Amino acid dipepetide frequency for Caudovirales sp. ctOwN3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.433AlaAla: 8.433 ± 0.911
0.57AlaCys: 0.57 ± 0.208
3.989AlaAsp: 3.989 ± 0.41
5.869AlaGlu: 5.869 ± 0.513
3.305AlaPhe: 3.305 ± 0.515
8.433AlaGly: 8.433 ± 1.143
1.538AlaHis: 1.538 ± 0.288
5.356AlaIle: 5.356 ± 0.512
5.983AlaLys: 5.983 ± 0.766
6.553AlaLeu: 6.553 ± 0.83
3.191AlaMet: 3.191 ± 0.492
4.387AlaAsn: 4.387 ± 0.594
3.761AlaPro: 3.761 ± 0.466
3.932AlaGln: 3.932 ± 0.657
3.419AlaArg: 3.419 ± 0.449
5.584AlaSer: 5.584 ± 0.59
5.926AlaThr: 5.926 ± 0.837
6.895AlaVal: 6.895 ± 0.718
0.912AlaTrp: 0.912 ± 0.231
3.476AlaTyr: 3.476 ± 0.54
0.0AlaXaa: 0.0 ± 0.0
Cys
0.399CysAla: 0.399 ± 0.182
0.0CysCys: 0.0 ± 0.0
0.798CysAsp: 0.798 ± 0.262
0.171CysGlu: 0.171 ± 0.102
0.342CysPhe: 0.342 ± 0.155
0.456CysGly: 0.456 ± 0.146
0.171CysHis: 0.171 ± 0.101
0.627CysIle: 0.627 ± 0.221
0.513CysLys: 0.513 ± 0.194
0.627CysLeu: 0.627 ± 0.184
0.114CysMet: 0.114 ± 0.079
0.228CysAsn: 0.228 ± 0.122
0.342CysPro: 0.342 ± 0.155
0.057CysGln: 0.057 ± 0.063
0.627CysArg: 0.627 ± 0.201
0.684CysSer: 0.684 ± 0.217
0.456CysThr: 0.456 ± 0.14
0.684CysVal: 0.684 ± 0.238
0.342CysTrp: 0.342 ± 0.167
0.114CysTyr: 0.114 ± 0.086
0.0CysXaa: 0.0 ± 0.0
Asp
4.16AspAla: 4.16 ± 0.503
0.228AspCys: 0.228 ± 0.13
3.419AspAsp: 3.419 ± 0.601
4.558AspGlu: 4.558 ± 0.608
1.937AspPhe: 1.937 ± 0.301
4.672AspGly: 4.672 ± 0.645
0.741AspHis: 0.741 ± 0.224
2.963AspIle: 2.963 ± 0.482
3.476AspLys: 3.476 ± 0.48
5.242AspLeu: 5.242 ± 0.625
1.311AspMet: 1.311 ± 0.249
1.823AspAsn: 1.823 ± 0.294
3.818AspPro: 3.818 ± 0.453
1.823AspGln: 1.823 ± 0.398
2.45AspArg: 2.45 ± 0.406
2.336AspSer: 2.336 ± 0.359
3.533AspThr: 3.533 ± 0.395
3.818AspVal: 3.818 ± 0.476
0.684AspTrp: 0.684 ± 0.198
1.994AspTyr: 1.994 ± 0.319
0.0AspXaa: 0.0 ± 0.0
Glu
5.869GluAla: 5.869 ± 0.77
0.399GluCys: 0.399 ± 0.156
3.02GluAsp: 3.02 ± 0.502
2.963GluGlu: 2.963 ± 0.402
2.735GluPhe: 2.735 ± 0.514
5.299GluGly: 5.299 ± 0.783
1.538GluHis: 1.538 ± 0.344
2.963GluIle: 2.963 ± 0.399
4.16GluLys: 4.16 ± 0.674
5.755GluLeu: 5.755 ± 0.634
2.051GluMet: 2.051 ± 0.363
2.165GluAsn: 2.165 ± 0.364
2.393GluPro: 2.393 ± 0.357
3.362GluGln: 3.362 ± 0.545
3.59GluArg: 3.59 ± 0.611
2.108GluSer: 2.108 ± 0.344
2.222GluThr: 2.222 ± 0.33
3.134GluVal: 3.134 ± 0.392
0.627GluTrp: 0.627 ± 0.286
2.849GluTyr: 2.849 ± 0.418
0.0GluXaa: 0.0 ± 0.0
Phe
2.849PheAla: 2.849 ± 0.312
0.228PheCys: 0.228 ± 0.13
2.165PheAsp: 2.165 ± 0.3
2.051PheGlu: 2.051 ± 0.352
1.083PhePhe: 1.083 ± 0.276
3.191PheGly: 3.191 ± 0.388
0.57PheHis: 0.57 ± 0.174
1.709PheIle: 1.709 ± 0.409
2.279PheLys: 2.279 ± 0.396
2.792PheLeu: 2.792 ± 0.444
0.912PheMet: 0.912 ± 0.21
1.652PheAsn: 1.652 ± 0.258
1.538PhePro: 1.538 ± 0.315
1.083PheGln: 1.083 ± 0.275
1.709PheArg: 1.709 ± 0.301
2.735PheSer: 2.735 ± 0.416
3.02PheThr: 3.02 ± 0.536
1.994PheVal: 1.994 ± 0.317
0.57PheTrp: 0.57 ± 0.243
1.425PheTyr: 1.425 ± 0.303
0.0PheXaa: 0.0 ± 0.0
Gly
7.578GlyAla: 7.578 ± 1.132
0.684GlyCys: 0.684 ± 0.216
3.989GlyAsp: 3.989 ± 0.57
3.932GlyGlu: 3.932 ± 0.399
2.906GlyPhe: 2.906 ± 0.532
7.464GlyGly: 7.464 ± 1.292
1.481GlyHis: 1.481 ± 0.373
5.299GlyIle: 5.299 ± 0.447
4.615GlyLys: 4.615 ± 0.694
6.496GlyLeu: 6.496 ± 0.771
1.595GlyMet: 1.595 ± 0.271
3.305GlyAsn: 3.305 ± 0.555
2.165GlyPro: 2.165 ± 0.365
4.046GlyGln: 4.046 ± 0.501
3.533GlyArg: 3.533 ± 0.572
6.781GlySer: 6.781 ± 0.851
7.863GlyThr: 7.863 ± 1.519
5.413GlyVal: 5.413 ± 0.708
1.311GlyTrp: 1.311 ± 0.322
2.963GlyTyr: 2.963 ± 0.495
0.0GlyXaa: 0.0 ± 0.0
His
1.14HisAla: 1.14 ± 0.302
0.399HisCys: 0.399 ± 0.174
0.513HisAsp: 0.513 ± 0.166
1.481HisGlu: 1.481 ± 0.329
0.741HisPhe: 0.741 ± 0.183
1.026HisGly: 1.026 ± 0.233
0.399HisHis: 0.399 ± 0.157
1.14HisIle: 1.14 ± 0.25
1.083HisLys: 1.083 ± 0.251
1.88HisLeu: 1.88 ± 0.449
0.513HisMet: 0.513 ± 0.194
0.627HisAsn: 0.627 ± 0.174
1.197HisPro: 1.197 ± 0.332
0.57HisGln: 0.57 ± 0.16
0.855HisArg: 0.855 ± 0.251
0.741HisSer: 0.741 ± 0.274
0.855HisThr: 0.855 ± 0.217
1.254HisVal: 1.254 ± 0.26
0.228HisTrp: 0.228 ± 0.113
0.741HisTyr: 0.741 ± 0.163
0.0HisXaa: 0.0 ± 0.0
Ile
3.989IleAla: 3.989 ± 0.509
0.171IleCys: 0.171 ± 0.111
3.932IleAsp: 3.932 ± 0.548
3.419IleGlu: 3.419 ± 0.586
1.937IlePhe: 1.937 ± 0.334
4.103IleGly: 4.103 ± 0.416
0.684IleHis: 0.684 ± 0.273
2.279IleIle: 2.279 ± 0.372
3.134IleLys: 3.134 ± 0.48
3.59IleLeu: 3.59 ± 0.427
1.652IleMet: 1.652 ± 0.34
3.191IleAsn: 3.191 ± 0.385
2.45IlePro: 2.45 ± 0.384
1.368IleGln: 1.368 ± 0.284
1.994IleArg: 1.994 ± 0.378
3.419IleSer: 3.419 ± 0.478
4.729IleThr: 4.729 ± 0.829
3.248IleVal: 3.248 ± 0.43
1.026IleTrp: 1.026 ± 0.327
2.621IleTyr: 2.621 ± 0.294
0.0IleXaa: 0.0 ± 0.0
Lys
5.413LysAla: 5.413 ± 0.734
0.513LysCys: 0.513 ± 0.177
3.59LysAsp: 3.59 ± 0.554
4.16LysGlu: 4.16 ± 0.629
1.595LysPhe: 1.595 ± 0.366
4.558LysGly: 4.558 ± 0.849
1.311LysHis: 1.311 ± 0.39
4.046LysIle: 4.046 ± 0.544
4.444LysLys: 4.444 ± 0.735
4.274LysLeu: 4.274 ± 0.743
1.994LysMet: 1.994 ± 0.277
2.393LysAsn: 2.393 ± 0.341
1.766LysPro: 1.766 ± 0.332
3.02LysGln: 3.02 ± 0.479
3.305LysArg: 3.305 ± 0.385
2.564LysSer: 2.564 ± 0.347
2.963LysThr: 2.963 ± 0.452
3.818LysVal: 3.818 ± 0.445
0.912LysTrp: 0.912 ± 0.198
1.88LysTyr: 1.88 ± 0.354
0.0LysXaa: 0.0 ± 0.0
Leu
7.749LeuAla: 7.749 ± 0.858
0.57LeuCys: 0.57 ± 0.211
4.33LeuAsp: 4.33 ± 0.548
4.957LeuGlu: 4.957 ± 0.6
2.678LeuPhe: 2.678 ± 0.353
5.869LeuGly: 5.869 ± 0.643
1.311LeuHis: 1.311 ± 0.323
3.818LeuIle: 3.818 ± 0.499
4.843LeuLys: 4.843 ± 0.815
4.9LeuLeu: 4.9 ± 0.569
1.88LeuMet: 1.88 ± 0.317
3.476LeuAsn: 3.476 ± 0.457
4.444LeuPro: 4.444 ± 0.466
4.103LeuGln: 4.103 ± 0.455
4.16LeuArg: 4.16 ± 0.605
5.185LeuSer: 5.185 ± 0.598
5.869LeuThr: 5.869 ± 0.817
4.217LeuVal: 4.217 ± 0.409
0.741LeuTrp: 0.741 ± 0.198
2.792LeuTyr: 2.792 ± 0.445
0.0LeuXaa: 0.0 ± 0.0
Met
3.134MetAla: 3.134 ± 0.417
0.228MetCys: 0.228 ± 0.121
1.311MetAsp: 1.311 ± 0.256
1.197MetGlu: 1.197 ± 0.247
0.969MetPhe: 0.969 ± 0.244
1.481MetGly: 1.481 ± 0.32
0.513MetHis: 0.513 ± 0.197
0.912MetIle: 0.912 ± 0.265
1.595MetLys: 1.595 ± 0.315
2.108MetLeu: 2.108 ± 0.389
0.684MetMet: 0.684 ± 0.255
0.912MetAsn: 0.912 ± 0.324
1.083MetPro: 1.083 ± 0.261
1.368MetGln: 1.368 ± 0.305
1.766MetArg: 1.766 ± 0.335
2.678MetSer: 2.678 ± 0.358
1.709MetThr: 1.709 ± 0.308
1.425MetVal: 1.425 ± 0.415
0.228MetTrp: 0.228 ± 0.119
0.798MetTyr: 0.798 ± 0.198
0.0MetXaa: 0.0 ± 0.0
Asn
3.989AsnAla: 3.989 ± 0.525
0.456AsnCys: 0.456 ± 0.163
2.564AsnAsp: 2.564 ± 0.387
2.222AsnGlu: 2.222 ± 0.358
1.026AsnPhe: 1.026 ± 0.241
3.875AsnGly: 3.875 ± 0.771
0.57AsnHis: 0.57 ± 0.164
2.45AsnIle: 2.45 ± 0.271
1.481AsnLys: 1.481 ± 0.335
3.875AsnLeu: 3.875 ± 0.439
1.14AsnMet: 1.14 ± 0.225
2.336AsnAsn: 2.336 ± 0.493
3.305AsnPro: 3.305 ± 0.388
2.507AsnGln: 2.507 ± 0.356
2.108AsnArg: 2.108 ± 0.303
2.678AsnSer: 2.678 ± 0.32
3.02AsnThr: 3.02 ± 0.582
2.564AsnVal: 2.564 ± 0.343
1.026AsnTrp: 1.026 ± 0.233
1.652AsnTyr: 1.652 ± 0.278
0.0AsnXaa: 0.0 ± 0.0
Pro
4.274ProAla: 4.274 ± 0.456
0.399ProCys: 0.399 ± 0.174
2.849ProAsp: 2.849 ± 0.344
4.16ProGlu: 4.16 ± 0.844
1.994ProPhe: 1.994 ± 0.346
3.248ProGly: 3.248 ± 0.533
0.798ProHis: 0.798 ± 0.212
2.564ProIle: 2.564 ± 0.466
2.222ProLys: 2.222 ± 0.372
3.476ProLeu: 3.476 ± 0.559
1.083ProMet: 1.083 ± 0.301
1.937ProAsn: 1.937 ± 0.342
1.368ProPro: 1.368 ± 0.269
2.222ProGln: 2.222 ± 0.384
2.393ProArg: 2.393 ± 0.355
3.419ProSer: 3.419 ± 0.406
2.564ProThr: 2.564 ± 0.457
3.077ProVal: 3.077 ± 0.369
0.399ProTrp: 0.399 ± 0.146
1.368ProTyr: 1.368 ± 0.249
0.0ProXaa: 0.0 ± 0.0
Gln
5.014GlnAla: 5.014 ± 0.66
0.285GlnCys: 0.285 ± 0.147
2.051GlnAsp: 2.051 ± 0.363
2.621GlnGlu: 2.621 ± 0.523
1.709GlnPhe: 1.709 ± 0.256
3.533GlnGly: 3.533 ± 0.584
0.627GlnHis: 0.627 ± 0.166
1.994GlnIle: 1.994 ± 0.282
2.564GlnLys: 2.564 ± 0.367
3.875GlnLeu: 3.875 ± 0.55
1.026GlnMet: 1.026 ± 0.257
1.368GlnAsn: 1.368 ± 0.28
1.481GlnPro: 1.481 ± 0.28
3.02GlnGln: 3.02 ± 0.738
2.621GlnArg: 2.621 ± 0.35
2.678GlnSer: 2.678 ± 0.29
2.735GlnThr: 2.735 ± 0.478
2.906GlnVal: 2.906 ± 0.613
0.57GlnTrp: 0.57 ± 0.192
2.222GlnTyr: 2.222 ± 0.343
0.0GlnXaa: 0.0 ± 0.0
Arg
4.217ArgAla: 4.217 ± 0.409
0.399ArgCys: 0.399 ± 0.155
2.108ArgAsp: 2.108 ± 0.382
3.305ArgGlu: 3.305 ± 0.505
1.994ArgPhe: 1.994 ± 0.416
3.305ArgGly: 3.305 ± 0.524
1.254ArgHis: 1.254 ± 0.298
2.564ArgIle: 2.564 ± 0.398
3.191ArgLys: 3.191 ± 0.554
4.33ArgLeu: 4.33 ± 0.568
1.652ArgMet: 1.652 ± 0.403
2.507ArgAsn: 2.507 ± 0.392
1.538ArgPro: 1.538 ± 0.3
2.45ArgGln: 2.45 ± 0.399
2.735ArgArg: 2.735 ± 0.45
2.849ArgSer: 2.849 ± 0.434
2.45ArgThr: 2.45 ± 0.379
2.621ArgVal: 2.621 ± 0.371
0.969ArgTrp: 0.969 ± 0.216
1.538ArgTyr: 1.538 ± 0.415
0.0ArgXaa: 0.0 ± 0.0
Ser
6.097SerAla: 6.097 ± 0.985
0.342SerCys: 0.342 ± 0.193
3.362SerAsp: 3.362 ± 0.356
2.735SerGlu: 2.735 ± 0.349
2.051SerPhe: 2.051 ± 0.367
7.464SerGly: 7.464 ± 0.958
0.57SerHis: 0.57 ± 0.253
3.02SerIle: 3.02 ± 0.368
3.134SerLys: 3.134 ± 0.54
4.16SerLeu: 4.16 ± 0.492
1.538SerMet: 1.538 ± 0.249
3.305SerAsn: 3.305 ± 0.495
2.849SerPro: 2.849 ± 0.391
2.735SerGln: 2.735 ± 0.326
2.678SerArg: 2.678 ± 0.386
4.103SerSer: 4.103 ± 0.568
5.071SerThr: 5.071 ± 0.789
5.014SerVal: 5.014 ± 0.546
0.855SerTrp: 0.855 ± 0.262
2.564SerTyr: 2.564 ± 0.33
0.0SerXaa: 0.0 ± 0.0
Thr
6.838ThrAla: 6.838 ± 1.143
0.228ThrCys: 0.228 ± 0.115
3.362ThrAsp: 3.362 ± 0.575
2.963ThrGlu: 2.963 ± 0.444
2.564ThrPhe: 2.564 ± 0.424
6.952ThrGly: 6.952 ± 0.904
0.912ThrHis: 0.912 ± 0.27
4.217ThrIle: 4.217 ± 0.722
3.191ThrLys: 3.191 ± 0.384
4.957ThrLeu: 4.957 ± 0.583
1.14ThrMet: 1.14 ± 0.234
3.704ThrAsn: 3.704 ± 0.671
4.217ThrPro: 4.217 ± 0.632
2.849ThrGln: 2.849 ± 0.492
2.735ThrArg: 2.735 ± 0.378
5.413ThrSer: 5.413 ± 1.08
5.812ThrThr: 5.812 ± 1.207
4.16ThrVal: 4.16 ± 0.669
0.627ThrTrp: 0.627 ± 0.192
2.621ThrTyr: 2.621 ± 0.565
0.0ThrXaa: 0.0 ± 0.0
Val
5.641ValAla: 5.641 ± 0.673
0.57ValCys: 0.57 ± 0.175
4.387ValAsp: 4.387 ± 0.57
3.761ValGlu: 3.761 ± 0.604
2.108ValPhe: 2.108 ± 0.379
4.615ValGly: 4.615 ± 0.447
1.083ValHis: 1.083 ± 0.274
2.849ValIle: 2.849 ± 0.399
3.704ValLys: 3.704 ± 0.508
5.413ValLeu: 5.413 ± 0.596
1.368ValMet: 1.368 ± 0.283
3.134ValAsn: 3.134 ± 0.422
3.875ValPro: 3.875 ± 0.569
1.88ValGln: 1.88 ± 0.317
3.02ValArg: 3.02 ± 0.459
4.33ValSer: 4.33 ± 0.616
5.014ValThr: 5.014 ± 0.863
4.274ValVal: 4.274 ± 0.62
0.912ValTrp: 0.912 ± 0.247
3.02ValTyr: 3.02 ± 0.518
0.0ValXaa: 0.0 ± 0.0
Trp
1.197TrpAla: 1.197 ± 0.245
0.399TrpCys: 0.399 ± 0.164
0.741TrpAsp: 0.741 ± 0.237
1.083TrpGlu: 1.083 ± 0.288
0.399TrpPhe: 0.399 ± 0.187
0.684TrpGly: 0.684 ± 0.189
0.513TrpHis: 0.513 ± 0.212
0.684TrpIle: 0.684 ± 0.242
0.684TrpLys: 0.684 ± 0.219
1.14TrpLeu: 1.14 ± 0.283
0.342TrpMet: 0.342 ± 0.132
0.456TrpAsn: 0.456 ± 0.184
0.513TrpPro: 0.513 ± 0.185
0.855TrpGln: 0.855 ± 0.179
0.798TrpArg: 0.798 ± 0.195
0.855TrpSer: 0.855 ± 0.21
0.741TrpThr: 0.741 ± 0.225
0.855TrpVal: 0.855 ± 0.19
0.171TrpTrp: 0.171 ± 0.09
0.798TrpTyr: 0.798 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.533TyrAla: 3.533 ± 0.441
0.684TyrCys: 0.684 ± 0.22
2.507TyrAsp: 2.507 ± 0.374
1.595TyrGlu: 1.595 ± 0.273
1.481TyrPhe: 1.481 ± 0.257
3.191TyrGly: 3.191 ± 0.494
0.798TyrHis: 0.798 ± 0.258
1.481TyrIle: 1.481 ± 0.261
2.222TyrLys: 2.222 ± 0.37
2.45TyrLeu: 2.45 ± 0.332
0.855TyrMet: 0.855 ± 0.2
1.937TyrAsn: 1.937 ± 0.332
1.709TyrPro: 1.709 ± 0.348
1.652TyrGln: 1.652 ± 0.438
1.481TyrArg: 1.481 ± 0.273
2.564TyrSer: 2.564 ± 0.404
2.906TyrThr: 2.906 ± 0.489
3.59TyrVal: 3.59 ± 0.445
0.798TyrTrp: 0.798 ± 0.207
1.823TyrTyr: 1.823 ± 0.312
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 68 proteins (17551 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski