Amino acid dipepetide frequency for Dishui Lake virophage 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.413AlaAla: 4.413 ± 1.532
0.63AlaCys: 0.63 ± 0.653
4.413AlaAsp: 4.413 ± 0.771
6.094AlaGlu: 6.094 ± 2.68
3.572AlaPhe: 3.572 ± 1.442
3.992AlaGly: 3.992 ± 0.984
0.63AlaHis: 0.63 ± 0.446
5.043AlaIle: 5.043 ± 0.811
7.985AlaLys: 7.985 ± 2.262
4.203AlaLeu: 4.203 ± 1.026
1.261AlaMet: 1.261 ± 0.519
3.992AlaAsn: 3.992 ± 0.973
3.572AlaPro: 3.572 ± 0.783
2.942AlaGln: 2.942 ± 0.986
5.043AlaArg: 5.043 ± 1.328
4.833AlaSer: 4.833 ± 0.539
3.992AlaThr: 3.992 ± 0.689
3.572AlaVal: 3.572 ± 0.638
0.63AlaTrp: 0.63 ± 0.296
1.471AlaTyr: 1.471 ± 0.821
0.0AlaXaa: 0.0 ± 0.0
Cys
0.42CysAla: 0.42 ± 0.335
0.42CysCys: 0.42 ± 0.217
0.841CysAsp: 0.841 ± 0.525
0.42CysGlu: 0.42 ± 0.285
0.42CysPhe: 0.42 ± 0.31
0.63CysGly: 0.63 ± 0.252
0.63CysHis: 0.63 ± 0.443
0.21CysIle: 0.21 ± 0.236
1.051CysLys: 1.051 ± 0.718
0.21CysLeu: 0.21 ± 0.273
0.841CysMet: 0.841 ± 0.444
0.21CysAsn: 0.21 ± 0.273
0.63CysPro: 0.63 ± 0.538
0.0CysGln: 0.0 ± 0.0
0.63CysArg: 0.63 ± 0.271
0.63CysSer: 0.63 ± 0.619
0.0CysThr: 0.0 ± 0.0
1.261CysVal: 1.261 ± 0.692
0.21CysTrp: 0.21 ± 0.265
0.21CysTyr: 0.21 ± 0.262
0.0CysXaa: 0.0 ± 0.0
Asp
6.934AspAla: 6.934 ± 1.704
0.63AspCys: 0.63 ± 0.377
5.884AspAsp: 5.884 ± 1.783
5.253AspGlu: 5.253 ± 1.308
2.732AspPhe: 2.732 ± 0.758
2.942AspGly: 2.942 ± 0.437
0.841AspHis: 0.841 ± 0.609
3.782AspIle: 3.782 ± 0.938
3.362AspLys: 3.362 ± 0.767
6.094AspLeu: 6.094 ± 1.337
1.891AspMet: 1.891 ± 0.483
2.732AspAsn: 2.732 ± 0.652
3.992AspPro: 3.992 ± 1.408
1.891AspGln: 1.891 ± 0.381
1.681AspArg: 1.681 ± 0.494
0.63AspSer: 0.63 ± 0.39
3.362AspThr: 3.362 ± 0.511
2.942AspVal: 2.942 ± 0.672
1.261AspTrp: 1.261 ± 0.541
3.992AspTyr: 3.992 ± 0.863
0.0AspXaa: 0.0 ± 0.0
Glu
3.992GluAla: 3.992 ± 1.897
0.42GluCys: 0.42 ± 0.351
5.253GluAsp: 5.253 ± 1.508
7.144GluGlu: 7.144 ± 3.251
2.942GluPhe: 2.942 ± 0.696
3.782GluGly: 3.782 ± 1.233
1.261GluHis: 1.261 ± 0.46
3.152GluIle: 3.152 ± 0.848
5.673GluLys: 5.673 ± 1.529
4.203GluLeu: 4.203 ± 1.156
4.413GluMet: 4.413 ± 1.068
2.732GluAsn: 2.732 ± 0.833
2.101GluPro: 2.101 ± 0.832
3.152GluGln: 3.152 ± 0.914
5.043GluArg: 5.043 ± 1.442
2.311GluSer: 2.311 ± 0.746
2.942GluThr: 2.942 ± 0.985
3.572GluVal: 3.572 ± 0.444
1.261GluTrp: 1.261 ± 0.552
3.152GluTyr: 3.152 ± 0.671
0.0GluXaa: 0.0 ± 0.0
Phe
3.362PheAla: 3.362 ± 0.606
0.63PheCys: 0.63 ± 0.464
2.101PheAsp: 2.101 ± 0.869
1.051PheGlu: 1.051 ± 0.457
2.311PhePhe: 2.311 ± 0.936
3.152PheGly: 3.152 ± 0.943
0.841PheHis: 0.841 ± 0.487
2.942PheIle: 2.942 ± 0.606
1.681PheLys: 1.681 ± 0.732
2.311PheLeu: 2.311 ± 1.027
0.841PheMet: 0.841 ± 0.349
4.203PheAsn: 4.203 ± 0.911
1.891PhePro: 1.891 ± 0.648
2.101PheGln: 2.101 ± 0.841
1.471PheArg: 1.471 ± 0.528
3.572PheSer: 3.572 ± 1.52
1.891PheThr: 1.891 ± 0.569
1.261PheVal: 1.261 ± 0.594
0.63PheTrp: 0.63 ± 0.469
2.311PheTyr: 2.311 ± 0.527
0.0PheXaa: 0.0 ± 0.0
Gly
5.884GlyAla: 5.884 ± 1.325
0.63GlyCys: 0.63 ± 0.387
3.572GlyAsp: 3.572 ± 1.027
3.782GlyGlu: 3.782 ± 0.783
0.841GlyPhe: 0.841 ± 0.423
4.413GlyGly: 4.413 ± 0.599
1.051GlyHis: 1.051 ± 0.648
3.572GlyIle: 3.572 ± 0.702
4.833GlyLys: 4.833 ± 1.3
4.203GlyLeu: 4.203 ± 0.816
2.101GlyMet: 2.101 ± 0.563
3.152GlyAsn: 3.152 ± 0.977
0.0GlyPro: 0.0 ± 0.0
2.732GlyGln: 2.732 ± 0.678
3.782GlyArg: 3.782 ± 0.836
3.992GlySer: 3.992 ± 0.757
2.942GlyThr: 2.942 ± 1.136
4.623GlyVal: 4.623 ± 1.088
0.63GlyTrp: 0.63 ± 0.351
1.471GlyTyr: 1.471 ± 0.803
0.0GlyXaa: 0.0 ± 0.0
His
0.42HisAla: 0.42 ± 0.255
0.0HisCys: 0.0 ± 0.0
1.051HisAsp: 1.051 ± 0.561
1.051HisGlu: 1.051 ± 0.774
1.051HisPhe: 1.051 ± 0.557
0.42HisGly: 0.42 ± 0.385
0.42HisHis: 0.42 ± 0.351
1.051HisIle: 1.051 ± 0.712
0.841HisLys: 0.841 ± 0.367
1.051HisLeu: 1.051 ± 0.58
0.21HisMet: 0.21 ± 0.223
0.0HisAsn: 0.0 ± 0.0
1.051HisPro: 1.051 ± 0.455
0.42HisGln: 0.42 ± 0.385
2.522HisArg: 2.522 ± 0.989
1.471HisSer: 1.471 ± 0.441
1.261HisThr: 1.261 ± 0.581
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.63HisTyr: 0.63 ± 0.333
0.0HisXaa: 0.0 ± 0.0
Ile
3.362IleAla: 3.362 ± 0.534
1.051IleCys: 1.051 ± 0.791
4.833IleAsp: 4.833 ± 1.062
3.782IleGlu: 3.782 ± 0.977
3.362IlePhe: 3.362 ± 1.054
5.253IleGly: 5.253 ± 0.884
0.63IleHis: 0.63 ± 0.302
2.942IleIle: 2.942 ± 1.214
3.362IleLys: 3.362 ± 0.839
4.413IleLeu: 4.413 ± 0.783
1.471IleMet: 1.471 ± 0.672
2.522IleAsn: 2.522 ± 0.983
2.942IlePro: 2.942 ± 1.041
1.891IleGln: 1.891 ± 0.921
2.732IleArg: 2.732 ± 0.817
2.311IleSer: 2.311 ± 0.589
3.152IleThr: 3.152 ± 1.279
3.992IleVal: 3.992 ± 0.87
0.21IleTrp: 0.21 ± 0.236
3.362IleTyr: 3.362 ± 0.571
0.0IleXaa: 0.0 ± 0.0
Lys
7.144LysAla: 7.144 ± 2.885
0.42LysCys: 0.42 ± 0.351
4.203LysAsp: 4.203 ± 0.828
7.354LysGlu: 7.354 ± 3.287
2.942LysPhe: 2.942 ± 1.177
3.362LysGly: 3.362 ± 0.977
0.63LysHis: 0.63 ± 0.358
4.413LysIle: 4.413 ± 1.107
6.934LysLys: 6.934 ± 1.926
5.884LysLeu: 5.884 ± 1.611
2.732LysMet: 2.732 ± 0.884
3.572LysAsn: 3.572 ± 1.195
5.253LysPro: 5.253 ± 0.916
2.732LysGln: 2.732 ± 1.445
4.413LysArg: 4.413 ± 1.781
6.094LysSer: 6.094 ± 1.21
3.572LysThr: 3.572 ± 1.245
3.782LysVal: 3.782 ± 0.965
1.051LysTrp: 1.051 ± 0.43
2.942LysTyr: 2.942 ± 0.819
0.0LysXaa: 0.0 ± 0.0
Leu
5.043LeuAla: 5.043 ± 1.027
0.841LeuCys: 0.841 ± 0.481
3.992LeuAsp: 3.992 ± 0.839
5.253LeuGlu: 5.253 ± 1.288
2.942LeuPhe: 2.942 ± 0.811
5.043LeuGly: 5.043 ± 0.64
1.471LeuHis: 1.471 ± 0.628
3.152LeuIle: 3.152 ± 0.598
6.724LeuLys: 6.724 ± 1.653
5.253LeuLeu: 5.253 ± 0.953
0.841LeuMet: 0.841 ± 0.316
2.732LeuAsn: 2.732 ± 0.794
4.623LeuPro: 4.623 ± 1.038
3.152LeuGln: 3.152 ± 0.617
5.253LeuArg: 5.253 ± 0.855
4.203LeuSer: 4.203 ± 1.192
6.514LeuThr: 6.514 ± 2.149
6.514LeuVal: 6.514 ± 1.215
1.051LeuTrp: 1.051 ± 0.409
2.732LeuTyr: 2.732 ± 0.769
0.0LeuXaa: 0.0 ± 0.0
Met
1.261MetAla: 1.261 ± 0.42
0.63MetCys: 0.63 ± 0.447
1.471MetAsp: 1.471 ± 0.388
1.471MetGlu: 1.471 ± 0.602
0.63MetPhe: 0.63 ± 0.35
1.261MetGly: 1.261 ± 0.52
0.0MetHis: 0.0 ± 0.0
1.681MetIle: 1.681 ± 0.494
3.782MetLys: 3.782 ± 0.976
2.522MetLeu: 2.522 ± 0.575
1.261MetMet: 1.261 ± 0.414
1.051MetAsn: 1.051 ± 0.47
1.261MetPro: 1.261 ± 0.767
0.0MetGln: 0.0 ± 0.0
1.891MetArg: 1.891 ± 0.68
2.101MetSer: 2.101 ± 0.697
3.362MetThr: 3.362 ± 0.698
1.891MetVal: 1.891 ± 0.706
0.42MetTrp: 0.42 ± 0.285
0.841MetTyr: 0.841 ± 0.508
0.0MetXaa: 0.0 ± 0.0
Asn
4.203AsnAla: 4.203 ± 1.053
0.21AsnCys: 0.21 ± 0.142
2.101AsnAsp: 2.101 ± 0.941
2.732AsnGlu: 2.732 ± 1.317
1.681AsnPhe: 1.681 ± 0.694
2.732AsnGly: 2.732 ± 1.038
0.42AsnHis: 0.42 ± 0.285
2.522AsnIle: 2.522 ± 0.804
5.673AsnLys: 5.673 ± 1.339
5.253AsnLeu: 5.253 ± 1.789
1.051AsnMet: 1.051 ± 0.406
4.833AsnAsn: 4.833 ± 2.293
3.992AsnPro: 3.992 ± 1.019
2.942AsnGln: 2.942 ± 1.144
2.732AsnArg: 2.732 ± 0.79
2.732AsnSer: 2.732 ± 0.831
2.732AsnThr: 2.732 ± 1.107
2.942AsnVal: 2.942 ± 0.99
1.051AsnTrp: 1.051 ± 0.456
3.152AsnTyr: 3.152 ± 1.302
0.0AsnXaa: 0.0 ± 0.0
Pro
3.782ProAla: 3.782 ± 1.006
0.0ProCys: 0.0 ± 0.0
3.782ProAsp: 3.782 ± 0.688
3.572ProGlu: 3.572 ± 0.95
2.942ProPhe: 2.942 ± 0.743
0.0ProGly: 0.0 ± 0.0
1.051ProHis: 1.051 ± 0.455
2.942ProIle: 2.942 ± 0.668
3.992ProLys: 3.992 ± 1.061
4.203ProLeu: 4.203 ± 0.79
0.42ProMet: 0.42 ± 0.345
3.362ProAsn: 3.362 ± 1.687
2.522ProPro: 2.522 ± 1.258
1.891ProGln: 1.891 ± 1.186
3.152ProArg: 3.152 ± 0.835
3.992ProSer: 3.992 ± 0.922
4.203ProThr: 4.203 ± 1.513
2.942ProVal: 2.942 ± 0.832
0.0ProTrp: 0.0 ± 0.0
0.841ProTyr: 0.841 ± 0.519
0.0ProXaa: 0.0 ± 0.0
Gln
2.732GlnAla: 2.732 ± 0.621
0.0GlnCys: 0.0 ± 0.0
3.152GlnAsp: 3.152 ± 0.911
1.681GlnGlu: 1.681 ± 0.558
0.841GlnPhe: 0.841 ± 0.294
1.681GlnGly: 1.681 ± 0.755
0.63GlnHis: 0.63 ± 0.472
2.942GlnIle: 2.942 ± 0.849
1.891GlnLys: 1.891 ± 0.702
3.782GlnLeu: 3.782 ± 0.962
1.681GlnMet: 1.681 ± 0.665
2.732GlnAsn: 2.732 ± 1.312
1.471GlnPro: 1.471 ± 0.459
2.942GlnGln: 2.942 ± 0.872
2.732GlnArg: 2.732 ± 0.897
2.101GlnSer: 2.101 ± 0.602
3.572GlnThr: 3.572 ± 1.359
1.891GlnVal: 1.891 ± 0.758
0.0GlnTrp: 0.0 ± 0.0
1.051GlnTyr: 1.051 ± 0.518
0.0GlnXaa: 0.0 ± 0.0
Arg
3.152ArgAla: 3.152 ± 1.163
0.63ArgCys: 0.63 ± 0.521
2.942ArgAsp: 2.942 ± 0.858
3.782ArgGlu: 3.782 ± 1.546
2.732ArgPhe: 2.732 ± 0.7
3.782ArgGly: 3.782 ± 1.097
1.051ArgHis: 1.051 ± 0.552
3.992ArgIle: 3.992 ± 1.266
5.884ArgLys: 5.884 ± 1.278
3.992ArgLeu: 3.992 ± 1.286
2.311ArgMet: 2.311 ± 0.714
3.572ArgAsn: 3.572 ± 0.784
1.891ArgPro: 1.891 ± 0.57
3.152ArgGln: 3.152 ± 0.999
3.152ArgArg: 3.152 ± 1.061
2.311ArgSer: 2.311 ± 0.631
1.471ArgThr: 1.471 ± 0.499
4.203ArgVal: 4.203 ± 0.74
1.681ArgTrp: 1.681 ± 0.622
1.261ArgTyr: 1.261 ± 0.651
0.0ArgXaa: 0.0 ± 0.0
Ser
5.253SerAla: 5.253 ± 1.449
0.841SerCys: 0.841 ± 0.401
2.522SerAsp: 2.522 ± 0.768
2.732SerGlu: 2.732 ± 0.764
1.891SerPhe: 1.891 ± 0.777
3.992SerGly: 3.992 ± 0.745
1.681SerHis: 1.681 ± 0.564
5.253SerIle: 5.253 ± 0.968
3.362SerLys: 3.362 ± 0.702
4.413SerLeu: 4.413 ± 1.015
1.681SerMet: 1.681 ± 0.63
4.833SerAsn: 4.833 ± 0.794
2.732SerPro: 2.732 ± 1.07
2.101SerGln: 2.101 ± 0.88
2.522SerArg: 2.522 ± 0.519
3.362SerSer: 3.362 ± 1.415
2.732SerThr: 2.732 ± 1.15
3.572SerVal: 3.572 ± 1.015
0.63SerTrp: 0.63 ± 0.291
1.891SerTyr: 1.891 ± 0.485
0.0SerXaa: 0.0 ± 0.0
Thr
3.362ThrAla: 3.362 ± 1.227
0.21ThrCys: 0.21 ± 0.225
3.782ThrAsp: 3.782 ± 0.572
4.623ThrGlu: 4.623 ± 0.87
2.311ThrPhe: 2.311 ± 0.881
4.203ThrGly: 4.203 ± 0.714
1.051ThrHis: 1.051 ± 0.591
2.942ThrIle: 2.942 ± 1.107
4.203ThrLys: 4.203 ± 1.488
5.463ThrLeu: 5.463 ± 1.229
0.42ThrMet: 0.42 ± 0.365
2.942ThrAsn: 2.942 ± 0.622
5.463ThrPro: 5.463 ± 1.424
2.732ThrGln: 2.732 ± 0.787
2.311ThrArg: 2.311 ± 0.599
3.152ThrSer: 3.152 ± 1.691
5.253ThrThr: 5.253 ± 1.616
1.471ThrVal: 1.471 ± 0.626
0.63ThrTrp: 0.63 ± 0.252
2.942ThrTyr: 2.942 ± 1.521
0.0ThrXaa: 0.0 ± 0.0
Val
4.203ValAla: 4.203 ± 1.146
1.051ValCys: 1.051 ± 0.367
2.942ValAsp: 2.942 ± 0.828
4.623ValGlu: 4.623 ± 1.082
2.942ValPhe: 2.942 ± 0.896
3.782ValGly: 3.782 ± 0.695
0.21ValHis: 0.21 ± 0.302
2.942ValIle: 2.942 ± 0.917
4.833ValLys: 4.833 ± 1.148
5.884ValLeu: 5.884 ± 1.739
1.681ValMet: 1.681 ± 0.67
3.362ValAsn: 3.362 ± 0.558
1.471ValPro: 1.471 ± 0.592
1.261ValGln: 1.261 ± 0.521
3.152ValArg: 3.152 ± 0.918
5.673ValSer: 5.673 ± 1.478
2.311ValThr: 2.311 ± 1.511
4.833ValVal: 4.833 ± 0.962
0.21ValTrp: 0.21 ± 0.223
1.681ValTyr: 1.681 ± 0.521
0.0ValXaa: 0.0 ± 0.0
Trp
0.841TrpAla: 0.841 ± 0.396
0.21TrpCys: 0.21 ± 0.302
0.63TrpAsp: 0.63 ± 0.302
1.261TrpGlu: 1.261 ± 0.449
0.63TrpPhe: 0.63 ± 0.325
0.63TrpGly: 0.63 ± 0.349
0.21TrpHis: 0.21 ± 0.142
0.63TrpIle: 0.63 ± 0.307
1.051TrpLys: 1.051 ± 0.449
0.63TrpLeu: 0.63 ± 0.472
0.21TrpMet: 0.21 ± 0.142
0.841TrpAsn: 0.841 ± 0.653
0.0TrpPro: 0.0 ± 0.0
0.63TrpGln: 0.63 ± 0.55
0.63TrpArg: 0.63 ± 0.314
0.63TrpSer: 0.63 ± 0.346
1.471TrpThr: 1.471 ± 0.747
0.63TrpVal: 0.63 ± 0.385
0.0TrpTrp: 0.0 ± 0.0
0.63TrpTyr: 0.63 ± 0.337
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.522TyrAla: 2.522 ± 0.556
0.42TyrCys: 0.42 ± 0.253
3.362TyrAsp: 3.362 ± 1.144
1.051TyrGlu: 1.051 ± 0.314
0.841TyrPhe: 0.841 ± 0.427
3.152TyrGly: 3.152 ± 0.732
0.21TyrHis: 0.21 ± 0.225
1.471TyrIle: 1.471 ± 0.365
2.311TyrLys: 2.311 ± 0.757
3.362TyrLeu: 3.362 ± 1.166
1.261TyrMet: 1.261 ± 0.543
2.311TyrAsn: 2.311 ± 1.084
2.732TyrPro: 2.732 ± 0.513
0.841TyrGln: 0.841 ± 0.322
2.101TyrArg: 2.101 ± 0.699
1.891TyrSer: 1.891 ± 0.748
2.732TyrThr: 2.732 ± 0.861
3.152TyrVal: 3.152 ± 0.673
0.841TyrTrp: 0.841 ± 0.39
2.522TyrTyr: 2.522 ± 1.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (4760 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski