Amino acid dipepetide frequency for Tropicimonas sp. IMCC6043

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.964AlaAla: 17.964 ± 0.164
1.178AlaCys: 1.178 ± 0.032
6.852AlaAsp: 6.852 ± 0.072
8.988AlaGlu: 8.988 ± 0.086
4.35AlaPhe: 4.35 ± 0.058
11.21AlaGly: 11.21 ± 0.107
2.222AlaHis: 2.222 ± 0.035
6.199AlaIle: 6.199 ± 0.064
3.157AlaLys: 3.157 ± 0.061
14.044AlaLeu: 14.044 ± 0.131
3.763AlaMet: 3.763 ± 0.057
2.613AlaAsn: 2.613 ± 0.047
5.901AlaPro: 5.901 ± 0.082
3.668AlaGln: 3.668 ± 0.049
9.513AlaArg: 9.513 ± 0.098
5.913AlaSer: 5.913 ± 0.073
6.259AlaThr: 6.259 ± 0.085
8.608AlaVal: 8.608 ± 0.073
1.591AlaTrp: 1.591 ± 0.038
2.392AlaTyr: 2.392 ± 0.039
0.0AlaXaa: 0.0 ± 0.0
Cys
1.057CysAla: 1.057 ± 0.028
0.099CysCys: 0.099 ± 0.008
0.568CysAsp: 0.568 ± 0.021
0.485CysGlu: 0.485 ± 0.018
0.341CysPhe: 0.341 ± 0.015
0.965CysGly: 0.965 ± 0.025
0.297CysHis: 0.297 ± 0.02
0.425CysIle: 0.425 ± 0.018
0.182CysLys: 0.182 ± 0.012
0.903CysLeu: 0.903 ± 0.021
0.172CysMet: 0.172 ± 0.011
0.237CysAsn: 0.237 ± 0.012
0.52CysPro: 0.52 ± 0.02
0.244CysGln: 0.244 ± 0.014
0.672CysArg: 0.672 ± 0.021
0.472CysSer: 0.472 ± 0.015
0.426CysThr: 0.426 ± 0.018
0.641CysVal: 0.641 ± 0.024
0.128CysTrp: 0.128 ± 0.009
0.213CysTyr: 0.213 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.154AspAla: 7.154 ± 0.081
0.55AspCys: 0.55 ± 0.02
3.031AspAsp: 3.031 ± 0.071
3.357AspGlu: 3.357 ± 0.055
2.37AspPhe: 2.37 ± 0.04
5.635AspGly: 5.635 ± 0.081
1.313AspHis: 1.313 ± 0.033
3.137AspIle: 3.137 ± 0.051
1.327AspLys: 1.327 ± 0.036
6.321AspLeu: 6.321 ± 0.061
1.521AspMet: 1.521 ± 0.028
1.202AspAsn: 1.202 ± 0.032
3.88AspPro: 3.88 ± 0.053
1.461AspGln: 1.461 ± 0.032
4.56AspArg: 4.56 ± 0.058
2.347AspSer: 2.347 ± 0.044
2.742AspThr: 2.742 ± 0.058
4.102AspVal: 4.102 ± 0.069
1.187AspTrp: 1.187 ± 0.032
1.448AspTyr: 1.448 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
8.857GluAla: 8.857 ± 0.096
0.377GluCys: 0.377 ± 0.014
3.418GluAsp: 3.418 ± 0.057
3.902GluGlu: 3.902 ± 0.064
1.9GluPhe: 1.9 ± 0.042
4.698GluGly: 4.698 ± 0.053
1.145GluHis: 1.145 ± 0.027
4.232GluIle: 4.232 ± 0.058
1.926GluLys: 1.926 ± 0.047
5.406GluLeu: 5.406 ± 0.062
1.935GluMet: 1.935 ± 0.035
1.616GluAsn: 1.616 ± 0.036
2.771GluPro: 2.771 ± 0.052
1.856GluGln: 1.856 ± 0.04
4.844GluArg: 4.844 ± 0.062
2.762GluSer: 2.762 ± 0.037
4.237GluThr: 4.237 ± 0.061
4.326GluVal: 4.326 ± 0.061
0.692GluTrp: 0.692 ± 0.022
1.037GluTyr: 1.037 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.518PheAla: 4.518 ± 0.06
0.416PheCys: 0.416 ± 0.016
2.751PheAsp: 2.751 ± 0.046
2.326PheGlu: 2.326 ± 0.042
1.518PhePhe: 1.518 ± 0.038
3.935PheGly: 3.935 ± 0.055
0.777PheHis: 0.777 ± 0.026
1.585PheIle: 1.585 ± 0.038
0.778PheLys: 0.778 ± 0.024
3.809PheLeu: 3.809 ± 0.058
0.763PheMet: 0.763 ± 0.023
0.998PheAsn: 0.998 ± 0.031
1.711PhePro: 1.711 ± 0.037
0.95PheGln: 0.95 ± 0.024
2.421PheArg: 2.421 ± 0.044
2.088PheSer: 2.088 ± 0.036
1.986PheThr: 1.986 ± 0.035
2.78PheVal: 2.78 ± 0.045
0.603PheTrp: 0.603 ± 0.022
0.903PheTyr: 0.903 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.062GlyAla: 10.062 ± 0.095
0.92GlyCys: 0.92 ± 0.027
4.68GlyAsp: 4.68 ± 0.082
5.061GlyGlu: 5.061 ± 0.063
3.76GlyPhe: 3.76 ± 0.052
7.555GlyGly: 7.555 ± 0.128
1.939GlyHis: 1.939 ± 0.039
4.801GlyIle: 4.801 ± 0.056
2.851GlyLys: 2.851 ± 0.051
9.444GlyLeu: 9.444 ± 0.09
2.624GlyMet: 2.624 ± 0.04
2.174GlyAsn: 2.174 ± 0.056
3.91GlyPro: 3.91 ± 0.057
2.831GlyGln: 2.831 ± 0.043
6.359GlyArg: 6.359 ± 0.073
4.38GlySer: 4.38 ± 0.074
4.784GlyThr: 4.784 ± 0.068
6.284GlyVal: 6.284 ± 0.071
1.598GlyTrp: 1.598 ± 0.035
2.286GlyTyr: 2.286 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.24HisAla: 2.24 ± 0.042
0.228HisCys: 0.228 ± 0.013
1.236HisAsp: 1.236 ± 0.023
1.108HisGlu: 1.108 ± 0.026
0.834HisPhe: 0.834 ± 0.026
1.953HisGly: 1.953 ± 0.038
0.527HisHis: 0.527 ± 0.021
0.902HisIle: 0.902 ± 0.028
0.444HisLys: 0.444 ± 0.018
2.029HisLeu: 2.029 ± 0.037
0.532HisMet: 0.532 ± 0.021
0.406HisAsn: 0.406 ± 0.016
1.359HisPro: 1.359 ± 0.032
0.525HisGln: 0.525 ± 0.018
1.48HisArg: 1.48 ± 0.035
1.003HisSer: 1.003 ± 0.026
0.776HisThr: 0.776 ± 0.024
1.551HisVal: 1.551 ± 0.033
0.359HisTrp: 0.359 ± 0.014
0.521HisTyr: 0.521 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.14IleAla: 7.14 ± 0.078
0.614IleCys: 0.614 ± 0.022
3.564IleAsp: 3.564 ± 0.051
3.403IleGlu: 3.403 ± 0.055
1.839IlePhe: 1.839 ± 0.039
5.103IleGly: 5.103 ± 0.062
0.919IleHis: 0.919 ± 0.022
1.971IleIle: 1.971 ± 0.045
1.069IleLys: 1.069 ± 0.028
5.09IleLeu: 5.09 ± 0.065
0.926IleMet: 0.926 ± 0.026
1.266IleAsn: 1.266 ± 0.036
2.371IlePro: 2.371 ± 0.041
1.041IleGln: 1.041 ± 0.026
3.507IleArg: 3.507 ± 0.05
2.911IleSer: 2.911 ± 0.044
2.59IleThr: 2.59 ± 0.053
4.008IleVal: 4.008 ± 0.058
0.707IleTrp: 0.707 ± 0.02
1.122IleTyr: 1.122 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.364LysAla: 3.364 ± 0.056
0.188LysCys: 0.188 ± 0.012
1.454LysAsp: 1.454 ± 0.031
1.384LysGlu: 1.384 ± 0.036
0.815LysPhe: 0.815 ± 0.028
2.301LysGly: 2.301 ± 0.048
0.512LysHis: 0.512 ± 0.02
1.472LysIle: 1.472 ± 0.033
0.979LysLys: 0.979 ± 0.033
2.628LysLeu: 2.628 ± 0.048
0.736LysMet: 0.736 ± 0.02
0.641LysAsn: 0.641 ± 0.025
1.571LysPro: 1.571 ± 0.039
0.716LysGln: 0.716 ± 0.027
1.999LysArg: 1.999 ± 0.044
1.56LysSer: 1.56 ± 0.033
1.625LysThr: 1.625 ± 0.035
2.164LysVal: 2.164 ± 0.044
0.341LysTrp: 0.341 ± 0.016
0.571LysTyr: 0.571 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.137LeuAla: 14.137 ± 0.134
0.956LeuCys: 0.956 ± 0.027
6.156LeuAsp: 6.156 ± 0.067
5.913LeuGlu: 5.913 ± 0.069
3.756LeuPhe: 3.756 ± 0.063
8.692LeuGly: 8.692 ± 0.085
1.924LeuHis: 1.924 ± 0.039
4.738LeuIle: 4.738 ± 0.066
2.912LeuLys: 2.912 ± 0.045
9.773LeuLeu: 9.773 ± 0.122
2.432LeuMet: 2.432 ± 0.042
2.332LeuAsn: 2.332 ± 0.042
5.836LeuPro: 5.836 ± 0.076
2.461LeuGln: 2.461 ± 0.042
7.257LeuArg: 7.257 ± 0.089
6.43LeuSer: 6.43 ± 0.081
5.715LeuThr: 5.715 ± 0.067
7.563LeuVal: 7.563 ± 0.082
1.274LeuTrp: 1.274 ± 0.032
2.03LeuTyr: 2.03 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.308MetAla: 3.308 ± 0.052
0.179MetCys: 0.179 ± 0.011
1.288MetAsp: 1.288 ± 0.027
1.423MetGlu: 1.423 ± 0.031
0.802MetPhe: 0.802 ± 0.024
2.051MetGly: 2.051 ± 0.039
0.447MetHis: 0.447 ± 0.016
1.503MetIle: 1.503 ± 0.033
0.983MetLys: 0.983 ± 0.023
2.589MetLeu: 2.589 ± 0.048
0.71MetMet: 0.71 ± 0.024
0.819MetAsn: 0.819 ± 0.024
1.491MetPro: 1.491 ± 0.036
0.871MetGln: 0.871 ± 0.026
1.867MetArg: 1.867 ± 0.037
1.771MetSer: 1.771 ± 0.037
1.96MetThr: 1.96 ± 0.035
1.9MetVal: 1.9 ± 0.037
0.209MetTrp: 0.209 ± 0.012
0.306MetTyr: 0.306 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.949AsnAla: 2.949 ± 0.047
0.242AsnCys: 0.242 ± 0.013
1.302AsnAsp: 1.302 ± 0.039
1.149AsnGlu: 1.149 ± 0.03
0.946AsnPhe: 0.946 ± 0.024
2.206AsnGly: 2.206 ± 0.046
0.491AsnHis: 0.491 ± 0.019
1.258AsnIle: 1.258 ± 0.03
0.521AsnLys: 0.521 ± 0.02
2.4AsnLeu: 2.4 ± 0.04
0.684AsnMet: 0.684 ± 0.023
0.609AsnAsn: 0.609 ± 0.024
1.723AsnPro: 1.723 ± 0.033
0.646AsnGln: 0.646 ± 0.019
1.729AsnArg: 1.729 ± 0.042
1.181AsnSer: 1.181 ± 0.034
1.165AsnThr: 1.165 ± 0.031
1.822AsnVal: 1.822 ± 0.045
0.412AsnTrp: 0.412 ± 0.017
0.572AsnTyr: 0.572 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
6.255ProAla: 6.255 ± 0.077
0.366ProCys: 0.366 ± 0.017
4.006ProAsp: 4.006 ± 0.054
4.607ProGlu: 4.607 ± 0.067
2.027ProPhe: 2.027 ± 0.035
5.023ProGly: 5.023 ± 0.067
1.028ProHis: 1.028 ± 0.025
2.241ProIle: 2.241 ± 0.044
1.416ProLys: 1.416 ± 0.037
4.747ProLeu: 4.747 ± 0.068
1.279ProMet: 1.279 ± 0.035
1.229ProAsn: 1.229 ± 0.029
2.605ProPro: 2.605 ± 0.05
1.376ProGln: 1.376 ± 0.034
3.018ProArg: 3.018 ± 0.051
2.539ProSer: 2.539 ± 0.043
2.446ProThr: 2.446 ± 0.04
4.408ProVal: 4.408 ± 0.058
0.719ProTrp: 0.719 ± 0.023
1.131ProTyr: 1.131 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.513GlnAla: 3.513 ± 0.043
0.177GlnCys: 0.177 ± 0.011
1.463GlnAsp: 1.463 ± 0.031
1.522GlnGlu: 1.522 ± 0.032
0.971GlnPhe: 0.971 ± 0.025
2.188GlnGly: 2.188 ± 0.04
0.496GlnHis: 0.496 ± 0.02
1.733GlnIle: 1.733 ± 0.036
0.88GlnLys: 0.88 ± 0.026
2.447GlnLeu: 2.447 ± 0.04
0.919GlnMet: 0.919 ± 0.024
0.733GlnAsn: 0.733 ± 0.021
1.5GlnPro: 1.5 ± 0.035
0.955GlnGln: 0.955 ± 0.028
2.08GlnArg: 2.08 ± 0.044
1.589GlnSer: 1.589 ± 0.031
1.496GlnThr: 1.496 ± 0.029
2.22GlnVal: 2.22 ± 0.04
0.356GlnTrp: 0.356 ± 0.015
0.549GlnTyr: 0.549 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
8.433ArgAla: 8.433 ± 0.092
0.543ArgCys: 0.543 ± 0.018
4.243ArgAsp: 4.243 ± 0.054
4.267ArgGlu: 4.267 ± 0.062
2.828ArgPhe: 2.828 ± 0.047
5.02ArgGly: 5.02 ± 0.062
1.689ArgHis: 1.689 ± 0.034
4.045ArgIle: 4.045 ± 0.057
2.168ArgLys: 2.168 ± 0.044
8.0ArgLeu: 8.0 ± 0.089
2.053ArgMet: 2.053 ± 0.037
1.781ArgAsn: 1.781 ± 0.036
3.783ArgPro: 3.783 ± 0.053
2.34ArgGln: 2.34 ± 0.043
6.05ArgArg: 6.05 ± 0.08
3.715ArgSer: 3.715 ± 0.052
3.319ArgThr: 3.319 ± 0.044
4.904ArgVal: 4.904 ± 0.062
0.976ArgTrp: 0.976 ± 0.029
1.584ArgTyr: 1.584 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.008SerAla: 6.008 ± 0.068
0.445SerCys: 0.445 ± 0.021
3.18SerAsp: 3.18 ± 0.056
3.223SerGlu: 3.223 ± 0.045
2.231SerPhe: 2.231 ± 0.04
5.751SerGly: 5.751 ± 0.092
1.065SerHis: 1.065 ± 0.025
2.467SerIle: 2.467 ± 0.044
1.327SerLys: 1.327 ± 0.033
5.213SerLeu: 5.213 ± 0.053
1.343SerMet: 1.343 ± 0.029
1.261SerAsn: 1.261 ± 0.03
2.655SerPro: 2.655 ± 0.043
1.482SerGln: 1.482 ± 0.033
3.516SerArg: 3.516 ± 0.057
2.629SerSer: 2.629 ± 0.052
2.525SerThr: 2.525 ± 0.048
4.113SerVal: 4.113 ± 0.07
0.744SerTrp: 0.744 ± 0.024
1.27SerTyr: 1.27 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.386ThrAla: 6.386 ± 0.093
0.534ThrCys: 0.534 ± 0.023
3.049ThrAsp: 3.049 ± 0.049
3.109ThrGlu: 3.109 ± 0.049
1.952ThrPhe: 1.952 ± 0.036
5.5ThrGly: 5.5 ± 0.073
1.11ThrHis: 1.11 ± 0.03
2.728ThrIle: 2.728 ± 0.048
1.247ThrLys: 1.247 ± 0.03
5.865ThrLeu: 5.865 ± 0.065
1.288ThrMet: 1.288 ± 0.029
1.179ThrAsn: 1.179 ± 0.031
3.282ThrPro: 3.282 ± 0.049
1.297ThrGln: 1.297 ± 0.029
3.612ThrArg: 3.612 ± 0.05
2.698ThrSer: 2.698 ± 0.055
2.713ThrThr: 2.713 ± 0.062
4.009ThrVal: 4.009 ± 0.057
0.726ThrTrp: 0.726 ± 0.024
1.162ThrTyr: 1.162 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.305ValAla: 9.305 ± 0.097
0.651ValCys: 0.651 ± 0.025
4.201ValAsp: 4.201 ± 0.06
4.729ValGlu: 4.729 ± 0.06
2.945ValPhe: 2.945 ± 0.047
5.576ValGly: 5.576 ± 0.069
1.319ValHis: 1.319 ± 0.03
4.109ValIle: 4.109 ± 0.052
1.903ValLys: 1.903 ± 0.046
7.642ValLeu: 7.642 ± 0.088
1.938ValMet: 1.938 ± 0.038
1.902ValAsn: 1.902 ± 0.037
3.817ValPro: 3.817 ± 0.048
1.863ValGln: 1.863 ± 0.034
4.484ValArg: 4.484 ± 0.057
4.392ValSer: 4.392 ± 0.061
4.808ValThr: 4.808 ± 0.06
5.779ValVal: 5.779 ± 0.074
0.895ValTrp: 0.895 ± 0.024
1.429ValTyr: 1.429 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.314TrpAla: 1.314 ± 0.029
0.143TrpCys: 0.143 ± 0.009
0.763TrpAsp: 0.763 ± 0.023
0.719TrpGlu: 0.719 ± 0.025
0.538TrpPhe: 0.538 ± 0.019
0.944TrpGly: 0.944 ± 0.028
0.343TrpHis: 0.343 ± 0.013
0.739TrpIle: 0.739 ± 0.021
0.452TrpLys: 0.452 ± 0.018
1.652TrpLeu: 1.652 ± 0.04
0.409TrpMet: 0.409 ± 0.017
0.464TrpAsn: 0.464 ± 0.018
0.7TrpPro: 0.7 ± 0.022
0.596TrpGln: 0.596 ± 0.019
1.134TrpArg: 1.134 ± 0.028
0.877TrpSer: 0.877 ± 0.027
0.838TrpThr: 0.838 ± 0.026
0.919TrpVal: 0.919 ± 0.025
0.239TrpTrp: 0.239 ± 0.015
0.322TrpTyr: 0.322 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.42TyrAla: 2.42 ± 0.041
0.239TyrCys: 0.239 ± 0.014
1.442TyrAsp: 1.442 ± 0.035
1.26TyrGlu: 1.26 ± 0.031
0.895TyrPhe: 0.895 ± 0.024
1.999TyrGly: 1.999 ± 0.041
0.448TyrHis: 0.448 ± 0.016
0.877TyrIle: 0.877 ± 0.027
0.502TyrLys: 0.502 ± 0.018
2.283TyrLeu: 2.283 ± 0.038
0.448TyrMet: 0.448 ± 0.018
0.545TyrAsn: 0.545 ± 0.02
1.081TyrPro: 1.081 ± 0.03
0.61TyrGln: 0.61 ± 0.019
1.639TyrArg: 1.639 ± 0.034
1.189TyrSer: 1.189 ± 0.03
1.038TyrThr: 1.038 ± 0.03
1.585TyrVal: 1.585 ± 0.031
0.349TyrTrp: 0.349 ± 0.014
0.571TyrTyr: 0.571 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5038 proteins (1561054 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski