Amino acid dipepetide frequency for Paenibacillus swuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.294AlaAla: 8.294 ± 0.109
0.675AlaCys: 0.675 ± 0.024
4.265AlaAsp: 4.265 ± 0.064
5.795AlaGlu: 5.795 ± 0.078
3.286AlaPhe: 3.286 ± 0.048
6.979AlaGly: 6.979 ± 0.084
1.493AlaHis: 1.493 ± 0.034
4.971AlaIle: 4.971 ± 0.062
4.302AlaLys: 4.302 ± 0.069
8.377AlaLeu: 8.377 ± 0.091
2.373AlaMet: 2.373 ± 0.043
2.867AlaAsn: 2.867 ± 0.048
2.677AlaPro: 2.677 ± 0.052
2.825AlaGln: 2.825 ± 0.052
3.432AlaArg: 3.432 ± 0.057
4.981AlaSer: 4.981 ± 0.073
3.812AlaThr: 3.812 ± 0.078
6.7AlaVal: 6.7 ± 0.083
1.027AlaTrp: 1.027 ± 0.031
2.841AlaTyr: 2.841 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.529CysAla: 0.529 ± 0.02
0.093CysCys: 0.093 ± 0.009
0.353CysAsp: 0.353 ± 0.016
0.414CysGlu: 0.414 ± 0.02
0.283CysPhe: 0.283 ± 0.015
0.714CysGly: 0.714 ± 0.027
0.196CysHis: 0.196 ± 0.013
0.481CysIle: 0.481 ± 0.021
0.309CysLys: 0.309 ± 0.015
0.683CysLeu: 0.683 ± 0.025
0.206CysMet: 0.206 ± 0.014
0.277CysAsn: 0.277 ± 0.015
0.332CysPro: 0.332 ± 0.018
0.189CysGln: 0.189 ± 0.011
0.382CysArg: 0.382 ± 0.018
0.52CysSer: 0.52 ± 0.021
0.394CysThr: 0.394 ± 0.019
0.482CysVal: 0.482 ± 0.021
0.08CysTrp: 0.08 ± 0.008
0.262CysTyr: 0.262 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.302AspAla: 4.302 ± 0.059
0.359AspCys: 0.359 ± 0.017
2.185AspAsp: 2.185 ± 0.055
3.625AspGlu: 3.625 ± 0.051
2.052AspPhe: 2.052 ± 0.041
3.927AspGly: 3.927 ± 0.06
1.105AspHis: 1.105 ± 0.032
3.424AspIle: 3.424 ± 0.052
2.57AspLys: 2.57 ± 0.05
4.928AspLeu: 4.928 ± 0.06
1.364AspMet: 1.364 ± 0.033
1.715AspAsn: 1.715 ± 0.033
2.4AspPro: 2.4 ± 0.041
1.909AspGln: 1.909 ± 0.037
2.668AspArg: 2.668 ± 0.05
2.668AspSer: 2.668 ± 0.054
2.675AspThr: 2.675 ± 0.048
3.627AspVal: 3.627 ± 0.056
0.839AspTrp: 0.839 ± 0.025
2.114AspTyr: 2.114 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
5.965GluAla: 5.965 ± 0.076
0.347GluCys: 0.347 ± 0.018
3.258GluAsp: 3.258 ± 0.057
5.298GluGlu: 5.298 ± 0.077
2.302GluPhe: 2.302 ± 0.048
4.627GluGly: 4.627 ± 0.07
1.646GluHis: 1.646 ± 0.037
4.259GluIle: 4.259 ± 0.059
3.524GluLys: 3.524 ± 0.05
6.922GluLeu: 6.922 ± 0.079
1.986GluMet: 1.986 ± 0.043
2.324GluAsn: 2.324 ± 0.049
2.346GluPro: 2.346 ± 0.044
3.471GluGln: 3.471 ± 0.057
3.91GluArg: 3.91 ± 0.062
3.417GluSer: 3.417 ± 0.059
3.646GluThr: 3.646 ± 0.055
4.591GluVal: 4.591 ± 0.065
0.898GluTrp: 0.898 ± 0.027
2.008GluTyr: 2.008 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.223PheAla: 3.223 ± 0.053
0.306PheCys: 0.306 ± 0.015
2.059PheAsp: 2.059 ± 0.041
2.314PheGlu: 2.314 ± 0.044
1.744PhePhe: 1.744 ± 0.046
3.27PheGly: 3.27 ± 0.052
0.978PheHis: 0.978 ± 0.028
2.988PheIle: 2.988 ± 0.055
2.058PheLys: 2.058 ± 0.04
3.844PheLeu: 3.844 ± 0.06
1.273PheMet: 1.273 ± 0.033
1.761PheAsn: 1.761 ± 0.038
1.623PhePro: 1.623 ± 0.037
1.496PheGln: 1.496 ± 0.032
2.1PheArg: 2.1 ± 0.044
2.678PheSer: 2.678 ± 0.045
2.741PheThr: 2.741 ± 0.048
2.851PheVal: 2.851 ± 0.046
0.521PheTrp: 0.521 ± 0.021
1.476PheTyr: 1.476 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.902GlyAla: 5.902 ± 0.09
0.684GlyCys: 0.684 ± 0.024
3.449GlyAsp: 3.449 ± 0.053
4.597GlyGlu: 4.597 ± 0.064
3.455GlyPhe: 3.455 ± 0.054
5.606GlyGly: 5.606 ± 0.089
1.549GlyHis: 1.549 ± 0.039
5.613GlyIle: 5.613 ± 0.071
4.433GlyLys: 4.433 ± 0.065
7.353GlyLeu: 7.353 ± 0.086
2.498GlyMet: 2.498 ± 0.055
3.063GlyAsn: 3.063 ± 0.072
1.996GlyPro: 1.996 ± 0.044
2.584GlyGln: 2.584 ± 0.038
3.418GlyArg: 3.418 ± 0.051
4.607GlySer: 4.607 ± 0.066
4.731GlyThr: 4.731 ± 0.075
5.501GlyVal: 5.501 ± 0.061
1.114GlyTrp: 1.114 ± 0.034
2.936GlyTyr: 2.936 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.644HisAla: 1.644 ± 0.04
0.206HisCys: 0.206 ± 0.013
0.988HisAsp: 0.988 ± 0.028
1.392HisGlu: 1.392 ± 0.032
1.019HisPhe: 1.019 ± 0.028
1.546HisGly: 1.546 ± 0.034
0.658HisHis: 0.658 ± 0.028
1.43HisIle: 1.43 ± 0.033
1.006HisLys: 1.006 ± 0.035
2.188HisLeu: 2.188 ± 0.041
0.663HisMet: 0.663 ± 0.021
0.745HisAsn: 0.745 ± 0.024
1.304HisPro: 1.304 ± 0.039
0.814HisGln: 0.814 ± 0.024
1.164HisArg: 1.164 ± 0.03
1.207HisSer: 1.207 ± 0.028
1.219HisThr: 1.219 ± 0.028
1.491HisVal: 1.491 ± 0.038
0.342HisTrp: 0.342 ± 0.016
0.918HisTyr: 0.918 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.592IleAla: 5.592 ± 0.057
0.569IleCys: 0.569 ± 0.023
3.343IleAsp: 3.343 ± 0.05
3.949IleGlu: 3.949 ± 0.055
2.379IlePhe: 2.379 ± 0.053
5.12IleGly: 5.12 ± 0.071
1.597IleHis: 1.597 ± 0.037
4.241IleIle: 4.241 ± 0.068
2.738IleLys: 2.738 ± 0.049
6.019IleLeu: 6.019 ± 0.076
1.667IleMet: 1.667 ± 0.04
2.39IleAsn: 2.39 ± 0.048
3.201IlePro: 3.201 ± 0.047
2.747IleGln: 2.747 ± 0.045
3.824IleArg: 3.824 ± 0.053
4.252IleSer: 4.252 ± 0.06
4.127IleThr: 4.127 ± 0.07
4.977IleVal: 4.977 ± 0.063
0.665IleTrp: 0.665 ± 0.022
2.187IleTyr: 2.187 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.423LysAla: 4.423 ± 0.069
0.213LysCys: 0.213 ± 0.012
3.046LysAsp: 3.046 ± 0.049
4.243LysGlu: 4.243 ± 0.057
1.725LysPhe: 1.725 ± 0.037
3.695LysGly: 3.695 ± 0.063
1.222LysHis: 1.222 ± 0.029
2.911LysIle: 2.911 ± 0.049
3.125LysLys: 3.125 ± 0.057
5.395LysLeu: 5.395 ± 0.073
1.559LysMet: 1.559 ± 0.034
1.961LysAsn: 1.961 ± 0.043
2.327LysPro: 2.327 ± 0.042
2.346LysGln: 2.346 ± 0.043
2.695LysArg: 2.695 ± 0.046
2.931LysSer: 2.931 ± 0.055
2.689LysThr: 2.689 ± 0.048
3.828LysVal: 3.828 ± 0.058
0.643LysTrp: 0.643 ± 0.023
1.863LysTyr: 1.863 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
8.028LeuAla: 8.028 ± 0.099
0.804LeuCys: 0.804 ± 0.026
4.92LeuAsp: 4.92 ± 0.058
6.169LeuGlu: 6.169 ± 0.078
4.447LeuPhe: 4.447 ± 0.073
6.798LeuGly: 6.798 ± 0.079
2.22LeuHis: 2.22 ± 0.044
6.376LeuIle: 6.376 ± 0.079
5.402LeuLys: 5.402 ± 0.064
10.667LeuLeu: 10.667 ± 0.121
2.737LeuMet: 2.737 ± 0.046
4.105LeuAsn: 4.105 ± 0.063
4.483LeuPro: 4.483 ± 0.056
4.091LeuGln: 4.091 ± 0.064
5.022LeuArg: 5.022 ± 0.078
6.951LeuSer: 6.951 ± 0.075
6.082LeuThr: 6.082 ± 0.069
6.304LeuVal: 6.304 ± 0.07
1.119LeuTrp: 1.119 ± 0.029
3.279LeuTyr: 3.279 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.236MetAla: 2.236 ± 0.047
0.153MetCys: 0.153 ± 0.01
1.696MetAsp: 1.696 ± 0.037
2.006MetGlu: 2.006 ± 0.039
1.165MetPhe: 1.165 ± 0.03
1.84MetGly: 1.84 ± 0.041
0.557MetHis: 0.557 ± 0.02
1.935MetIle: 1.935 ± 0.043
2.115MetLys: 2.115 ± 0.04
2.972MetLeu: 2.972 ± 0.05
0.949MetMet: 0.949 ± 0.027
1.632MetAsn: 1.632 ± 0.035
1.201MetPro: 1.201 ± 0.03
1.035MetGln: 1.035 ± 0.028
1.433MetArg: 1.433 ± 0.038
1.811MetSer: 1.811 ± 0.034
1.676MetThr: 1.676 ± 0.034
1.892MetVal: 1.892 ± 0.037
0.236MetTrp: 0.236 ± 0.013
0.809MetTyr: 0.809 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.0AsnAla: 3.0 ± 0.051
0.247AsnCys: 0.247 ± 0.014
1.888AsnAsp: 1.888 ± 0.041
2.574AsnGlu: 2.574 ± 0.047
1.383AsnPhe: 1.383 ± 0.037
3.429AsnGly: 3.429 ± 0.066
0.89AsnHis: 0.89 ± 0.026
2.509AsnIle: 2.509 ± 0.05
2.154AsnLys: 2.154 ± 0.046
3.582AsnLeu: 3.582 ± 0.055
1.079AsnMet: 1.079 ± 0.023
1.827AsnAsn: 1.827 ± 0.049
2.168AsnPro: 2.168 ± 0.044
1.603AsnGln: 1.603 ± 0.04
2.165AsnArg: 2.165 ± 0.037
2.169AsnSer: 2.169 ± 0.049
2.314AsnThr: 2.314 ± 0.047
2.922AsnVal: 2.922 ± 0.05
0.528AsnTrp: 0.528 ± 0.022
1.49AsnTyr: 1.49 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
3.359ProAla: 3.359 ± 0.058
0.213ProCys: 0.213 ± 0.015
2.578ProAsp: 2.578 ± 0.044
3.37ProGlu: 3.37 ± 0.061
1.854ProPhe: 1.854 ± 0.043
3.043ProGly: 3.043 ± 0.055
0.986ProHis: 0.986 ± 0.03
2.378ProIle: 2.378 ± 0.041
1.835ProLys: 1.835 ± 0.038
3.969ProLeu: 3.969 ± 0.055
1.052ProMet: 1.052 ± 0.027
1.657ProAsn: 1.657 ± 0.039
1.26ProPro: 1.26 ± 0.039
1.403ProGln: 1.403 ± 0.031
1.468ProArg: 1.468 ± 0.039
2.571ProSer: 2.571 ± 0.048
1.985ProThr: 1.985 ± 0.042
3.41ProVal: 3.41 ± 0.05
0.594ProTrp: 0.594 ± 0.02
1.576ProTyr: 1.576 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.415GlnAla: 3.415 ± 0.058
0.232GlnCys: 0.232 ± 0.014
1.766GlnAsp: 1.766 ± 0.038
2.577GlnGlu: 2.577 ± 0.044
1.565GlnPhe: 1.565 ± 0.039
2.788GlnGly: 2.788 ± 0.049
0.847GlnHis: 0.847 ± 0.028
2.402GlnIle: 2.402 ± 0.045
1.742GlnLys: 1.742 ± 0.035
4.163GlnLeu: 4.163 ± 0.053
1.167GlnMet: 1.167 ± 0.032
1.273GlnAsn: 1.273 ± 0.027
1.598GlnPro: 1.598 ± 0.035
1.853GlnGln: 1.853 ± 0.04
1.828GlnArg: 1.828 ± 0.042
2.212GlnSer: 2.212 ± 0.044
2.07GlnThr: 2.07 ± 0.042
2.711GlnVal: 2.711 ± 0.047
0.59GlnTrp: 0.59 ± 0.022
1.354GlnTyr: 1.354 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
3.262ArgAla: 3.262 ± 0.046
0.325ArgCys: 0.325 ± 0.017
2.429ArgAsp: 2.429 ± 0.044
3.638ArgGlu: 3.638 ± 0.062
2.181ArgPhe: 2.181 ± 0.043
3.022ArgGly: 3.022 ± 0.058
1.034ArgHis: 1.034 ± 0.031
3.782ArgIle: 3.782 ± 0.062
3.182ArgLys: 3.182 ± 0.051
4.957ArgLeu: 4.957 ± 0.086
1.832ArgMet: 1.832 ± 0.039
2.235ArgAsn: 2.235 ± 0.04
1.576ArgPro: 1.576 ± 0.034
1.859ArgGln: 1.859 ± 0.042
2.499ArgArg: 2.499 ± 0.057
2.888ArgSer: 2.888 ± 0.054
2.855ArgThr: 2.855 ± 0.045
3.341ArgVal: 3.341 ± 0.057
0.704ArgTrp: 0.704 ± 0.023
1.891ArgTyr: 1.891 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
4.912SerAla: 4.912 ± 0.062
0.408SerCys: 0.408 ± 0.018
2.945SerAsp: 2.945 ± 0.058
3.736SerGlu: 3.736 ± 0.051
2.853SerPhe: 2.853 ± 0.051
5.304SerGly: 5.304 ± 0.078
1.202SerHis: 1.202 ± 0.029
3.996SerIle: 3.996 ± 0.06
3.078SerLys: 3.078 ± 0.059
6.081SerLeu: 6.081 ± 0.076
1.869SerMet: 1.869 ± 0.039
2.376SerAsn: 2.376 ± 0.047
2.384SerPro: 2.384 ± 0.05
1.974SerGln: 1.974 ± 0.039
2.937SerArg: 2.937 ± 0.053
3.985SerSer: 3.985 ± 0.066
3.238SerThr: 3.238 ± 0.054
4.712SerVal: 4.712 ± 0.068
0.806SerTrp: 0.806 ± 0.027
2.317SerTyr: 2.317 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.802ThrAla: 4.802 ± 0.065
0.36ThrCys: 0.36 ± 0.018
3.063ThrAsp: 3.063 ± 0.049
3.511ThrGlu: 3.511 ± 0.052
2.457ThrPhe: 2.457 ± 0.046
5.089ThrGly: 5.089 ± 0.177
1.117ThrHis: 1.117 ± 0.032
3.647ThrIle: 3.647 ± 0.057
2.65ThrLys: 2.65 ± 0.048
5.826ThrLeu: 5.826 ± 0.065
1.451ThrMet: 1.451 ± 0.03
2.242ThrAsn: 2.242 ± 0.042
2.653ThrPro: 2.653 ± 0.044
1.717ThrGln: 1.717 ± 0.033
2.378ThrArg: 2.378 ± 0.044
3.462ThrSer: 3.462 ± 0.057
3.075ThrThr: 3.075 ± 0.051
4.717ThrVal: 4.717 ± 0.068
0.703ThrTrp: 0.703 ± 0.028
2.061ThrTyr: 2.061 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.396ValAla: 5.396 ± 0.07
0.616ValCys: 0.616 ± 0.024
3.613ValAsp: 3.613 ± 0.053
4.455ValGlu: 4.455 ± 0.063
2.958ValPhe: 2.958 ± 0.051
4.635ValGly: 4.635 ± 0.069
1.603ValHis: 1.603 ± 0.034
5.033ValIle: 5.033 ± 0.069
4.068ValLys: 4.068 ± 0.06
7.349ValLeu: 7.349 ± 0.082
2.142ValMet: 2.142 ± 0.041
3.145ValAsn: 3.145 ± 0.054
3.106ValPro: 3.106 ± 0.045
2.577ValGln: 2.577 ± 0.047
3.577ValArg: 3.577 ± 0.053
4.857ValSer: 4.857 ± 0.07
4.817ValThr: 4.817 ± 0.077
5.033ValVal: 5.033 ± 0.075
0.883ValTrp: 0.883 ± 0.027
2.614ValTyr: 2.614 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.844TrpAla: 0.844 ± 0.025
0.1TrpCys: 0.1 ± 0.009
0.668TrpAsp: 0.668 ± 0.024
0.765TrpGlu: 0.765 ± 0.025
0.619TrpPhe: 0.619 ± 0.021
0.858TrpGly: 0.858 ± 0.03
0.285TrpHis: 0.285 ± 0.014
0.941TrpIle: 0.941 ± 0.028
0.769TrpLys: 0.769 ± 0.025
1.336TrpLeu: 1.336 ± 0.038
0.458TrpMet: 0.458 ± 0.021
0.769TrpAsn: 0.769 ± 0.023
0.401TrpPro: 0.401 ± 0.017
0.479TrpGln: 0.479 ± 0.02
0.569TrpArg: 0.569 ± 0.024
0.823TrpSer: 0.823 ± 0.023
0.807TrpThr: 0.807 ± 0.026
0.861TrpVal: 0.861 ± 0.03
0.186TrpTrp: 0.186 ± 0.012
0.445TrpTyr: 0.445 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.844TyrAla: 2.844 ± 0.042
0.271TyrCys: 0.271 ± 0.014
1.944TyrAsp: 1.944 ± 0.045
2.319TyrGlu: 2.319 ± 0.044
1.577TyrPhe: 1.577 ± 0.039
2.8TyrGly: 2.8 ± 0.047
0.759TyrHis: 0.759 ± 0.025
2.27TyrIle: 2.27 ± 0.041
1.78TyrLys: 1.78 ± 0.038
3.394TyrLeu: 3.394 ± 0.053
1.021TyrMet: 1.021 ± 0.027
1.554TyrAsn: 1.554 ± 0.04
1.523TyrPro: 1.523 ± 0.033
1.183TyrGln: 1.183 ± 0.034
2.019TyrArg: 2.019 ± 0.04
2.125TyrSer: 2.125 ± 0.047
2.028TyrThr: 2.028 ± 0.04
2.525TyrVal: 2.525 ± 0.044
0.505TyrTrp: 0.505 ± 0.018
1.418TyrTyr: 1.418 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4095 proteins (1341642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski