.923 ± 0.026	0.985HisVal: 0.985 ± 0.025	0.304HisTrp: 0.304 ± 0.013	0.845HisTyr: 0.845 ± 0.025	0.001HisXaa: 0.001 ± 0.001
Ile	4.857IleAla: 4.857 ± 0.054	0.622IleCys: 0.622 ± 0.022	4.331IleAsp: 4.331 ± 0.054	4.652IleGlu: 4.652 ± 0.048	3.145IlePhe: 3.145 ± 0.047	4.664IleGly: 4.664 ± 0.066	1.32IleHis: 1.32 ± 0.028	4.443IleIle: 4.443 ± 0.061	4.172IleLys: 4.172 ± 0.056	6.142IleLeu: 6.142 ± 0.067	1.298IleMet: 1.298 ± 0.029	3.565IleAsn: 3.565 ± 0.05	3.096IlePro: 3.096 ± 0.039	2.406IleGln: 2.406 ± 0.04	3.229IleArg: 3.229 ± 0.04	5.076IleSer: 5.076 ± 0.056	3.899IleThr: 3.899 ± 0.052	4.362IleVal: 4.362 ± 0.058	0.801IleTrp: 0.801 ± 0.027	2.554IleTyr: 2.554 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.756LysAla: 4.756 ± 0.065	0.401LysCys: 0.401 ± 0.019	3.599LysAsp: 3.599 ± 0.046	5.158LysGlu: 5.158 ± 0.063	2.433LysPhe: 2.433 ± 0.045	4.228LysGly: 4.228 ± 0.051	1.199LysHis: 1.199 ± 0.026	4.809LysIle: 4.809 ± 0.063	5.054LysLys: 5.054 ± 0.059	5.879LysLeu: 5.879 ± 0.06	1.911LysMet: 1.911 ± 0.037	4.027LysAsn: 4.027 ± 0.055	2.358LysPro: 2.358 ± 0.037	2.461LysGln: 2.461 ± 0.043	2.782LysArg: 2.782 ± 0.042	3.678LysSer: 3.678 ± 0.052	3.959LysThr: 3.959 ± 0.051	4.468LysVal: 4.468 ± 0.049	0.92LysTrp: 0.92 ± 0.022	2.852LysTyr: 2.852 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	6.72LeuAla: 6.72 ± 0.063	0.75LeuCys: 0.75 ± 0.02	4.699LeuAsp: 4.699 ± 0.05	5.814LeuGlu: 5.814 ± 0.069	4.831LeuPhe: 4.831 ± 0.067	5.879LeuGly: 5.879 ± 0.059	1.605LeuHis: 1.605 ± 0.03	6.109LeuIle: 6.109 ± 0.066	6.846LeuLys: 6.846 ± 0.064	9.079LeuLeu: 9.079 ± 0.104	2.151LeuMet: 2.151 ± 0.036	5.156LeuAsn: 5.156 ± 0.061	4.001LeuPro: 4.001 ± 0.049	3.21LeuGln: 3.21 ± 0.047	3.63LeuArg: 3.63 ± 0.053	6.542LeuSer: 6.542 ± 0.067	5.038LeuThr: 5.038 ± 0.057	5.902LeuVal: 5.902 ± 0.065	1.003LeuTrp: 1.003 ± 0.027	3.185LeuTyr: 3.185 ± 0.047	0.001LeuXaa: 0.001 ± 0.0
Met	1.883MetAla: 1.883 ± 0.035	0.144MetCys: 0.144 ± 0.008	1.263MetAsp: 1.263 ± 0.03	1.625MetGlu: 1.625 ± 0.032	0.961MetPhe: 0.961 ± 0.023	1.684MetGly: 1.684 ± 0.032	0.415MetHis: 0.415 ± 0.016	1.5MetIle: 1.5 ± 0.031	2.19MetLys: 2.19 ± 0.032	2.227MetLeu: 2.227 ± 0.037	0.599MetMet: 0.599 ± 0.02	1.439MetAsn: 1.439 ± 0.03	1.016MetPro: 1.016 ± 0.025	0.936MetGln: 0.936 ± 0.025	0.998MetArg: 0.998 ± 0.025	1.282MetSer: 1.282 ± 0.025	1.21MetThr: 1.21 ± 0.031	1.56MetVal: 1.56 ± 0.031	0.241MetTrp: 0.241 ± 0.013	0.722MetTyr: 0.722 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.479AsnAla: 3.479 ± 0.048	0.485AsnCys: 0.485 ± 0.02	2.905AsnAsp: 2.905 ± 0.04	3.448AsnGlu: 3.448 ± 0.046	2.563AsnPhe: 2.563 ± 0.041	3.99AsnGly: 3.99 ± 0.054	0.999AsnHis: 0.999 ± 0.021	3.944AsnIle: 3.944 ± 0.052	3.325AsnLys: 3.325 ± 0.048	4.832AsnLeu: 4.832 ± 0.059	1.24AsnMet: 1.24 ± 0.029	2.942AsnAsn: 2.942 ± 0.049	2.751AsnPro: 2.751 ± 0.044	1.993AsnGln: 1.993 ± 0.037	2.383AsnArg: 2.383 ± 0.036	3.349AsnSer: 3.349 ± 0.046	3.005AsnThr: 3.005 ± 0.042	3.233AsnVal: 3.233 ± 0.052	0.873AsnTrp: 0.873 ± 0.025	2.571AsnTyr: 2.571 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.943ProAla: 2.943 ± 0.047	0.236ProCys: 0.236 ± 0.012	2.758ProAsp: 2.758 ± 0.044	3.735ProGlu: 3.735 ± 0.048	1.951ProPhe: 1.951 ± 0.036	3.124ProGly: 3.124 ± 0.044	0.718ProHis: 0.718 ± 0.021	2.074ProIle: 2.074 ± 0.04	1.999ProLys: 1.999 ± 0.032	3.265ProLeu: 3.265 ± 0.045	0.803ProMet: 0.803 ± 0.021	1.85ProAsn: 1.85 ± 0.034	1.091ProPro: 1.091 ± 0.032	1.306ProGln: 1.306 ± 0.027	1.344ProArg: 1.344 ± 0.028	2.203ProSer: 2.203 ± 0.035	1.885ProThr: 1.885 ± 0.036	3.415ProVal: 3.415 ± 0.048	0.536ProTrp: 0.536 ± 0.016	1.502ProTyr: 1.502 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	2.359GlnAla: 2.359 ± 0.04	0.203GlnCys: 0.203 ± 0.011	1.516GlnAsp: 1.516 ± 0.03	2.32GlnGlu: 2.32 ± 0.039	1.541GlnPhe: 1.541 ± 0.026	1.946GlnGly: 1.946 ± 0.033	0.657GlnHis: 0.657 ± 0.021	2.444GlnIle: 2.444 ± 0.039	2.916GlnLys: 2.916 ± 0.041	3.596GlnLeu: 3.596 ± 0.052	0.95GlnMet: 0.95 ± 0.023	2.121GlnAsn: 2.121 ± 0.034	1.398GlnPro: 1.398 ± 0.028	1.648GlnGln: 1.648 ± 0.038	1.492GlnArg: 1.492 ± 0.031	1.995GlnSer: 1.995 ± 0.04	1.9GlnThr: 1.9 ± 0.035	2.259GlnVal: 2.259 ± 0.034	0.483GlnTrp: 0.483 ± 0.018	1.333GlnTyr: 1.333 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.552ArgAla: 2.552 ± 0.044	0.282ArgCys: 0.282 ± 0.013	2.101ArgAsp: 2.101 ± 0.038	2.999ArgGlu: 2.999 ± 0.047	2.361ArgPhe: 2.361 ± 0.04	2.385ArgGly: 2.385 ± 0.041	0.78ArgHis: 0.78 ± 0.025	3.287ArgIle: 3.287 ± 0.044	3.07ArgLys: 3.07 ± 0.044	3.866ArgLeu: 3.866 ± 0.054	1.107ArgMet: 1.107 ± 0.025	2.451ArgAsn: 2.451 ± 0.04	1.427ArgPro: 1.427 ± 0.032	1.456ArgGln: 1.456 ± 0.03	1.818ArgArg: 1.818 ± 0.042	2.327ArgSer: 2.327 ± 0.034	2.151ArgThr: 2.151 ± 0.033	2.554ArgVal: 2.554 ± 0.041	0.621ArgTrp: 0.621 ± 0.021	1.917ArgTyr: 1.917 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.295SerAla: 4.295 ± 0.046	0.713SerCys: 0.713 ± 0.029	3.576SerAsp: 3.576 ± 0.055	4.174SerGlu: 4.174 ± 0.052	3.571SerPhe: 3.571 ± 0.047	5.163SerGly: 5.163 ± 0.057	1.154SerHis: 1.154 ± 0.027	4.283SerIle: 4.283 ± 0.056	3.734SerLys: 3.734 ± 0.051	5.71SerLeu: 5.71 ± 0.07	1.48SerMet: 1.48 ± 0.028	3.122SerAsn: 3.122 ± 0.046	2.435SerPro: 2.435 ± 0.041	2.03SerGln: 2.03 ± 0.034	2.517SerArg: 2.517 ± 0.042	4.136SerSer: 4.136 ± 0.065	3.256SerThr: 3.256 ± 0.046	4.54SerVal: 4.54 ± 0.053	0.985SerTrp: 0.985 ± 0.028	2.727SerTyr: 2.727 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	3.813ThrAla: 3.813 ± 0.052	0.419ThrCys: 0.419 ± 0.017	3.208ThrAsp: 3.208 ± 0.044	3.317ThrGlu: 3.317 ± 0.044	2.712ThrPhe: 2.712 ± 0.043	4.457ThrGly: 4.457 ± 0.057	0.991ThrHis: 0.991 ± 0.024	3.951ThrIle: 3.951 ± 0.056	2.859ThrLys: 2.859 ± 0.04	4.942ThrLeu: 4.942 ± 0.056	1.081ThrMet: 1.081 ± 0.024	2.571ThrAsn: 2.571 ± 0.041	2.54ThrPro: 2.54 ± 0.037	1.819ThrGln: 1.819 ± 0.032	2.143ThrArg: 2.143 ± 0.036	3.413ThrSer: 3.413 ± 0.044	3.038ThrThr: 3.038 ± 0.051	3.882ThrVal: 3.882 ± 0.062	0.731ThrTrp: 0.731 ± 0.019	2.234ThrTyr: 2.234 ± 0.04	0.001ThrXaa: 0.001 ± 0.001
Val	4.771ValAla: 4.771 ± 0.056	0.622ValCys: 0.622 ± 0.02	3.84ValAsp: 3.84 ± 0.044	4.353ValGlu: 4.353 ± 0.057	3.621ValPhe: 3.621 ± 0.047	4.051ValGly: 4.051 ± 0.049	1.125ValHis: 1.125 ± 0.027	4.368ValIle: 4.368 ± 0.056	4.414ValLys: 4.414 ± 0.054	6.369ValLeu: 6.369 ± 0.069	1.462ValMet: 1.462 ± 0.031	3.46ValAsn: 3.46 ± 0.045	2.71ValPro: 2.71 ± 0.041	2.064ValGln: 2.064 ± 0.035	2.546ValArg: 2.546 ± 0.036	4.705ValSer: 4.705 ± 0.06	3.744ValThr: 3.744 ± 0.065	4.777ValVal: 4.777 ± 0.056	0.809ValTrp: 0.809 ± 0.023	2.594ValTyr: 2.594 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.856TrpAla: 0.856 ± 0.025	0.145TrpCys: 0.145 ± 0.01	0.819TrpAsp: 0.819 ± 0.023	0.967TrpGlu: 0.967 ± 0.023	0.642TrpPhe: 0.642 ± 0.019	1.046TrpGly: 1.046 ± 0.026	0.301TrpHis: 0.301 ± 0.014	0.88TrpIle: 0.88 ± 0.026	1.019TrpLys: 1.019 ± 0.024	1.271TrpLeu: 1.271 ± 0.028	0.409TrpMet: 0.409 ± 0.016	0.834TrpAsn: 0.834 ± 0.021	0.386TrpPro: 0.386 ± 0.015	0.569TrpGln: 0.569 ± 0.017	0.588TrpArg: 0.588 ± 0.02	0.824TrpSer: 0.824 ± 0.025	0.737TrpThr: 0.737 ± 0.025	0.78TrpVal: 0.78 ± 0.02	0.209TrpTrp: 0.209 ± 0.011	0.557TrpTyr: 0.557 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.629TyrAla: 2.629 ± 0.041	0.392TyrCys: 0.392 ± 0.016	2.356TyrAsp: 2.356 ± 0.04	2.335TyrGlu: 2.335 ± 0.036	2.338TyrPhe: 2.338 ± 0.042	2.787TyrGly: 2.787 ± 0.049	0.849TyrHis: 0.849 ± 0.02	2.394TyrIle: 2.394 ± 0.038	2.451TyrLys: 2.451 ± 0.043	3.862TyrLeu: 3.862 ± 0.047	0.845TyrMet: 0.845 ± 0.022	2.356TyrAsn: 2.356 ± 0.047	1.854TyrPro: 1.854 ± 0.035	1.617TyrGln: 1.617 ± 0.03	2.021TyrArg: 2.021 ± 0.037	3.032TyrSer: 3.032 ± 0.044	2.245TyrThr: 2.245 ± 0.045	2.153TyrVal: 2.153 ± 0.035	0.609TyrTrp: 0.609 ± 0.021	1.954TyrTyr: 1.954 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4999 proteins (1801786 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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