Amino acid dipepetide frequency for Litomosoides sigmodontis (Filarial nematode worm)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.613AlaAla: 5.613 ± 0.063	1.259AlaCys: 1.259 ± 0.019	3.291AlaAsp: 3.291 ± 0.031	4.417AlaGlu: 4.417 ± 0.037	2.6AlaPhe: 2.6 ± 0.023	3.172AlaGly: 3.172 ± 0.032	1.434AlaHis: 1.434 ± 0.019	3.986AlaIle: 3.986 ± 0.033	3.761AlaLys: 3.761 ± 0.033	6.236AlaLeu: 6.236 ± 0.044	1.6AlaMet: 1.6 ± 0.02	2.993AlaAsn: 2.993 ± 0.029	2.513AlaPro: 2.513 ± 0.031	2.508AlaGln: 2.508 ± 0.025	3.338AlaArg: 3.338 ± 0.029	5.168AlaSer: 5.168 ± 0.038	4.002AlaThr: 4.002 ± 0.037	4.965AlaVal: 4.965 ± 0.036	0.574AlaTrp: 0.574 ± 0.011	1.842AlaTyr: 1.842 ± 0.021	0.003AlaXaa: 0.003 ± 0.001
Cys	1.402CysAla: 1.402 ± 0.022	0.669CysCys: 0.669 ± 0.016	1.296CysAsp: 1.296 ± 0.022	1.349CysGlu: 1.349 ± 0.023	0.96CysPhe: 0.96 ± 0.015	1.452CysGly: 1.452 ± 0.02	0.555CysHis: 0.555 ± 0.013	1.345CysIle: 1.345 ± 0.022	1.195CysLys: 1.195 ± 0.021	1.93CysLeu: 1.93 ± 0.027	0.49CysMet: 0.49 ± 0.012	1.067CysAsn: 1.067 ± 0.018	1.033CysPro: 1.033 ± 0.023	0.807CysGln: 0.807 ± 0.017	1.339CysArg: 1.339 ± 0.023	2.045CysSer: 2.045 ± 0.027	1.16CysThr: 1.16 ± 0.02	1.318CysVal: 1.318 ± 0.021	0.252CysTrp: 0.252 ± 0.009	0.696CysTyr: 0.696 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.387AspAla: 3.387 ± 0.03	1.134AspCys: 1.134 ± 0.017	4.298AspAsp: 4.298 ± 0.051	4.842AspGlu: 4.842 ± 0.041	2.379AspPhe: 2.379 ± 0.024	3.599AspGly: 3.599 ± 0.043	1.119AspHis: 1.119 ± 0.018	3.344AspIle: 3.344 ± 0.035	2.793AspLys: 2.793 ± 0.026	4.724AspLeu: 4.724 ± 0.035	1.23AspMet: 1.23 ± 0.017	2.434AspAsn: 2.434 ± 0.028	2.059AspPro: 2.059 ± 0.025	1.757AspGln: 1.757 ± 0.021	2.916AspArg: 2.916 ± 0.028	4.193AspSer: 4.193 ± 0.035	2.384AspThr: 2.384 ± 0.025	3.666AspVal: 3.666 ± 0.027	0.638AspTrp: 0.638 ± 0.013	1.759AspTyr: 1.759 ± 0.02	0.003AspXaa: 0.003 ± 0.001
Glu	4.168GluAla: 4.168 ± 0.041	1.375GluCys: 1.375 ± 0.024	3.312GluAsp: 3.312 ± 0.036	5.615GluGlu: 5.615 ± 0.063	2.275GluPhe: 2.275 ± 0.021	2.907GluGly: 2.907 ± 0.031	1.499GluHis: 1.499 ± 0.021	4.324GluIle: 4.324 ± 0.036	5.288GluLys: 5.288 ± 0.047	6.096GluLeu: 6.096 ± 0.047	2.074GluMet: 2.074 ± 0.025	3.672GluAsn: 3.672 ± 0.036	2.076GluPro: 2.076 ± 0.026	3.144GluGln: 3.144 ± 0.031	4.383GluArg: 4.383 ± 0.041	4.599GluSer: 4.599 ± 0.04	3.4GluThr: 3.4 ± 0.031	3.802GluVal: 3.802 ± 0.029	0.769GluTrp: 0.769 ± 0.015	1.935GluTyr: 1.935 ± 0.023	0.001GluXaa: 0.001 ± 0.001
Phe	2.786PheAla: 2.786 ± 0.025	1.065PheCys: 1.065 ± 0.017	2.506PheAsp: 2.506 ± 0.023	2.495PheGlu: 2.495 ± 0.025	1.756PhePhe: 1.756 ± 0.024	2.625PheGly: 2.625 ± 0.032	1.073PheHis: 1.073 ± 0.016	2.641PheIle: 2.641 ± 0.027	1.876PheLys: 1.876 ± 0.02	3.819PheLeu: 3.819 ± 0.036	0.976PheMet: 0.976 ± 0.015	1.739PheAsn: 1.739 ± 0.02	1.759PhePro: 1.759 ± 0.02	1.39PheGln: 1.39 ± 0.016	2.242PheArg: 2.242 ± 0.024	3.262PheSer: 3.262 ± 0.03	2.256PheThr: 2.256 ± 0.022	2.753PheVal: 2.753 ± 0.03	0.512PheTrp: 0.512 ± 0.011	1.427PheTyr: 1.427 ± 0.019	0.001PheXaa: 0.001 ± 0.0
Gly	3.197GlyAla: 3.197 ± 0.034	1.148GlyCys: 1.148 ± 0.019	2.915GlyAsp: 2.915 ± 0.032	3.258GlyGlu: 3.258 ± 0.035	2.216GlyPhe: 2.216 ± 0.029	3.584GlyGly: 3.584 ± 0.055	1.278GlyHis: 1.278 ± 0.02	3.293GlyIle: 3.293 ± 0.03	3.292GlyLys: 3.292 ± 0.035	4.106GlyLeu: 4.106 ± 0.045	1.261GlyMet: 1.261 ± 0.018	2.675GlyAsn: 2.675 ± 0.029	1.896GlyPro: 1.896 ± 0.036	1.958GlyGln: 1.958 ± 0.021	3.306GlyArg: 3.306 ± 0.036	4.538GlySer: 4.538 ± 0.042	3.141GlyThr: 3.141 ± 0.03	3.091GlyVal: 3.091 ± 0.029	0.642GlyTrp: 0.642 ± 0.014	1.781GlyTyr: 1.781 ± 0.027	0.002GlyXaa: 0.002 ± 0.001
His	1.397HisAla: 1.397 ± 0.019	0.681HisCys: 0.681 ± 0.015	1.143HisAsp: 1.143 ± 0.016	1.433HisGlu: 1.433 ± 0.018	1.247HisPhe: 1.247 ± 0.017	1.294HisGly: 1.294 ± 0.018	0.789HisHis: 0.789 ± 0.021	1.493HisIle: 1.493 ± 0.017	1.13HisLys: 1.13 ± 0.016	2.451HisLeu: 2.451 ± 0.026	0.554HisMet: 0.554 ± 0.011	1.013HisAsn: 1.013 ± 0.015	1.166HisPro: 1.166 ± 0.018	0.977HisGln: 0.977 ± 0.015	1.53HisArg: 1.53 ± 0.021	2.092HisSer: 2.092 ± 0.027	1.122HisThr: 1.122 ± 0.016	1.429HisVal: 1.429 ± 0.018	0.309HisTrp: 0.309 ± 0.008	0.885HisTyr: 0.885 ± 0.016	0.001HisXaa: 0.001 ± 0.0
Ile	4.414IleAla: 4.414 ± 0.035	1.527IleCys: 1.527 ± 0.024	3.654IleAsp: 3.654 ± 0.031	3.779IleGlu: 3.779 ± 0.031	2.588IlePhe: 2.588 ± 0.031	3.273IleGly: 3.273 ± 0.028	1.451IleHis: 1.451 ± 0.02	3.749IleIle: 3.749 ± 0.036	3.106IleLys: 3.106 ± 0.028	5.309IleLeu: 5.309 ± 0.047	1.321IleMet: 1.321 ± 0.015	2.839IleAsn: 2.839 ± 0.027	2.883IlePro: 2.883 ± 0.03	2.112IleGln: 2.112 ± 0.024	3.583IleArg: 3.583 ± 0.032	5.381IleSer: 5.381 ± 0.042	3.464IleThr: 3.464 ± 0.03	3.81IleVal: 3.81 ± 0.033	0.675IleTrp: 0.675 ± 0.013	1.905IleTyr: 1.905 ± 0.023	0.001IleXaa: 0.001 ± 0.0
Lys	3.567LysAla: 3.567 ± 0.033	1.408LysCys: 1.408 ± 0.025	2.884LysAsp: 2.884 ± 0.032	4.343LysGlu: 4.343 ± 0.042	2.266LysPhe: 2.266 ± 0.024	2.643LysGly: 2.643 ± 0.033	1.51LysHis: 1.51 ± 0.02	3.747LysIle: 3.747 ± 0.033	4.795LysLys: 4.795 ± 0.051	5.802LysLeu: 5.802 ± 0.041	1.698LysMet: 1.698 ± 0.021	2.991LysAsn: 2.991 ± 0.03	2.266LysPro: 2.266 ± 0.029	2.77LysGln: 2.77 ± 0.028	4.134LysArg: 4.134 ± 0.036	4.346LysSer: 4.346 ± 0.034	3.075LysThr: 3.075 ± 0.031	3.237LysVal: 3.237 ± 0.03	0.726LysTrp: 0.726 ± 0.013	2.0LysTyr: 2.0 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	5.908LeuAla: 5.908 ± 0.046	2.103LeuCys: 2.103 ± 0.023	4.605LeuAsp: 4.605 ± 0.039	5.771LeuGlu: 5.771 ± 0.048	3.853LeuPhe: 3.853 ± 0.035	3.834LeuGly: 3.834 ± 0.034	2.499LeuHis: 2.499 ± 0.029	5.472LeuIle: 5.472 ± 0.047	5.949LeuLys: 5.949 ± 0.045	9.797LeuLeu: 9.797 ± 0.076	2.295LeuMet: 2.295 ± 0.024	4.418LeuAsn: 4.418 ± 0.038	4.629LeuPro: 4.629 ± 0.043	4.254LeuGln: 4.254 ± 0.036	5.816LeuArg: 5.816 ± 0.04	7.847LeuSer: 7.847 ± 0.052	4.915LeuThr: 4.915 ± 0.036	4.87LeuVal: 4.87 ± 0.037	0.999LeuTrp: 0.999 ± 0.016	2.768LeuTyr: 2.768 ± 0.027	0.002LeuXaa: 0.002 ± 0.001
Met	1.572MetAla: 1.572 ± 0.02	0.487MetCys: 0.487 ± 0.012	1.419MetAsp: 1.419 ± 0.019	1.839MetGlu: 1.839 ± 0.023	0.894MetPhe: 0.894 ± 0.016	1.09MetGly: 1.09 ± 0.017	0.638MetHis: 0.638 ± 0.013	1.441MetIle: 1.441 ± 0.018	1.831MetLys: 1.831 ± 0.022	2.362MetLeu: 2.362 ± 0.028	0.705MetMet: 0.705 ± 0.015	1.316MetAsn: 1.316 ± 0.017	1.052MetPro: 1.052 ± 0.015	1.215MetGln: 1.215 ± 0.019	1.466MetArg: 1.466 ± 0.019	1.812MetSer: 1.812 ± 0.019	1.251MetThr: 1.251 ± 0.018	1.383MetVal: 1.383 ± 0.02	0.239MetTrp: 0.239 ± 0.008	0.63MetTyr: 0.63 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	3.309AsnAla: 3.309 ± 0.029	1.112AsnCys: 1.112 ± 0.02	3.112AsnAsp: 3.112 ± 0.036	3.732AsnGlu: 3.732 ± 0.037	2.089AsnPhe: 2.089 ± 0.025	3.18AsnGly: 3.18 ± 0.031	1.037AsnHis: 1.037 ± 0.014	3.002AsnIle: 3.002 ± 0.03	2.459AsnLys: 2.459 ± 0.026	4.119AsnLeu: 4.119 ± 0.032	1.126AsnMet: 1.126 ± 0.015	2.399AsnAsn: 2.399 ± 0.029	1.863AsnPro: 1.863 ± 0.023	1.632AsnGln: 1.632 ± 0.022	2.644AsnArg: 2.644 ± 0.024	4.049AsnSer: 4.049 ± 0.039	2.329AsnThr: 2.329 ± 0.025	3.289AsnVal: 3.289 ± 0.03	0.537AsnTrp: 0.537 ± 0.012	1.61AsnTyr: 1.61 ± 0.021	0.002AsnXaa: 0.002 ± 0.001
Pro	2.46ProAla: 2.46 ± 0.028	0.786ProCys: 0.786 ± 0.018	2.098ProAsp: 2.098 ± 0.022	2.686ProGlu: 2.686 ± 0.031	1.813ProPhe: 1.813 ± 0.022	2.271ProGly: 2.271 ± 0.07	0.986ProHis: 0.986 ± 0.015	2.394ProIle: 2.394 ± 0.024	2.32ProLys: 2.32 ± 0.027	3.883ProLeu: 3.883 ± 0.034	0.907ProMet: 0.907 ± 0.015	2.04ProAsn: 2.04 ± 0.022	3.148ProPro: 3.148 ± 0.067	1.731ProGln: 1.731 ± 0.026	2.068ProArg: 2.068 ± 0.027	4.1ProSer: 4.1 ± 0.038	2.617ProThr: 2.617 ± 0.032	2.819ProVal: 2.819 ± 0.033	0.41ProTrp: 0.41 ± 0.011	1.39ProTyr: 1.39 ± 0.018	0.003ProXaa: 0.003 ± 0.001
Gln	2.308GlnAla: 2.308 ± 0.025	0.991GlnCys: 0.991 ± 0.021	1.418GlnAsp: 1.418 ± 0.018	2.277GlnGlu: 2.277 ± 0.026	1.666GlnPhe: 1.666 ± 0.021	1.467GlnGly: 1.467 ± 0.02	1.127GlnHis: 1.127 ± 0.017	2.583GlnIle: 2.583 ± 0.028	2.712GlnLys: 2.712 ± 0.03	4.479GlnLeu: 4.479 ± 0.039	1.243GlnMet: 1.243 ± 0.018	2.057GlnAsn: 2.057 ± 0.022	1.735GlnPro: 1.735 ± 0.028	3.204GlnGln: 3.204 ± 0.067	2.715GlnArg: 2.715 ± 0.03	3.019GlnSer: 3.019 ± 0.029	2.098GlnThr: 2.098 ± 0.024	2.023GlnVal: 2.023 ± 0.023	0.503GlnTrp: 0.503 ± 0.012	1.309GlnTyr: 1.309 ± 0.017	0.003GlnXaa: 0.003 ± 0.001
Arg	3.248ArgAla: 3.248 ± 0.03	1.408ArgCys: 1.408 ± 0.023	2.813ArgAsp: 2.813 ± 0.031	3.754ArgGlu: 3.754 ± 0.037	2.382ArgPhe: 2.382 ± 0.023	2.75ArgGly: 2.75 ± 0.034	1.543ArgHis: 1.543 ± 0.02	3.795ArgIle: 3.795 ± 0.029	4.335ArgLys: 4.335 ± 0.041	5.522ArgLeu: 5.522 ± 0.042	1.508ArgMet: 1.508 ± 0.019	3.315ArgAsn: 3.315 ± 0.028	2.233ArgPro: 2.233 ± 0.026	2.518ArgGln: 2.518 ± 0.027	4.662ArgArg: 4.662 ± 0.045	4.841ArgSer: 4.841 ± 0.039	3.09ArgThr: 3.09 ± 0.028	3.027ArgVal: 3.027 ± 0.03	0.688ArgTrp: 0.688 ± 0.016	1.907ArgTyr: 1.907 ± 0.024	0.002ArgXaa: 0.002 ± 0.001
Ser	5.526SerAla: 5.526 ± 0.041	1.718SerCys: 1.718 ± 0.023	4.768SerAsp: 4.768 ± 0.04	4.998SerGlu: 4.998 ± 0.045	3.399SerPhe: 3.399 ± 0.027	4.885SerGly: 4.885 ± 0.044	1.801SerHis: 1.801 ± 0.024	4.544SerIle: 4.544 ± 0.034	4.484SerLys: 4.484 ± 0.037	7.458SerLeu: 7.458 ± 0.051	1.825SerMet: 1.825 ± 0.02	4.106SerAsn: 4.106 ± 0.039	3.5SerPro: 3.5 ± 0.042	2.961SerGln: 2.961 ± 0.031	4.507SerArg: 4.507 ± 0.037	9.389SerSer: 9.389 ± 0.092	5.22SerThr: 5.22 ± 0.048	5.425SerVal: 5.425 ± 0.041	0.819SerTrp: 0.819 ± 0.015	2.234SerTyr: 2.234 ± 0.023	0.003SerXaa: 0.003 ± 0.001
Thr	4.174ThrAla: 4.174 ± 0.032	1.145ThrCys: 1.145 ± 0.022	3.028ThrAsp: 3.028 ± 0.029	3.317ThrGlu: 3.317 ± 0.033	2.238ThrPhe: 2.238 ± 0.021	2.971ThrGly: 2.971 ± 0.029	1.149ThrHis: 1.149 ± 0.015	3.218ThrIle: 3.218 ± 0.029	2.919ThrLys: 2.919 ± 0.03	4.842ThrLeu: 4.842 ± 0.034	1.229ThrMet: 1.229 ± 0.016	2.627ThrAsn: 2.627 ± 0.029	2.512ThrPro: 2.512 ± 0.032	1.799ThrGln: 1.799 ± 0.024	2.514ThrArg: 2.514 ± 0.025	5.142ThrSer: 5.142 ± 0.048	3.907ThrThr: 3.907 ± 0.057	4.265ThrVal: 4.265 ± 0.033	0.504ThrTrp: 0.504 ± 0.012	1.58ThrTyr: 1.58 ± 0.021	0.003ThrXaa: 0.003 ± 0.001
Val	4.341ValAla: 4.341 ± 0.033	1.304ValCys: 1.304 ± 0.022	3.656ValAsp: 3.656 ± 0.032	4.294ValGlu: 4.294 ± 0.037	2.385ValPhe: 2.385 ± 0.029	3.196ValGly: 3.196 ± 0.031	1.493ValHis: 1.493 ± 0.02	3.901ValIle: 3.901 ± 0.033	3.54ValLys: 3.54 ± 0.031	5.703ValLeu: 5.703 ± 0.041	1.514ValMet: 1.514 ± 0.019	2.859ValAsn: 2.859 ± 0.024	2.883ValPro: 2.883 ± 0.026	2.514ValGln: 2.514 ± 0.025	3.479ValArg: 3.479 ± 0.028	4.57ValSer: 4.57 ± 0.032	3.555ValThr: 3.555 ± 0.03	4.375ValVal: 4.375 ± 0.045	0.649ValTrp: 0.649 ± 0.013	1.752ValTyr: 1.752 ± 0.022	0.003ValXaa: 0.003 ± 0.001
Trp	0.55TrpAla: 0.55 ± 0.011	0.235TrpCys: 0.235 ± 0.007	0.571TrpAsp: 0.571 ± 0.013	0.595TrpGlu: 0.595 ± 0.014	0.49TrpPhe: 0.49 ± 0.014	0.427TrpGly: 0.427 ± 0.012	0.294TrpHis: 0.294 ± 0.008	0.77TrpIle: 0.77 ± 0.013	0.854TrpLys: 0.854 ± 0.016	1.116TrpLeu: 1.116 ± 0.018	0.324TrpMet: 0.324 ± 0.009	0.658TrpAsn: 0.658 ± 0.015	0.418TrpPro: 0.418 ± 0.01	0.455TrpGln: 0.455 ± 0.011	0.712TrpArg: 0.712 ± 0.013	0.877TrpSer: 0.877 ± 0.016	0.653TrpThr: 0.653 ± 0.013	0.476TrpVal: 0.476 ± 0.012	0.168TrpTrp: 0.168 ± 0.008	0.361TrpTyr: 0.361 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.945TyrAla: 1.945 ± 0.019	0.805TyrCys: 0.805 ± 0.017	1.866TyrAsp: 1.866 ± 0.023	1.92TyrGlu: 1.92 ± 0.022	1.462TyrPhe: 1.462 ± 0.021	1.958TyrGly: 1.958 ± 0.025	0.859TyrHis: 0.859 ± 0.015	1.782TyrIle: 1.782 ± 0.02	1.569TyrLys: 1.569 ± 0.019	2.847TyrLeu: 2.847 ± 0.029	0.762TyrMet: 0.762 ± 0.013	1.408TyrAsn: 1.408 ± 0.018	1.305TyrPro: 1.305 ± 0.021	1.228TyrGln: 1.228 ± 0.018	1.984TyrArg: 1.984 ± 0.021	2.298TyrSer: 2.298 ± 0.025	1.443TyrThr: 1.443 ± 0.02	1.94TyrVal: 1.94 ± 0.023	0.389TyrTrp: 0.389 ± 0.01	1.219TyrTyr: 1.219 ± 0.017	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.003XaaAla: 0.003 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.002XaaAsn: 0.002 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.003XaaGln: 0.003 ± 0.001	0.002XaaArg: 0.002 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.004XaaThr: 0.004 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.556XaaXaa: 0.556 ± 0.053

Statistics based on 9894 proteins (4320305 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---