Amino acid dipepetide frequency for Aeropyrum coil-shaped virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.742AlaAla: 7.742 ± 1.027
0.516AlaCys: 0.516 ± 0.293
2.194AlaAsp: 2.194 ± 0.591
5.161AlaGlu: 5.161 ± 0.733
3.484AlaPhe: 3.484 ± 0.624
4.387AlaGly: 4.387 ± 0.734
1.29AlaHis: 1.29 ± 0.405
5.548AlaIle: 5.548 ± 0.756
4.903AlaLys: 4.903 ± 0.582
7.484AlaLeu: 7.484 ± 1.032
2.581AlaMet: 2.581 ± 0.453
1.677AlaAsn: 1.677 ± 0.394
1.935AlaPro: 1.935 ± 0.452
1.548AlaGln: 1.548 ± 0.482
6.71AlaArg: 6.71 ± 0.968
4.645AlaSer: 4.645 ± 0.715
3.355AlaThr: 3.355 ± 0.76
4.903AlaVal: 4.903 ± 0.823
1.032AlaTrp: 1.032 ± 0.334
3.097AlaTyr: 3.097 ± 0.58
0.0AlaXaa: 0.0 ± 0.0
Cys
0.129CysAla: 0.129 ± 0.129
0.129CysCys: 0.129 ± 0.12
0.516CysAsp: 0.516 ± 0.23
0.516CysGlu: 0.516 ± 0.397
0.516CysPhe: 0.516 ± 0.237
0.387CysGly: 0.387 ± 0.232
0.0CysHis: 0.0 ± 0.0
0.645CysIle: 0.645 ± 0.257
1.161CysLys: 1.161 ± 0.502
0.903CysLeu: 0.903 ± 0.318
0.129CysMet: 0.129 ± 0.123
0.258CysAsn: 0.258 ± 0.199
0.645CysPro: 0.645 ± 0.342
0.387CysGln: 0.387 ± 0.227
0.387CysArg: 0.387 ± 0.201
0.387CysSer: 0.387 ± 0.201
0.516CysThr: 0.516 ± 0.227
1.032CysVal: 1.032 ± 0.312
0.129CysTrp: 0.129 ± 0.125
0.516CysTyr: 0.516 ± 0.271
0.0CysXaa: 0.0 ± 0.0
Asp
2.968AspAla: 2.968 ± 0.74
0.903AspCys: 0.903 ± 0.312
2.452AspAsp: 2.452 ± 0.523
3.484AspGlu: 3.484 ± 0.661
1.935AspPhe: 1.935 ± 0.523
2.968AspGly: 2.968 ± 0.716
0.0AspHis: 0.0 ± 0.0
4.903AspIle: 4.903 ± 0.814
2.065AspLys: 2.065 ± 0.495
3.484AspLeu: 3.484 ± 0.695
1.935AspMet: 1.935 ± 0.413
1.677AspAsn: 1.677 ± 0.521
1.935AspPro: 1.935 ± 0.389
0.387AspGln: 0.387 ± 0.234
2.839AspArg: 2.839 ± 0.517
1.935AspSer: 1.935 ± 0.58
2.323AspThr: 2.323 ± 0.76
5.032AspVal: 5.032 ± 0.976
0.516AspTrp: 0.516 ± 0.293
2.452AspTyr: 2.452 ± 0.705
0.0AspXaa: 0.0 ± 0.0
Glu
7.226GluAla: 7.226 ± 0.977
1.032GluCys: 1.032 ± 0.406
4.645GluAsp: 4.645 ± 0.736
10.71GluGlu: 10.71 ± 1.686
2.452GluPhe: 2.452 ± 0.562
5.935GluGly: 5.935 ± 0.967
1.419GluHis: 1.419 ± 0.497
5.806GluIle: 5.806 ± 0.878
5.29GluLys: 5.29 ± 1.099
9.161GluLeu: 9.161 ± 0.957
2.065GluMet: 2.065 ± 0.455
1.935GluAsn: 1.935 ± 0.548
2.452GluPro: 2.452 ± 0.49
2.194GluGln: 2.194 ± 0.551
6.323GluArg: 6.323 ± 0.884
3.226GluSer: 3.226 ± 0.677
3.355GluThr: 3.355 ± 0.673
7.613GluVal: 7.613 ± 1.19
0.516GluTrp: 0.516 ± 0.251
3.355GluTyr: 3.355 ± 0.579
0.0GluXaa: 0.0 ± 0.0
Phe
2.839PheAla: 2.839 ± 0.656
0.129PheCys: 0.129 ± 0.123
2.194PheAsp: 2.194 ± 0.524
2.968PheGlu: 2.968 ± 0.752
1.29PhePhe: 1.29 ± 0.423
2.452PheGly: 2.452 ± 0.554
0.645PheHis: 0.645 ± 0.257
2.839PheIle: 2.839 ± 0.531
1.419PheLys: 1.419 ± 0.408
2.839PheLeu: 2.839 ± 0.686
1.677PheMet: 1.677 ± 0.642
2.581PheAsn: 2.581 ± 0.62
1.548PhePro: 1.548 ± 0.443
1.161PheGln: 1.161 ± 0.486
2.71PheArg: 2.71 ± 0.436
2.065PheSer: 2.065 ± 0.433
2.323PheThr: 2.323 ± 0.56
3.097PheVal: 3.097 ± 0.673
0.774PheTrp: 0.774 ± 0.414
0.903PheTyr: 0.903 ± 0.31
0.0PheXaa: 0.0 ± 0.0
Gly
3.871GlyAla: 3.871 ± 0.71
0.258GlyCys: 0.258 ± 0.152
3.226GlyAsp: 3.226 ± 0.616
4.387GlyGlu: 4.387 ± 0.788
1.419GlyPhe: 1.419 ± 0.408
4.645GlyGly: 4.645 ± 0.667
0.516GlyHis: 0.516 ± 0.266
5.548GlyIle: 5.548 ± 0.723
4.0GlyLys: 4.0 ± 0.679
5.548GlyLeu: 5.548 ± 0.984
1.935GlyMet: 1.935 ± 0.493
1.677GlyAsn: 1.677 ± 0.43
1.935GlyPro: 1.935 ± 0.578
2.065GlyGln: 2.065 ± 0.557
5.29GlyArg: 5.29 ± 0.848
3.742GlySer: 3.742 ± 0.825
2.71GlyThr: 2.71 ± 0.693
6.323GlyVal: 6.323 ± 0.786
1.29GlyTrp: 1.29 ± 0.384
2.968GlyTyr: 2.968 ± 0.668
0.0GlyXaa: 0.0 ± 0.0
His
0.903HisAla: 0.903 ± 0.337
0.387HisCys: 0.387 ± 0.238
0.129HisAsp: 0.129 ± 0.145
1.161HisGlu: 1.161 ± 0.377
0.903HisPhe: 0.903 ± 0.308
1.29HisGly: 1.29 ± 0.373
0.0HisHis: 0.0 ± 0.0
1.419HisIle: 1.419 ± 0.501
0.645HisLys: 0.645 ± 0.315
1.161HisLeu: 1.161 ± 0.303
0.516HisMet: 0.516 ± 0.256
0.258HisAsn: 0.258 ± 0.178
0.903HisPro: 0.903 ± 0.335
0.129HisGln: 0.129 ± 0.124
0.903HisArg: 0.903 ± 0.297
0.903HisSer: 0.903 ± 0.289
0.645HisThr: 0.645 ± 0.313
1.161HisVal: 1.161 ± 0.375
0.387HisTrp: 0.387 ± 0.196
0.387HisTyr: 0.387 ± 0.185
0.0HisXaa: 0.0 ± 0.0
Ile
5.161IleAla: 5.161 ± 0.87
0.903IleCys: 0.903 ± 0.408
2.71IleAsp: 2.71 ± 0.659
6.71IleGlu: 6.71 ± 0.884
2.968IlePhe: 2.968 ± 0.687
3.871IleGly: 3.871 ± 0.801
1.161IleHis: 1.161 ± 0.39
4.645IleIle: 4.645 ± 0.722
5.161IleLys: 5.161 ± 1.051
7.097IleLeu: 7.097 ± 0.993
2.839IleMet: 2.839 ± 0.548
2.323IleAsn: 2.323 ± 0.569
3.226IlePro: 3.226 ± 0.505
1.29IleGln: 1.29 ± 0.338
5.161IleArg: 5.161 ± 0.699
4.516IleSer: 4.516 ± 0.914
2.968IleThr: 2.968 ± 0.516
7.226IleVal: 7.226 ± 0.971
1.032IleTrp: 1.032 ± 0.319
3.097IleTyr: 3.097 ± 0.554
0.0IleXaa: 0.0 ± 0.0
Lys
5.29LysAla: 5.29 ± 0.962
0.387LysCys: 0.387 ± 0.227
1.806LysAsp: 1.806 ± 0.528
6.71LysGlu: 6.71 ± 1.361
2.194LysPhe: 2.194 ± 0.522
3.613LysGly: 3.613 ± 0.563
1.419LysHis: 1.419 ± 0.415
3.742LysIle: 3.742 ± 0.649
4.516LysLys: 4.516 ± 0.873
5.677LysLeu: 5.677 ± 1.044
1.548LysMet: 1.548 ± 0.443
1.161LysAsn: 1.161 ± 0.368
2.065LysPro: 2.065 ± 0.657
1.935LysGln: 1.935 ± 0.501
5.161LysArg: 5.161 ± 0.922
2.065LysSer: 2.065 ± 0.636
2.065LysThr: 2.065 ± 0.539
6.194LysVal: 6.194 ± 0.803
1.032LysTrp: 1.032 ± 0.471
2.323LysTyr: 2.323 ± 0.585
0.0LysXaa: 0.0 ± 0.0
Leu
6.968LeuAla: 6.968 ± 1.103
0.774LeuCys: 0.774 ± 0.291
4.387LeuAsp: 4.387 ± 0.768
9.032LeuGlu: 9.032 ± 1.132
3.484LeuPhe: 3.484 ± 0.647
7.226LeuGly: 7.226 ± 0.898
1.677LeuHis: 1.677 ± 0.486
6.452LeuIle: 6.452 ± 1.073
7.742LeuLys: 7.742 ± 1.223
9.677LeuLeu: 9.677 ± 1.284
1.935LeuMet: 1.935 ± 0.557
1.419LeuAsn: 1.419 ± 0.494
4.129LeuPro: 4.129 ± 0.626
3.226LeuGln: 3.226 ± 0.504
8.387LeuArg: 8.387 ± 0.783
4.129LeuSer: 4.129 ± 0.616
3.871LeuThr: 3.871 ± 0.751
8.129LeuVal: 8.129 ± 1.021
0.903LeuTrp: 0.903 ± 0.355
3.097LeuTyr: 3.097 ± 0.498
0.0LeuXaa: 0.0 ± 0.0
Met
2.71MetAla: 2.71 ± 0.688
0.0MetCys: 0.0 ± 0.0
1.032MetAsp: 1.032 ± 0.366
1.806MetGlu: 1.806 ± 0.478
0.903MetPhe: 0.903 ± 0.399
2.194MetGly: 2.194 ± 0.634
0.516MetHis: 0.516 ± 0.244
2.452MetIle: 2.452 ± 0.607
2.065MetLys: 2.065 ± 0.529
2.71MetLeu: 2.71 ± 0.539
1.419MetMet: 1.419 ± 0.599
0.903MetAsn: 0.903 ± 0.294
2.323MetPro: 2.323 ± 0.609
0.516MetGln: 0.516 ± 0.216
2.839MetArg: 2.839 ± 0.632
1.677MetSer: 1.677 ± 0.532
1.677MetThr: 1.677 ± 0.413
2.581MetVal: 2.581 ± 0.539
0.258MetTrp: 0.258 ± 0.181
1.032MetTyr: 1.032 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
2.194AsnAla: 2.194 ± 0.612
0.129AsnCys: 0.129 ± 0.114
1.677AsnAsp: 1.677 ± 0.438
2.839AsnGlu: 2.839 ± 0.529
0.774AsnPhe: 0.774 ± 0.317
1.935AsnGly: 1.935 ± 0.51
0.645AsnHis: 0.645 ± 0.235
2.194AsnIle: 2.194 ± 0.545
1.419AsnLys: 1.419 ± 0.452
2.581AsnLeu: 2.581 ± 0.63
0.774AsnMet: 0.774 ± 0.27
0.645AsnAsn: 0.645 ± 0.252
1.677AsnPro: 1.677 ± 0.387
0.258AsnGln: 0.258 ± 0.172
1.032AsnArg: 1.032 ± 0.353
1.419AsnSer: 1.419 ± 0.46
1.161AsnThr: 1.161 ± 0.372
2.968AsnVal: 2.968 ± 0.892
0.516AsnTrp: 0.516 ± 0.225
1.548AsnTyr: 1.548 ± 0.453
0.0AsnXaa: 0.0 ± 0.0
Pro
2.839ProAla: 2.839 ± 0.528
0.516ProCys: 0.516 ± 0.357
2.194ProAsp: 2.194 ± 0.506
4.0ProGlu: 4.0 ± 0.73
1.935ProPhe: 1.935 ± 0.509
2.581ProGly: 2.581 ± 0.655
0.516ProHis: 0.516 ± 0.267
2.839ProIle: 2.839 ± 0.611
2.065ProLys: 2.065 ± 0.533
3.355ProLeu: 3.355 ± 0.667
1.677ProMet: 1.677 ± 0.507
1.032ProAsn: 1.032 ± 0.444
2.452ProPro: 2.452 ± 0.677
0.387ProGln: 0.387 ± 0.22
2.194ProArg: 2.194 ± 0.582
2.581ProSer: 2.581 ± 0.649
1.806ProThr: 1.806 ± 0.548
3.613ProVal: 3.613 ± 0.762
0.387ProTrp: 0.387 ± 0.19
1.419ProTyr: 1.419 ± 0.381
0.0ProXaa: 0.0 ± 0.0
Gln
2.194GlnAla: 2.194 ± 0.499
0.129GlnCys: 0.129 ± 0.128
1.161GlnAsp: 1.161 ± 0.355
0.774GlnGlu: 0.774 ± 0.273
1.032GlnPhe: 1.032 ± 0.379
2.194GlnGly: 2.194 ± 0.515
0.258GlnHis: 0.258 ± 0.179
1.548GlnIle: 1.548 ± 0.383
1.29GlnLys: 1.29 ± 0.405
2.194GlnLeu: 2.194 ± 0.506
1.161GlnMet: 1.161 ± 0.409
0.645GlnAsn: 0.645 ± 0.294
1.548GlnPro: 1.548 ± 0.439
0.645GlnGln: 0.645 ± 0.281
2.194GlnArg: 2.194 ± 0.439
0.645GlnSer: 0.645 ± 0.281
0.387GlnThr: 0.387 ± 0.24
1.161GlnVal: 1.161 ± 0.315
0.258GlnTrp: 0.258 ± 0.171
1.806GlnTyr: 1.806 ± 0.565
0.0GlnXaa: 0.0 ± 0.0
Arg
5.161ArgAla: 5.161 ± 0.673
0.903ArgCys: 0.903 ± 0.353
4.774ArgAsp: 4.774 ± 0.956
6.194ArgGlu: 6.194 ± 0.961
2.71ArgPhe: 2.71 ± 0.687
3.613ArgGly: 3.613 ± 0.705
1.161ArgHis: 1.161 ± 0.366
5.806ArgIle: 5.806 ± 0.785
3.871ArgLys: 3.871 ± 0.82
7.871ArgLeu: 7.871 ± 1.056
2.581ArgMet: 2.581 ± 0.768
2.839ArgAsn: 2.839 ± 0.679
2.452ArgPro: 2.452 ± 0.521
1.677ArgGln: 1.677 ± 0.412
7.226ArgArg: 7.226 ± 1.344
2.839ArgSer: 2.839 ± 0.612
2.71ArgThr: 2.71 ± 0.587
7.742ArgVal: 7.742 ± 1.028
1.935ArgTrp: 1.935 ± 0.388
2.323ArgTyr: 2.323 ± 0.498
0.0ArgXaa: 0.0 ± 0.0
Ser
1.935SerAla: 1.935 ± 0.487
0.516SerCys: 0.516 ± 0.274
1.29SerAsp: 1.29 ± 0.441
3.613SerGlu: 3.613 ± 0.54
2.323SerPhe: 2.323 ± 0.551
3.097SerGly: 3.097 ± 0.621
0.645SerHis: 0.645 ± 0.252
5.161SerIle: 5.161 ± 0.76
3.097SerLys: 3.097 ± 0.537
5.29SerLeu: 5.29 ± 0.791
2.194SerMet: 2.194 ± 0.646
1.935SerAsn: 1.935 ± 0.497
2.71SerPro: 2.71 ± 0.53
1.419SerGln: 1.419 ± 0.417
2.839SerArg: 2.839 ± 0.657
3.613SerSer: 3.613 ± 0.6
2.194SerThr: 2.194 ± 0.566
3.613SerVal: 3.613 ± 0.632
0.774SerTrp: 0.774 ± 0.275
2.581SerTyr: 2.581 ± 0.631
0.0SerXaa: 0.0 ± 0.0
Thr
3.613ThrAla: 3.613 ± 0.743
0.0ThrCys: 0.0 ± 0.0
1.548ThrAsp: 1.548 ± 0.474
2.71ThrGlu: 2.71 ± 0.793
1.806ThrPhe: 1.806 ± 0.504
3.871ThrGly: 3.871 ± 0.845
0.645ThrHis: 0.645 ± 0.26
4.129ThrIle: 4.129 ± 0.912
1.548ThrLys: 1.548 ± 0.478
5.419ThrLeu: 5.419 ± 0.729
1.548ThrMet: 1.548 ± 0.512
1.161ThrAsn: 1.161 ± 0.296
1.806ThrPro: 1.806 ± 0.487
0.516ThrGln: 0.516 ± 0.247
2.323ThrArg: 2.323 ± 0.521
1.29ThrSer: 1.29 ± 0.397
1.677ThrThr: 1.677 ± 0.396
4.903ThrVal: 4.903 ± 0.788
0.774ThrTrp: 0.774 ± 0.272
0.645ThrTyr: 0.645 ± 0.282
0.0ThrXaa: 0.0 ± 0.0
Val
7.097ValAla: 7.097 ± 0.933
1.032ValCys: 1.032 ± 0.345
5.806ValAsp: 5.806 ± 0.848
9.29ValGlu: 9.29 ± 1.313
4.645ValPhe: 4.645 ± 1.003
3.613ValGly: 3.613 ± 0.566
0.774ValHis: 0.774 ± 0.292
5.419ValIle: 5.419 ± 0.773
5.161ValLys: 5.161 ± 0.665
8.903ValLeu: 8.903 ± 1.008
1.935ValMet: 1.935 ± 0.528
1.677ValAsn: 1.677 ± 0.513
3.226ValPro: 3.226 ± 0.611
2.065ValGln: 2.065 ± 0.486
6.968ValArg: 6.968 ± 0.79
5.419ValSer: 5.419 ± 0.921
3.742ValThr: 3.742 ± 0.665
7.613ValVal: 7.613 ± 1.323
1.29ValTrp: 1.29 ± 0.419
3.355ValTyr: 3.355 ± 0.692
0.0ValXaa: 0.0 ± 0.0
Trp
1.032TrpAla: 1.032 ± 0.306
0.258TrpCys: 0.258 ± 0.172
0.387TrpAsp: 0.387 ± 0.287
1.29TrpGlu: 1.29 ± 0.392
0.387TrpPhe: 0.387 ± 0.198
1.032TrpGly: 1.032 ± 0.384
0.387TrpHis: 0.387 ± 0.194
0.903TrpIle: 0.903 ± 0.339
1.29TrpLys: 1.29 ± 0.351
2.323TrpLeu: 2.323 ± 0.527
0.258TrpMet: 0.258 ± 0.191
0.387TrpAsn: 0.387 ± 0.2
0.0TrpPro: 0.0 ± 0.0
0.258TrpGln: 0.258 ± 0.227
1.161TrpArg: 1.161 ± 0.367
0.903TrpSer: 0.903 ± 0.415
0.387TrpThr: 0.387 ± 0.201
0.903TrpVal: 0.903 ± 0.359
0.258TrpTrp: 0.258 ± 0.172
0.645TrpTyr: 0.645 ± 0.268
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.323TyrAla: 2.323 ± 0.579
0.387TyrCys: 0.387 ± 0.192
2.065TyrAsp: 2.065 ± 0.536
3.355TyrGlu: 3.355 ± 0.586
1.29TyrPhe: 1.29 ± 0.381
2.452TyrGly: 2.452 ± 0.507
0.516TyrHis: 0.516 ± 0.319
2.065TyrIle: 2.065 ± 0.484
2.194TyrLys: 2.194 ± 0.581
2.968TyrLeu: 2.968 ± 0.484
0.774TyrMet: 0.774 ± 0.275
2.194TyrAsn: 2.194 ± 0.443
1.419TyrPro: 1.419 ± 0.334
1.161TyrGln: 1.161 ± 0.312
3.871TyrArg: 3.871 ± 0.641
2.839TyrSer: 2.839 ± 0.511
2.065TyrThr: 2.065 ± 0.372
3.226TyrVal: 3.226 ± 0.842
0.387TyrTrp: 0.387 ± 0.225
2.194TyrTyr: 2.194 ± 0.469
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (7751 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski