Amino acid dipepetide frequency for Corynebacterium cystitidis DSM 20524

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.164AlaAla: 13.164 ± 0.18	0.868AlaCys: 0.868 ± 0.037	6.914AlaAsp: 6.914 ± 0.1	7.111AlaGlu: 7.111 ± 0.102	3.443AlaPhe: 3.443 ± 0.063	9.762AlaGly: 9.762 ± 0.126	2.435AlaHis: 2.435 ± 0.06	5.508AlaIle: 5.508 ± 0.08	3.293AlaLys: 3.293 ± 0.067	10.944AlaLeu: 10.944 ± 0.13	2.597AlaMet: 2.597 ± 0.056	2.851AlaAsn: 2.851 ± 0.057	4.859AlaPro: 4.859 ± 0.104	4.327AlaGln: 4.327 ± 0.07	6.663AlaArg: 6.663 ± 0.108	5.856AlaSer: 5.856 ± 0.085	7.127AlaThr: 7.127 ± 0.104	9.16AlaVal: 9.16 ± 0.111	1.537AlaTrp: 1.537 ± 0.044	2.41AlaTyr: 2.41 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.755CysAla: 0.755 ± 0.033	0.072CysCys: 0.072 ± 0.01	0.427CysAsp: 0.427 ± 0.025	0.378CysGlu: 0.378 ± 0.021	0.224CysPhe: 0.224 ± 0.017	0.7CysGly: 0.7 ± 0.03	0.169CysHis: 0.169 ± 0.014	0.282CysIle: 0.282 ± 0.018	0.15CysLys: 0.15 ± 0.014	0.551CysLeu: 0.551 ± 0.028	0.132CysMet: 0.132 ± 0.012	0.18CysAsn: 0.18 ± 0.015	0.332CysPro: 0.332 ± 0.02	0.246CysGln: 0.246 ± 0.016	0.293CysArg: 0.293 ± 0.017	0.451CysSer: 0.451 ± 0.024	0.433CysThr: 0.433 ± 0.021	0.536CysVal: 0.536 ± 0.024	0.097CysTrp: 0.097 ± 0.009	0.14CysTyr: 0.14 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.469AspAla: 6.469 ± 0.095	0.324AspCys: 0.324 ± 0.019	4.46AspAsp: 4.46 ± 0.088	4.85AspGlu: 4.85 ± 0.089	2.16AspPhe: 2.16 ± 0.047	5.151AspGly: 5.151 ± 0.086	1.439AspHis: 1.439 ± 0.04	3.164AspIle: 3.164 ± 0.062	2.189AspLys: 2.189 ± 0.056	5.49AspLeu: 5.49 ± 0.09	1.265AspMet: 1.265 ± 0.038	2.007AspAsn: 2.007 ± 0.059	3.685AspPro: 3.685 ± 0.069	2.164AspGln: 2.164 ± 0.046	3.356AspArg: 3.356 ± 0.061	3.341AspSer: 3.341 ± 0.054	3.682AspThr: 3.682 ± 0.064	4.79AspVal: 4.79 ± 0.078	0.878AspTrp: 0.878 ± 0.04	1.759AspTyr: 1.759 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.741GluAla: 6.741 ± 0.102	0.341GluCys: 0.341 ± 0.018	3.458GluAsp: 3.458 ± 0.076	4.354GluGlu: 4.354 ± 0.089	2.187GluPhe: 2.187 ± 0.052	4.267GluGly: 4.267 ± 0.08	1.571GluHis: 1.571 ± 0.04	3.692GluIle: 3.692 ± 0.061	2.527GluLys: 2.527 ± 0.062	6.824GluLeu: 6.824 ± 0.111	1.417GluMet: 1.417 ± 0.044	1.894GluAsn: 1.894 ± 0.052	2.898GluPro: 2.898 ± 0.071	2.713GluGln: 2.713 ± 0.055	3.78GluArg: 3.78 ± 0.074	3.274GluSer: 3.274 ± 0.066	3.415GluThr: 3.415 ± 0.067	5.005GluVal: 5.005 ± 0.084	0.803GluTrp: 0.803 ± 0.031	1.463GluTyr: 1.463 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.638PheAla: 3.638 ± 0.058	0.231PheCys: 0.231 ± 0.017	2.448PheAsp: 2.448 ± 0.057	1.924PheGlu: 1.924 ± 0.046	1.313PhePhe: 1.313 ± 0.043	3.285PheGly: 3.285 ± 0.065	0.742PheHis: 0.742 ± 0.031	1.649PheIle: 1.649 ± 0.046	0.813PheLys: 0.813 ± 0.026	3.043PheLeu: 3.043 ± 0.074	0.68PheMet: 0.68 ± 0.029	1.145PheAsn: 1.145 ± 0.035	1.453PhePro: 1.453 ± 0.041	0.938PheGln: 0.938 ± 0.031	1.665PheArg: 1.665 ± 0.044	2.291PheSer: 2.291 ± 0.052	2.352PheThr: 2.352 ± 0.05	2.659PheVal: 2.659 ± 0.06	0.49PheTrp: 0.49 ± 0.027	0.808PheTyr: 0.808 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.426GlyAla: 8.426 ± 0.119	0.629GlyCys: 0.629 ± 0.03	4.543GlyAsp: 4.543 ± 0.087	5.012GlyGlu: 5.012 ± 0.085	3.084GlyPhe: 3.084 ± 0.058	6.534GlyGly: 6.534 ± 0.13	1.85GlyHis: 1.85 ± 0.048	4.457GlyIle: 4.457 ± 0.076	3.06GlyLys: 3.06 ± 0.067	7.765GlyLeu: 7.765 ± 0.099	2.152GlyMet: 2.152 ± 0.048	2.344GlyAsn: 2.344 ± 0.056	3.337GlyPro: 3.337 ± 0.058	2.991GlyGln: 2.991 ± 0.068	4.727GlyArg: 4.727 ± 0.084	5.014GlySer: 5.014 ± 0.104	5.289GlyThr: 5.289 ± 0.081	7.194GlyVal: 7.194 ± 0.112	1.412GlyTrp: 1.412 ± 0.043	2.252GlyTyr: 2.252 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.209HisAla: 2.209 ± 0.054	0.172HisCys: 0.172 ± 0.014	1.476HisAsp: 1.476 ± 0.042	1.321HisGlu: 1.321 ± 0.044	0.731HisPhe: 0.731 ± 0.03	1.984HisGly: 1.984 ± 0.051	0.63HisHis: 0.63 ± 0.027	1.133HisIle: 1.133 ± 0.033	0.562HisLys: 0.562 ± 0.023	2.088HisLeu: 2.088 ± 0.048	0.466HisMet: 0.466 ± 0.025	0.733HisAsn: 0.733 ± 0.024	1.505HisPro: 1.505 ± 0.045	0.791HisGln: 0.791 ± 0.027	1.347HisArg: 1.347 ± 0.041	1.288HisSer: 1.288 ± 0.037	1.356HisThr: 1.356 ± 0.047	1.722HisVal: 1.722 ± 0.044	0.287HisTrp: 0.287 ± 0.017	0.566HisTyr: 0.566 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.464IleAla: 6.464 ± 0.099	0.333IleCys: 0.333 ± 0.019	3.938IleAsp: 3.938 ± 0.072	3.125IleGlu: 3.125 ± 0.063	1.641IlePhe: 1.641 ± 0.046	4.445IleGly: 4.445 ± 0.082	0.97IleHis: 0.97 ± 0.038	2.708IleIle: 2.708 ± 0.069	1.436IleLys: 1.436 ± 0.046	4.075IleLeu: 4.075 ± 0.076	1.058IleMet: 1.058 ± 0.035	1.725IleAsn: 1.725 ± 0.045	2.623IlePro: 2.623 ± 0.055	1.364IleGln: 1.364 ± 0.037	2.604IleArg: 2.604 ± 0.057	3.124IleSer: 3.124 ± 0.068	3.603IleThr: 3.603 ± 0.073	4.696IleVal: 4.696 ± 0.082	0.53IleTrp: 0.53 ± 0.025	1.161IleTyr: 1.161 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.355LysAla: 3.355 ± 0.078	0.149LysCys: 0.149 ± 0.015	1.984LysAsp: 1.984 ± 0.055	1.902LysGlu: 1.902 ± 0.05	0.933LysPhe: 0.933 ± 0.033	2.122LysGly: 2.122 ± 0.051	0.797LysHis: 0.797 ± 0.029	1.649LysIle: 1.649 ± 0.045	1.715LysLys: 1.715 ± 0.056	2.957LysLeu: 2.957 ± 0.057	0.734LysMet: 0.734 ± 0.029	1.171LysAsn: 1.171 ± 0.037	1.691LysPro: 1.691 ± 0.057	1.239LysGln: 1.239 ± 0.039	2.23LysArg: 2.23 ± 0.049	1.652LysSer: 1.652 ± 0.044	1.886LysThr: 1.886 ± 0.051	2.439LysVal: 2.439 ± 0.058	0.424LysTrp: 0.424 ± 0.019	0.792LysTyr: 0.792 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.337LeuAla: 11.337 ± 0.147	0.601LeuCys: 0.601 ± 0.021	6.075LeuAsp: 6.075 ± 0.076	5.347LeuGlu: 5.347 ± 0.097	2.887LeuPhe: 2.887 ± 0.06	7.926LeuGly: 7.926 ± 0.109	1.996LeuHis: 1.996 ± 0.054	5.075LeuIle: 5.075 ± 0.081	2.69LeuLys: 2.69 ± 0.065	8.689LeuLeu: 8.689 ± 0.133	1.965LeuMet: 1.965 ± 0.048	2.886LeuAsn: 2.886 ± 0.059	4.972LeuPro: 4.972 ± 0.085	2.566LeuGln: 2.566 ± 0.051	5.932LeuArg: 5.932 ± 0.1	5.825LeuSer: 5.825 ± 0.09	5.872LeuThr: 5.872 ± 0.087	8.034LeuVal: 8.034 ± 0.12	1.17LeuTrp: 1.17 ± 0.04	1.902LeuTyr: 1.902 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.548MetAla: 2.548 ± 0.05	0.15MetCys: 0.15 ± 0.013	1.158MetAsp: 1.158 ± 0.038	1.144MetGlu: 1.144 ± 0.038	0.691MetPhe: 0.691 ± 0.031	1.649MetGly: 1.649 ± 0.046	0.429MetHis: 0.429 ± 0.024	1.331MetIle: 1.331 ± 0.042	0.782MetLys: 0.782 ± 0.029	2.118MetLeu: 2.118 ± 0.052	0.528MetMet: 0.528 ± 0.027	0.747MetAsn: 0.747 ± 0.028	1.129MetPro: 1.129 ± 0.036	0.669MetGln: 0.669 ± 0.025	1.423MetArg: 1.423 ± 0.034	1.788MetSer: 1.788 ± 0.049	1.694MetThr: 1.694 ± 0.048	1.805MetVal: 1.805 ± 0.045	0.31MetTrp: 0.31 ± 0.02	0.447MetTyr: 0.447 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.095AsnAla: 3.095 ± 0.068	0.194AsnCys: 0.194 ± 0.014	1.786AsnAsp: 1.786 ± 0.045	1.713AsnGlu: 1.713 ± 0.044	1.004AsnPhe: 1.004 ± 0.036	2.296AsnGly: 2.296 ± 0.056	0.729AsnHis: 0.729 ± 0.032	1.469AsnIle: 1.469 ± 0.039	1.06AsnLys: 1.06 ± 0.036	2.842AsnLeu: 2.842 ± 0.064	0.694AsnMet: 0.694 ± 0.027	1.116AsnAsn: 1.116 ± 0.04	2.2AsnPro: 2.2 ± 0.05	1.238AsnGln: 1.238 ± 0.045	1.813AsnArg: 1.813 ± 0.05	1.759AsnSer: 1.759 ± 0.042	1.84AsnThr: 1.84 ± 0.048	2.287AsnVal: 2.287 ± 0.052	0.475AsnTrp: 0.475 ± 0.022	0.83AsnTyr: 0.83 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.636ProAla: 5.636 ± 0.097	0.197ProCys: 0.197 ± 0.016	3.395ProAsp: 3.395 ± 0.056	4.237ProGlu: 4.237 ± 0.076	1.571ProPhe: 1.571 ± 0.042	4.458ProGly: 4.458 ± 0.086	1.208ProHis: 1.208 ± 0.037	2.14ProIle: 2.14 ± 0.046	1.538ProLys: 1.538 ± 0.047	4.148ProLeu: 4.148 ± 0.082	0.991ProMet: 0.991 ± 0.03	1.517ProAsn: 1.517 ± 0.043	1.956ProPro: 1.956 ± 0.062	1.983ProGln: 1.983 ± 0.052	2.704ProArg: 2.704 ± 0.052	2.767ProSer: 2.767 ± 0.062	3.328ProThr: 3.328 ± 0.07	4.397ProVal: 4.397 ± 0.083	0.759ProTrp: 0.759 ± 0.029	1.146ProTyr: 1.146 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.121GlnAla: 4.121 ± 0.078	0.186GlnCys: 0.186 ± 0.015	1.729GlnAsp: 1.729 ± 0.043	1.989GlnGlu: 1.989 ± 0.048	1.139GlnPhe: 1.139 ± 0.04	2.397GlnGly: 2.397 ± 0.052	0.835GlnHis: 0.835 ± 0.032	1.777GlnIle: 1.777 ± 0.047	1.078GlnLys: 1.078 ± 0.038	3.802GlnLeu: 3.802 ± 0.067	0.815GlnMet: 0.815 ± 0.03	0.94GlnAsn: 0.94 ± 0.033	2.058GlnPro: 2.058 ± 0.064	1.678GlnGln: 1.678 ± 0.06	2.753GlnArg: 2.753 ± 0.062	1.707GlnSer: 1.707 ± 0.042	1.666GlnThr: 1.666 ± 0.042	2.756GlnVal: 2.756 ± 0.056	0.7GlnTrp: 0.7 ± 0.03	0.79GlnTyr: 0.79 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.146ArgAla: 6.146 ± 0.1	0.363ArgCys: 0.363 ± 0.021	3.829ArgAsp: 3.829 ± 0.069	4.019ArgGlu: 4.019 ± 0.075	2.169ArgPhe: 2.169 ± 0.058	4.375ArgGly: 4.375 ± 0.071	1.402ArgHis: 1.402 ± 0.041	3.205ArgIle: 3.205 ± 0.06	2.129ArgLys: 2.129 ± 0.053	5.418ArgLeu: 5.418 ± 0.092	1.615ArgMet: 1.615 ± 0.047	1.912ArgAsn: 1.912 ± 0.045	2.66ArgPro: 2.66 ± 0.052	2.225ArgGln: 2.225 ± 0.053	4.698ArgArg: 4.698 ± 0.099	3.324ArgSer: 3.324 ± 0.079	3.665ArgThr: 3.665 ± 0.062	4.468ArgVal: 4.468 ± 0.071	0.923ArgTrp: 0.923 ± 0.032	1.646ArgTyr: 1.646 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.209SerAla: 6.209 ± 0.096	0.365SerCys: 0.365 ± 0.02	3.298SerAsp: 3.298 ± 0.069	3.22SerGlu: 3.22 ± 0.07	2.11SerPhe: 2.11 ± 0.046	5.498SerGly: 5.498 ± 0.092	1.279SerHis: 1.279 ± 0.036	2.792SerIle: 2.792 ± 0.059	1.704SerLys: 1.704 ± 0.046	5.254SerLeu: 5.254 ± 0.087	1.5SerMet: 1.5 ± 0.043	1.647SerAsn: 1.647 ± 0.047	3.0SerPro: 3.0 ± 0.054	2.107SerGln: 2.107 ± 0.052	3.418SerArg: 3.418 ± 0.066	4.247SerSer: 4.247 ± 0.091	4.222SerThr: 4.222 ± 0.086	4.607SerVal: 4.607 ± 0.069	0.936SerTrp: 0.936 ± 0.04	1.391SerTyr: 1.391 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.738ThrAla: 6.738 ± 0.093	0.42ThrCys: 0.42 ± 0.023	3.62ThrAsp: 3.62 ± 0.072	3.49ThrGlu: 3.49 ± 0.063	2.047ThrPhe: 2.047 ± 0.05	5.498ThrGly: 5.498 ± 0.083	1.374ThrHis: 1.374 ± 0.043	3.339ThrIle: 3.339 ± 0.055	1.85ThrLys: 1.85 ± 0.057	5.895ThrLeu: 5.895 ± 0.087	1.382ThrMet: 1.382 ± 0.039	1.918ThrAsn: 1.918 ± 0.054	3.793ThrPro: 3.793 ± 0.073	1.988ThrGln: 1.988 ± 0.053	3.487ThrArg: 3.487 ± 0.064	3.819ThrSer: 3.819 ± 0.072	4.671ThrThr: 4.671 ± 0.098	5.87ThrVal: 5.87 ± 0.088	0.972ThrTrp: 0.972 ± 0.035	1.497ThrTyr: 1.497 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.842ValAla: 9.842 ± 0.122	0.622ValCys: 0.622 ± 0.027	5.745ValAsp: 5.745 ± 0.079	5.308ValGlu: 5.308 ± 0.08	2.729ValPhe: 2.729 ± 0.062	6.715ValGly: 6.715 ± 0.113	1.663ValHis: 1.663 ± 0.044	4.449ValIle: 4.449 ± 0.067	2.21ValLys: 2.21 ± 0.052	7.9ValLeu: 7.9 ± 0.098	1.757ValMet: 1.757 ± 0.045	2.402ValAsn: 2.402 ± 0.052	4.019ValPro: 4.019 ± 0.072	2.187ValGln: 2.187 ± 0.05	4.761ValArg: 4.761 ± 0.076	4.887ValSer: 4.887 ± 0.072	5.366ValThr: 5.366 ± 0.077	7.876ValVal: 7.876 ± 0.111	1.107ValTrp: 1.107 ± 0.038	1.775ValTyr: 1.775 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	1.538TrpAla: 1.538 ± 0.042	0.128TrpCys: 0.128 ± 0.013	0.821TrpAsp: 0.821 ± 0.03	0.757TrpGlu: 0.757 ± 0.03	0.559TrpPhe: 0.559 ± 0.028	0.946TrpGly: 0.946 ± 0.037	0.317TrpHis: 0.317 ± 0.019	0.831TrpIle: 0.831 ± 0.032	0.437TrpLys: 0.437 ± 0.023	1.667TrpLeu: 1.667 ± 0.042	0.352TrpMet: 0.352 ± 0.02	0.481TrpAsn: 0.481 ± 0.024	0.66TrpPro: 0.66 ± 0.032	0.61TrpGln: 0.61 ± 0.026	0.958TrpArg: 0.958 ± 0.035	0.813TrpSer: 0.813 ± 0.031	0.787TrpThr: 0.787 ± 0.031	1.257TrpVal: 1.257 ± 0.039	0.345TrpTrp: 0.345 ± 0.021	0.279TrpTyr: 0.279 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.4TyrAla: 2.4 ± 0.048	0.203TyrCys: 0.203 ± 0.014	1.518TyrAsp: 1.518 ± 0.046	1.423TyrGlu: 1.423 ± 0.047	0.946TyrPhe: 0.946 ± 0.038	2.063TyrGly: 2.063 ± 0.052	0.53TyrHis: 0.53 ± 0.023	0.974TyrIle: 0.974 ± 0.043	0.598TyrLys: 0.598 ± 0.026	2.279TyrLeu: 2.279 ± 0.064	0.439TyrMet: 0.439 ± 0.024	0.824TyrAsn: 0.824 ± 0.031	1.247TyrPro: 1.247 ± 0.04	0.891TyrGln: 0.891 ± 0.033	1.579TyrArg: 1.579 ± 0.044	1.575TyrSer: 1.575 ± 0.041	1.415TyrThr: 1.415 ± 0.041	1.762TyrVal: 1.762 ± 0.044	0.388TyrTrp: 0.388 ± 0.021	0.62TyrTyr: 0.62 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2787 proteins (873279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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