Amino acid dipepetide frequency for Actinophytocola oryzae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.411AlaAla: 19.411 ± 0.145	1.069AlaCys: 1.069 ± 0.02	8.496AlaAsp: 8.496 ± 0.061	8.026AlaGlu: 8.026 ± 0.058	3.467AlaPhe: 3.467 ± 0.042	12.667AlaGly: 12.667 ± 0.084	2.623AlaHis: 2.623 ± 0.036	3.928AlaIle: 3.928 ± 0.039	2.421AlaLys: 2.421 ± 0.036	13.324AlaLeu: 13.324 ± 0.108	2.623AlaMet: 2.623 ± 0.032	2.532AlaAsn: 2.532 ± 0.033	6.018AlaPro: 6.018 ± 0.049	3.33AlaGln: 3.33 ± 0.031	9.501AlaArg: 9.501 ± 0.068	5.853AlaSer: 5.853 ± 0.045	8.064AlaThr: 8.064 ± 0.056	12.46AlaVal: 12.46 ± 0.102	1.793AlaTrp: 1.793 ± 0.023	2.384AlaTyr: 2.384 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.048CysAla: 1.048 ± 0.023	0.091CysCys: 0.091 ± 0.006	0.507CysAsp: 0.507 ± 0.012	0.383CysGlu: 0.383 ± 0.011	0.222CysPhe: 0.222 ± 0.007	0.899CysGly: 0.899 ± 0.018	0.209CysHis: 0.209 ± 0.009	0.127CysIle: 0.127 ± 0.005	0.099CysLys: 0.099 ± 0.006	0.755CysLeu: 0.755 ± 0.015	0.112CysMet: 0.112 ± 0.005	0.125CysAsn: 0.125 ± 0.007	0.457CysPro: 0.457 ± 0.013	0.206CysGln: 0.206 ± 0.008	0.601CysArg: 0.601 ± 0.014	0.419CysSer: 0.419 ± 0.012	0.443CysThr: 0.443 ± 0.013	0.765CysVal: 0.765 ± 0.016	0.136CysTrp: 0.136 ± 0.008	0.184CysTyr: 0.184 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.478AspAla: 7.478 ± 0.061	0.41AspCys: 0.41 ± 0.013	4.138AspAsp: 4.138 ± 0.04	4.192AspGlu: 4.192 ± 0.041	1.685AspPhe: 1.685 ± 0.026	6.652AspGly: 6.652 ± 0.058	1.538AspHis: 1.538 ± 0.022	1.889AspIle: 1.889 ± 0.028	1.023AspLys: 1.023 ± 0.024	6.989AspLeu: 6.989 ± 0.057	0.87AspMet: 0.87 ± 0.018	1.175AspAsn: 1.175 ± 0.021	4.564AspPro: 4.564 ± 0.043	1.799AspGln: 1.799 ± 0.022	5.346AspArg: 5.346 ± 0.048	2.513AspSer: 2.513 ± 0.032	3.534AspThr: 3.534 ± 0.032	5.663AspVal: 5.663 ± 0.039	1.045AspTrp: 1.045 ± 0.021	1.297AspTyr: 1.297 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.096GluAla: 6.096 ± 0.061	0.371GluCys: 0.371 ± 0.011	2.726GluAsp: 2.726 ± 0.037	2.751GluGlu: 2.751 ± 0.039	1.649GluPhe: 1.649 ± 0.024	3.309GluGly: 3.309 ± 0.032	1.629GluHis: 1.629 ± 0.023	2.171GluIle: 2.171 ± 0.032	1.153GluLys: 1.153 ± 0.023	6.972GluLeu: 6.972 ± 0.053	0.84GluMet: 0.84 ± 0.018	1.049GluAsn: 1.049 ± 0.021	3.399GluPro: 3.399 ± 0.04	2.051GluGln: 2.051 ± 0.027	4.85GluArg: 4.85 ± 0.047	2.575GluSer: 2.575 ± 0.037	2.799GluThr: 2.799 ± 0.029	4.92GluVal: 4.92 ± 0.041	0.855GluTrp: 0.855 ± 0.017	1.09GluTyr: 1.09 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.921PheAla: 3.921 ± 0.038	0.261PheCys: 0.261 ± 0.009	2.286PheAsp: 2.286 ± 0.026	1.405PheGlu: 1.405 ± 0.023	0.877PhePhe: 0.877 ± 0.017	3.297PheGly: 3.297 ± 0.036	0.627PheHis: 0.627 ± 0.015	0.633PheIle: 0.633 ± 0.014	0.334PheLys: 0.334 ± 0.011	2.6PheLeu: 2.6 ± 0.029	0.402PheMet: 0.402 ± 0.012	0.581PheAsn: 0.581 ± 0.014	1.443PhePro: 1.443 ± 0.023	0.7PheGln: 0.7 ± 0.014	1.957PheArg: 1.957 ± 0.027	1.504PheSer: 1.504 ± 0.019	2.137PheThr: 2.137 ± 0.027	2.689PheVal: 2.689 ± 0.035	0.417PheTrp: 0.417 ± 0.011	0.606PheTyr: 0.606 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	10.049GlyAla: 10.049 ± 0.067	0.791GlyCys: 0.791 ± 0.018	5.488GlyAsp: 5.488 ± 0.048	4.958GlyGlu: 4.958 ± 0.04	2.977GlyPhe: 2.977 ± 0.03	8.376GlyGly: 8.376 ± 0.075	2.235GlyHis: 2.235 ± 0.032	3.32GlyIle: 3.32 ± 0.034	1.974GlyLys: 1.974 ± 0.031	9.229GlyLeu: 9.229 ± 0.072	2.133GlyMet: 2.133 ± 0.028	1.982GlyAsn: 1.982 ± 0.032	4.671GlyPro: 4.671 ± 0.044	2.707GlyGln: 2.707 ± 0.028	7.36GlyArg: 7.36 ± 0.058	4.916GlySer: 4.916 ± 0.047	6.274GlyThr: 6.274 ± 0.057	8.367GlyVal: 8.367 ± 0.068	1.704GlyTrp: 1.704 ± 0.026	2.281GlyTyr: 2.281 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.71HisAla: 2.71 ± 0.033	0.199HisCys: 0.199 ± 0.009	1.525HisAsp: 1.525 ± 0.022	1.225HisGlu: 1.225 ± 0.022	0.598HisPhe: 0.598 ± 0.015	2.249HisGly: 2.249 ± 0.029	0.69HisHis: 0.69 ± 0.018	0.561HisIle: 0.561 ± 0.015	0.295HisLys: 0.295 ± 0.01	2.401HisLeu: 2.401 ± 0.031	0.309HisMet: 0.309 ± 0.009	0.44HisAsn: 0.44 ± 0.015	1.659HisPro: 1.659 ± 0.027	0.611HisGln: 0.611 ± 0.012	1.996HisArg: 1.996 ± 0.025	0.982HisSer: 0.982 ± 0.018	1.283HisThr: 1.283 ± 0.019	1.99HisVal: 1.99 ± 0.024	0.367HisTrp: 0.367 ± 0.011	0.492HisTyr: 0.492 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.691IleAla: 4.691 ± 0.047	0.256IleCys: 0.256 ± 0.01	2.28IleAsp: 2.28 ± 0.032	1.9IleGlu: 1.9 ± 0.027	0.685IlePhe: 0.685 ± 0.016	3.422IleGly: 3.422 ± 0.032	0.58IleHis: 0.58 ± 0.012	0.916IleIle: 0.916 ± 0.021	0.557IleLys: 0.557 ± 0.016	2.354IleLeu: 2.354 ± 0.031	0.469IleMet: 0.469 ± 0.013	0.682IleAsn: 0.682 ± 0.017	1.729IlePro: 1.729 ± 0.024	0.699IleGln: 0.699 ± 0.016	2.239IleArg: 2.239 ± 0.031	1.642IleSer: 1.642 ± 0.021	2.295IleThr: 2.295 ± 0.031	2.946IleVal: 2.946 ± 0.034	0.359IleTrp: 0.359 ± 0.011	0.548IleTyr: 0.548 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	2.233LysAla: 2.233 ± 0.038	0.102LysCys: 0.102 ± 0.006	1.023LysAsp: 1.023 ± 0.025	0.871LysGlu: 0.871 ± 0.02	0.434LysPhe: 0.434 ± 0.013	1.273LysGly: 1.273 ± 0.026	0.372LysHis: 0.372 ± 0.011	0.744LysIle: 0.744 ± 0.018	0.484LysLys: 0.484 ± 0.018	1.855LysLeu: 1.855 ± 0.031	0.326LysMet: 0.326 ± 0.01	0.373LysAsn: 0.373 ± 0.014	1.145LysPro: 1.145 ± 0.021	0.571LysGln: 0.571 ± 0.016	1.231LysArg: 1.231 ± 0.024	0.975LysSer: 0.975 ± 0.023	1.017LysThr: 1.017 ± 0.023	1.725LysVal: 1.725 ± 0.03	0.247LysTrp: 0.247 ± 0.009	0.377LysTyr: 0.377 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.575LeuAla: 15.575 ± 0.125	0.819LeuCys: 0.819 ± 0.018	7.151LeuAsp: 7.151 ± 0.05	4.156LeuGlu: 4.156 ± 0.038	2.763LeuPhe: 2.763 ± 0.035	9.378LeuGly: 9.378 ± 0.075	2.173LeuHis: 2.173 ± 0.033	2.716LeuIle: 2.716 ± 0.036	1.386LeuLys: 1.386 ± 0.027	10.635LeuLeu: 10.635 ± 0.096	1.478LeuMet: 1.478 ± 0.024	1.769LeuAsn: 1.769 ± 0.029	6.4LeuPro: 6.4 ± 0.052	1.866LeuGln: 1.866 ± 0.025	9.029LeuArg: 9.029 ± 0.067	5.733LeuSer: 5.733 ± 0.046	7.065LeuThr: 7.065 ± 0.046	10.394LeuVal: 10.394 ± 0.082	1.323LeuTrp: 1.323 ± 0.022	1.743LeuTyr: 1.743 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.314MetAla: 2.314 ± 0.03	0.135MetCys: 0.135 ± 0.006	0.869MetAsp: 0.869 ± 0.018	0.572MetGlu: 0.572 ± 0.012	0.542MetPhe: 0.542 ± 0.013	1.217MetGly: 1.217 ± 0.023	0.335MetHis: 0.335 ± 0.012	0.702MetIle: 0.702 ± 0.016	0.356MetLys: 0.356 ± 0.012	1.813MetLeu: 1.813 ± 0.025	0.293MetMet: 0.293 ± 0.01	0.441MetAsn: 0.441 ± 0.013	1.091MetPro: 1.091 ± 0.02	0.379MetGln: 0.379 ± 0.01	1.539MetArg: 1.539 ± 0.02	1.286MetSer: 1.286 ± 0.021	1.699MetThr: 1.699 ± 0.021	1.483MetVal: 1.483 ± 0.022	0.223MetTrp: 0.223 ± 0.009	0.308MetTyr: 0.308 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.408AsnAla: 2.408 ± 0.031	0.181AsnCys: 0.181 ± 0.007	1.1AsnAsp: 1.1 ± 0.02	0.924AsnGlu: 0.924 ± 0.019	0.546AsnPhe: 0.546 ± 0.014	2.196AsnGly: 2.196 ± 0.035	0.425AsnHis: 0.425 ± 0.01	0.663AsnIle: 0.663 ± 0.014	0.377AsnLys: 0.377 ± 0.014	1.966AsnLeu: 1.966 ± 0.028	0.301AsnMet: 0.301 ± 0.01	0.535AsnAsn: 0.535 ± 0.016	1.579AsnPro: 1.579 ± 0.027	0.656AsnGln: 0.656 ± 0.019	1.509AsnArg: 1.509 ± 0.024	1.001AsnSer: 1.001 ± 0.02	1.312AsnThr: 1.312 ± 0.026	1.639AsnVal: 1.639 ± 0.024	0.326AsnTrp: 0.326 ± 0.012	0.479AsnTyr: 0.479 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.8ProAla: 7.8 ± 0.067	0.34ProCys: 0.34 ± 0.012	4.736ProAsp: 4.736 ± 0.044	3.682ProGlu: 3.682 ± 0.037	1.592ProPhe: 1.592 ± 0.025	6.006ProGly: 6.006 ± 0.057	1.223ProHis: 1.223 ± 0.02	1.555ProIle: 1.555 ± 0.025	1.089ProLys: 1.089 ± 0.02	5.001ProLeu: 5.001 ± 0.045	1.054ProMet: 1.054 ± 0.018	1.259ProAsn: 1.259 ± 0.025	3.716ProPro: 3.716 ± 0.058	1.384ProGln: 1.384 ± 0.023	3.842ProArg: 3.842 ± 0.036	3.199ProSer: 3.199 ± 0.032	3.689ProThr: 3.689 ± 0.039	5.836ProVal: 5.836 ± 0.05	0.877ProTrp: 0.877 ± 0.016	1.106ProTyr: 1.106 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.513GlnAla: 3.513 ± 0.033	0.19GlnCys: 0.19 ± 0.007	1.361GlnAsp: 1.361 ± 0.024	1.232GlnGlu: 1.232 ± 0.023	0.75GlnPhe: 0.75 ± 0.015	1.927GlnGly: 1.927 ± 0.028	0.607GlnHis: 0.607 ± 0.016	0.929GlnIle: 0.929 ± 0.02	0.499GlnLys: 0.499 ± 0.014	3.061GlnLeu: 3.061 ± 0.033	0.405GlnMet: 0.405 ± 0.013	0.546GlnAsn: 0.546 ± 0.014	1.69GlnPro: 1.69 ± 0.034	1.15GlnGln: 1.15 ± 0.029	2.318GlnArg: 2.318 ± 0.027	1.27GlnSer: 1.27 ± 0.025	1.388GlnThr: 1.388 ± 0.025	2.594GlnVal: 2.594 ± 0.029	0.475GlnTrp: 0.475 ± 0.013	0.583GlnTyr: 0.583 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.363ArgAla: 9.363 ± 0.064	0.587ArgCys: 0.587 ± 0.013	4.695ArgAsp: 4.695 ± 0.037	4.456ArgGlu: 4.456 ± 0.043	2.555ArgPhe: 2.555 ± 0.027	5.78ArgGly: 5.78 ± 0.046	2.089ArgHis: 2.089 ± 0.027	2.89ArgIle: 2.89 ± 0.034	1.425ArgLys: 1.425 ± 0.028	8.996ArgLeu: 8.996 ± 0.079	1.799ArgMet: 1.799 ± 0.024	1.54ArgAsn: 1.54 ± 0.025	4.625ArgPro: 4.625 ± 0.05	2.419ArgGln: 2.419 ± 0.03	7.485ArgArg: 7.485 ± 0.057	3.883ArgSer: 3.883 ± 0.047	5.166ArgThr: 5.166 ± 0.045	6.743ArgVal: 6.743 ± 0.052	1.45ArgTrp: 1.45 ± 0.021	1.885ArgTyr: 1.885 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.486SerAla: 6.486 ± 0.052	0.428SerCys: 0.428 ± 0.013	2.81SerAsp: 2.81 ± 0.032	2.203SerGlu: 2.203 ± 0.03	1.609SerPhe: 1.609 ± 0.023	5.849SerGly: 5.849 ± 0.059	0.97SerHis: 0.97 ± 0.018	1.609SerIle: 1.609 ± 0.028	0.84SerLys: 0.84 ± 0.021	4.866SerLeu: 4.866 ± 0.04	1.145SerMet: 1.145 ± 0.022	0.982SerAsn: 0.982 ± 0.021	3.055SerPro: 3.055 ± 0.03	1.225SerGln: 1.225 ± 0.021	3.688SerArg: 3.688 ± 0.035	2.978SerSer: 2.978 ± 0.037	3.506SerThr: 3.506 ± 0.039	4.786SerVal: 4.786 ± 0.034	1.01SerTrp: 1.01 ± 0.021	1.159SerTyr: 1.159 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	8.327ThrAla: 8.327 ± 0.07	0.455ThrCys: 0.455 ± 0.014	3.958ThrAsp: 3.958 ± 0.035	3.445ThrGlu: 3.445 ± 0.034	1.872ThrPhe: 1.872 ± 0.028	6.749ThrGly: 6.749 ± 0.057	1.289ThrHis: 1.289 ± 0.019	2.132ThrIle: 2.132 ± 0.028	1.119ThrLys: 1.119 ± 0.022	5.914ThrLeu: 5.914 ± 0.05	1.145ThrMet: 1.145 ± 0.018	1.342ThrAsn: 1.342 ± 0.024	4.156ThrPro: 4.156 ± 0.043	1.486ThrGln: 1.486 ± 0.029	4.51ThrArg: 4.51 ± 0.034	3.537ThrSer: 3.537 ± 0.037	4.583ThrThr: 4.583 ± 0.052	6.684ThrVal: 6.684 ± 0.047	1.046ThrTrp: 1.046 ± 0.019	1.39ThrTyr: 1.39 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	12.619ValAla: 12.619 ± 0.089	0.757ValCys: 0.757 ± 0.014	6.412ValAsp: 6.412 ± 0.055	5.179ValGlu: 5.179 ± 0.043	2.686ValPhe: 2.686 ± 0.034	7.547ValGly: 7.547 ± 0.059	2.04ValHis: 2.04 ± 0.03	2.922ValIle: 2.922 ± 0.035	1.421ValLys: 1.421 ± 0.026	10.517ValLeu: 10.517 ± 0.076	1.419ValMet: 1.419 ± 0.022	1.98ValAsn: 1.98 ± 0.025	5.508ValPro: 5.508 ± 0.051	1.921ValGln: 1.921 ± 0.025	7.428ValArg: 7.428 ± 0.053	4.934ValSer: 4.934 ± 0.044	6.568ValThr: 6.568 ± 0.05	9.996ValVal: 9.996 ± 0.071	1.231ValTrp: 1.231 ± 0.022	1.572ValTyr: 1.572 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.574TrpAla: 1.574 ± 0.025	0.168TrpCys: 0.168 ± 0.008	0.841TrpAsp: 0.841 ± 0.018	0.643TrpGlu: 0.643 ± 0.016	0.518TrpPhe: 0.518 ± 0.013	1.039TrpGly: 1.039 ± 0.02	0.454TrpHis: 0.454 ± 0.015	0.444TrpIle: 0.444 ± 0.01	0.232TrpLys: 0.232 ± 0.01	2.002TrpLeu: 2.002 ± 0.028	0.262TrpMet: 0.262 ± 0.009	0.366TrpAsn: 0.366 ± 0.012	0.908TrpPro: 0.908 ± 0.018	0.683TrpGln: 0.683 ± 0.015	1.501TrpArg: 1.501 ± 0.022	1.009TrpSer: 1.009 ± 0.02	1.102TrpThr: 1.102 ± 0.02	1.173TrpVal: 1.173 ± 0.019	0.354TrpTrp: 0.354 ± 0.01	0.343TrpTyr: 0.343 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.372TyrAla: 2.372 ± 0.029	0.178TyrCys: 0.178 ± 0.007	1.397TyrAsp: 1.397 ± 0.031	1.048TyrGlu: 1.048 ± 0.019	0.652TyrPhe: 0.652 ± 0.015	1.959TyrGly: 1.959 ± 0.025	0.473TyrHis: 0.473 ± 0.012	0.4TyrIle: 0.4 ± 0.013	0.293TyrLys: 0.293 ± 0.011	2.303TyrLeu: 2.303 ± 0.034	0.211TyrMet: 0.211 ± 0.008	0.427TyrAsn: 0.427 ± 0.014	1.172TyrPro: 1.172 ± 0.02	0.642TyrGln: 0.642 ± 0.017	1.902TyrArg: 1.902 ± 0.026	0.997TyrSer: 0.997 ± 0.02	1.219TyrThr: 1.219 ± 0.021	1.802TyrVal: 1.802 ± 0.026	0.379TyrTrp: 0.379 ± 0.01	0.475TyrTyr: 0.475 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9429 proteins (3264173 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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