Amino acid dipepetide frequency for Pontibacter sp. GY10130

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.057AlaAla: 8.057 ± 0.104
0.744AlaCys: 0.744 ± 0.024
4.201AlaAsp: 4.201 ± 0.058
5.088AlaGlu: 5.088 ± 0.063
3.672AlaPhe: 3.672 ± 0.055
6.62AlaGly: 6.62 ± 0.085
1.467AlaHis: 1.467 ± 0.032
5.147AlaIle: 5.147 ± 0.071
4.172AlaLys: 4.172 ± 0.058
7.895AlaLeu: 7.895 ± 0.085
1.948AlaMet: 1.948 ± 0.033
3.551AlaAsn: 3.551 ± 0.05
3.273AlaPro: 3.273 ± 0.061
3.411AlaGln: 3.411 ± 0.047
3.445AlaArg: 3.445 ± 0.058
4.974AlaSer: 4.974 ± 0.064
5.1AlaThr: 5.1 ± 0.067
5.454AlaVal: 5.454 ± 0.061
0.931AlaTrp: 0.931 ± 0.026
3.091AlaTyr: 3.091 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.523CysAla: 0.523 ± 0.021
0.135CysCys: 0.135 ± 0.009
0.366CysAsp: 0.366 ± 0.018
0.402CysGlu: 0.402 ± 0.017
0.365CysPhe: 0.365 ± 0.015
0.573CysGly: 0.573 ± 0.024
0.207CysHis: 0.207 ± 0.011
0.458CysIle: 0.458 ± 0.019
0.356CysLys: 0.356 ± 0.016
0.77CysLeu: 0.77 ± 0.024
0.161CysMet: 0.161 ± 0.01
0.326CysAsn: 0.326 ± 0.014
0.345CysPro: 0.345 ± 0.017
0.307CysGln: 0.307 ± 0.016
0.339CysArg: 0.339 ± 0.015
0.535CysSer: 0.535 ± 0.02
0.457CysThr: 0.457 ± 0.019
0.405CysVal: 0.405 ± 0.016
0.079CysTrp: 0.079 ± 0.007
0.276CysTyr: 0.276 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
3.87AspAla: 3.87 ± 0.052
0.348AspCys: 0.348 ± 0.016
2.13AspAsp: 2.13 ± 0.045
3.134AspGlu: 3.134 ± 0.045
2.794AspPhe: 2.794 ± 0.043
3.536AspGly: 3.536 ± 0.055
0.925AspHis: 0.925 ± 0.025
3.326AspIle: 3.326 ± 0.054
3.367AspLys: 3.367 ± 0.052
4.92AspLeu: 4.92 ± 0.066
1.229AspMet: 1.229 ± 0.031
2.412AspAsn: 2.412 ± 0.041
2.081AspPro: 2.081 ± 0.038
1.807AspGln: 1.807 ± 0.034
2.324AspArg: 2.324 ± 0.04
2.586AspSer: 2.586 ± 0.047
2.555AspThr: 2.555 ± 0.046
3.309AspVal: 3.309 ± 0.048
0.736AspTrp: 0.736 ± 0.022
2.221AspTyr: 2.221 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
5.579GluAla: 5.579 ± 0.062
0.293GluCys: 0.293 ± 0.015
2.806GluAsp: 2.806 ± 0.044
4.916GluGlu: 4.916 ± 0.075
2.422GluPhe: 2.422 ± 0.04
3.902GluGly: 3.902 ± 0.055
1.368GluHis: 1.368 ± 0.033
3.809GluIle: 3.809 ± 0.054
4.406GluLys: 4.406 ± 0.061
6.603GluLeu: 6.603 ± 0.083
1.464GluMet: 1.464 ± 0.032
3.139GluAsn: 3.139 ± 0.046
2.178GluPro: 2.178 ± 0.034
3.57GluGln: 3.57 ± 0.046
3.088GluArg: 3.088 ± 0.049
2.904GluSer: 2.904 ± 0.044
3.207GluThr: 3.207 ± 0.048
4.714GluVal: 4.714 ± 0.054
0.713GluTrp: 0.713 ± 0.023
2.04GluTyr: 2.04 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.347PheAla: 3.347 ± 0.043
0.428PheCys: 0.428 ± 0.019
2.617PheAsp: 2.617 ± 0.041
2.746PheGlu: 2.746 ± 0.045
2.26PhePhe: 2.26 ± 0.047
3.374PheGly: 3.374 ± 0.046
0.823PheHis: 0.823 ± 0.023
2.734PheIle: 2.734 ± 0.048
2.537PheLys: 2.537 ± 0.051
4.494PheLeu: 4.494 ± 0.069
1.123PheMet: 1.123 ± 0.03
2.381PheAsn: 2.381 ± 0.043
1.69PhePro: 1.69 ± 0.033
1.45PheGln: 1.45 ± 0.024
2.268PheArg: 2.268 ± 0.035
3.537PheSer: 3.537 ± 0.055
3.048PheThr: 3.048 ± 0.043
3.035PheVal: 3.035 ± 0.042
0.603PheTrp: 0.603 ± 0.02
1.91PheTyr: 1.91 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.302GlyAla: 5.302 ± 0.076
0.609GlyCys: 0.609 ± 0.023
3.179GlyAsp: 3.179 ± 0.048
3.757GlyGlu: 3.757 ± 0.059
3.485GlyPhe: 3.485 ± 0.052
5.063GlyGly: 5.063 ± 0.099
1.274GlyHis: 1.274 ± 0.031
4.775GlyIle: 4.775 ± 0.06
4.708GlyLys: 4.708 ± 0.059
6.529GlyLeu: 6.529 ± 0.063
1.751GlyMet: 1.751 ± 0.038
3.616GlyAsn: 3.616 ± 0.06
1.883GlyPro: 1.883 ± 0.039
2.735GlyGln: 2.735 ± 0.047
3.008GlyArg: 3.008 ± 0.046
4.413GlySer: 4.413 ± 0.064
4.522GlyThr: 4.522 ± 0.071
4.653GlyVal: 4.653 ± 0.064
0.973GlyTrp: 0.973 ± 0.027
2.969GlyTyr: 2.969 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.444HisAla: 1.444 ± 0.03
0.164HisCys: 0.164 ± 0.01
0.994HisAsp: 0.994 ± 0.031
1.16HisGlu: 1.16 ± 0.028
1.109HisPhe: 1.109 ± 0.029
1.301HisGly: 1.301 ± 0.03
0.631HisHis: 0.631 ± 0.021
1.308HisIle: 1.308 ± 0.026
1.057HisLys: 1.057 ± 0.028
2.206HisLeu: 2.206 ± 0.04
0.444HisMet: 0.444 ± 0.016
1.008HisAsn: 1.008 ± 0.03
1.074HisPro: 1.074 ± 0.027
0.992HisGln: 0.992 ± 0.027
0.941HisArg: 0.941 ± 0.024
1.091HisSer: 1.091 ± 0.026
1.203HisThr: 1.203 ± 0.026
1.243HisVal: 1.243 ± 0.025
0.255HisTrp: 0.255 ± 0.013
0.962HisTyr: 0.962 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.096IleAla: 5.096 ± 0.07
0.554IleCys: 0.554 ± 0.019
3.291IleAsp: 3.291 ± 0.047
3.63IleGlu: 3.63 ± 0.057
2.56IlePhe: 2.56 ± 0.042
4.486IleGly: 4.486 ± 0.062
1.017IleHis: 1.017 ± 0.024
3.716IleIle: 3.716 ± 0.061
3.572IleLys: 3.572 ± 0.048
5.202IleLeu: 5.202 ± 0.068
1.217IleMet: 1.217 ± 0.03
3.022IleAsn: 3.022 ± 0.05
2.646IlePro: 2.646 ± 0.046
2.088IleGln: 2.088 ± 0.037
3.047IleArg: 3.047 ± 0.043
4.271IleSer: 4.271 ± 0.055
3.892IleThr: 3.892 ± 0.065
3.771IleVal: 3.771 ± 0.06
0.627IleTrp: 0.627 ± 0.021
2.129IleTyr: 2.129 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
5.165LysAla: 5.165 ± 0.062
0.267LysCys: 0.267 ± 0.014
3.111LysAsp: 3.111 ± 0.049
4.384LysGlu: 4.384 ± 0.062
2.07LysPhe: 2.07 ± 0.039
3.953LysGly: 3.953 ± 0.05
1.237LysHis: 1.237 ± 0.029
3.501LysIle: 3.501 ± 0.052
4.137LysLys: 4.137 ± 0.077
5.873LysLeu: 5.873 ± 0.08
1.438LysMet: 1.438 ± 0.029
2.883LysAsn: 2.883 ± 0.04
2.661LysPro: 2.661 ± 0.053
2.678LysGln: 2.678 ± 0.047
2.662LysArg: 2.662 ± 0.039
3.129LysSer: 3.129 ± 0.049
3.279LysThr: 3.279 ± 0.044
4.283LysVal: 4.283 ± 0.058
0.672LysTrp: 0.672 ± 0.022
2.156LysTyr: 2.156 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
8.123LeuAla: 8.123 ± 0.09
0.797LeuCys: 0.797 ± 0.025
4.756LeuAsp: 4.756 ± 0.064
6.135LeuGlu: 6.135 ± 0.085
4.594LeuPhe: 4.594 ± 0.065
6.032LeuGly: 6.032 ± 0.074
2.293LeuHis: 2.293 ± 0.044
5.172LeuIle: 5.172 ± 0.072
6.027LeuLys: 6.027 ± 0.068
11.607LeuLeu: 11.607 ± 0.151
2.209LeuMet: 2.209 ± 0.038
4.842LeuAsn: 4.842 ± 0.061
4.757LeuPro: 4.757 ± 0.057
5.353LeuGln: 5.353 ± 0.079
4.599LeuArg: 4.599 ± 0.055
6.477LeuSer: 6.477 ± 0.07
5.675LeuThr: 5.675 ± 0.066
6.719LeuVal: 6.719 ± 0.076
1.041LeuTrp: 1.041 ± 0.027
3.581LeuTyr: 3.581 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
2.161MetAla: 2.161 ± 0.039
0.113MetCys: 0.113 ± 0.008
1.004MetAsp: 1.004 ± 0.025
1.39MetGlu: 1.39 ± 0.026
0.823MetPhe: 0.823 ± 0.023
1.521MetGly: 1.521 ± 0.035
0.476MetHis: 0.476 ± 0.016
1.16MetIle: 1.16 ± 0.027
1.638MetLys: 1.638 ± 0.033
2.487MetLeu: 2.487 ± 0.038
0.563MetMet: 0.563 ± 0.018
1.071MetAsn: 1.071 ± 0.026
1.122MetPro: 1.122 ± 0.027
1.145MetGln: 1.145 ± 0.026
1.163MetArg: 1.163 ± 0.024
1.319MetSer: 1.319 ± 0.027
1.084MetThr: 1.084 ± 0.026
1.623MetVal: 1.623 ± 0.031
0.192MetTrp: 0.192 ± 0.01
0.668MetTyr: 0.668 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.436AsnAla: 3.436 ± 0.055
0.346AsnCys: 0.346 ± 0.016
2.171AsnAsp: 2.171 ± 0.043
2.592AsnGlu: 2.592 ± 0.041
2.401AsnPhe: 2.401 ± 0.045
3.428AsnGly: 3.428 ± 0.056
0.946AsnHis: 0.946 ± 0.022
3.205AsnIle: 3.205 ± 0.055
2.805AsnLys: 2.805 ± 0.045
4.826AsnLeu: 4.826 ± 0.06
1.161AsnMet: 1.161 ± 0.026
2.656AsnAsn: 2.656 ± 0.049
2.665AsnPro: 2.665 ± 0.036
2.047AsnGln: 2.047 ± 0.038
2.517AsnArg: 2.517 ± 0.048
2.943AsnSer: 2.943 ± 0.042
2.974AsnThr: 2.974 ± 0.055
2.809AsnVal: 2.809 ± 0.046
0.754AsnTrp: 0.754 ± 0.023
2.196AsnTyr: 2.196 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
4.255ProAla: 4.255 ± 0.071
0.225ProCys: 0.225 ± 0.013
2.783ProAsp: 2.783 ± 0.044
3.478ProGlu: 3.478 ± 0.046
1.933ProPhe: 1.933 ± 0.037
3.025ProGly: 3.025 ± 0.057
0.884ProHis: 0.884 ± 0.025
2.183ProIle: 2.183 ± 0.033
2.01ProLys: 2.01 ± 0.038
3.711ProLeu: 3.711 ± 0.055
0.836ProMet: 0.836 ± 0.021
1.934ProAsn: 1.934 ± 0.03
1.203ProPro: 1.203 ± 0.033
1.61ProGln: 1.61 ± 0.031
1.399ProArg: 1.399 ± 0.031
2.144ProSer: 2.144 ± 0.038
2.298ProThr: 2.298 ± 0.042
3.554ProVal: 3.554 ± 0.051
0.463ProTrp: 0.463 ± 0.018
1.625ProTyr: 1.625 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.668GlnAla: 3.668 ± 0.05
0.197GlnCys: 0.197 ± 0.011
1.993GlnAsp: 1.993 ± 0.034
3.523GlnGlu: 3.523 ± 0.054
1.636GlnPhe: 1.636 ± 0.031
2.511GlnGly: 2.511 ± 0.041
1.195GlnHis: 1.195 ± 0.028
2.231GlnIle: 2.231 ± 0.039
2.742GlnLys: 2.742 ± 0.048
4.825GlnLeu: 4.825 ± 0.073
0.914GlnMet: 0.914 ± 0.024
2.184GlnAsn: 2.184 ± 0.042
1.912GlnPro: 1.912 ± 0.036
3.146GlnGln: 3.146 ± 0.059
1.996GlnArg: 1.996 ± 0.039
1.978GlnSer: 1.978 ± 0.033
2.241GlnThr: 2.241 ± 0.037
3.421GlnVal: 3.421 ± 0.049
0.46GlnTrp: 0.46 ± 0.016
1.564GlnTyr: 1.564 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
3.094ArgAla: 3.094 ± 0.046
0.269ArgCys: 0.269 ± 0.013
2.166ArgAsp: 2.166 ± 0.041
2.927ArgGlu: 2.927 ± 0.046
2.371ArgPhe: 2.371 ± 0.04
2.581ArgGly: 2.581 ± 0.05
1.111ArgHis: 1.111 ± 0.025
2.963ArgIle: 2.963 ± 0.05
2.912ArgLys: 2.912 ± 0.048
4.748ArgLeu: 4.748 ± 0.065
1.205ArgMet: 1.205 ± 0.028
2.468ArgAsn: 2.468 ± 0.044
1.717ArgPro: 1.717 ± 0.038
2.336ArgGln: 2.336 ± 0.047
2.129ArgArg: 2.129 ± 0.042
2.511ArgSer: 2.511 ± 0.044
2.539ArgThr: 2.539 ± 0.042
3.045ArgVal: 3.045 ± 0.046
0.614ArgTrp: 0.614 ± 0.023
2.007ArgTyr: 2.007 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.453SerAla: 4.453 ± 0.056
0.58SerCys: 0.58 ± 0.017
2.954SerAsp: 2.954 ± 0.044
3.458SerGlu: 3.458 ± 0.047
3.412SerPhe: 3.412 ± 0.055
4.745SerGly: 4.745 ± 0.075
1.188SerHis: 1.188 ± 0.027
3.708SerIle: 3.708 ± 0.055
3.319SerLys: 3.319 ± 0.047
6.001SerLeu: 6.001 ± 0.074
1.338SerMet: 1.338 ± 0.029
2.754SerAsn: 2.754 ± 0.052
2.442SerPro: 2.442 ± 0.036
2.208SerGln: 2.208 ± 0.038
2.741SerArg: 2.741 ± 0.039
4.003SerSer: 4.003 ± 0.066
3.453SerThr: 3.453 ± 0.059
3.995SerVal: 3.995 ± 0.053
0.755SerTrp: 0.755 ± 0.021
2.554SerTyr: 2.554 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.06ThrAla: 5.06 ± 0.07
0.378ThrCys: 0.378 ± 0.016
3.307ThrAsp: 3.307 ± 0.046
3.342ThrGlu: 3.342 ± 0.047
2.817ThrPhe: 2.817 ± 0.041
4.802ThrGly: 4.802 ± 0.072
1.095ThrHis: 1.095 ± 0.03
3.889ThrIle: 3.889 ± 0.059
2.849ThrLys: 2.849 ± 0.039
5.616ThrLeu: 5.616 ± 0.061
1.078ThrMet: 1.078 ± 0.025
2.624ThrAsn: 2.624 ± 0.048
2.887ThrPro: 2.887 ± 0.044
2.004ThrGln: 2.004 ± 0.037
2.267ThrArg: 2.267 ± 0.037
3.664ThrSer: 3.664 ± 0.058
3.813ThrThr: 3.813 ± 0.074
4.031ThrVal: 4.031 ± 0.071
0.728ThrTrp: 0.728 ± 0.029
2.35ThrTyr: 2.35 ± 0.043
0.0ThrXaa: 0.0 ± 0.0
Val
5.91ValAla: 5.91 ± 0.071
0.555ValCys: 0.555 ± 0.019
3.14ValAsp: 3.14 ± 0.048
4.13ValGlu: 4.13 ± 0.051
3.091ValPhe: 3.091 ± 0.049
4.321ValGly: 4.321 ± 0.059
1.281ValHis: 1.281 ± 0.026
3.822ValIle: 3.822 ± 0.058
3.944ValLys: 3.944 ± 0.054
7.184ValLeu: 7.184 ± 0.072
1.514ValMet: 1.514 ± 0.03
3.197ValAsn: 3.197 ± 0.049
3.056ValPro: 3.056 ± 0.048
3.003ValGln: 3.003 ± 0.05
3.053ValArg: 3.053 ± 0.048
4.361ValSer: 4.361 ± 0.058
4.149ValThr: 4.149 ± 0.071
5.219ValVal: 5.219 ± 0.066
0.761ValTrp: 0.761 ± 0.024
2.566ValTyr: 2.566 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
0.87TrpAla: 0.87 ± 0.024
0.102TrpCys: 0.102 ± 0.009
0.604TrpAsp: 0.604 ± 0.02
0.746TrpGlu: 0.746 ± 0.025
0.55TrpPhe: 0.55 ± 0.022
0.791TrpGly: 0.791 ± 0.024
0.304TrpHis: 0.304 ± 0.015
0.597TrpIle: 0.597 ± 0.022
0.625TrpLys: 0.625 ± 0.021
1.327TrpLeu: 1.327 ± 0.031
0.312TrpMet: 0.312 ± 0.015
0.611TrpAsn: 0.611 ± 0.02
0.386TrpPro: 0.386 ± 0.016
0.719TrpGln: 0.719 ± 0.022
0.646TrpArg: 0.646 ± 0.02
0.733TrpSer: 0.733 ± 0.025
0.653TrpThr: 0.653 ± 0.025
0.82TrpVal: 0.82 ± 0.023
0.19TrpTrp: 0.19 ± 0.011
0.452TrpTyr: 0.452 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.827TyrAla: 2.827 ± 0.04
0.279TyrCys: 0.279 ± 0.014
2.037TyrAsp: 2.037 ± 0.038
2.18TyrGlu: 2.18 ± 0.034
2.04TyrPhe: 2.04 ± 0.033
2.642TyrGly: 2.642 ± 0.055
0.864TyrHis: 0.864 ± 0.023
2.129TyrIle: 2.129 ± 0.042
2.357TyrLys: 2.357 ± 0.042
3.968TyrLeu: 3.968 ± 0.056
0.816TyrMet: 0.816 ± 0.021
2.2TyrAsn: 2.2 ± 0.039
1.574TyrPro: 1.574 ± 0.032
1.728TyrGln: 1.728 ± 0.032
2.082TyrArg: 2.082 ± 0.038
2.487TyrSer: 2.487 ± 0.042
2.46TyrThr: 2.46 ± 0.047
2.156TyrVal: 2.156 ± 0.036
0.491TyrTrp: 0.491 ± 0.019
1.804TyrTyr: 1.804 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4726 proteins (1649456 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski