Amino acid dipepetide frequency for Lactobacillus tucceti DSM 20183

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.773AlaAla: 4.773 ± 0.103	0.353AlaCys: 0.353 ± 0.024	4.002AlaAsp: 4.002 ± 0.093	3.31AlaGlu: 3.31 ± 0.079	2.914AlaPhe: 2.914 ± 0.078	4.736AlaGly: 4.736 ± 0.098	1.029AlaHis: 1.029 ± 0.046	5.728AlaIle: 5.728 ± 0.104	5.028AlaLys: 5.028 ± 0.098	6.073AlaLeu: 6.073 ± 0.098	1.905AlaMet: 1.905 ± 0.06	3.23AlaAsn: 3.23 ± 0.076	1.908AlaPro: 1.908 ± 0.062	2.287AlaGln: 2.287 ± 0.063	1.998AlaArg: 1.998 ± 0.058	3.979AlaSer: 3.979 ± 0.081	3.907AlaThr: 3.907 ± 0.086	4.578AlaVal: 4.578 ± 0.087	0.559AlaTrp: 0.559 ± 0.032	2.068AlaTyr: 2.068 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.299CysAla: 0.299 ± 0.02	0.054CysCys: 0.054 ± 0.01	0.287CysAsp: 0.287 ± 0.022	0.188CysGlu: 0.188 ± 0.021	0.225CysPhe: 0.225 ± 0.021	0.439CysGly: 0.439 ± 0.029	0.147CysHis: 0.147 ± 0.015	0.317CysIle: 0.317 ± 0.025	0.23CysLys: 0.23 ± 0.02	0.469CysLeu: 0.469 ± 0.027	0.103CysMet: 0.103 ± 0.012	0.212CysAsn: 0.212 ± 0.021	0.226CysPro: 0.226 ± 0.018	0.173CysGln: 0.173 ± 0.018	0.163CysArg: 0.163 ± 0.017	0.307CysSer: 0.307 ± 0.025	0.245CysThr: 0.245 ± 0.02	0.279CysVal: 0.279 ± 0.023	0.043CysTrp: 0.043 ± 0.009	0.166CysTyr: 0.166 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.77AspAla: 3.77 ± 0.072	0.228AspCys: 0.228 ± 0.019	4.47AspAsp: 4.47 ± 0.117	4.415AspGlu: 4.415 ± 0.106	3.063AspPhe: 3.063 ± 0.072	3.949AspGly: 3.949 ± 0.083	1.2AspHis: 1.2 ± 0.046	4.833AspIle: 4.833 ± 0.09	5.256AspLys: 5.256 ± 0.109	5.975AspLeu: 5.975 ± 0.11	1.625AspMet: 1.625 ± 0.056	3.728AspAsn: 3.728 ± 0.081	2.331AspPro: 2.331 ± 0.075	2.34AspGln: 2.34 ± 0.07	2.092AspArg: 2.092 ± 0.054	4.218AspSer: 4.218 ± 0.108	3.363AspThr: 3.363 ± 0.087	4.12AspVal: 4.12 ± 0.091	0.703AspTrp: 0.703 ± 0.036	2.751AspTyr: 2.751 ± 0.077	0.0AspXaa: 0.0 ± 0.0
Glu	3.441GluAla: 3.441 ± 0.095	0.219GluCys: 0.219 ± 0.017	3.571GluAsp: 3.571 ± 0.084	3.77GluGlu: 3.77 ± 0.102	2.554GluPhe: 2.554 ± 0.063	2.758GluGly: 2.758 ± 0.077	1.096GluHis: 1.096 ± 0.039	4.755GluIle: 4.755 ± 0.101	4.918GluLys: 4.918 ± 0.095	5.72GluLeu: 5.72 ± 0.112	1.827GluMet: 1.827 ± 0.057	3.766GluAsn: 3.766 ± 0.084	1.595GluPro: 1.595 ± 0.05	2.228GluGln: 2.228 ± 0.064	1.892GluArg: 1.892 ± 0.068	3.387GluSer: 3.387 ± 0.076	3.007GluThr: 3.007 ± 0.068	3.8GluVal: 3.8 ± 0.084	0.511GluTrp: 0.511 ± 0.032	2.111GluTyr: 2.111 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.922PheAla: 2.922 ± 0.07	0.23PheCys: 0.23 ± 0.02	3.178PheAsp: 3.178 ± 0.069	2.39PheGlu: 2.39 ± 0.058	2.163PhePhe: 2.163 ± 0.075	3.412PheGly: 3.412 ± 0.083	0.679PheHis: 0.679 ± 0.031	3.56PheIle: 3.56 ± 0.094	2.974PheLys: 2.974 ± 0.08	4.017PheLeu: 4.017 ± 0.102	1.21PheMet: 1.21 ± 0.048	2.6PheAsn: 2.6 ± 0.057	1.392PhePro: 1.392 ± 0.046	1.302PheGln: 1.302 ± 0.044	1.289PheArg: 1.289 ± 0.047	3.417PheSer: 3.417 ± 0.083	2.513PheThr: 2.513 ± 0.056	3.048PheVal: 3.048 ± 0.078	0.507PheTrp: 0.507 ± 0.031	1.728PheTyr: 1.728 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	4.358GlyAla: 4.358 ± 0.103	0.385GlyCys: 0.385 ± 0.027	3.729GlyAsp: 3.729 ± 0.092	3.2GlyGlu: 3.2 ± 0.073	3.197GlyPhe: 3.197 ± 0.083	4.28GlyGly: 4.28 ± 0.111	1.292GlyHis: 1.292 ± 0.045	6.166GlyIle: 6.166 ± 0.126	4.846GlyLys: 4.846 ± 0.094	6.182GlyLeu: 6.182 ± 0.114	1.93GlyMet: 1.93 ± 0.064	3.229GlyAsn: 3.229 ± 0.075	1.466GlyPro: 1.466 ± 0.05	2.323GlyGln: 2.323 ± 0.056	2.152GlyArg: 2.152 ± 0.061	4.58GlySer: 4.58 ± 0.105	4.332GlyThr: 4.332 ± 0.094	4.732GlyVal: 4.732 ± 0.099	0.635GlyTrp: 0.635 ± 0.031	2.836GlyTyr: 2.836 ± 0.078	0.0GlyXaa: 0.0 ± 0.0
His	1.034HisAla: 1.034 ± 0.041	0.09HisCys: 0.09 ± 0.012	1.173HisAsp: 1.173 ± 0.045	0.996HisGlu: 0.996 ± 0.039	0.887HisPhe: 0.887 ± 0.031	1.278HisGly: 1.278 ± 0.047	0.502HisHis: 0.502 ± 0.033	1.26HisIle: 1.26 ± 0.047	1.053HisLys: 1.053 ± 0.044	1.685HisLeu: 1.685 ± 0.062	0.439HisMet: 0.439 ± 0.027	0.922HisAsn: 0.922 ± 0.042	0.817HisPro: 0.817 ± 0.038	0.649HisGln: 0.649 ± 0.033	0.714HisArg: 0.714 ± 0.032	1.048HisSer: 1.048 ± 0.041	0.828HisThr: 0.828 ± 0.032	1.2HisVal: 1.2 ± 0.046	0.182HisTrp: 0.182 ± 0.015	0.76HisTyr: 0.76 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.773IleAla: 5.773 ± 0.107	0.516IleCys: 0.516 ± 0.029	5.333IleAsp: 5.333 ± 0.087	4.402IleGlu: 4.402 ± 0.096	3.712IlePhe: 3.712 ± 0.095	5.785IleGly: 5.785 ± 0.105	1.317IleHis: 1.317 ± 0.049	6.608IleIle: 6.608 ± 0.148	5.889IleLys: 5.889 ± 0.098	7.754IleLeu: 7.754 ± 0.15	2.066IleMet: 2.066 ± 0.058	4.789IleAsn: 4.789 ± 0.105	3.177IlePro: 3.177 ± 0.067	2.486IleGln: 2.486 ± 0.054	2.397IleArg: 2.397 ± 0.059	5.932IleSer: 5.932 ± 0.108	4.714IleThr: 4.714 ± 0.095	5.786IleVal: 5.786 ± 0.108	0.652IleTrp: 0.652 ± 0.041	2.785IleTyr: 2.785 ± 0.079	0.0IleXaa: 0.0 ± 0.0
Lys	4.478LysAla: 4.478 ± 0.106	0.179LysCys: 0.179 ± 0.018	5.142LysAsp: 5.142 ± 0.114	5.34LysGlu: 5.34 ± 0.104	2.763LysPhe: 2.763 ± 0.07	3.672LysGly: 3.672 ± 0.079	1.351LysHis: 1.351 ± 0.051	6.044LysIle: 6.044 ± 0.102	7.072LysLys: 7.072 ± 0.131	6.823LysLeu: 6.823 ± 0.107	2.409LysMet: 2.409 ± 0.06	5.157LysAsn: 5.157 ± 0.101	2.28LysPro: 2.28 ± 0.06	2.83LysGln: 2.83 ± 0.076	2.88LysArg: 2.88 ± 0.077	4.888LysSer: 4.888 ± 0.097	4.412LysThr: 4.412 ± 0.089	5.151LysVal: 5.151 ± 0.086	0.599LysTrp: 0.599 ± 0.029	3.205LysTyr: 3.205 ± 0.076	0.0LysXaa: 0.0 ± 0.0
Leu	6.404LeuAla: 6.404 ± 0.121	0.431LeuCys: 0.431 ± 0.03	5.609LeuAsp: 5.609 ± 0.119	4.671LeuGlu: 4.671 ± 0.097	3.96LeuPhe: 3.96 ± 0.109	6.317LeuGly: 6.317 ± 0.139	1.504LeuHis: 1.504 ± 0.045	7.702LeuIle: 7.702 ± 0.163	7.097LeuLys: 7.097 ± 0.127	8.568LeuLeu: 8.568 ± 0.186	2.435LeuMet: 2.435 ± 0.065	5.675LeuAsn: 5.675 ± 0.098	3.666LeuPro: 3.666 ± 0.079	2.888LeuGln: 2.888 ± 0.078	2.953LeuArg: 2.953 ± 0.071	7.142LeuSer: 7.142 ± 0.13	6.025LeuThr: 6.025 ± 0.11	6.363LeuVal: 6.363 ± 0.114	0.716LeuTrp: 0.716 ± 0.034	2.811LeuTyr: 2.811 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	1.932MetAla: 1.932 ± 0.058	0.141MetCys: 0.141 ± 0.015	1.669MetAsp: 1.669 ± 0.054	1.419MetGlu: 1.419 ± 0.053	1.148MetPhe: 1.148 ± 0.054	1.824MetGly: 1.824 ± 0.062	0.456MetHis: 0.456 ± 0.024	2.226MetIle: 2.226 ± 0.061	2.215MetLys: 2.215 ± 0.052	2.185MetLeu: 2.185 ± 0.062	0.828MetMet: 0.828 ± 0.034	1.698MetAsn: 1.698 ± 0.047	1.047MetPro: 1.047 ± 0.047	0.987MetGln: 0.987 ± 0.043	0.972MetArg: 0.972 ± 0.041	1.997MetSer: 1.997 ± 0.06	1.797MetThr: 1.797 ± 0.056	1.761MetVal: 1.761 ± 0.054	0.187MetTrp: 0.187 ± 0.017	0.806MetTyr: 0.806 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	3.303AsnAla: 3.303 ± 0.071	0.298AsnCys: 0.298 ± 0.021	3.728AsnAsp: 3.728 ± 0.084	3.362AsnGlu: 3.362 ± 0.077	2.369AsnPhe: 2.369 ± 0.062	4.198AsnGly: 4.198 ± 0.089	1.078AsnHis: 1.078 ± 0.041	4.581AsnIle: 4.581 ± 0.097	4.553AsnLys: 4.553 ± 0.085	5.319AsnLeu: 5.319 ± 0.106	1.571AsnMet: 1.571 ± 0.051	4.144AsnAsn: 4.144 ± 0.125	2.252AsnPro: 2.252 ± 0.063	2.321AsnGln: 2.321 ± 0.077	1.995AsnArg: 1.995 ± 0.056	3.967AsnSer: 3.967 ± 0.108	3.159AsnThr: 3.159 ± 0.082	3.707AsnVal: 3.707 ± 0.083	0.662AsnTrp: 0.662 ± 0.034	2.447AsnTyr: 2.447 ± 0.065	0.0AsnXaa: 0.0 ± 0.0
Pro	2.087ProAla: 2.087 ± 0.062	0.105ProCys: 0.105 ± 0.013	2.391ProAsp: 2.391 ± 0.072	2.654ProGlu: 2.654 ± 0.074	1.523ProPhe: 1.523 ± 0.055	2.019ProGly: 2.019 ± 0.064	0.515ProHis: 0.515 ± 0.031	2.758ProIle: 2.758 ± 0.072	2.534ProLys: 2.534 ± 0.071	2.839ProLeu: 2.839 ± 0.072	0.849ProMet: 0.849 ± 0.032	1.932ProAsn: 1.932 ± 0.059	0.507ProPro: 0.507 ± 0.032	1.104ProGln: 1.104 ± 0.043	0.96ProArg: 0.96 ± 0.041	2.122ProSer: 2.122 ± 0.056	2.043ProThr: 2.043 ± 0.065	2.668ProVal: 2.668 ± 0.075	0.326ProTrp: 0.326 ± 0.024	1.327ProTyr: 1.327 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	2.363GlnAla: 2.363 ± 0.07	0.065GlnCys: 0.065 ± 0.01	1.865GlnAsp: 1.865 ± 0.06	2.062GlnGlu: 2.062 ± 0.063	1.373GlnPhe: 1.373 ± 0.043	1.848GlnGly: 1.848 ± 0.061	0.532GlnHis: 0.532 ± 0.028	2.996GlnIle: 2.996 ± 0.068	2.88GlnLys: 2.88 ± 0.071	3.523GlnLeu: 3.523 ± 0.084	1.061GlnMet: 1.061 ± 0.045	2.18GlnAsn: 2.18 ± 0.065	1.069GlnPro: 1.069 ± 0.039	1.489GlnGln: 1.489 ± 0.059	1.406GlnArg: 1.406 ± 0.05	2.277GlnSer: 2.277 ± 0.072	2.051GlnThr: 2.051 ± 0.064	2.516GlnVal: 2.516 ± 0.066	0.312GlnTrp: 0.312 ± 0.021	1.186GlnTyr: 1.186 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	2.066ArgAla: 2.066 ± 0.059	0.15ArgCys: 0.15 ± 0.016	2.013ArgAsp: 2.013 ± 0.055	2.038ArgGlu: 2.038 ± 0.07	1.55ArgPhe: 1.55 ± 0.045	2.0ArgGly: 2.0 ± 0.052	0.621ArgHis: 0.621 ± 0.031	2.675ArgIle: 2.675 ± 0.057	2.592ArgLys: 2.592 ± 0.058	3.036ArgLeu: 3.036 ± 0.08	0.972ArgMet: 0.972 ± 0.038	1.976ArgAsn: 1.976 ± 0.061	1.069ArgPro: 1.069 ± 0.046	1.319ArgGln: 1.319 ± 0.052	1.549ArgArg: 1.549 ± 0.056	2.006ArgSer: 2.006 ± 0.066	1.755ArgThr: 1.755 ± 0.056	2.39ArgVal: 2.39 ± 0.064	0.277ArgTrp: 0.277 ± 0.018	1.267ArgTyr: 1.267 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	4.18SerAla: 4.18 ± 0.09	0.247SerCys: 0.247 ± 0.023	4.758SerAsp: 4.758 ± 0.097	3.905SerGlu: 3.905 ± 0.089	3.256SerPhe: 3.256 ± 0.083	5.115SerGly: 5.115 ± 0.12	1.162SerHis: 1.162 ± 0.046	5.34SerIle: 5.34 ± 0.097	5.36SerLys: 5.36 ± 0.104	6.29SerLeu: 6.29 ± 0.125	1.758SerMet: 1.758 ± 0.057	4.185SerAsn: 4.185 ± 0.104	1.922SerPro: 1.922 ± 0.051	2.342SerGln: 2.342 ± 0.078	2.144SerArg: 2.144 ± 0.063	4.595SerSer: 4.595 ± 0.119	3.937SerThr: 3.937 ± 0.103	4.534SerVal: 4.534 ± 0.09	0.614SerTrp: 0.614 ± 0.033	2.477SerTyr: 2.477 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.85ThrAla: 3.85 ± 0.083	0.244ThrCys: 0.244 ± 0.022	3.979ThrAsp: 3.979 ± 0.115	2.898ThrGlu: 2.898 ± 0.07	2.583ThrPhe: 2.583 ± 0.066	4.382ThrGly: 4.382 ± 0.084	1.032ThrHis: 1.032 ± 0.042	5.005ThrIle: 5.005 ± 0.09	4.206ThrLys: 4.206 ± 0.071	5.26ThrLeu: 5.26 ± 0.101	1.395ThrMet: 1.395 ± 0.045	3.338ThrAsn: 3.338 ± 0.086	2.435ThrPro: 2.435 ± 0.068	1.715ThrGln: 1.715 ± 0.065	1.709ThrArg: 1.709 ± 0.052	4.076ThrSer: 4.076 ± 0.104	3.799ThrThr: 3.799 ± 0.117	4.28ThrVal: 4.28 ± 0.109	0.562ThrTrp: 0.562 ± 0.028	2.233ThrTyr: 2.233 ± 0.068	0.002ThrXaa: 0.002 ± 0.002
Val	4.738ValAla: 4.738 ± 0.096	0.393ValCys: 0.393 ± 0.029	4.6ValAsp: 4.6 ± 0.111	3.728ValGlu: 3.728 ± 0.08	2.904ValPhe: 2.904 ± 0.074	4.85ValGly: 4.85 ± 0.09	1.037ValHis: 1.037 ± 0.051	5.929ValIle: 5.929 ± 0.1	4.945ValLys: 4.945 ± 0.1	6.206ValLeu: 6.206 ± 0.118	1.656ValMet: 1.656 ± 0.058	3.61ValAsn: 3.61 ± 0.082	2.575ValPro: 2.575 ± 0.059	2.021ValGln: 2.021 ± 0.06	2.128ValArg: 2.128 ± 0.057	5.093ValSer: 5.093 ± 0.109	4.515ValThr: 4.515 ± 0.096	4.95ValVal: 4.95 ± 0.11	0.58ValTrp: 0.58 ± 0.026	2.336ValTyr: 2.336 ± 0.072	0.0ValXaa: 0.0 ± 0.0
Trp	0.518TrpAla: 0.518 ± 0.032	0.043TrpCys: 0.043 ± 0.008	0.511TrpAsp: 0.511 ± 0.03	0.353TrpGlu: 0.353 ± 0.023	0.467TrpPhe: 0.467 ± 0.029	0.564TrpGly: 0.564 ± 0.03	0.225TrpHis: 0.225 ± 0.019	0.836TrpIle: 0.836 ± 0.035	0.581TrpLys: 0.581 ± 0.032	0.982TrpLeu: 0.982 ± 0.044	0.296TrpMet: 0.296 ± 0.022	0.58TrpAsn: 0.58 ± 0.032	0.236TrpPro: 0.236 ± 0.023	0.413TrpGln: 0.413 ± 0.028	0.336TrpArg: 0.336 ± 0.023	0.599TrpSer: 0.599 ± 0.029	0.516TrpThr: 0.516 ± 0.031	0.591TrpVal: 0.591 ± 0.028	0.131TrpTrp: 0.131 ± 0.016	0.375TrpTyr: 0.375 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.074TyrAla: 2.074 ± 0.062	0.203TyrCys: 0.203 ± 0.018	2.421TyrAsp: 2.421 ± 0.074	1.827TyrGlu: 1.827 ± 0.048	1.919TyrPhe: 1.919 ± 0.059	2.424TyrGly: 2.424 ± 0.07	0.741TyrHis: 0.741 ± 0.032	2.556TyrIle: 2.556 ± 0.065	2.447TyrLys: 2.447 ± 0.067	4.032TyrLeu: 4.032 ± 0.094	0.956TyrMet: 0.956 ± 0.037	2.063TyrAsn: 2.063 ± 0.063	1.292TyrPro: 1.292 ± 0.044	1.838TyrGln: 1.838 ± 0.055	1.59TyrArg: 1.59 ± 0.054	2.491TyrSer: 2.491 ± 0.07	2.065TyrThr: 2.065 ± 0.064	2.339TyrVal: 2.339 ± 0.053	0.394TyrTrp: 0.394 ± 0.027	1.618TyrTyr: 1.618 ± 0.058	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.002XaaMet: 0.002 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.035XaaXaa: 0.035 ± 0.033

Statistics based on 2050 proteins (631509 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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