Amino acid dipepetide frequency for Propionibacterium australiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.621AlaAla: 17.621 ± 0.21	1.267AlaCys: 1.267 ± 0.041	7.695AlaAsp: 7.695 ± 0.099	8.109AlaGlu: 8.109 ± 0.116	3.162AlaPhe: 3.162 ± 0.059	12.663AlaGly: 12.663 ± 0.168	2.357AlaHis: 2.357 ± 0.053	5.158AlaIle: 5.158 ± 0.089	2.391AlaLys: 2.391 ± 0.057	12.86AlaLeu: 12.86 ± 0.151	3.149AlaMet: 3.149 ± 0.067	2.316AlaAsn: 2.316 ± 0.049	5.622AlaPro: 5.622 ± 0.115	4.211AlaGln: 4.211 ± 0.082	9.526AlaArg: 9.526 ± 0.139	6.573AlaSer: 6.573 ± 0.09	6.514AlaThr: 6.514 ± 0.088	10.221AlaVal: 10.221 ± 0.122	1.868AlaTrp: 1.868 ± 0.053	2.245AlaTyr: 2.245 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	1.169CysAla: 1.169 ± 0.043	0.138CysCys: 0.138 ± 0.012	0.529CysAsp: 0.529 ± 0.028	0.554CysGlu: 0.554 ± 0.026	0.347CysPhe: 0.347 ± 0.018	1.073CysGly: 1.073 ± 0.036	0.251CysHis: 0.251 ± 0.02	0.344CysIle: 0.344 ± 0.024	0.129CysLys: 0.129 ± 0.013	0.913CysLeu: 0.913 ± 0.036	0.186CysMet: 0.186 ± 0.013	0.151CysAsn: 0.151 ± 0.015	0.569CysPro: 0.569 ± 0.031	0.284CysGln: 0.284 ± 0.019	0.709CysArg: 0.709 ± 0.03	0.605CysSer: 0.605 ± 0.025	0.658CysThr: 0.658 ± 0.031	0.682CysVal: 0.682 ± 0.026	0.212CysTrp: 0.212 ± 0.016	0.259CysTyr: 0.259 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	7.333AspAla: 7.333 ± 0.111	0.484AspCys: 0.484 ± 0.022	3.872AspAsp: 3.872 ± 0.081	5.338AspGlu: 5.338 ± 0.084	1.668AspPhe: 1.668 ± 0.048	5.673AspGly: 5.673 ± 0.101	1.251AspHis: 1.251 ± 0.038	2.256AspIle: 2.256 ± 0.06	1.232AspLys: 1.232 ± 0.041	5.794AspLeu: 5.794 ± 0.095	1.181AspMet: 1.181 ± 0.036	1.135AspAsn: 1.135 ± 0.034	4.309AspPro: 4.309 ± 0.092	2.001AspGln: 2.001 ± 0.053	4.447AspArg: 4.447 ± 0.077	2.705AspSer: 2.705 ± 0.053	3.059AspThr: 3.059 ± 0.067	4.864AspVal: 4.864 ± 0.083	0.942AspTrp: 0.942 ± 0.041	1.447AspTyr: 1.447 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.045GluAla: 7.045 ± 0.102	0.42GluCys: 0.42 ± 0.024	2.97GluAsp: 2.97 ± 0.074	2.974GluGlu: 2.974 ± 0.064	1.625GluPhe: 1.625 ± 0.042	3.875GluGly: 3.875 ± 0.065	1.608GluHis: 1.608 ± 0.042	2.646GluIle: 2.646 ± 0.062	1.466GluLys: 1.466 ± 0.048	7.135GluLeu: 7.135 ± 0.103	1.259GluMet: 1.259 ± 0.04	1.389GluAsn: 1.389 ± 0.043	3.544GluPro: 3.544 ± 0.079	2.93GluGln: 2.93 ± 0.063	4.848GluArg: 4.848 ± 0.091	2.762GluSer: 2.762 ± 0.062	2.89GluThr: 2.89 ± 0.059	4.12GluVal: 4.12 ± 0.078	0.754GluTrp: 0.754 ± 0.032	1.261GluTyr: 1.261 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.381PheAla: 3.381 ± 0.067	0.366PheCys: 0.366 ± 0.023	2.113PheAsp: 2.113 ± 0.05	1.524PheGlu: 1.524 ± 0.042	0.996PhePhe: 0.996 ± 0.044	3.081PheGly: 3.081 ± 0.063	0.567PheHis: 0.567 ± 0.027	1.223PheIle: 1.223 ± 0.047	0.605PheLys: 0.605 ± 0.03	2.499PheLeu: 2.499 ± 0.058	0.575PheMet: 0.575 ± 0.03	0.705PheAsn: 0.705 ± 0.028	1.291PhePro: 1.291 ± 0.043	0.693PheGln: 0.693 ± 0.031	1.487PheArg: 1.487 ± 0.038	1.732PheSer: 1.732 ± 0.043	2.074PheThr: 2.074 ± 0.053	2.441PheVal: 2.441 ± 0.061	0.444PheTrp: 0.444 ± 0.023	0.621PheTyr: 0.621 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.574GlyAla: 10.574 ± 0.138	1.014GlyCys: 1.014 ± 0.034	4.816GlyAsp: 4.816 ± 0.076	5.044GlyGlu: 5.044 ± 0.088	3.084GlyPhe: 3.084 ± 0.063	7.388GlyGly: 7.388 ± 0.124	2.051GlyHis: 2.051 ± 0.051	4.173GlyIle: 4.173 ± 0.078	2.061GlyLys: 2.061 ± 0.06	9.634GlyLeu: 9.634 ± 0.124	2.285GlyMet: 2.285 ± 0.056	1.851GlyAsn: 1.851 ± 0.05	4.293GlyPro: 4.293 ± 0.068	3.188GlyGln: 3.188 ± 0.067	7.459GlyArg: 7.459 ± 0.126	5.467GlySer: 5.467 ± 0.073	5.576GlyThr: 5.576 ± 0.084	7.365GlyVal: 7.365 ± 0.099	1.774GlyTrp: 1.774 ± 0.049	2.343GlyTyr: 2.343 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.249HisAla: 2.249 ± 0.053	0.214HisCys: 0.214 ± 0.015	1.483HisAsp: 1.483 ± 0.041	1.374HisGlu: 1.374 ± 0.041	0.528HisPhe: 0.528 ± 0.027	2.045HisGly: 2.045 ± 0.055	0.612HisHis: 0.612 ± 0.028	0.768HisIle: 0.768 ± 0.03	0.323HisLys: 0.323 ± 0.02	2.113HisLeu: 2.113 ± 0.051	0.414HisMet: 0.414 ± 0.021	0.457HisAsn: 0.457 ± 0.023	1.455HisPro: 1.455 ± 0.036	0.621HisGln: 0.621 ± 0.028	1.797HisArg: 1.797 ± 0.047	0.99HisSer: 0.99 ± 0.04	1.013HisThr: 1.013 ± 0.042	1.788HisVal: 1.788 ± 0.051	0.337HisTrp: 0.337 ± 0.019	0.478HisTyr: 0.478 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.175IleAla: 6.175 ± 0.1	0.561IleCys: 0.561 ± 0.03	3.338IleAsp: 3.338 ± 0.066	2.79IleGlu: 2.79 ± 0.064	1.07IlePhe: 1.07 ± 0.045	4.957IleGly: 4.957 ± 0.09	0.747IleHis: 0.747 ± 0.033	2.133IleIle: 2.133 ± 0.067	0.879IleLys: 0.879 ± 0.036	3.372IleLeu: 3.372 ± 0.071	0.873IleMet: 0.873 ± 0.035	1.137IleAsn: 1.137 ± 0.036	2.081IlePro: 2.081 ± 0.053	0.925IleGln: 0.925 ± 0.033	2.588IleArg: 2.588 ± 0.06	2.501IleSer: 2.501 ± 0.062	3.116IleThr: 3.116 ± 0.062	4.179IleVal: 4.179 ± 0.088	0.502IleTrp: 0.502 ± 0.024	0.754IleTyr: 0.754 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.645LysAla: 2.645 ± 0.068	0.112LysCys: 0.112 ± 0.012	1.287LysAsp: 1.287 ± 0.04	1.029LysGlu: 1.029 ± 0.041	0.466LysPhe: 0.466 ± 0.023	1.659LysGly: 1.659 ± 0.047	0.428LysHis: 0.428 ± 0.026	1.046LysIle: 1.046 ± 0.037	0.96LysLys: 0.96 ± 0.045	1.722LysLeu: 1.722 ± 0.047	0.433LysMet: 0.433 ± 0.024	0.656LysAsn: 0.656 ± 0.029	1.189LysPro: 1.189 ± 0.041	0.812LysGln: 0.812 ± 0.032	1.371LysArg: 1.371 ± 0.043	1.061LysSer: 1.061 ± 0.04	1.338LysThr: 1.338 ± 0.038	1.625LysVal: 1.625 ± 0.045	0.218LysTrp: 0.218 ± 0.016	0.484LysTyr: 0.484 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.993LeuAla: 13.993 ± 0.149	1.006LeuCys: 1.006 ± 0.034	6.876LeuAsp: 6.876 ± 0.103	4.567LeuGlu: 4.567 ± 0.084	2.632LeuPhe: 2.632 ± 0.063	9.361LeuGly: 9.361 ± 0.11	1.965LeuHis: 1.965 ± 0.049	4.212LeuIle: 4.212 ± 0.086	1.778LeuLys: 1.778 ± 0.055	9.717LeuLeu: 9.717 ± 0.175	2.124LeuMet: 2.124 ± 0.056	1.981LeuAsn: 1.981 ± 0.042	5.232LeuPro: 5.232 ± 0.073	2.103LeuGln: 2.103 ± 0.05	7.121LeuArg: 7.121 ± 0.104	5.915LeuSer: 5.915 ± 0.101	6.412LeuThr: 6.412 ± 0.095	9.375LeuVal: 9.375 ± 0.128	1.092LeuTrp: 1.092 ± 0.037	1.746LeuTyr: 1.746 ± 0.049	0.001LeuXaa: 0.001 ± 0.001
Met	2.992MetAla: 2.992 ± 0.061	0.224MetCys: 0.224 ± 0.014	1.08MetAsp: 1.08 ± 0.035	0.807MetGlu: 0.807 ± 0.033	0.598MetPhe: 0.598 ± 0.028	1.839MetGly: 1.839 ± 0.055	0.372MetHis: 0.372 ± 0.021	1.175MetIle: 1.175 ± 0.044	0.53MetLys: 0.53 ± 0.025	2.146MetLeu: 2.146 ± 0.049	0.51MetMet: 0.51 ± 0.026	0.671MetAsn: 0.671 ± 0.029	1.321MetPro: 1.321 ± 0.038	0.561MetGln: 0.561 ± 0.026	1.621MetArg: 1.621 ± 0.042	1.957MetSer: 1.957 ± 0.049	1.841MetThr: 1.841 ± 0.055	1.782MetVal: 1.782 ± 0.047	0.246MetTrp: 0.246 ± 0.017	0.341MetTyr: 0.341 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.506AsnAla: 2.506 ± 0.049	0.215AsnCys: 0.215 ± 0.019	1.335AsnAsp: 1.335 ± 0.044	1.232AsnGlu: 1.232 ± 0.036	0.574AsnPhe: 0.574 ± 0.029	2.111AsnGly: 2.111 ± 0.054	0.518AsnHis: 0.518 ± 0.025	0.993AsnIle: 0.993 ± 0.038	0.538AsnLys: 0.538 ± 0.03	1.981AsnLeu: 1.981 ± 0.049	0.458AsnMet: 0.458 ± 0.027	0.557AsnAsn: 0.557 ± 0.029	1.667AsnPro: 1.667 ± 0.047	0.79AsnGln: 0.79 ± 0.036	1.511AsnArg: 1.511 ± 0.046	1.116AsnSer: 1.116 ± 0.034	1.296AsnThr: 1.296 ± 0.039	1.561AsnVal: 1.561 ± 0.042	0.328AsnTrp: 0.328 ± 0.021	0.572AsnTyr: 0.572 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.239ProAla: 7.239 ± 0.124	0.402ProCys: 0.402 ± 0.022	4.04ProAsp: 4.04 ± 0.069	3.786ProGlu: 3.786 ± 0.067	1.46ProPhe: 1.46 ± 0.04	5.856ProGly: 5.856 ± 0.099	1.112ProHis: 1.112 ± 0.039	1.867ProIle: 1.867 ± 0.05	0.992ProLys: 0.992 ± 0.038	4.534ProLeu: 4.534 ± 0.079	1.047ProMet: 1.047 ± 0.036	1.09ProAsn: 1.09 ± 0.035	2.225ProPro: 2.225 ± 0.062	1.773ProGln: 1.773 ± 0.044	3.495ProArg: 3.495 ± 0.08	3.009ProSer: 3.009 ± 0.061	3.023ProThr: 3.023 ± 0.072	4.874ProVal: 4.874 ± 0.081	0.809ProTrp: 0.809 ± 0.032	1.128ProTyr: 1.128 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.231GlnAla: 4.231 ± 0.082	0.22GlnCys: 0.22 ± 0.017	1.562GlnAsp: 1.562 ± 0.041	1.472GlnGlu: 1.472 ± 0.038	0.826GlnPhe: 0.826 ± 0.03	2.42GlnGly: 2.42 ± 0.059	0.613GlnHis: 0.613 ± 0.026	1.659GlnIle: 1.659 ± 0.051	0.621GlnLys: 0.621 ± 0.029	3.383GlnLeu: 3.383 ± 0.073	0.789GlnMet: 0.789 ± 0.031	0.729GlnAsn: 0.729 ± 0.028	1.661GlnPro: 1.661 ± 0.058	1.386GlnGln: 1.386 ± 0.058	2.454GlnArg: 2.454 ± 0.063	1.589GlnSer: 1.589 ± 0.048	1.702GlnThr: 1.702 ± 0.047	3.054GlnVal: 3.054 ± 0.057	0.508GlnTrp: 0.508 ± 0.027	0.682GlnTyr: 0.682 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.982ArgAla: 8.982 ± 0.127	0.685ArgCys: 0.685 ± 0.032	3.768ArgAsp: 3.768 ± 0.086	4.244ArgGlu: 4.244 ± 0.075	2.209ArgPhe: 2.209 ± 0.058	5.29ArgGly: 5.29 ± 0.084	1.827ArgHis: 1.827 ± 0.05	3.992ArgIle: 3.992 ± 0.07	1.509ArgLys: 1.509 ± 0.049	8.059ArgLeu: 8.059 ± 0.122	1.994ArgMet: 1.994 ± 0.046	1.492ArgAsn: 1.492 ± 0.045	4.063ArgPro: 4.063 ± 0.07	2.344ArgGln: 2.344 ± 0.051	7.051ArgArg: 7.051 ± 0.118	3.979ArgSer: 3.979 ± 0.066	4.543ArgThr: 4.543 ± 0.082	5.761ArgVal: 5.761 ± 0.089	1.225ArgTrp: 1.225 ± 0.037	1.628ArgTyr: 1.628 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.54SerAla: 6.54 ± 0.098	0.548SerCys: 0.548 ± 0.029	3.12SerAsp: 3.12 ± 0.062	2.83SerGlu: 2.83 ± 0.063	1.823SerPhe: 1.823 ± 0.052	6.168SerGly: 6.168 ± 0.089	1.132SerHis: 1.132 ± 0.035	2.397SerIle: 2.397 ± 0.061	1.007SerLys: 1.007 ± 0.035	5.112SerLeu: 5.112 ± 0.084	1.389SerMet: 1.389 ± 0.044	1.21SerAsn: 1.21 ± 0.044	3.166SerPro: 3.166 ± 0.07	1.694SerGln: 1.694 ± 0.045	4.072SerArg: 4.072 ± 0.065	3.773SerSer: 3.773 ± 0.102	3.539SerThr: 3.539 ± 0.068	4.315SerVal: 4.315 ± 0.061	1.065SerTrp: 1.065 ± 0.038	1.395SerTyr: 1.395 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	7.145ThrAla: 7.145 ± 0.103	0.514ThrCys: 0.514 ± 0.027	3.572ThrAsp: 3.572 ± 0.075	3.081ThrGlu: 3.081 ± 0.057	1.531ThrPhe: 1.531 ± 0.047	6.417ThrGly: 6.417 ± 0.106	1.164ThrHis: 1.164 ± 0.035	3.088ThrIle: 3.088 ± 0.071	1.227ThrLys: 1.227 ± 0.043	5.105ThrLeu: 5.105 ± 0.09	1.362ThrMet: 1.362 ± 0.042	1.418ThrAsn: 1.418 ± 0.038	3.624ThrPro: 3.624 ± 0.071	1.647ThrGln: 1.647 ± 0.047	4.193ThrArg: 4.193 ± 0.089	3.559ThrSer: 3.559 ± 0.064	4.057ThrThr: 4.057 ± 0.092	5.501ThrVal: 5.501 ± 0.092	0.913ThrTrp: 0.913 ± 0.039	1.125ThrTyr: 1.125 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.62ValAla: 9.62 ± 0.122	0.963ValCys: 0.963 ± 0.036	5.114ValAsp: 5.114 ± 0.078	4.845ValGlu: 4.845 ± 0.081	2.536ValPhe: 2.536 ± 0.051	6.472ValGly: 6.472 ± 0.1	1.773ValHis: 1.773 ± 0.044	4.246ValIle: 4.246 ± 0.082	1.661ValLys: 1.661 ± 0.051	9.24ValLeu: 9.24 ± 0.117	1.91ValMet: 1.91 ± 0.052	2.0ValAsn: 2.0 ± 0.048	4.604ValPro: 4.604 ± 0.074	2.215ValGln: 2.215 ± 0.054	5.931ValArg: 5.931 ± 0.079	4.986ValSer: 4.986 ± 0.072	5.589ValThr: 5.589 ± 0.092	7.743ValVal: 7.743 ± 0.106	1.093ValTrp: 1.093 ± 0.04	1.459ValTyr: 1.459 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.723TrpAla: 1.723 ± 0.048	0.189TrpCys: 0.189 ± 0.017	0.859TrpAsp: 0.859 ± 0.035	0.567TrpGlu: 0.567 ± 0.027	0.608TrpPhe: 0.608 ± 0.03	1.157TrpGly: 1.157 ± 0.036	0.334TrpHis: 0.334 ± 0.018	0.631TrpIle: 0.631 ± 0.028	0.273TrpLys: 0.273 ± 0.017	1.743TrpLeu: 1.743 ± 0.05	0.342TrpMet: 0.342 ± 0.019	0.402TrpAsn: 0.402 ± 0.025	0.738TrpPro: 0.738 ± 0.03	0.639TrpGln: 0.639 ± 0.028	1.329TrpArg: 1.329 ± 0.042	0.838TrpSer: 0.838 ± 0.036	0.872TrpThr: 0.872 ± 0.028	1.163TrpVal: 1.163 ± 0.037	0.331TrpTrp: 0.331 ± 0.023	0.285TrpTyr: 0.285 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.365TyrAla: 2.365 ± 0.05	0.219TyrCys: 0.219 ± 0.017	1.562TyrAsp: 1.562 ± 0.066	1.351TyrGlu: 1.351 ± 0.05	0.678TyrPhe: 0.678 ± 0.029	1.932TyrGly: 1.932 ± 0.05	0.38TyrHis: 0.38 ± 0.022	0.67TyrIle: 0.67 ± 0.03	0.359TyrLys: 0.359 ± 0.02	2.148TyrLeu: 2.148 ± 0.059	0.332TyrMet: 0.332 ± 0.02	0.512TyrAsn: 0.512 ± 0.026	1.104TyrPro: 1.104 ± 0.043	0.743TyrGln: 0.743 ± 0.033	1.634TyrArg: 1.634 ± 0.035	1.18TyrSer: 1.18 ± 0.042	1.135TyrThr: 1.135 ± 0.042	1.586TyrVal: 1.586 ± 0.049	0.363TyrTrp: 0.363 ± 0.021	0.495TyrTyr: 0.495 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.093XaaXaa: 0.093 ± 0.105

Statistics based on 2569 proteins (845120 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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