Amino acid dipepetide frequency for Vibrio phage 11895-B1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.512AlaAla: 3.512 ± 0.573
0.751AlaCys: 0.751 ± 0.166
2.44AlaAsp: 2.44 ± 0.239
3.405AlaGlu: 3.405 ± 0.303
1.823AlaPhe: 1.823 ± 0.211
2.681AlaGly: 2.681 ± 0.34
0.992AlaHis: 0.992 ± 0.148
3.003AlaIle: 3.003 ± 0.342
4.048AlaLys: 4.048 ± 0.336
3.941AlaLeu: 3.941 ± 0.367
0.965AlaMet: 0.965 ± 0.154
2.547AlaAsn: 2.547 ± 0.288
1.233AlaPro: 1.233 ± 0.202
1.582AlaGln: 1.582 ± 0.222
1.957AlaArg: 1.957 ± 0.277
3.19AlaSer: 3.19 ± 0.323
2.761AlaThr: 2.761 ± 0.316
3.217AlaVal: 3.217 ± 0.273
0.59AlaTrp: 0.59 ± 0.115
2.252AlaTyr: 2.252 ± 0.223
0.0AlaXaa: 0.0 ± 0.0
Cys
0.617CysAla: 0.617 ± 0.147
0.375CysCys: 0.375 ± 0.107
1.153CysAsp: 1.153 ± 0.162
1.367CysGlu: 1.367 ± 0.18
0.751CysPhe: 0.751 ± 0.159
1.153CysGly: 1.153 ± 0.172
0.375CysHis: 0.375 ± 0.105
1.126CysIle: 1.126 ± 0.218
1.555CysLys: 1.555 ± 0.213
1.206CysLeu: 1.206 ± 0.173
0.456CysMet: 0.456 ± 0.112
1.287CysAsn: 1.287 ± 0.209
0.509CysPro: 0.509 ± 0.104
0.777CysGln: 0.777 ± 0.127
0.992CysArg: 0.992 ± 0.183
1.474CysSer: 1.474 ± 0.299
0.885CysThr: 0.885 ± 0.148
1.072CysVal: 1.072 ± 0.17
0.295CysTrp: 0.295 ± 0.118
0.804CysTyr: 0.804 ± 0.141
0.0CysXaa: 0.0 ± 0.0
Asp
3.163AspAla: 3.163 ± 0.326
0.911AspCys: 0.911 ± 0.149
3.592AspAsp: 3.592 ± 0.418
5.094AspGlu: 5.094 ± 0.427
3.137AspPhe: 3.137 ± 0.271
4.289AspGly: 4.289 ± 0.324
1.153AspHis: 1.153 ± 0.169
5.335AspIle: 5.335 ± 0.36
6.193AspLys: 6.193 ± 0.371
5.522AspLeu: 5.522 ± 0.402
2.306AspMet: 2.306 ± 0.255
4.155AspAsn: 4.155 ± 0.338
1.823AspPro: 1.823 ± 0.266
2.198AspGln: 2.198 ± 0.251
2.359AspArg: 2.359 ± 0.249
4.45AspSer: 4.45 ± 0.319
4.048AspThr: 4.048 ± 0.329
4.316AspVal: 4.316 ± 0.351
1.421AspTrp: 1.421 ± 0.239
3.485AspTyr: 3.485 ± 0.301
0.0AspXaa: 0.0 ± 0.0
Glu
3.834GluAla: 3.834 ± 0.259
1.528GluCys: 1.528 ± 0.24
6.407GluAsp: 6.407 ± 0.45
7.051GluGlu: 7.051 ± 0.453
2.815GluPhe: 2.815 ± 0.263
4.557GluGly: 4.557 ± 0.338
1.582GluHis: 1.582 ± 0.206
5.281GluIle: 5.281 ± 0.458
4.209GluLys: 4.209 ± 0.366
6.488GluLeu: 6.488 ± 0.454
2.252GluMet: 2.252 ± 0.209
3.968GluAsn: 3.968 ± 0.346
1.153GluPro: 1.153 ± 0.17
2.815GluGln: 2.815 ± 0.231
2.493GluArg: 2.493 ± 0.268
4.236GluSer: 4.236 ± 0.306
3.86GluThr: 3.86 ± 0.32
5.925GluVal: 5.925 ± 0.557
1.608GluTrp: 1.608 ± 0.198
3.565GluTyr: 3.565 ± 0.316
0.0GluXaa: 0.0 ± 0.0
Phe
1.796PheAla: 1.796 ± 0.224
0.804PheCys: 0.804 ± 0.155
2.976PheAsp: 2.976 ± 0.292
2.868PheGlu: 2.868 ± 0.253
1.26PhePhe: 1.26 ± 0.173
2.493PheGly: 2.493 ± 0.247
0.831PheHis: 0.831 ± 0.125
2.842PheIle: 2.842 ± 0.271
3.217PheLys: 3.217 ± 0.248
2.922PheLeu: 2.922 ± 0.285
1.287PheMet: 1.287 ± 0.192
2.788PheAsn: 2.788 ± 0.293
1.528PhePro: 1.528 ± 0.207
1.072PheGln: 1.072 ± 0.153
1.206PheArg: 1.206 ± 0.153
2.949PheSer: 2.949 ± 0.267
3.297PheThr: 3.297 ± 0.364
2.574PheVal: 2.574 ± 0.247
0.643PheTrp: 0.643 ± 0.133
2.171PheTyr: 2.171 ± 0.215
0.0PheXaa: 0.0 ± 0.0
Gly
2.198GlyAla: 2.198 ± 0.292
1.394GlyCys: 1.394 ± 0.199
3.458GlyAsp: 3.458 ± 0.299
4.102GlyGlu: 4.102 ± 0.339
2.815GlyPhe: 2.815 ± 0.301
3.244GlyGly: 3.244 ± 0.31
0.965GlyHis: 0.965 ± 0.181
3.753GlyIle: 3.753 ± 0.288
6.032GlyLys: 6.032 ± 0.431
4.182GlyLeu: 4.182 ± 0.307
1.34GlyMet: 1.34 ± 0.167
3.378GlyAsn: 3.378 ± 0.27
0.027GlyPro: 0.027 ± 0.023
1.608GlyGln: 1.608 ± 0.218
2.708GlyArg: 2.708 ± 0.262
4.236GlySer: 4.236 ± 0.352
3.163GlyThr: 3.163 ± 0.324
5.603GlyVal: 5.603 ± 0.377
1.287GlyTrp: 1.287 ± 0.197
3.163GlyTyr: 3.163 ± 0.262
0.0GlyXaa: 0.0 ± 0.0
His
0.643HisAla: 0.643 ± 0.139
0.349HisCys: 0.349 ± 0.105
1.18HisAsp: 1.18 ± 0.208
1.421HisGlu: 1.421 ± 0.17
0.804HisPhe: 0.804 ± 0.141
1.099HisGly: 1.099 ± 0.159
0.697HisHis: 0.697 ± 0.155
1.26HisIle: 1.26 ± 0.179
1.474HisLys: 1.474 ± 0.227
1.689HisLeu: 1.689 ± 0.224
0.483HisMet: 0.483 ± 0.118
1.528HisAsn: 1.528 ± 0.202
0.911HisPro: 0.911 ± 0.145
0.402HisGln: 0.402 ± 0.106
0.804HisArg: 0.804 ± 0.14
1.18HisSer: 1.18 ± 0.178
1.367HisThr: 1.367 ± 0.165
1.072HisVal: 1.072 ± 0.145
0.375HisTrp: 0.375 ± 0.083
1.046HisTyr: 1.046 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
3.056IleAla: 3.056 ± 0.281
0.885IleCys: 0.885 ± 0.166
5.013IleAsp: 5.013 ± 0.3
5.12IleGlu: 5.12 ± 0.353
2.547IlePhe: 2.547 ± 0.257
3.539IleGly: 3.539 ± 0.31
0.992IleHis: 0.992 ± 0.176
3.592IleIle: 3.592 ± 0.256
6.005IleLys: 6.005 ± 0.509
5.147IleLeu: 5.147 ± 0.366
1.314IleMet: 1.314 ± 0.161
3.914IleAsn: 3.914 ± 0.356
2.734IlePro: 2.734 ± 0.299
1.877IleGln: 1.877 ± 0.205
2.359IleArg: 2.359 ± 0.255
4.236IleSer: 4.236 ± 0.318
4.316IleThr: 4.316 ± 0.39
3.941IleVal: 3.941 ± 0.304
0.804IleTrp: 0.804 ± 0.137
2.252IleTyr: 2.252 ± 0.252
0.0IleXaa: 0.0 ± 0.0
Lys
4.182LysAla: 4.182 ± 0.335
1.153LysCys: 1.153 ± 0.21
5.978LysAsp: 5.978 ± 0.443
6.434LysGlu: 6.434 ± 0.564
3.378LysPhe: 3.378 ± 0.283
5.496LysGly: 5.496 ± 0.342
2.171LysHis: 2.171 ± 0.255
5.281LysIle: 5.281 ± 0.328
5.04LysLys: 5.04 ± 0.416
7.185LysLeu: 7.185 ± 0.449
2.413LysMet: 2.413 ± 0.267
3.458LysAsn: 3.458 ± 0.304
2.466LysPro: 2.466 ± 0.226
3.485LysGln: 3.485 ± 0.368
3.807LysArg: 3.807 ± 0.308
5.228LysSer: 5.228 ± 0.372
4.075LysThr: 4.075 ± 0.295
6.085LysVal: 6.085 ± 0.471
1.233LysTrp: 1.233 ± 0.185
3.834LysTyr: 3.834 ± 0.318
0.0LysXaa: 0.0 ± 0.0
Leu
4.128LeuAla: 4.128 ± 0.334
1.555LeuCys: 1.555 ± 0.216
6.005LeuAsp: 6.005 ± 0.356
6.488LeuGlu: 6.488 ± 0.426
3.003LeuPhe: 3.003 ± 0.255
4.477LeuGly: 4.477 ± 0.378
1.528LeuHis: 1.528 ± 0.185
4.397LeuIle: 4.397 ± 0.414
6.407LeuLys: 6.407 ± 0.406
5.978LeuLeu: 5.978 ± 0.436
1.93LeuMet: 1.93 ± 0.2
4.504LeuAsn: 4.504 ± 0.343
3.351LeuPro: 3.351 ± 0.28
3.378LeuGln: 3.378 ± 0.314
4.155LeuArg: 4.155 ± 0.33
6.327LeuSer: 6.327 ± 0.39
5.12LeuThr: 5.12 ± 0.424
4.665LeuVal: 4.665 ± 0.353
0.965LeuTrp: 0.965 ± 0.168
3.324LeuTyr: 3.324 ± 0.283
0.0LeuXaa: 0.0 ± 0.0
Met
1.582MetAla: 1.582 ± 0.213
0.59MetCys: 0.59 ± 0.144
1.34MetAsp: 1.34 ± 0.189
1.823MetGlu: 1.823 ± 0.199
1.233MetPhe: 1.233 ± 0.215
0.885MetGly: 0.885 ± 0.156
0.375MetHis: 0.375 ± 0.11
1.662MetIle: 1.662 ± 0.21
2.332MetLys: 2.332 ± 0.26
2.171MetLeu: 2.171 ± 0.252
0.59MetMet: 0.59 ± 0.107
1.528MetAsn: 1.528 ± 0.208
0.563MetPro: 0.563 ± 0.129
1.153MetGln: 1.153 ± 0.177
0.777MetArg: 0.777 ± 0.128
2.145MetSer: 2.145 ± 0.249
1.528MetThr: 1.528 ± 0.176
1.421MetVal: 1.421 ± 0.198
0.509MetTrp: 0.509 ± 0.145
1.126MetTyr: 1.126 ± 0.177
0.0MetXaa: 0.0 ± 0.0
Asn
1.582AsnAla: 1.582 ± 0.221
0.831AsnCys: 0.831 ± 0.135
3.405AsnAsp: 3.405 ± 0.293
2.922AsnGlu: 2.922 ± 0.287
2.574AsnPhe: 2.574 ± 0.261
4.102AsnGly: 4.102 ± 0.322
1.099AsnHis: 1.099 ± 0.162
3.914AsnIle: 3.914 ± 0.312
5.791AsnLys: 5.791 ± 0.474
4.772AsnLeu: 4.772 ± 0.364
1.394AsnMet: 1.394 ± 0.175
3.968AsnAsn: 3.968 ± 0.383
2.091AsnPro: 2.091 ± 0.227
1.689AsnGln: 1.689 ± 0.196
2.359AsnArg: 2.359 ± 0.266
3.271AsnSer: 3.271 ± 0.319
4.128AsnThr: 4.128 ± 0.319
3.137AsnVal: 3.137 ± 0.29
0.724AsnTrp: 0.724 ± 0.129
2.332AsnTyr: 2.332 ± 0.202
0.0AsnXaa: 0.0 ± 0.0
Pro
1.421ProAla: 1.421 ± 0.2
0.59ProCys: 0.59 ± 0.124
2.574ProAsp: 2.574 ± 0.268
2.976ProGlu: 2.976 ± 0.319
1.367ProPhe: 1.367 ± 0.178
0.054ProGly: 0.054 ± 0.038
0.509ProHis: 0.509 ± 0.119
1.769ProIle: 1.769 ± 0.203
2.145ProLys: 2.145 ± 0.255
2.011ProLeu: 2.011 ± 0.223
0.804ProMet: 0.804 ± 0.132
1.608ProAsn: 1.608 ± 0.217
0.831ProPro: 0.831 ± 0.153
1.019ProGln: 1.019 ± 0.168
1.153ProArg: 1.153 ± 0.184
2.198ProSer: 2.198 ± 0.228
1.957ProThr: 1.957 ± 0.225
2.037ProVal: 2.037 ± 0.223
0.67ProTrp: 0.67 ± 0.157
1.474ProTyr: 1.474 ± 0.195
0.0ProXaa: 0.0 ± 0.0
Gln
1.984GlnAla: 1.984 ± 0.289
0.563GlnCys: 0.563 ± 0.112
2.145GlnAsp: 2.145 ± 0.243
2.681GlnGlu: 2.681 ± 0.241
1.448GlnPhe: 1.448 ± 0.215
2.037GlnGly: 2.037 ± 0.199
0.831GlnHis: 0.831 ± 0.175
1.903GlnIle: 1.903 ± 0.21
2.466GlnLys: 2.466 ± 0.263
2.842GlnLeu: 2.842 ± 0.325
0.751GlnMet: 0.751 ± 0.146
1.635GlnAsn: 1.635 ± 0.205
1.099GlnPro: 1.099 ± 0.156
1.582GlnGln: 1.582 ± 0.245
1.796GlnArg: 1.796 ± 0.225
2.064GlnSer: 2.064 ± 0.213
1.608GlnThr: 1.608 ± 0.214
2.279GlnVal: 2.279 ± 0.235
0.59GlnTrp: 0.59 ± 0.132
1.582GlnTyr: 1.582 ± 0.189
0.0GlnXaa: 0.0 ± 0.0
Arg
1.716ArgAla: 1.716 ± 0.231
1.233ArgCys: 1.233 ± 0.187
2.922ArgAsp: 2.922 ± 0.255
2.734ArgGlu: 2.734 ± 0.225
2.118ArgPhe: 2.118 ± 0.233
2.574ArgGly: 2.574 ± 0.256
0.724ArgHis: 0.724 ± 0.123
2.413ArgIle: 2.413 ± 0.243
3.592ArgLys: 3.592 ± 0.32
3.592ArgLeu: 3.592 ± 0.3
0.992ArgMet: 0.992 ± 0.16
2.145ArgAsn: 2.145 ± 0.254
0.804ArgPro: 0.804 ± 0.154
1.582ArgGln: 1.582 ± 0.175
1.716ArgArg: 1.716 ± 0.195
2.52ArgSer: 2.52 ± 0.275
2.037ArgThr: 2.037 ± 0.235
2.949ArgVal: 2.949 ± 0.263
0.563ArgTrp: 0.563 ± 0.118
1.984ArgTyr: 1.984 ± 0.264
0.0ArgXaa: 0.0 ± 0.0
Ser
2.761SerAla: 2.761 ± 0.365
1.233SerCys: 1.233 ± 0.201
4.852SerAsp: 4.852 ± 0.359
4.933SerGlu: 4.933 ± 0.401
2.842SerPhe: 2.842 ± 0.279
5.174SerGly: 5.174 ± 0.383
1.34SerHis: 1.34 ± 0.177
4.37SerIle: 4.37 ± 0.323
5.871SerLys: 5.871 ± 0.422
5.12SerLeu: 5.12 ± 0.401
1.474SerMet: 1.474 ± 0.187
3.271SerAsn: 3.271 ± 0.313
2.198SerPro: 2.198 ± 0.264
2.011SerGln: 2.011 ± 0.217
2.547SerArg: 2.547 ± 0.277
4.209SerSer: 4.209 ± 0.393
3.619SerThr: 3.619 ± 0.335
4.397SerVal: 4.397 ± 0.332
1.046SerTrp: 1.046 ± 0.159
3.271SerTyr: 3.271 ± 0.251
0.0SerXaa: 0.0 ± 0.0
Thr
3.083ThrAla: 3.083 ± 0.307
0.965ThrCys: 0.965 ± 0.16
3.083ThrAsp: 3.083 ± 0.327
3.941ThrGlu: 3.941 ± 0.374
2.681ThrPhe: 2.681 ± 0.268
3.592ThrGly: 3.592 ± 0.292
1.099ThrHis: 1.099 ± 0.148
4.075ThrIle: 4.075 ± 0.394
4.718ThrLys: 4.718 ± 0.408
5.576ThrLeu: 5.576 ± 0.354
1.18ThrMet: 1.18 ± 0.176
2.922ThrAsn: 2.922 ± 0.271
2.386ThrPro: 2.386 ± 0.24
2.198ThrGln: 2.198 ± 0.267
2.118ThrArg: 2.118 ± 0.224
4.397ThrSer: 4.397 ± 0.36
3.968ThrThr: 3.968 ± 0.468
3.565ThrVal: 3.565 ± 0.39
0.911ThrTrp: 0.911 ± 0.147
3.19ThrTyr: 3.19 ± 0.278
0.0ThrXaa: 0.0 ± 0.0
Val
3.217ValAla: 3.217 ± 0.342
1.233ValCys: 1.233 ± 0.146
5.415ValAsp: 5.415 ± 0.352
5.254ValGlu: 5.254 ± 0.371
2.734ValPhe: 2.734 ± 0.267
3.673ValGly: 3.673 ± 0.303
1.019ValHis: 1.019 ± 0.174
3.914ValIle: 3.914 ± 0.302
6.193ValLys: 6.193 ± 0.402
5.469ValLeu: 5.469 ± 0.463
1.689ValMet: 1.689 ± 0.181
3.458ValAsn: 3.458 ± 0.305
1.796ValPro: 1.796 ± 0.219
1.823ValGln: 1.823 ± 0.196
3.056ValArg: 3.056 ± 0.259
4.343ValSer: 4.343 ± 0.325
4.289ValThr: 4.289 ± 0.385
5.067ValVal: 5.067 ± 0.408
1.072ValTrp: 1.072 ± 0.145
2.895ValTyr: 2.895 ± 0.317
0.0ValXaa: 0.0 ± 0.0
Trp
0.831TrpAla: 0.831 ± 0.154
0.375TrpCys: 0.375 ± 0.105
1.367TrpAsp: 1.367 ± 0.185
1.394TrpGlu: 1.394 ± 0.216
0.536TrpPhe: 0.536 ± 0.108
0.697TrpGly: 0.697 ± 0.123
0.241TrpHis: 0.241 ± 0.082
1.046TrpIle: 1.046 ± 0.172
1.689TrpLys: 1.689 ± 0.207
1.608TrpLeu: 1.608 ± 0.238
0.429TrpMet: 0.429 ± 0.121
1.046TrpAsn: 1.046 ± 0.182
0.08TrpPro: 0.08 ± 0.05
0.429TrpGln: 0.429 ± 0.099
0.483TrpArg: 0.483 ± 0.109
1.019TrpSer: 1.019 ± 0.194
0.724TrpThr: 0.724 ± 0.148
1.689TrpVal: 1.689 ± 0.215
0.322TrpTrp: 0.322 ± 0.086
0.59TrpTyr: 0.59 ± 0.116
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.582TyrAla: 1.582 ± 0.188
0.911TyrCys: 0.911 ± 0.165
3.646TyrAsp: 3.646 ± 0.26
3.619TyrGlu: 3.619 ± 0.382
1.662TyrPhe: 1.662 ± 0.188
2.842TyrGly: 2.842 ± 0.285
1.26TyrHis: 1.26 ± 0.196
2.708TyrIle: 2.708 ± 0.265
3.405TyrLys: 3.405 ± 0.336
4.263TyrLeu: 4.263 ± 0.353
1.26TyrMet: 1.26 ± 0.185
2.976TyrAsn: 2.976 ± 0.263
1.582TyrPro: 1.582 ± 0.167
1.206TyrGln: 1.206 ± 0.166
2.064TyrArg: 2.064 ± 0.251
2.868TyrSer: 2.868 ± 0.269
2.895TyrThr: 2.895 ± 0.313
2.6TyrVal: 2.6 ± 0.268
0.992TyrTrp: 0.992 ± 0.159
2.52TyrTyr: 2.52 ± 0.227
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 196 proteins (37303 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski