Amino acid dipepetide frequency for Streptococcus satellite phage Javan463

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.74AlaAla: 0.74 ± 0.46
1.234AlaCys: 1.234 ± 0.556
2.962AlaAsp: 2.962 ± 0.824
5.429AlaGlu: 5.429 ± 1.264
3.455AlaPhe: 3.455 ± 0.844
2.715AlaGly: 2.715 ± 0.83
0.247AlaHis: 0.247 ± 0.302
6.663AlaIle: 6.663 ± 1.26
4.442AlaLys: 4.442 ± 1.015
4.195AlaLeu: 4.195 ± 1.058
1.728AlaMet: 1.728 ± 0.577
3.949AlaAsn: 3.949 ± 0.973
1.481AlaPro: 1.481 ± 0.624
1.974AlaGln: 1.974 ± 0.541
2.715AlaArg: 2.715 ± 0.677
3.949AlaSer: 3.949 ± 1.412
4.195AlaThr: 4.195 ± 0.683
3.208AlaVal: 3.208 ± 0.939
1.234AlaTrp: 1.234 ± 0.649
1.481AlaTyr: 1.481 ± 0.481
0.0AlaXaa: 0.0 ± 0.0
Cys
0.987CysAla: 0.987 ± 0.433
0.247CysCys: 0.247 ± 0.26
0.494CysAsp: 0.494 ± 0.371
0.247CysGlu: 0.247 ± 0.26
0.0CysPhe: 0.0 ± 0.0
0.247CysGly: 0.247 ± 0.26
0.494CysHis: 0.494 ± 0.406
0.0CysIle: 0.0 ± 0.0
0.247CysLys: 0.247 ± 0.211
0.987CysLeu: 0.987 ± 0.521
0.0CysMet: 0.0 ± 0.0
0.247CysAsn: 0.247 ± 0.247
0.74CysPro: 0.74 ± 0.411
0.494CysGln: 0.494 ± 0.3
0.247CysArg: 0.247 ± 0.26
0.247CysSer: 0.247 ± 0.28
0.247CysThr: 0.247 ± 0.212
0.247CysVal: 0.247 ± 0.247
0.0CysTrp: 0.0 ± 0.0
0.494CysTyr: 0.494 ± 0.34
0.0CysXaa: 0.0 ± 0.0
Asp
2.468AspAla: 2.468 ± 0.671
0.74AspCys: 0.74 ± 0.467
2.715AspAsp: 2.715 ± 0.651
3.949AspGlu: 3.949 ± 1.015
2.715AspPhe: 2.715 ± 0.95
2.468AspGly: 2.468 ± 0.818
0.987AspHis: 0.987 ± 0.65
7.651AspIle: 7.651 ± 1.354
4.936AspLys: 4.936 ± 0.908
5.429AspLeu: 5.429 ± 0.834
1.234AspMet: 1.234 ± 0.693
2.221AspAsn: 2.221 ± 0.586
1.234AspPro: 1.234 ± 0.495
1.234AspGln: 1.234 ± 0.521
3.455AspArg: 3.455 ± 0.635
3.949AspSer: 3.949 ± 1.294
3.455AspThr: 3.455 ± 0.975
1.481AspVal: 1.481 ± 0.509
0.247AspTrp: 0.247 ± 0.277
3.949AspTyr: 3.949 ± 0.903
0.0AspXaa: 0.0 ± 0.0
Glu
6.417GluAla: 6.417 ± 0.985
1.481GluCys: 1.481 ± 0.685
4.936GluAsp: 4.936 ± 1.313
7.404GluGlu: 7.404 ± 1.961
1.974GluPhe: 1.974 ± 0.877
2.221GluGly: 2.221 ± 0.626
2.962GluHis: 2.962 ± 0.752
5.923GluIle: 5.923 ± 1.353
6.17GluLys: 6.17 ± 0.852
9.378GluLeu: 9.378 ± 1.166
2.221GluMet: 2.221 ± 0.599
1.974GluAsn: 1.974 ± 0.623
2.221GluPro: 2.221 ± 0.71
3.949GluGln: 3.949 ± 1.1
2.715GluArg: 2.715 ± 0.939
1.234GluSer: 1.234 ± 0.518
4.195GluThr: 4.195 ± 0.895
3.208GluVal: 3.208 ± 0.866
0.74GluTrp: 0.74 ± 0.408
3.949GluTyr: 3.949 ± 1.116
0.0GluXaa: 0.0 ± 0.0
Phe
1.234PheAla: 1.234 ± 0.382
0.0PheCys: 0.0 ± 0.0
3.208PheAsp: 3.208 ± 0.723
2.962PheGlu: 2.962 ± 0.697
1.728PhePhe: 1.728 ± 0.481
1.481PheGly: 1.481 ± 0.424
1.974PheHis: 1.974 ± 0.525
3.455PheIle: 3.455 ± 1.137
4.689PheLys: 4.689 ± 1.163
3.455PheLeu: 3.455 ± 0.756
0.247PheMet: 0.247 ± 0.212
1.974PheAsn: 1.974 ± 0.584
1.234PhePro: 1.234 ± 0.587
0.74PheGln: 0.74 ± 0.362
2.221PheArg: 2.221 ± 0.677
2.468PheSer: 2.468 ± 0.579
2.962PheThr: 2.962 ± 0.679
2.468PheVal: 2.468 ± 0.633
0.247PheTrp: 0.247 ± 0.179
1.234PheTyr: 1.234 ± 0.46
0.0PheXaa: 0.0 ± 0.0
Gly
2.221GlyAla: 2.221 ± 0.958
0.0GlyCys: 0.0 ± 0.0
4.936GlyAsp: 4.936 ± 1.279
1.728GlyGlu: 1.728 ± 0.48
2.221GlyPhe: 2.221 ± 0.672
2.221GlyGly: 2.221 ± 0.745
0.74GlyHis: 0.74 ± 0.483
2.715GlyIle: 2.715 ± 0.863
3.702GlyLys: 3.702 ± 0.961
5.676GlyLeu: 5.676 ± 1.259
1.234GlyMet: 1.234 ± 0.436
1.974GlyAsn: 1.974 ± 0.585
0.247GlyPro: 0.247 ± 0.237
3.702GlyGln: 3.702 ± 1.035
2.221GlyArg: 2.221 ± 0.575
1.974GlySer: 1.974 ± 0.79
2.468GlyThr: 2.468 ± 0.623
3.702GlyVal: 3.702 ± 0.752
0.494GlyTrp: 0.494 ± 0.258
3.702GlyTyr: 3.702 ± 0.66
0.0GlyXaa: 0.0 ± 0.0
His
2.715HisAla: 2.715 ± 0.974
0.0HisCys: 0.0 ± 0.0
0.247HisAsp: 0.247 ± 0.263
0.247HisGlu: 0.247 ± 0.179
0.494HisPhe: 0.494 ± 0.379
1.728HisGly: 1.728 ± 0.553
0.247HisHis: 0.247 ± 0.179
1.234HisIle: 1.234 ± 0.495
2.468HisLys: 2.468 ± 0.734
2.221HisLeu: 2.221 ± 0.804
0.494HisMet: 0.494 ± 0.377
1.234HisAsn: 1.234 ± 0.724
0.494HisPro: 0.494 ± 0.289
1.234HisGln: 1.234 ± 0.637
0.74HisArg: 0.74 ± 0.338
0.74HisSer: 0.74 ± 0.537
1.234HisThr: 1.234 ± 0.411
0.494HisVal: 0.494 ± 0.295
0.494HisTrp: 0.494 ± 0.3
1.974HisTyr: 1.974 ± 0.808
0.0HisXaa: 0.0 ± 0.0
Ile
5.429IleAla: 5.429 ± 1.128
0.74IleCys: 0.74 ± 0.42
7.157IleAsp: 7.157 ± 1.164
5.183IleGlu: 5.183 ± 0.954
2.715IlePhe: 2.715 ± 0.65
2.715IleGly: 2.715 ± 0.821
0.987IleHis: 0.987 ± 0.617
4.936IleIle: 4.936 ± 1.108
9.378IleLys: 9.378 ± 1.385
3.702IleLeu: 3.702 ± 0.806
1.481IleMet: 1.481 ± 0.581
4.195IleAsn: 4.195 ± 0.986
2.468IlePro: 2.468 ± 1.036
3.208IleGln: 3.208 ± 0.621
3.702IleArg: 3.702 ± 0.886
6.17IleSer: 6.17 ± 1.457
5.676IleThr: 5.676 ± 1.055
1.974IleVal: 1.974 ± 0.505
0.0IleTrp: 0.0 ± 0.0
2.468IleTyr: 2.468 ± 0.894
0.0IleXaa: 0.0 ± 0.0
Lys
8.144LysAla: 8.144 ± 1.219
0.247LysCys: 0.247 ± 0.212
4.689LysAsp: 4.689 ± 1.36
8.144LysGlu: 8.144 ± 1.703
2.962LysPhe: 2.962 ± 0.913
4.689LysGly: 4.689 ± 1.254
2.221LysHis: 2.221 ± 0.583
4.442LysIle: 4.442 ± 0.823
7.404LysLys: 7.404 ± 1.656
7.404LysLeu: 7.404 ± 1.229
2.221LysMet: 2.221 ± 0.727
5.183LysAsn: 5.183 ± 0.946
4.689LysPro: 4.689 ± 0.931
4.689LysGln: 4.689 ± 0.974
3.949LysArg: 3.949 ± 0.895
4.936LysSer: 4.936 ± 1.412
5.183LysThr: 5.183 ± 1.295
5.183LysVal: 5.183 ± 1.168
0.247LysTrp: 0.247 ± 0.237
3.949LysTyr: 3.949 ± 1.275
0.0LysXaa: 0.0 ± 0.0
Leu
4.442LeuAla: 4.442 ± 1.044
0.247LeuCys: 0.247 ± 0.212
4.442LeuAsp: 4.442 ± 0.956
11.599LeuGlu: 11.599 ± 1.198
4.195LeuPhe: 4.195 ± 0.797
5.676LeuGly: 5.676 ± 1.269
1.481LeuHis: 1.481 ± 0.572
6.91LeuIle: 6.91 ± 1.106
9.378LeuLys: 9.378 ± 1.369
7.651LeuLeu: 7.651 ± 1.362
1.974LeuMet: 1.974 ± 0.659
6.663LeuAsn: 6.663 ± 1.454
4.689LeuPro: 4.689 ± 1.08
3.208LeuGln: 3.208 ± 0.671
2.468LeuArg: 2.468 ± 0.538
7.404LeuSer: 7.404 ± 1.375
4.442LeuThr: 4.442 ± 0.754
5.183LeuVal: 5.183 ± 1.25
0.74LeuTrp: 0.74 ± 0.352
4.936LeuTyr: 4.936 ± 0.895
0.0LeuXaa: 0.0 ± 0.0
Met
2.715MetAla: 2.715 ± 1.061
0.0MetCys: 0.0 ± 0.0
1.481MetAsp: 1.481 ± 0.524
0.987MetGlu: 0.987 ± 0.437
0.494MetPhe: 0.494 ± 0.385
0.247MetGly: 0.247 ± 0.247
0.0MetHis: 0.0 ± 0.0
1.234MetIle: 1.234 ± 0.473
2.221MetLys: 2.221 ± 0.629
2.468MetLeu: 2.468 ± 0.685
0.247MetMet: 0.247 ± 0.205
1.974MetAsn: 1.974 ± 0.616
0.247MetPro: 0.247 ± 0.211
0.494MetGln: 0.494 ± 0.41
1.974MetArg: 1.974 ± 0.646
0.987MetSer: 0.987 ± 0.435
4.195MetThr: 4.195 ± 1.06
0.494MetVal: 0.494 ± 0.386
0.0MetTrp: 0.0 ± 0.0
0.247MetTyr: 0.247 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
3.455AsnAla: 3.455 ± 0.847
0.0AsnCys: 0.0 ± 0.0
1.974AsnAsp: 1.974 ± 0.783
3.208AsnGlu: 3.208 ± 0.767
1.481AsnPhe: 1.481 ± 0.624
3.949AsnGly: 3.949 ± 0.956
1.481AsnHis: 1.481 ± 0.595
3.949AsnIle: 3.949 ± 1.066
4.442AsnLys: 4.442 ± 0.799
6.17AsnLeu: 6.17 ± 1.053
1.234AsnMet: 1.234 ± 0.469
1.974AsnAsn: 1.974 ± 0.63
2.221AsnPro: 2.221 ± 0.625
3.455AsnGln: 3.455 ± 1.195
3.949AsnArg: 3.949 ± 0.677
2.221AsnSer: 2.221 ± 0.649
1.728AsnThr: 1.728 ± 0.649
2.468AsnVal: 2.468 ± 0.845
0.494AsnTrp: 0.494 ± 0.35
2.715AsnTyr: 2.715 ± 0.704
0.0AsnXaa: 0.0 ± 0.0
Pro
0.494ProAla: 0.494 ± 0.338
0.247ProCys: 0.247 ± 0.28
1.481ProAsp: 1.481 ± 0.668
3.702ProGlu: 3.702 ± 1.019
1.481ProPhe: 1.481 ± 0.629
0.74ProGly: 0.74 ± 0.364
0.0ProHis: 0.0 ± 0.0
1.234ProIle: 1.234 ± 0.634
4.195ProLys: 4.195 ± 0.938
3.455ProLeu: 3.455 ± 0.824
0.247ProMet: 0.247 ± 0.26
1.974ProAsn: 1.974 ± 0.631
0.494ProPro: 0.494 ± 0.32
1.234ProGln: 1.234 ± 0.587
2.221ProArg: 2.221 ± 0.761
1.481ProSer: 1.481 ± 0.602
3.455ProThr: 3.455 ± 0.513
1.974ProVal: 1.974 ± 0.763
0.0ProTrp: 0.0 ± 0.0
1.234ProTyr: 1.234 ± 0.605
0.0ProXaa: 0.0 ± 0.0
Gln
3.455GlnAla: 3.455 ± 0.772
0.247GlnCys: 0.247 ± 0.263
1.728GlnAsp: 1.728 ± 0.522
2.715GlnGlu: 2.715 ± 0.737
1.234GlnPhe: 1.234 ± 0.389
2.715GlnGly: 2.715 ± 0.918
1.234GlnHis: 1.234 ± 0.45
2.468GlnIle: 2.468 ± 0.62
4.442GlnLys: 4.442 ± 0.934
7.157GlnLeu: 7.157 ± 1.18
1.234GlnMet: 1.234 ± 0.845
1.728GlnAsn: 1.728 ± 0.789
1.974GlnPro: 1.974 ± 0.807
2.468GlnGln: 2.468 ± 0.574
3.455GlnArg: 3.455 ± 0.659
2.715GlnSer: 2.715 ± 0.795
1.234GlnThr: 1.234 ± 0.514
3.949GlnVal: 3.949 ± 0.97
0.247GlnTrp: 0.247 ± 0.212
1.234GlnTyr: 1.234 ± 0.456
0.0GlnXaa: 0.0 ± 0.0
Arg
2.468ArgAla: 2.468 ± 0.581
0.494ArgCys: 0.494 ± 0.305
2.221ArgAsp: 2.221 ± 0.559
1.974ArgGlu: 1.974 ± 0.662
2.468ArgPhe: 2.468 ± 0.562
2.221ArgGly: 2.221 ± 0.751
1.234ArgHis: 1.234 ± 0.525
2.715ArgIle: 2.715 ± 0.795
6.417ArgLys: 6.417 ± 1.003
5.923ArgLeu: 5.923 ± 1.21
0.74ArgMet: 0.74 ± 0.37
2.221ArgAsn: 2.221 ± 0.678
1.234ArgPro: 1.234 ± 0.629
3.208ArgGln: 3.208 ± 0.831
1.974ArgArg: 1.974 ± 0.741
3.455ArgSer: 3.455 ± 0.903
2.221ArgThr: 2.221 ± 0.689
3.208ArgVal: 3.208 ± 0.736
0.494ArgTrp: 0.494 ± 0.355
3.208ArgTyr: 3.208 ± 0.959
0.0ArgXaa: 0.0 ± 0.0
Ser
2.468SerAla: 2.468 ± 0.774
0.247SerCys: 0.247 ± 0.26
4.689SerAsp: 4.689 ± 0.985
4.195SerGlu: 4.195 ± 1.141
1.974SerPhe: 1.974 ± 0.485
2.468SerGly: 2.468 ± 0.603
0.74SerHis: 0.74 ± 0.367
5.676SerIle: 5.676 ± 0.858
3.949SerLys: 3.949 ± 0.82
6.417SerLeu: 6.417 ± 0.863
1.481SerMet: 1.481 ± 0.671
2.715SerAsn: 2.715 ± 0.965
0.74SerPro: 0.74 ± 0.337
3.455SerGln: 3.455 ± 0.811
2.221SerArg: 2.221 ± 0.764
1.974SerSer: 1.974 ± 0.798
3.949SerThr: 3.949 ± 1.128
3.455SerVal: 3.455 ± 0.83
0.494SerTrp: 0.494 ± 0.287
2.221SerTyr: 2.221 ± 0.702
0.0SerXaa: 0.0 ± 0.0
Thr
3.702ThrAla: 3.702 ± 0.826
0.0ThrCys: 0.0 ± 0.0
1.481ThrAsp: 1.481 ± 0.481
4.442ThrGlu: 4.442 ± 0.845
2.715ThrPhe: 2.715 ± 1.238
4.689ThrGly: 4.689 ± 1.108
1.974ThrHis: 1.974 ± 0.647
4.689ThrIle: 4.689 ± 1.175
3.702ThrLys: 3.702 ± 0.909
6.17ThrLeu: 6.17 ± 1.054
1.481ThrMet: 1.481 ± 0.724
1.728ThrAsn: 1.728 ± 0.679
2.962ThrPro: 2.962 ± 0.925
2.962ThrGln: 2.962 ± 0.719
3.949ThrArg: 3.949 ± 0.986
2.962ThrSer: 2.962 ± 0.774
3.455ThrThr: 3.455 ± 1.303
2.962ThrVal: 2.962 ± 0.852
0.987ThrTrp: 0.987 ± 0.432
4.689ThrTyr: 4.689 ± 0.901
0.0ThrXaa: 0.0 ± 0.0
Val
2.715ValAla: 2.715 ± 0.581
0.247ValCys: 0.247 ± 0.26
2.221ValAsp: 2.221 ± 0.649
2.715ValGlu: 2.715 ± 0.868
2.468ValPhe: 2.468 ± 0.738
1.728ValGly: 1.728 ± 0.546
0.247ValHis: 0.247 ± 0.26
6.17ValIle: 6.17 ± 1.075
4.442ValLys: 4.442 ± 0.806
5.429ValLeu: 5.429 ± 1.038
1.728ValMet: 1.728 ± 0.611
3.702ValAsn: 3.702 ± 0.78
0.247ValPro: 0.247 ± 0.237
2.962ValGln: 2.962 ± 0.921
1.974ValArg: 1.974 ± 0.675
3.455ValSer: 3.455 ± 0.833
3.702ValThr: 3.702 ± 1.075
2.715ValVal: 2.715 ± 0.716
0.74ValTrp: 0.74 ± 0.378
1.974ValTyr: 1.974 ± 0.664
0.0ValXaa: 0.0 ± 0.0
Trp
0.247TrpAla: 0.247 ± 0.253
0.0TrpCys: 0.0 ± 0.0
0.74TrpAsp: 0.74 ± 0.428
0.987TrpGlu: 0.987 ± 0.443
0.247TrpPhe: 0.247 ± 0.205
0.247TrpGly: 0.247 ± 0.211
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.494TrpLys: 0.494 ± 0.357
1.728TrpLeu: 1.728 ± 0.61
0.0TrpMet: 0.0 ± 0.0
0.494TrpAsn: 0.494 ± 0.297
0.247TrpPro: 0.247 ± 0.179
0.494TrpGln: 0.494 ± 0.34
0.494TrpArg: 0.494 ± 0.395
0.494TrpSer: 0.494 ± 0.382
0.0TrpThr: 0.0 ± 0.0
0.987TrpVal: 0.987 ± 0.515
0.494TrpTrp: 0.494 ± 0.297
0.494TrpTyr: 0.494 ± 0.298
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.481TyrAla: 1.481 ± 0.636
0.494TyrCys: 0.494 ± 0.29
2.715TyrAsp: 2.715 ± 0.91
3.455TyrGlu: 3.455 ± 0.714
2.962TyrPhe: 2.962 ± 0.785
2.715TyrGly: 2.715 ± 0.792
1.481TyrHis: 1.481 ± 0.507
2.221TyrIle: 2.221 ± 0.692
3.455TyrLys: 3.455 ± 0.931
2.715TyrLeu: 2.715 ± 0.534
1.234TyrMet: 1.234 ± 0.678
4.442TyrAsn: 4.442 ± 0.842
1.481TyrPro: 1.481 ± 0.738
2.468TyrGln: 2.468 ± 0.803
3.455TyrArg: 3.455 ± 0.879
2.962TyrSer: 2.962 ± 1.22
3.702TyrThr: 3.702 ± 0.569
2.221TyrVal: 2.221 ± 0.648
0.494TyrTrp: 0.494 ± 0.52
3.949TyrTyr: 3.949 ± 1.164
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 23 proteins (4053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski