Amino acid dipepetide frequency for Cuneatibacter caecimuris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.675AlaAla: 9.675 ± 0.151	1.312AlaCys: 1.312 ± 0.037	4.617AlaAsp: 4.617 ± 0.076	6.731AlaGlu: 6.731 ± 0.092	3.062AlaPhe: 3.062 ± 0.06	7.931AlaGly: 7.931 ± 0.118	1.167AlaHis: 1.167 ± 0.032	3.997AlaIle: 3.997 ± 0.083	3.854AlaLys: 3.854 ± 0.061	7.73AlaLeu: 7.73 ± 0.095	2.383AlaMet: 2.383 ± 0.054	2.234AlaAsn: 2.234 ± 0.053	2.317AlaPro: 2.317 ± 0.062	2.552AlaGln: 2.552 ± 0.058	3.877AlaArg: 3.877 ± 0.066	4.307AlaSer: 4.307 ± 0.063	2.81AlaThr: 2.81 ± 0.06	7.506AlaVal: 7.506 ± 0.093	0.818AlaTrp: 0.818 ± 0.03	2.749AlaTyr: 2.749 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.106CysAla: 1.106 ± 0.035	0.359CysCys: 0.359 ± 0.021	0.726CysAsp: 0.726 ± 0.03	0.848CysGlu: 0.848 ± 0.029	0.677CysPhe: 0.677 ± 0.025	1.713CysGly: 1.713 ± 0.041	0.289CysHis: 0.289 ± 0.018	0.941CysIle: 0.941 ± 0.031	0.605CysLys: 0.605 ± 0.028	1.444CysLeu: 1.444 ± 0.04	0.447CysMet: 0.447 ± 0.019	0.476CysAsn: 0.476 ± 0.023	0.694CysPro: 0.694 ± 0.033	0.46CysGln: 0.46 ± 0.02	1.204CysArg: 1.204 ± 0.04	1.049CysSer: 1.049 ± 0.034	0.724CysThr: 0.724 ± 0.028	0.981CysVal: 0.981 ± 0.032	0.187CysTrp: 0.187 ± 0.014	0.584CysTyr: 0.584 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.135AspAla: 4.135 ± 0.071	0.88AspCys: 0.88 ± 0.032	2.215AspAsp: 2.215 ± 0.062	3.889AspGlu: 3.889 ± 0.067	2.545AspPhe: 2.545 ± 0.05	4.605AspGly: 4.605 ± 0.092	0.914AspHis: 0.914 ± 0.037	3.537AspIle: 3.537 ± 0.066	2.721AspLys: 2.721 ± 0.058	4.784AspLeu: 4.784 ± 0.075	1.743AspMet: 1.743 ± 0.04	1.736AspAsn: 1.736 ± 0.047	2.026AspPro: 2.026 ± 0.051	1.78AspGln: 1.78 ± 0.045	2.873AspArg: 2.873 ± 0.054	3.173AspSer: 3.173 ± 0.059	2.77AspThr: 2.77 ± 0.053	3.432AspVal: 3.432 ± 0.068	0.707AspTrp: 0.707 ± 0.03	2.519AspTyr: 2.519 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.292GluAla: 6.292 ± 0.094	0.812GluCys: 0.812 ± 0.028	4.359GluAsp: 4.359 ± 0.072	8.011GluGlu: 8.011 ± 0.114	2.56GluPhe: 2.56 ± 0.054	5.064GluGly: 5.064 ± 0.085	1.242GluHis: 1.242 ± 0.033	5.53GluIle: 5.53 ± 0.08	6.113GluLys: 6.113 ± 0.094	7.157GluLeu: 7.157 ± 0.096	2.573GluMet: 2.573 ± 0.051	3.879GluAsn: 3.879 ± 0.067	2.077GluPro: 2.077 ± 0.044	3.367GluGln: 3.367 ± 0.072	3.622GluArg: 3.622 ± 0.07	3.571GluSer: 3.571 ± 0.064	4.055GluThr: 4.055 ± 0.077	4.327GluVal: 4.327 ± 0.072	0.763GluTrp: 0.763 ± 0.032	2.982GluTyr: 2.982 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.082PheAla: 3.082 ± 0.058	0.796PheCys: 0.796 ± 0.031	2.368PheAsp: 2.368 ± 0.051	2.469PheGlu: 2.469 ± 0.058	1.69PhePhe: 1.69 ± 0.046	3.118PheGly: 3.118 ± 0.067	0.835PheHis: 0.835 ± 0.03	2.329PheIle: 2.329 ± 0.054	1.466PheLys: 1.466 ± 0.042	4.166PheLeu: 4.166 ± 0.077	1.063PheMet: 1.063 ± 0.036	1.181PheAsn: 1.181 ± 0.034	1.487PhePro: 1.487 ± 0.041	1.523PheGln: 1.523 ± 0.037	2.237PheArg: 2.237 ± 0.049	3.1PheSer: 3.1 ± 0.062	2.31PheThr: 2.31 ± 0.051	2.477PheVal: 2.477 ± 0.055	0.547PheTrp: 0.547 ± 0.026	1.725PheTyr: 1.725 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	5.858GlyAla: 5.858 ± 0.102	1.438GlyCys: 1.438 ± 0.045	3.691GlyAsp: 3.691 ± 0.069	5.303GlyGlu: 5.303 ± 0.074	3.194GlyPhe: 3.194 ± 0.065	5.652GlyGly: 5.652 ± 0.119	1.29GlyHis: 1.29 ± 0.038	5.861GlyIle: 5.861 ± 0.084	5.364GlyLys: 5.364 ± 0.082	6.829GlyLeu: 6.829 ± 0.095	2.684GlyMet: 2.684 ± 0.056	3.129GlyAsn: 3.129 ± 0.073	1.708GlyPro: 1.708 ± 0.057	2.593GlyGln: 2.593 ± 0.061	4.288GlyArg: 4.288 ± 0.076	4.517GlySer: 4.517 ± 0.083	4.271GlyThr: 4.271 ± 0.084	5.092GlyVal: 5.092 ± 0.079	0.916GlyTrp: 0.916 ± 0.037	3.293GlyTyr: 3.293 ± 0.071	0.0GlyXaa: 0.0 ± 0.0
His	1.072HisAla: 1.072 ± 0.03	0.343HisCys: 0.343 ± 0.019	0.842HisAsp: 0.842 ± 0.028	1.009HisGlu: 1.009 ± 0.028	0.852HisPhe: 0.852 ± 0.028	1.251HisGly: 1.251 ± 0.039	0.405HisHis: 0.405 ± 0.024	1.227HisIle: 1.227 ± 0.033	0.744HisLys: 0.744 ± 0.026	1.569HisLeu: 1.569 ± 0.048	0.51HisMet: 0.51 ± 0.021	0.644HisAsn: 0.644 ± 0.027	0.908HisPro: 0.908 ± 0.029	0.609HisGln: 0.609 ± 0.028	0.859HisArg: 0.859 ± 0.034	0.963HisSer: 0.963 ± 0.032	0.928HisThr: 0.928 ± 0.03	1.115HisVal: 1.115 ± 0.033	0.207HisTrp: 0.207 ± 0.016	0.8HisTyr: 0.8 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.01IleAla: 5.01 ± 0.081	1.166IleCys: 1.166 ± 0.041	3.239IleAsp: 3.239 ± 0.064	3.766IleGlu: 3.766 ± 0.067	2.744IlePhe: 2.744 ± 0.058	4.501IleGly: 4.501 ± 0.08	1.2IleHis: 1.2 ± 0.035	3.75IleIle: 3.75 ± 0.066	2.959IleLys: 2.959 ± 0.059	6.638IleLeu: 6.638 ± 0.088	1.605IleMet: 1.605 ± 0.042	2.315IleAsn: 2.315 ± 0.049	3.01IlePro: 3.01 ± 0.059	2.359IleGln: 2.359 ± 0.047	3.941IleArg: 3.941 ± 0.07	4.743IleSer: 4.743 ± 0.071	3.484IleThr: 3.484 ± 0.06	4.009IleVal: 4.009 ± 0.066	0.673IleTrp: 0.673 ± 0.024	2.433IleTyr: 2.433 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.5LysAla: 4.5 ± 0.07	0.605LysCys: 0.605 ± 0.027	3.074LysAsp: 3.074 ± 0.055	5.456LysGlu: 5.456 ± 0.09	1.707LysPhe: 1.707 ± 0.048	3.745LysGly: 3.745 ± 0.064	0.838LysHis: 0.838 ± 0.029	4.094LysIle: 4.094 ± 0.062	4.862LysLys: 4.862 ± 0.076	5.001LysLeu: 5.001 ± 0.078	1.921LysMet: 1.921 ± 0.048	2.936LysAsn: 2.936 ± 0.054	1.954LysPro: 1.954 ± 0.045	2.159LysGln: 2.159 ± 0.047	2.933LysArg: 2.933 ± 0.062	2.975LysSer: 2.975 ± 0.058	3.258LysThr: 3.258 ± 0.062	3.455LysVal: 3.455 ± 0.058	0.64LysTrp: 0.64 ± 0.027	2.307LysTyr: 2.307 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	7.88LeuAla: 7.88 ± 0.115	1.613LeuCys: 1.613 ± 0.044	5.244LeuAsp: 5.244 ± 0.088	7.549LeuGlu: 7.549 ± 0.108	3.829LeuPhe: 3.829 ± 0.072	6.327LeuGly: 6.327 ± 0.089	1.547LeuHis: 1.547 ± 0.039	5.6LeuIle: 5.6 ± 0.079	5.993LeuLys: 5.993 ± 0.076	9.455LeuLeu: 9.455 ± 0.136	2.685LeuMet: 2.685 ± 0.057	3.62LeuAsn: 3.62 ± 0.065	4.032LeuPro: 4.032 ± 0.065	3.462LeuGln: 3.462 ± 0.066	4.719LeuArg: 4.719 ± 0.07	6.245LeuSer: 6.245 ± 0.085	5.08LeuThr: 5.08 ± 0.074	5.733LeuVal: 5.733 ± 0.09	0.925LeuTrp: 0.925 ± 0.029	3.448LeuTyr: 3.448 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.517MetAla: 2.517 ± 0.055	0.322MetCys: 0.322 ± 0.018	1.771MetAsp: 1.771 ± 0.041	2.655MetGlu: 2.655 ± 0.053	0.996MetPhe: 0.996 ± 0.033	2.135MetGly: 2.135 ± 0.047	0.391MetHis: 0.391 ± 0.02	1.932MetIle: 1.932 ± 0.05	2.401MetLys: 2.401 ± 0.046	2.749MetLeu: 2.749 ± 0.051	0.965MetMet: 0.965 ± 0.031	1.456MetAsn: 1.456 ± 0.039	1.107MetPro: 1.107 ± 0.027	1.065MetGln: 1.065 ± 0.034	1.495MetArg: 1.495 ± 0.042	1.583MetSer: 1.583 ± 0.05	1.696MetThr: 1.696 ± 0.047	1.907MetVal: 1.907 ± 0.046	0.226MetTrp: 0.226 ± 0.015	0.879MetTyr: 0.879 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.9AsnAla: 2.9 ± 0.063	0.617AsnCys: 0.617 ± 0.025	1.692AsnAsp: 1.692 ± 0.047	2.356AsnGlu: 2.356 ± 0.047	1.448AsnPhe: 1.448 ± 0.037	3.314AsnGly: 3.314 ± 0.069	0.747AsnHis: 0.747 ± 0.03	2.718AsnIle: 2.718 ± 0.06	1.96AsnLys: 1.96 ± 0.051	3.522AsnLeu: 3.522 ± 0.057	1.186AsnMet: 1.186 ± 0.033	1.406AsnAsn: 1.406 ± 0.045	1.972AsnPro: 1.972 ± 0.043	1.487AsnGln: 1.487 ± 0.034	2.145AsnArg: 2.145 ± 0.053	2.187AsnSer: 2.187 ± 0.05	2.106AsnThr: 2.106 ± 0.047	2.411AsnVal: 2.411 ± 0.054	0.472AsnTrp: 0.472 ± 0.02	1.603AsnTyr: 1.603 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.199ProAla: 3.199 ± 0.073	0.551ProCys: 0.551 ± 0.025	2.436ProAsp: 2.436 ± 0.056	4.249ProGlu: 4.249 ± 0.071	1.558ProPhe: 1.558 ± 0.044	3.198ProGly: 3.198 ± 0.064	0.641ProHis: 0.641 ± 0.028	1.615ProIle: 1.615 ± 0.043	1.515ProLys: 1.515 ± 0.041	2.924ProLeu: 2.924 ± 0.06	0.903ProMet: 0.903 ± 0.027	1.086ProAsn: 1.086 ± 0.033	0.921ProPro: 0.921 ± 0.036	1.155ProGln: 1.155 ± 0.033	1.299ProArg: 1.299 ± 0.037	1.981ProSer: 1.981 ± 0.052	1.424ProThr: 1.424 ± 0.048	3.468ProVal: 3.468 ± 0.062	0.402ProTrp: 0.402 ± 0.02	1.423ProTyr: 1.423 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.071GlnAla: 3.071 ± 0.053	0.365GlnCys: 0.365 ± 0.018	1.807GlnAsp: 1.807 ± 0.044	3.302GlnGlu: 3.302 ± 0.062	1.312GlnPhe: 1.312 ± 0.035	2.36GlnGly: 2.36 ± 0.05	0.465GlnHis: 0.465 ± 0.022	2.585GlnIle: 2.585 ± 0.056	2.709GlnLys: 2.709 ± 0.061	3.201GlnLeu: 3.201 ± 0.061	1.313GlnMet: 1.313 ± 0.041	1.623GlnAsn: 1.623 ± 0.045	1.161GlnPro: 1.161 ± 0.037	1.299GlnGln: 1.299 ± 0.039	1.574GlnArg: 1.574 ± 0.041	1.742GlnSer: 1.742 ± 0.042	1.661GlnThr: 1.661 ± 0.045	2.542GlnVal: 2.542 ± 0.05	0.387GlnTrp: 0.387 ± 0.021	1.439GlnTyr: 1.439 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.538ArgAla: 3.538 ± 0.056	0.721ArgCys: 0.721 ± 0.027	2.565ArgAsp: 2.565 ± 0.055	4.612ArgGlu: 4.612 ± 0.081	2.109ArgPhe: 2.109 ± 0.045	3.114ArgGly: 3.114 ± 0.054	0.875ArgHis: 0.875 ± 0.027	3.718ArgIle: 3.718 ± 0.066	3.635ArgLys: 3.635 ± 0.063	5.165ArgLeu: 5.165 ± 0.088	1.816ArgMet: 1.816 ± 0.047	2.175ArgAsn: 2.175 ± 0.045	1.826ArgPro: 1.826 ± 0.052	2.237ArgGln: 2.237 ± 0.052	3.485ArgArg: 3.485 ± 0.068	2.551ArgSer: 2.551 ± 0.055	2.566ArgThr: 2.566 ± 0.049	3.12ArgVal: 3.12 ± 0.066	0.511ArgTrp: 0.511 ± 0.026	2.173ArgTyr: 2.173 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.924SerAla: 4.924 ± 0.088	0.931SerCys: 0.931 ± 0.031	2.907SerAsp: 2.907 ± 0.059	3.913SerGlu: 3.913 ± 0.067	2.643SerPhe: 2.643 ± 0.055	5.829SerGly: 5.829 ± 0.105	0.984SerHis: 0.984 ± 0.034	3.448SerIle: 3.448 ± 0.074	2.604SerLys: 2.604 ± 0.058	5.626SerLeu: 5.626 ± 0.082	1.735SerMet: 1.735 ± 0.042	1.916SerAsn: 1.916 ± 0.049	2.075SerPro: 2.075 ± 0.045	1.951SerGln: 1.951 ± 0.05	3.475SerArg: 3.475 ± 0.054	3.869SerSer: 3.869 ± 0.075	2.57SerThr: 2.57 ± 0.062	4.366SerVal: 4.366 ± 0.068	0.735SerTrp: 0.735 ± 0.033	2.235SerTyr: 2.235 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.954ThrAla: 4.954 ± 0.088	0.613ThrCys: 0.613 ± 0.025	2.985ThrAsp: 2.985 ± 0.052	4.176ThrGlu: 4.176 ± 0.091	1.911ThrPhe: 1.911 ± 0.045	5.189ThrGly: 5.189 ± 0.106	0.78ThrHis: 0.78 ± 0.031	2.973ThrIle: 2.973 ± 0.057	2.324ThrLys: 2.324 ± 0.058	4.513ThrLeu: 4.513 ± 0.067	1.283ThrMet: 1.283 ± 0.036	1.583ThrAsn: 1.583 ± 0.044	2.074ThrPro: 2.074 ± 0.045	1.382ThrGln: 1.382 ± 0.038	2.025ThrArg: 2.025 ± 0.042	2.624ThrSer: 2.624 ± 0.065	2.347ThrThr: 2.347 ± 0.059	4.615ThrVal: 4.615 ± 0.079	0.559ThrTrp: 0.559 ± 0.028	1.884ThrTyr: 1.884 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.502ValAla: 4.502 ± 0.07	1.228ValCys: 1.228 ± 0.037	3.513ValAsp: 3.513 ± 0.067	4.478ValGlu: 4.478 ± 0.066	2.935ValPhe: 2.935 ± 0.064	4.071ValGly: 4.071 ± 0.069	1.164ValHis: 1.164 ± 0.032	4.645ValIle: 4.645 ± 0.064	4.043ValLys: 4.043 ± 0.065	7.333ValLeu: 7.333 ± 0.086	2.06ValMet: 2.06 ± 0.044	2.74ValAsn: 2.74 ± 0.046	2.799ValPro: 2.799 ± 0.049	2.237ValGln: 2.237 ± 0.052	3.596ValArg: 3.596 ± 0.06	4.666ValSer: 4.666 ± 0.075	4.148ValThr: 4.148 ± 0.068	4.396ValVal: 4.396 ± 0.074	0.737ValTrp: 0.737 ± 0.024	2.677ValTyr: 2.677 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.721TrpAla: 0.721 ± 0.03	0.168TrpCys: 0.168 ± 0.013	0.655TrpAsp: 0.655 ± 0.027	0.827TrpGlu: 0.827 ± 0.031	0.454TrpPhe: 0.454 ± 0.024	0.771TrpGly: 0.771 ± 0.031	0.195TrpHis: 0.195 ± 0.015	0.717TrpIle: 0.717 ± 0.029	0.888TrpLys: 0.888 ± 0.032	1.138TrpLeu: 1.138 ± 0.036	0.396TrpMet: 0.396 ± 0.019	0.582TrpAsn: 0.582 ± 0.025	0.281TrpPro: 0.281 ± 0.017	0.414TrpGln: 0.414 ± 0.02	0.497TrpArg: 0.497 ± 0.024	0.554TrpSer: 0.554 ± 0.024	0.532TrpThr: 0.532 ± 0.023	0.606TrpVal: 0.606 ± 0.024	0.153TrpTrp: 0.153 ± 0.014	0.449TrpTyr: 0.449 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.692TyrAla: 2.692 ± 0.054	0.675TyrCys: 0.675 ± 0.025	2.277TyrAsp: 2.277 ± 0.053	2.756TyrGlu: 2.756 ± 0.057	1.74TyrPhe: 1.74 ± 0.045	3.084TyrGly: 3.084 ± 0.065	0.891TyrHis: 0.891 ± 0.028	2.326TyrIle: 2.326 ± 0.051	1.661TyrLys: 1.661 ± 0.042	4.043TyrLeu: 4.043 ± 0.069	0.977TyrMet: 0.977 ± 0.031	1.529TyrAsn: 1.529 ± 0.039	1.518TyrPro: 1.518 ± 0.039	1.827TyrGln: 1.827 ± 0.046	2.368TyrArg: 2.368 ± 0.047	2.336TyrSer: 2.336 ± 0.052	2.056TyrThr: 2.056 ± 0.06	2.412TyrVal: 2.412 ± 0.053	0.435TyrTrp: 0.435 ± 0.021	1.797TyrTyr: 1.797 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3170 proteins (1036976 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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