Amino acid dipepetide frequency for marine gamma proteobacterium HTCC2143

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.622AlaAla: 9.622 ± 0.139	1.033AlaCys: 1.033 ± 0.031	5.549AlaAsp: 5.549 ± 0.083	5.917AlaGlu: 5.917 ± 0.084	3.308AlaPhe: 3.308 ± 0.057	7.255AlaGly: 7.255 ± 0.103	1.636AlaHis: 1.636 ± 0.042	6.291AlaIle: 6.291 ± 0.075	4.169AlaLys: 4.169 ± 0.079	9.463AlaLeu: 9.463 ± 0.115	2.75AlaMet: 2.75 ± 0.055	3.472AlaAsn: 3.472 ± 0.053	3.144AlaPro: 3.144 ± 0.059	3.268AlaGln: 3.268 ± 0.046	4.16AlaArg: 4.16 ± 0.06	5.821AlaSer: 5.821 ± 0.081	4.894AlaThr: 4.894 ± 0.072	6.824AlaVal: 6.824 ± 0.077	0.968AlaTrp: 0.968 ± 0.029	2.378AlaTyr: 2.378 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.874CysAla: 0.874 ± 0.03	0.189CysCys: 0.189 ± 0.013	0.676CysAsp: 0.676 ± 0.028	0.607CysGlu: 0.607 ± 0.026	0.432CysPhe: 0.432 ± 0.02	0.957CysGly: 0.957 ± 0.033	0.343CysHis: 0.343 ± 0.019	0.595CysIle: 0.595 ± 0.023	0.38CysLys: 0.38 ± 0.018	0.955CysLeu: 0.955 ± 0.029	0.218CysMet: 0.218 ± 0.015	0.335CysAsn: 0.335 ± 0.019	0.496CysPro: 0.496 ± 0.022	0.414CysGln: 0.414 ± 0.021	0.564CysArg: 0.564 ± 0.023	0.732CysSer: 0.732 ± 0.026	0.501CysThr: 0.501 ± 0.023	0.678CysVal: 0.678 ± 0.023	0.143CysTrp: 0.143 ± 0.011	0.312CysTyr: 0.312 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.94AspAla: 4.94 ± 0.073	0.627AspCys: 0.627 ± 0.027	3.667AspAsp: 3.667 ± 0.068	3.805AspGlu: 3.805 ± 0.07	2.484AspPhe: 2.484 ± 0.05	4.328AspGly: 4.328 ± 0.07	1.311AspHis: 1.311 ± 0.036	4.189AspIle: 4.189 ± 0.059	2.701AspLys: 2.701 ± 0.048	5.443AspLeu: 5.443 ± 0.079	1.507AspMet: 1.507 ± 0.04	2.552AspAsn: 2.552 ± 0.052	2.504AspPro: 2.504 ± 0.049	2.465AspGln: 2.465 ± 0.05	3.198AspArg: 3.198 ± 0.06	3.656AspSer: 3.656 ± 0.06	2.863AspThr: 2.863 ± 0.049	4.154AspVal: 4.154 ± 0.06	0.909AspTrp: 0.909 ± 0.031	2.153AspTyr: 2.153 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	5.11GluAla: 5.11 ± 0.068	0.475GluCys: 0.475 ± 0.021	2.901GluAsp: 2.901 ± 0.053	3.599GluGlu: 3.599 ± 0.062	2.212GluPhe: 2.212 ± 0.045	3.837GluGly: 3.837 ± 0.067	1.377GluHis: 1.377 ± 0.037	3.981GluIle: 3.981 ± 0.068	3.524GluLys: 3.524 ± 0.068	6.495GluLeu: 6.495 ± 0.077	1.637GluMet: 1.637 ± 0.039	2.472GluAsn: 2.472 ± 0.05	2.078GluPro: 2.078 ± 0.061	3.356GluGln: 3.356 ± 0.07	3.412GluArg: 3.412 ± 0.056	3.632GluSer: 3.632 ± 0.061	3.208GluThr: 3.208 ± 0.062	3.975GluVal: 3.975 ± 0.069	0.766GluTrp: 0.766 ± 0.028	1.628GluTyr: 1.628 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.239PheAla: 3.239 ± 0.049	0.533PheCys: 0.533 ± 0.023	2.806PheAsp: 2.806 ± 0.052	2.265PheGlu: 2.265 ± 0.044	1.807PhePhe: 1.807 ± 0.058	3.318PheGly: 3.318 ± 0.057	0.825PheHis: 0.825 ± 0.027	2.452PheIle: 2.452 ± 0.048	1.537PheLys: 1.537 ± 0.034	3.459PheLeu: 3.459 ± 0.064	0.957PheMet: 0.957 ± 0.034	1.736PheAsn: 1.736 ± 0.046	1.578PhePro: 1.578 ± 0.037	1.305PheGln: 1.305 ± 0.032	1.697PheArg: 1.697 ± 0.04	3.393PheSer: 3.393 ± 0.062	2.181PheThr: 2.181 ± 0.052	2.705PheVal: 2.705 ± 0.05	0.481PheTrp: 0.481 ± 0.022	1.312PheTyr: 1.312 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	6.294GlyAla: 6.294 ± 0.088	0.873GlyCys: 0.873 ± 0.029	4.394GlyAsp: 4.394 ± 0.07	4.38GlyGlu: 4.38 ± 0.072	3.518GlyPhe: 3.518 ± 0.067	5.659GlyGly: 5.659 ± 0.094	1.724GlyHis: 1.724 ± 0.036	5.114GlyIle: 5.114 ± 0.077	3.767GlyLys: 3.767 ± 0.051	7.5GlyLeu: 7.5 ± 0.091	2.249GlyMet: 2.249 ± 0.048	2.67GlyAsn: 2.67 ± 0.049	2.285GlyPro: 2.285 ± 0.046	2.745GlyGln: 2.745 ± 0.051	3.79GlyArg: 3.79 ± 0.061	4.85GlySer: 4.85 ± 0.071	3.599GlyThr: 3.599 ± 0.065	5.494GlyVal: 5.494 ± 0.078	1.097GlyTrp: 1.097 ± 0.03	2.506GlyTyr: 2.506 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.542HisAla: 1.542 ± 0.036	0.339HisCys: 0.339 ± 0.019	1.029HisAsp: 1.029 ± 0.03	0.978HisGlu: 0.978 ± 0.029	0.95HisPhe: 0.95 ± 0.028	1.667HisGly: 1.667 ± 0.041	0.692HisHis: 0.692 ± 0.026	1.364HisIle: 1.364 ± 0.032	0.786HisLys: 0.786 ± 0.027	2.09HisLeu: 2.09 ± 0.042	0.52HisMet: 0.52 ± 0.02	0.826HisAsn: 0.826 ± 0.031	1.236HisPro: 1.236 ± 0.04	1.102HisGln: 1.102 ± 0.03	1.362HisArg: 1.362 ± 0.041	1.472HisSer: 1.472 ± 0.034	1.017HisThr: 1.017 ± 0.028	1.239HisVal: 1.239 ± 0.033	0.384HisTrp: 0.384 ± 0.021	0.867HisTyr: 0.867 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.886IleAla: 6.886 ± 0.094	0.706IleCys: 0.706 ± 0.028	4.92IleAsp: 4.92 ± 0.068	4.33IleGlu: 4.33 ± 0.071	2.321IlePhe: 2.321 ± 0.049	4.861IleGly: 4.861 ± 0.072	1.276IleHis: 1.276 ± 0.039	3.88IleIle: 3.88 ± 0.057	2.844IleLys: 2.844 ± 0.053	5.176IleLeu: 5.176 ± 0.081	1.372IleMet: 1.372 ± 0.038	2.974IleAsn: 2.974 ± 0.052	2.841IlePro: 2.841 ± 0.054	1.961IleGln: 1.961 ± 0.044	3.022IleArg: 3.022 ± 0.047	4.453IleSer: 4.453 ± 0.07	3.669IleThr: 3.669 ± 0.05	4.484IleVal: 4.484 ± 0.063	0.596IleTrp: 0.596 ± 0.022	1.74IleTyr: 1.74 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.018LysAla: 4.018 ± 0.077	0.28LysCys: 0.28 ± 0.016	2.342LysAsp: 2.342 ± 0.052	2.624LysGlu: 2.624 ± 0.05	1.266LysPhe: 1.266 ± 0.037	2.94LysGly: 2.94 ± 0.055	0.956LysHis: 0.956 ± 0.03	2.953LysIle: 2.953 ± 0.056	2.718LysLys: 2.718 ± 0.063	4.442LysLeu: 4.442 ± 0.069	1.197LysMet: 1.197 ± 0.036	2.047LysAsn: 2.047 ± 0.049	2.165LysPro: 2.165 ± 0.042	2.034LysGln: 2.034 ± 0.048	2.473LysArg: 2.473 ± 0.052	2.837LysSer: 2.837 ± 0.048	2.804LysThr: 2.804 ± 0.054	3.044LysVal: 3.044 ± 0.054	0.452LysTrp: 0.452 ± 0.02	1.124LysTyr: 1.124 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	9.944LeuAla: 9.944 ± 0.1	1.053LeuCys: 1.053 ± 0.032	5.945LeuAsp: 5.945 ± 0.089	5.708LeuGlu: 5.708 ± 0.087	3.982LeuPhe: 3.982 ± 0.073	7.149LeuGly: 7.149 ± 0.08	1.946LeuHis: 1.946 ± 0.043	6.053LeuIle: 6.053 ± 0.082	4.55LeuLys: 4.55 ± 0.072	10.492LeuLeu: 10.492 ± 0.157	2.727LeuMet: 2.727 ± 0.054	3.814LeuAsn: 3.814 ± 0.059	4.704LeuPro: 4.704 ± 0.072	4.064LeuGln: 4.064 ± 0.065	5.0LeuArg: 5.0 ± 0.077	7.551LeuSer: 7.551 ± 0.096	5.379LeuThr: 5.379 ± 0.071	6.952LeuVal: 6.952 ± 0.084	1.195LeuTrp: 1.195 ± 0.035	2.43LeuTyr: 2.43 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.727MetAla: 2.727 ± 0.056	0.202MetCys: 0.202 ± 0.013	1.33MetAsp: 1.33 ± 0.029	1.436MetGlu: 1.436 ± 0.037	0.8MetPhe: 0.8 ± 0.028	2.039MetGly: 2.039 ± 0.051	0.509MetHis: 0.509 ± 0.023	1.658MetIle: 1.658 ± 0.038	1.227MetLys: 1.227 ± 0.028	2.615MetLeu: 2.615 ± 0.051	0.784MetMet: 0.784 ± 0.028	1.098MetAsn: 1.098 ± 0.032	1.327MetPro: 1.327 ± 0.038	1.029MetGln: 1.029 ± 0.03	1.321MetArg: 1.321 ± 0.033	2.015MetSer: 2.015 ± 0.042	1.762MetThr: 1.762 ± 0.044	1.879MetVal: 1.879 ± 0.039	0.23MetTrp: 0.23 ± 0.014	0.493MetTyr: 0.493 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.411AsnAla: 3.411 ± 0.059	0.409AsnCys: 0.409 ± 0.021	2.3AsnAsp: 2.3 ± 0.046	2.102AsnGlu: 2.102 ± 0.044	1.558AsnPhe: 1.558 ± 0.04	2.956AsnGly: 2.956 ± 0.055	0.832AsnHis: 0.832 ± 0.029	2.725AsnIle: 2.725 ± 0.049	1.682AsnLys: 1.682 ± 0.043	3.52AsnLeu: 3.52 ± 0.06	0.938AsnMet: 0.938 ± 0.03	1.85AsnAsn: 1.85 ± 0.042	2.102AsnPro: 2.102 ± 0.045	1.578AsnGln: 1.578 ± 0.035	2.139AsnArg: 2.139 ± 0.051	2.626AsnSer: 2.626 ± 0.049	2.299AsnThr: 2.299 ± 0.056	2.536AsnVal: 2.536 ± 0.049	0.583AsnTrp: 0.583 ± 0.021	1.298AsnTyr: 1.298 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.754ProAla: 3.754 ± 0.065	0.322ProCys: 0.322 ± 0.017	2.721ProAsp: 2.721 ± 0.051	3.178ProGlu: 3.178 ± 0.062	1.759ProPhe: 1.759 ± 0.038	3.086ProGly: 3.086 ± 0.059	0.883ProHis: 0.883 ± 0.027	2.556ProIle: 2.556 ± 0.05	1.755ProLys: 1.755 ± 0.04	4.283ProLeu: 4.283 ± 0.065	1.172ProMet: 1.172 ± 0.035	1.586ProAsn: 1.586 ± 0.035	1.55ProPro: 1.55 ± 0.039	1.559ProGln: 1.559 ± 0.044	1.769ProArg: 1.769 ± 0.041	2.677ProSer: 2.677 ± 0.051	2.24ProThr: 2.24 ± 0.051	3.246ProVal: 3.246 ± 0.052	0.559ProTrp: 0.559 ± 0.022	1.191ProTyr: 1.191 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.806GlnAla: 3.806 ± 0.055	0.438GlnCys: 0.438 ± 0.024	1.692GlnAsp: 1.692 ± 0.038	1.995GlnGlu: 1.995 ± 0.051	1.61GlnPhe: 1.61 ± 0.036	2.694GlnGly: 2.694 ± 0.049	1.102GlnHis: 1.102 ± 0.031	2.223GlnIle: 2.223 ± 0.043	1.684GlnLys: 1.684 ± 0.043	5.152GlnLeu: 5.152 ± 0.096	1.089GlnMet: 1.089 ± 0.031	1.266GlnAsn: 1.266 ± 0.038	1.676GlnPro: 1.676 ± 0.037	3.145GlnGln: 3.145 ± 0.077	2.697GlnArg: 2.697 ± 0.05	2.686GlnSer: 2.686 ± 0.052	1.973GlnThr: 1.973 ± 0.039	2.633GlnVal: 2.633 ± 0.05	0.729GlnTrp: 0.729 ± 0.023	1.099GlnTyr: 1.099 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	4.193ArgAla: 4.193 ± 0.053	0.546ArgCys: 0.546 ± 0.023	2.991ArgAsp: 2.991 ± 0.053	3.255ArgGlu: 3.255 ± 0.063	2.273ArgPhe: 2.273 ± 0.056	3.377ArgGly: 3.377 ± 0.056	1.258ArgHis: 1.258 ± 0.033	3.227ArgIle: 3.227 ± 0.055	2.314ArgLys: 2.314 ± 0.053	5.523ArgLeu: 5.523 ± 0.079	1.363ArgMet: 1.363 ± 0.034	1.897ArgAsn: 1.897 ± 0.04	1.933ArgPro: 1.933 ± 0.042	2.567ArgGln: 2.567 ± 0.051	3.109ArgArg: 3.109 ± 0.06	3.289ArgSer: 3.289 ± 0.057	2.269ArgThr: 2.269 ± 0.044	3.524ArgVal: 3.524 ± 0.062	0.845ArgTrp: 0.845 ± 0.025	1.865ArgTyr: 1.865 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.182SerAla: 6.182 ± 0.083	0.672SerCys: 0.672 ± 0.027	4.066SerAsp: 4.066 ± 0.06	3.896SerGlu: 3.896 ± 0.064	2.728SerPhe: 2.728 ± 0.053	5.651SerGly: 5.651 ± 0.071	1.443SerHis: 1.443 ± 0.037	4.336SerIle: 4.336 ± 0.064	2.745SerLys: 2.745 ± 0.054	6.965SerLeu: 6.965 ± 0.086	1.804SerMet: 1.804 ± 0.04	2.61SerAsn: 2.61 ± 0.053	2.885SerPro: 2.885 ± 0.053	2.543SerGln: 2.543 ± 0.046	3.528SerArg: 3.528 ± 0.058	4.633SerSer: 4.633 ± 0.064	3.361SerThr: 3.361 ± 0.056	4.659SerVal: 4.659 ± 0.067	0.914SerTrp: 0.914 ± 0.029	1.933SerTyr: 1.933 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	5.189ThrAla: 5.189 ± 0.083	0.43ThrCys: 0.43 ± 0.02	3.168ThrAsp: 3.168 ± 0.069	3.195ThrGlu: 3.195 ± 0.053	1.947ThrPhe: 1.947 ± 0.047	4.517ThrGly: 4.517 ± 0.074	1.081ThrHis: 1.081 ± 0.029	3.577ThrIle: 3.577 ± 0.054	1.863ThrLys: 1.863 ± 0.043	5.717ThrLeu: 5.717 ± 0.07	1.332ThrMet: 1.332 ± 0.034	1.902ThrAsn: 1.902 ± 0.043	2.628ThrPro: 2.628 ± 0.052	1.825ThrGln: 1.825 ± 0.036	2.385ThrArg: 2.385 ± 0.051	3.324ThrSer: 3.324 ± 0.058	2.981ThrThr: 2.981 ± 0.057	4.114ThrVal: 4.114 ± 0.066	0.524ThrTrp: 0.524 ± 0.022	1.368ThrTyr: 1.368 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.934ValAla: 6.934 ± 0.095	0.723ValCys: 0.723 ± 0.025	4.667ValAsp: 4.667 ± 0.071	4.381ValGlu: 4.381 ± 0.068	2.75ValPhe: 2.75 ± 0.049	5.069ValGly: 5.069 ± 0.071	1.25ValHis: 1.25 ± 0.036	4.817ValIle: 4.817 ± 0.068	2.892ValLys: 2.892 ± 0.059	6.748ValLeu: 6.748 ± 0.091	1.89ValMet: 1.89 ± 0.038	2.85ValAsn: 2.85 ± 0.055	2.861ValPro: 2.861 ± 0.047	2.005ValGln: 2.005 ± 0.045	3.336ValArg: 3.336 ± 0.056	4.941ValSer: 4.941 ± 0.074	3.956ValThr: 3.956 ± 0.065	5.554ValVal: 5.554 ± 0.082	0.823ValTrp: 0.823 ± 0.03	1.809ValTyr: 1.809 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.941TrpAla: 0.941 ± 0.034	0.176TrpCys: 0.176 ± 0.013	0.674TrpAsp: 0.674 ± 0.023	0.585TrpGlu: 0.585 ± 0.024	0.52TrpPhe: 0.52 ± 0.02	0.848TrpGly: 0.848 ± 0.03	0.334TrpHis: 0.334 ± 0.016	0.769TrpIle: 0.769 ± 0.025	0.456TrpLys: 0.456 ± 0.021	1.578TrpLeu: 1.578 ± 0.036	0.366TrpMet: 0.366 ± 0.017	0.483TrpAsn: 0.483 ± 0.022	0.56TrpPro: 0.56 ± 0.024	0.807TrpGln: 0.807 ± 0.029	0.793TrpArg: 0.793 ± 0.025	0.895TrpSer: 0.895 ± 0.031	0.634TrpThr: 0.634 ± 0.026	0.886TrpVal: 0.886 ± 0.032	0.198TrpTrp: 0.198 ± 0.013	0.351TrpTyr: 0.351 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.315TyrAla: 2.315 ± 0.049	0.376TyrCys: 0.376 ± 0.019	1.615TyrAsp: 1.615 ± 0.042	1.442TyrGlu: 1.442 ± 0.033	1.363TyrPhe: 1.363 ± 0.04	2.299TyrGly: 2.299 ± 0.05	0.683TyrHis: 0.683 ± 0.025	1.552TyrIle: 1.552 ± 0.031	1.123TyrLys: 1.123 ± 0.033	3.023TyrLeu: 3.023 ± 0.055	0.604TyrMet: 0.604 ± 0.024	1.005TyrAsn: 1.005 ± 0.029	1.29TyrPro: 1.29 ± 0.036	1.614TyrGln: 1.614 ± 0.042	1.866TyrArg: 1.866 ± 0.043	2.075TyrSer: 2.075 ± 0.05	1.479TyrThr: 1.479 ± 0.034	1.676TyrVal: 1.676 ± 0.037	0.456TyrTrp: 0.456 ± 0.021	0.954TyrTyr: 0.954 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3661 proteins (1126783 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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